DEDUCT | Database of Endocrine Disrupting chemicals and their Toxicity profiles

Tributylstannane

Curated chemical-phenotype interactions from CTD

GO ID	GO name	Interaction type	Reference
GO:0000226	Microtubule cytoskeleton organization	Decreases phenotype	PMID:21626652
GO:0001541	Ovarian follicle development	Affects phenotype	PMID:29908848
GO:0001547	Antral ovarian follicle growth	Decreases phenotype	PMID:32239163
GO:0001553	Luteinization	Decreases phenotype	PMID:28161095
GO:0001782	B cell homeostasis	Affects phenotype	PMID:28398592
GO:0001892	Embryonic placenta development	Affects phenotype	PMID:33720505
GO:0001944	Vasculature development	Increases phenotype	PMID:38936095
GO:0002420	Natural killer cell mediated cytotoxicity directed against tumor cell target	Decreases phenotype	PMID:17149696
GO:0002523	Leukocyte migration involved in inflammatory response	Increases phenotype	PMID:38936095
GO:0002693	Positive regulation of cellular extravasation	Increases phenotype	PMID:28161095
GO:0003309	Type b pancreatic cell differentiation	Decreases phenotype	PMID:31306684
GO:0004016	Adenylate cyclase activity	Decreases phenotype	PMID:29549738
GO:0004035	Alkaline phosphatase activity	Affects phenotype	PMID:28011154; PMID:32473317
GO:0004198	Calcium-dependent cysteine-type endopeptidase activity	Increases phenotype	PMID:28707438
GO:0004449	Isocitrate dehydrogenase (nad+) activity	Decreases phenotype	PMID:26961604
GO:0004561	Alpha-n-acetylglucosaminidase activity	Increases phenotype	PMID:38936095
GO:0004602	Glutathione peroxidase activity	Decreases phenotype	PMID:32783468
GO:0004707	Map kinase activity	Increases phenotype	PMID:21626652
GO:0004784	Superoxide dismutase activity	Decreases phenotype	PMID:33720505
GO:0005977	Glycogen metabolic process	Increases phenotype	PMID:31306684
GO:0006006	Glucose metabolic process	Decreases phenotype	PMID:28993852
GO:0006090	Pyruvate metabolic process	Decreases phenotype	PMID:28993852
GO:0006171	Camp biosynthetic process	Decreases phenotype	PMID:29549738
GO:0006309	Apoptotic dna fragmentation	Increases phenotype	PMID:11097871; PMID:1649056
GO:0006523	Alanine biosynthetic process	Decreases phenotype	PMID:28993852
GO:0006629	Lipid metabolic process	Increases phenotype	PMID:38936095
GO:0006686	Sphingomyelin biosynthetic process	Decreases phenotype	PMID:38630605
GO:0006695	Cholesterol biosynthetic process	Increases phenotype	PMID:29908848; PMID:30172001
GO:0006749	Glutathione metabolic process	Increases phenotype	PMID:25895139; PMID:26079211; PMID:27521499
GO:0006750	Glutathione biosynthetic process	Decreases phenotype	PMID:26961604; PMID:28707438
GO:0006754	Atp biosynthetic process	Decreases phenotype	PMID:17149696; PMID:27129022; PMID:29549738
GO:0006915	Apoptotic process	Increases phenotype	PMID:11097871; PMID:21626652; PMID:22223438; PMID:25062436; PMID:27678064; PMID:29908848; PMID:35430282; PMID:35563431; PMID:36613676; PMID:8048048
GO:0006919	Activation of cysteine-type endopeptidase activity involved in apoptotic process	Increases phenotype	PMID:25841707
GO:0006954	Inflammatory response	Increases phenotype	PMID:32239163
GO:0007204	Positive regulation of cytosolic calcium ion concentration	Increases phenotype	PMID:28180948
GO:0007283	Spermatogenesis	Affects phenotype	PMID:28707438; PMID:32783468
GO:0007613	Memory	Affects phenotype	PMID:35295135
GO:0008210	Estrogen metabolic process	Affects phenotype	PMID:26873547
GO:0008219	Cell death	Increases phenotype	PMID:1649056; PMID:34329126
GO:0008234	Cysteine-type peptidase activity	Increases phenotype	PMID:35563431
GO:0008283	Cell population proliferation	Decreases phenotype	PMID:25062436; PMID:27678064; PMID:28709983; PMID:30172001; PMID:33720505; PMID:35430282
