| GO ID | GO name | Interaction type | Reference |
|---|---|---|---|
| GO:0000045 | Autophagosome assembly | Increases phenotype | PMID:27470402 |
| GO:0000050 | Urea cycle | Increases phenotype | PMID:24946265 |
| GO:0000075 | Cell cycle checkpoint signaling | Affects phenotype | PMID:26476374 |
| GO:0000077 | Dna damage checkpoint signaling | Increases phenotype | PMID:24595819 |
| GO:0000080 | Mitotic g1 phase | Affects phenotype | PMID:32910239 |
| GO:0000084 | Mitotic s phase | Affects phenotype | PMID:32530119; PMID:36982678 |
| GO:0000086 | G2/m transition of mitotic cell cycle | Decreases phenotype | PMID:32530119; PMID:32910239 |
| GO:0000104 | Succinate dehydrogenase activity | Decreases phenotype | PMID:35510228 |
| GO:0000278 | Mitotic cell cycle | Affects phenotype | PMID:25543474; PMID:32910239 |
| GO:0001516 | Prostaglandin biosynthetic process | Affects phenotype | PMID:11164475; PMID:16552572; PMID:18096136; PMID:19605544; PMID:21341175; PMID:23353651; PMID:23735482; PMID:24134915 |
| GO:0001525 | Angiogenesis | Increases phenotype | PMID:23094058 |
| GO:0001541 | Ovarian follicle development | Decreases phenotype | PMID:32666839 |
| GO:0001551 | Ovarian follicle endowment | Decreases phenotype | PMID:32666839 |
| GO:0001552 | Ovarian follicle atresia | Increases phenotype | PMID:32666839 |
| GO:0001568 | Blood vessel development | Decreases phenotype | PMID:26011145 |
| GO:0001774 | Microglial cell activation | Decreases phenotype | PMID:27583449 |
| GO:0001821 | Histamine secretion | Affects phenotype | PMID:18547560; PMID:31672514 |
| GO:0001836 | Release of cytochrome c from mitochondria | Increases phenotype | PMID:14505808; PMID:16082193; PMID:18455702; PMID:20386985; PMID:21165570; PMID:21933852; PMID:22275840; PMID:24126416; PMID:24535669; PMID:25830055; PMID:27389774 |
| GO:0001890 | Placenta development | Affects phenotype | PMID:38387710 |
| GO:0001954 | Positive regulation of cell-matrix adhesion | Decreases phenotype | PMID:11597122 |
| GO:0002076 | Osteoblast development | Increases phenotype | PMID:27028516 |
| GO:0002232 | Leukocyte chemotaxis involved in inflammatory response | Increases phenotype | PMID:27527349 |
| GO:0002523 | Leukocyte migration involved in inflammatory response | Increases phenotype | PMID:17927767; PMID:22257724; PMID:22535755; PMID:22869926; PMID:24117263; PMID:25714890; PMID:25995762; PMID:26054880; PMID:27224288; PMID:29432836; PMID:34922902; PMID:38447874 |
| GO:0002537 | Nitric oxide production involved in inflammatory response | Increases phenotype | PMID:18809656; PMID:25532488 |
| GO:0002553 | Histamine secretion by mast cell | Affects phenotype | PMID:31672514 |
| GO:0002554 | Serotonin secretion by platelet | Increases phenotype | PMID:8928743 |
| GO:0002638 | Negative regulation of immunoglobulin production | Increases phenotype | PMID:29667781 |
| GO:0002686 | Negative regulation of leukocyte migration | Increases phenotype | PMID:29667781 |
| GO:0002862 | Negative regulation of inflammatory response to antigenic stimulus | Increases phenotype | PMID:29740324 |
| GO:0002931 | Response to ischemia | Affects phenotype | PMID:25322861 |
