Maneb


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000737 Dna catabolic process, endonucleolytic Increases phenotype PMID:34830855
GO:0001662 Behavioral fear response Affects phenotype PMID:33368748
GO:0001774 Microglial cell activation Increases phenotype PMID:28202386; PMID:29568078; PMID:32375810; PMID:34052309
GO:0001775 Cell activation Increases phenotype PMID:23562983
GO:0001836 Release of cytochrome c from mitochondria Increases phenotype PMID:18266926
GO:0004030 Aldehyde dehydrogenase [nad(p)+] activity Decreases phenotype PMID:24491970
GO:0004457 Lactate dehydrogenase activity Increases phenotype PMID:30797899
GO:0006117 Acetaldehyde metabolic process Affects phenotype PMID:34830855
GO:0006749 Glutathione metabolic process Affects phenotype PMID:26210702
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:30797899
GO:0006915 Apoptotic process Increases phenotype PMID:23985028; PMID:24290359
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:19591892; PMID:24764117
GO:0007005 Mitochondrion organization Decreases phenotype PMID:33368748
GO:0007029 Endoplasmic reticulum organization Decreases phenotype PMID:33368748
GO:0007030 Golgi organization Decreases phenotype PMID:33368748
GO:0007204 Positive regulation of cytosolic calcium ion concentration Increases phenotype PMID:34897981
GO:0007613 Memory Affects phenotype PMID:33368748
GO:0008137 Nadh dehydrogenase (ubiquinone) activity Decreases phenotype PMID:23562983
GO:0008219 Cell death Increases phenotype PMID:23744253; PMID:28202386; PMID:30797899
GO:0008283 Cell population proliferation Decreases phenotype PMID:23744253; PMID:24764117; PMID:29859004; PMID:34830855
GO:0009060 Aerobic respiration Affects phenotype PMID:29767788
GO:0010729 Positive regulation of hydrogen peroxide biosynthetic process Increases phenotype PMID:26210702
GO:0010917 Negative regulation of mitochondrial membrane potential Increases phenotype PMID:34897981
GO:0010942 Positive regulation of cell death Increases phenotype PMID:24486957; PMID:26498265
GO:0016042 Lipid catabolic process Increases phenotype PMID:29568078; PMID:30797899; PMID:32375810; PMID:34052309
GO:0016049 Cell growth Decreases phenotype PMID:30797899
GO:0018158 Protein oxidation Increases phenotype PMID:26210702
GO:0019852 L-ascorbic acid metabolic process Affects phenotype PMID:26210702
GO:0030262 Apoptotic nuclear changes Increases phenotype PMID:34897981
GO:0030263 Apoptotic chromosome condensation Increases phenotype PMID:33368748
GO:0032790 Ribosome disassembly Affects phenotype PMID:33368748
GO:0033212 Iron import into cell Increases phenotype PMID:30797899
GO:0034440 Lipid oxidation Increases phenotype PMID:26210702
GO:0042416 Dopamine biosynthetic process Decreases phenotype PMID:23562983
GO:0042554 Superoxide anion generation Increases phenotype PMID:28202386; PMID:29568078; PMID:30797899
GO:0042755 Eating behavior Affects phenotype PMID:33368748
GO:0044850 Menstrual cycle Affects phenotype PMID:15583372
GO:0045820 Negative regulation of glycolytic process Increases phenotype PMID:29767788
GO:0046058 Camp metabolic process Affects phenotype PMID:27460631; PMID:33368748; PMID:33368748
GO:0050808 Synapse organization Decreases phenotype PMID:33368748
GO:0055088 Lipid homeostasis Decreases phenotype PMID:26210702
GO:0061621 Canonical glycolysis Decreases phenotype PMID:29767788
GO:0070050 Neuron cellular homeostasis Affects phenotype PMID:32375810
GO:0070997 Neuron death Increases phenotype PMID:29568078; PMID:33368748; PMID:34052309
GO:0072593 Reactive oxygen species metabolic process Affects phenotype PMID:32375810; PMID:34052309
GO:0090398 Cellular senescence Increases phenotype PMID:34830855
GO:0090659 Walking behavior Affects phenotype PMID:29568078; PMID:30797899; PMID:34052309
GO:0097707 Ferroptosis Increases phenotype PMID:30797899
GO:0099558 Maintenance of synapse structure Decreases phenotype PMID:32169474
GO:1901216 Positive regulation of neuron death Increases phenotype PMID:32169474
GO:1901671 Positive regulation of superoxide dismutase activity Decreases phenotype PMID:26210702
GO:1903284 Positive regulation of glutathione peroxidase activity Decreases phenotype PMID:26210702
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:29859004
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:34897981
GO:1903626 Positive regulation of dna catabolic process Increases phenotype PMID:26210702
GO:1903980 Positive regulation of microglial cell activation Increases phenotype PMID:32169474
GO:1905809 Negative regulation of synapse organization Increases phenotype PMID:32169474
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.