GO:0008284	Positive regulation of cell population proliferation	Affects phenotype	PMID:25743928; PMID:28161095
GO:0008285	Negative regulation of cell population proliferation	Increases phenotype	PMID:28398592; PMID:29580985; PMID:32353385
GO:0008361	Regulation of cell size	Affects phenotype	PMID:30172001
GO:0008610	Lipid biosynthetic process	Increases phenotype	PMID:25819109; PMID:27815650; PMID:28011154; PMID:29787037; PMID:29787037
GO:0009060	Aerobic respiration	Decreases phenotype	PMID:27129022
GO:0010508	Positive regulation of autophagy	Decreases phenotype	PMID:26079211
GO:0010635	Regulation of mitochondrial fusion	Affects phenotype	PMID:33481012
GO:0010729	Positive regulation of hydrogen peroxide biosynthetic process	Increases phenotype	PMID:27521499
GO:0010759	Positive regulation of macrophage chemotaxis	Increases phenotype	PMID:27521499
GO:0010867	Positive regulation of triglyceride biosynthetic process	Increases phenotype	PMID:38630605
GO:0010884	Positive regulation of lipid storage	Increases phenotype	PMID:25777084; PMID:32353385
GO:0010942	Positive regulation of cell death	Increases phenotype	PMID:25841707; PMID:29162470
GO:0014005	Microglia development	Decreases phenotype	PMID:31270303
GO:0016042	Lipid catabolic process	Increases phenotype	PMID:28707438; PMID:33720505; PMID:34902535
GO:0016049	Cell growth	Decreases phenotype	PMID:25382723
GO:0016505	Peptidase activator activity involved in apoptotic process	Increases phenotype	PMID:28709983
GO:0018158	Protein oxidation	Increases phenotype	PMID:25895139; PMID:28707438
GO:0019249	Lactate biosynthetic process	Decreases phenotype	PMID:28993852
GO:0019432	Triglyceride biosynthetic process	Increases phenotype	PMID:30172001
GO:0022602	Ovulation cycle process	Affects phenotype	PMID:29908848
GO:0030001	Metal ion transport	Increases phenotype	PMID:31306684
GO:0030183	B cell differentiation	Decreases phenotype	PMID:28398592
GO:0030199	Collagen fibril organization	Increases phenotype	PMID:36638932; PMID:38936095
GO:0030263	Apoptotic chromosome condensation	Increases phenotype	PMID:32783468
GO:0030424	Axon	Decreases phenotype	PMID:33481012
GO:0030501	Positive regulation of bone mineralization	Decreases phenotype	PMID:25777084
GO:0032049	Cardiolipin biosynthetic process	Decreases phenotype	PMID:38630605
GO:0032148	Activation of protein kinase b activity	Decreases phenotype	PMID:25895139; PMID:29675927
GO:0032930	Positive regulation of superoxide anion generation	Increases phenotype	PMID:27521499
GO:0032964	Collagen biosynthetic process	Increases phenotype	PMID:29908848
GO:0032967	Positive regulation of collagen biosynthetic process	Increases phenotype	PMID:26873547; PMID:27521499; PMID:28161095
GO:0034440	Lipid oxidation	Increases phenotype	PMID:25895139; PMID:26079211; PMID:27521499; PMID:32783468
GO:0035584	Calcium-mediated signaling using intracellular calcium source	Affects phenotype	PMID:33481012
GO:0035633	Maintenance of blood-brain barrier	Decreases phenotype	PMID:26079211
GO:0035640	Exploration behavior	Affects phenotype	PMID:35295135
GO:0035774	Positive regulation of insulin secretion involved in cellular response to glucose stimulus	Increases phenotype	PMID:28180948
GO:0035932	Aldosterone secretion	Decreases phenotype	PMID:29549738
GO:0035936	Testosterone secretion	Increases phenotype	PMID:29549738
GO:0035937	Estrogen secretion	Decreases phenotype	PMID:29908848
GO:0035938	Estradiol secretion	Decreases phenotype	PMID:29549738
GO:0040018	Positive regulation of multicellular organism growth	Affects phenotype	PMID:26079211; PMID:31306684; PMID:34619157