| GO:0003073 | Regulation of systemic arterial blood pressure | Affects phenotype | PMID:25460361 |
| GO:0003084 | Positive regulation of systemic arterial blood pressure | Decreases phenotype | PMID:18551111 |
| GO:0003093 | Regulation of glomerular filtration | Affects phenotype | PMID:25578686 |
| GO:0003677 | Dna binding | Increases phenotype | PMID:20438634 |
| GO:0003958 | Nadph-hemoprotein reductase activity | Increases phenotype | PMID:9920463 |
| GO:0003990 | Acetylcholinesterase activity | Decreases phenotype | PMID:21472459 |
| GO:0003993 | Acid phosphatase activity | Affects phenotype | PMID:25882133; PMID:27113704; PMID:28040552 |
| GO:0004021 | L-alanine:2-oxoglutarate aminotransferase activity | Increases phenotype | PMID:22915297; PMID:24946265; PMID:39988050 |
| GO:0004032 | Alditol:nadp+ 1-oxidoreductase activity | Increases phenotype | PMID:17211565 |
| GO:0004035 | Alkaline phosphatase activity | Affects phenotype | PMID:17927767; PMID:20804811; PMID:22356231; PMID:22535755; PMID:24946265; PMID:26136938; PMID:27113704; PMID:28040552; PMID:32810592; PMID:34748891; PMID:36808657 |
| GO:0004064 | Arylesterase activity | Decreases phenotype | PMID:10232833 |
| GO:0004069 | L-aspartate:2-oxoglutarate aminotransferase activity | Affects phenotype | PMID:16758767; PMID:17927767; PMID:20804811; PMID:22356231; PMID:22897171; PMID:22915297; PMID:24117263; PMID:24946265; PMID:34748891; PMID:36808657; PMID:39988050 |
| GO:0004096 | Catalase activity | Decreases phenotype | PMID:39613240 |
| GO:0004111 | Creatine kinase activity | Affects phenotype | PMID:21472459; PMID:24117263; PMID:27224288 |
| GO:0004129 | Cytochrome-c oxidase activity | Decreases phenotype | PMID:27389774 |
| GO:0004346 | Glucose-6-phosphatase activity | Increases phenotype | PMID:16758767; PMID:24946265 |
| GO:0004364 | Glutathione transferase activity | Affects phenotype | PMID:16758767; PMID:20804811; PMID:22356231; PMID:22897171; PMID:23543441; PMID:24745150; PMID:24946265; PMID:24952260; PMID:25046308; PMID:27113704; PMID:28040552; PMID:33439051; PMID:34748891; PMID:35122929 |
| GO:0004396 | Hexokinase activity | Decreases phenotype | PMID:24946265; PMID:35945655 |
| GO:0004402 | Histone acetyltransferase activity | Decreases phenotype | PMID:21857970 |
| GO:0004407 | Histone deacetylase activity | Decreases phenotype | PMID:21165570 |
| GO:0004430 | 1-phosphatidylinositol 4-kinase activity | Decreases phenotype | PMID:9381980 |
| GO:0004457 | Lactate dehydrogenase activity | Affects phenotype | PMID:18057710; PMID:20804811; PMID:22275840; PMID:22535755; PMID:22897171; PMID:24117263; PMID:28040552; PMID:35945655 |
| GO:0004517 | Nitric-oxide synthase activity | Increases phenotype | PMID:24017971; PMID:24860958; PMID:27260466 |
| GO:0004565 | Beta-galactosidase activity | Increases phenotype | PMID:25070040 |
| GO:0004602 | Glutathione peroxidase activity | Affects phenotype | PMID:11424224; PMID:17211565; PMID:18057710; PMID:20804811; PMID:21337715; PMID:22356231; PMID:22391854; PMID:22467373; PMID:22897171; PMID:23534466; PMID:23543441; PMID:23607047; PMID:23994749; PMID:24745150; PMID:24860958; PMID:25108166; PMID:25578686; PMID:25737657; PMID:25995762; PMID:26277538; PMID:27111109; PMID:27923682; PMID:32347499; PMID:34748891; PMID:36808657; PMID:38387710; PMID:39613240; PMID:9528125 |