GO:0042310	Vasoconstriction	Increases phenotype	PMID:34902535
GO:0042448	Progesterone metabolic process	Affects phenotype	PMID:38936095
GO:0042554	Superoxide anion generation	Increases phenotype	PMID:29908848
GO:0042593	Glucose homeostasis	Decreases phenotype	PMID:28180948; PMID:31306684
GO:0042701	Progesterone secretion	Increases phenotype	PMID:29908848
GO:0043065	Positive regulation of apoptotic process	Increases phenotype	PMID:26079211; PMID:27521499; PMID:28161095; PMID:28398592; PMID:31401084
GO:0043400	Cortisol secretion	Decreases phenotype	PMID:29549738
GO:0043525	Positive regulation of neuron apoptotic process	Increases phenotype	PMID:25895139
GO:0044026	Dna hypermethylation	Increases phenotype	PMID:28011154
GO:0044028	Dna hypomethylation	Increases phenotype	PMID:28011154
GO:0044237	Cellular metabolic process	Decreases phenotype	PMID:32783468; PMID:35430282; PMID:35563431; PMID:36319700; PMID:36613676; PMID:38936095
GO:0044255	Cellular lipid metabolic process	Affects phenotype	PMID:34323617
GO:0044849	Estrous cycle	Affects phenotype	PMID:28161095; PMID:32239163; PMID:38936095
GO:0045429	Positive regulation of nitric oxide biosynthetic process	Decreases phenotype	PMID:26873547
GO:0045444	Fat cell differentiation	Increases phenotype	PMID:24155963; PMID:24503497; PMID:24513447; PMID:28011154; PMID:32473317; PMID:37142754; PMID:39955080
GO:0045454	Cell redox homeostasis	Decreases phenotype	PMID:27521499
GO:0045600	Positive regulation of fat cell differentiation	Increases phenotype	PMID:25777084; PMID:25932594; PMID:28398592
GO:0045669	Positive regulation of osteoblast differentiation	Decreases phenotype	PMID:25777084
GO:0045780	Positive regulation of bone resorption	Increases phenotype	PMID:34619157
GO:0045892	Negative regulation of dna-templated transcription	Increases phenotype	PMID:30639747
GO:0045893	Positive regulation of dna-templated transcription	Increases phenotype	PMID:30639747
GO:0045907	Positive regulation of vasoconstriction	Increases phenotype	PMID:26873547; PMID:29580985
GO:0045930	Negative regulation of mitotic cell cycle	Increases phenotype	PMID:26961604
GO:0046209	Nitric oxide metabolic process	Increases phenotype	PMID:26079211
GO:0046460	Neutral lipid biosynthetic process	Increases phenotype	PMID:38630605
GO:0048143	Astrocyte activation	Increases phenotype	PMID:26079211
GO:0048878	Chemical homeostasis	Decreases phenotype	PMID:34619157
GO:0048936	Peripheral nervous system neuron axonogenesis	Decreases phenotype	PMID:33481012
GO:0050665	Hydrogen peroxide biosynthetic process	Decreases phenotype	PMID:27129022
GO:0050872	White fat cell differentiation	Affects phenotype	PMID:36638932
GO:0050873	Brown fat cell differentiation	Affects phenotype	PMID:36638932
GO:0051881	Regulation of mitochondrial membrane potential	Affects phenotype	PMID:27129022; PMID:33481012
GO:0055065	Metal ion homeostasis	Decreases phenotype	PMID:28161095
GO:0055088	Lipid homeostasis	Decreases phenotype	PMID:32353385; PMID:36638932; PMID:38630605
GO:0060206	Estrous cycle phase	Affects phenotype	PMID:31129395
GO:0060207	Diestrus	Decreases phenotype	PMID:31129395
GO:0060208	Proestrus	Decreases phenotype	PMID:31129395
GO:0060210	Metestrus	Increases phenotype	PMID:31129395
GO:0060612	Adipose tissue development	Increases phenotype	PMID:30172001
GO:0060615	Mammary gland bud formation	Decreases phenotype	PMID:38936095
GO:0060749	Mammary gland alveolus development	Decreases phenotype	PMID:38936095
GO:0060754	Positive regulation of mast cell chemotaxis	Increases phenotype	PMID:27521499
GO:0061040	Female gonad morphogenesis	Affects phenotype	PMID:38936095
GO:0061370	Testosterone biosynthetic process	Affects phenotype	PMID:32783468; PMID:32783468; PMID:34902535; PMID:35430282; PMID:32783468; PMID:35430282; PMID:34902535; PMID:35430282
GO:0070342	Brown fat cell proliferation	Decreases phenotype	PMID:36638932
GO:0070343	White fat cell proliferation	Increases phenotype	PMID:30172001; PMID:36638932
GO:0070374	Positive regulation of erk1 and erk2 cascade	Increases phenotype	PMID:28180948
GO:0070417	Cellular response to cold	Affects phenotype	PMID:36638932
GO:0070662	Mast cell proliferation	Increases phenotype	PMID:30172001; PMID:36638932; PMID:38936095
GO:0070994	Detection of oxidative stress	Increases phenotype	PMID:35295135; PMID:36638932; PMID:38936095
GO:0070997	Neuron death	Increases phenotype	PMID:26961604
GO:0072593	Reactive oxygen species metabolic process	Increases phenotype	PMID:22223438; PMID:35430282; PMID:36613676
GO:0090023	Positive regulation of neutrophil chemotaxis	Increases phenotype	PMID:27521499
GO:0090140	Regulation of mitochondrial fission	Affects phenotype	PMID:33481012
GO:0090630	Activation of gtpase activity	Decreases phenotype	PMID:24038145
GO:0097722	Sperm motility	Decreases phenotype	PMID:32783468
GO:0098657	Import into cell	Affects phenotype	PMID:28707438
GO:0140042	Lipid droplet formation	Increases phenotype	PMID:29908848; PMID:30172001; PMID:37142754; PMID:39955080; PMID:31016361; PMID:34864131; PMID:32353385; PMID:32407875; PMID:36638932; PMID:37142754; PMID:38630605; PMID:38936095; PMID:39778647
GO:1900020	Positive regulation of protein kinase c activity	Increases phenotype	PMID:28180948
GO:1900482	Positive regulation of diacylglycerol biosynthetic process	Increases phenotype	PMID:38630605
GO:1901216	Positive regulation of neuron death	Increases phenotype	PMID:33481012
GO:1901671	Positive regulation of superoxide dismutase activity	Increases phenotype	PMID:26079211
GO:1901687	Glutathione derivative biosynthetic process	Decreases phenotype	PMID:26079211
GO:1903012	Positive regulation of bone development	Increases phenotype	PMID:25932594
GO:1903284	Positive regulation of glutathione peroxidase activity	Increases phenotype	PMID:26079211
GO:1903409	Reactive oxygen species biosynthetic process	Increases phenotype	PMID:26961604; PMID:28707438
GO:1903428	Positive regulation of reactive oxygen species biosynthetic process	Increases phenotype	PMID:25895139; PMID:26079211; PMID:26873547; PMID:28180948; PMID:31401084
GO:1903709	Uterine gland development	Decreases phenotype	PMID:32239163
GO:1904179	Positive regulation of adipose tissue development	Increases phenotype	PMID:29675927; PMID:31306684
GO:1905706	Regulation of mitochondrial atp synthesis coupled proton transport	Affects phenotype	PMID:33481012
GO:1990051	Activation of protein kinase c activity	Increases phenotype	PMID:26228090
GO:1990079	Cartilage homeostasis	Affects phenotype	PMID:36319700
GO:2000194	Regulation of female gonad development	Affects phenotype	PMID:32239163
GO:2000227	Negative regulation of pancreatic a cell differentiation	Increases phenotype	PMID:31306684
GO:2000355	Negative regulation of ovarian follicle development	Increases phenotype	PMID:32239163
GO:2000845	Positive regulation of testosterone secretion	Increases phenotype	PMID:28161095
GO:2000863	Positive regulation of estrogen secretion	Decreases phenotype	PMID:27521499; PMID:28161095
GO:2001057	Reactive nitrogen species metabolic process	Increases phenotype	PMID:27521499
GO:2001272	Positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis	Increases phenotype	PMID:31401084
GO:2001290	Hydroperoxide metabolic process	Affects phenotype	PMID:33720505

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.