| GO:0004672 | Protein kinase activity | Decreases phenotype | PMID:10556937 |
| GO:0004697 | Protein kinase c activity | Affects phenotype | PMID:10484327; PMID:18436224; PMID:26076811 |
| GO:0004713 | Protein tyrosine kinase activity | Decreases phenotype | PMID:1812286 |
| GO:0004743 | Pyruvate kinase activity | Decreases phenotype | PMID:35945655 |
| GO:0004784 | Superoxide dismutase activity | Affects phenotype | PMID:15198074; PMID:16758767; PMID:17211565; PMID:18057710; PMID:20804811; PMID:21337715; PMID:21664865; PMID:22356231; PMID:22391854; PMID:22467373; PMID:22524206; PMID:22870923; PMID:22897171; PMID:22989100; PMID:23265624; PMID:23994557; PMID:23357119; PMID:23543441; PMID:23607047; PMID:23994749; PMID:24117263; PMID:24122261; PMID:24745150; PMID:24860958; PMID:24946265; PMID:25046308; PMID:25737657; PMID:25882133; PMID:25926722; PMID:25929518; PMID:25995762; PMID:26054880; PMID:26218279; PMID:26277538; PMID:26690102; PMID:27050422; PMID:27111109; PMID:28040552; PMID:32034696; PMID:32347499; PMID:33439051; PMID:34748891; PMID:36808657; PMID:38387710; PMID:39613240; PMID:39988050 |
| GO:0004791 | Thioredoxin-disulfide reductase activity | Decreases phenotype | PMID:16618767; PMID:27252111 |
| GO:0004833 | Tryptophan 2,3-dioxygenase activity | Increases phenotype | PMID:34748891 |
| GO:0004855 | Xanthine oxidase activity | Increases phenotype | PMID:28400101 |
| GO:0005388 | P-type calcium transporter activity | Decreases phenotype | PMID:9826030 |
| GO:0005757 | Mitochondrial permeability transition pore complex | Affects phenotype | PMID:24026541 |
| GO:0005977 | Glycogen metabolic process | Affects phenotype | PMID:37566541 |
| GO:0005978 | Glycogen biosynthetic process | Increases phenotype | PMID:21439094; PMID:26627467; PMID:27923682 |
| GO:0006054 | N-acetylneuraminate metabolic process | Affects phenotype | PMID:18547560 |
| GO:0006089 | Lactate metabolic process | Affects phenotype | PMID:35945655 |
| GO:0006094 | Gluconeogenesis | Affects phenotype | PMID:24338341 |
| GO:0006109 | Regulation of carbohydrate metabolic process | Affects phenotype | PMID:21250691 |
| GO:0006119 | Oxidative phosphorylation | Decreases phenotype | PMID:35337893 |
| GO:0006171 | Camp biosynthetic process | Increases phenotype | PMID:21290442 |
| GO:0006182 | Cgmp biosynthetic process | Increases phenotype | PMID:25967872 |
| GO:0006264 | Mitochondrial dna replication | Increases phenotype | PMID:21775390 |
| GO:0006304 | Dna modification | Increases phenotype | PMID:10647909; PMID:24999622; PMID:35122929 |
| GO:0006306 | Dna methylation | Increases phenotype | PMID:25957741 |
| GO:0006309 | Apoptotic dna fragmentation | Increases phenotype | PMID:10556937; PMID:12168845; PMID:14505808; PMID:14688022; PMID:22200874; PMID:23727915; PMID:14750173; PMID:15538571; PMID:16647178; PMID:21165570; PMID:22431435; PMID:22524206; PMID:27923682; PMID:9381980 |
| GO:0006412 | Translation | Increases phenotype | PMID:15611226; PMID:22125951; PMID:24039778 |
| GO:0006468 | Protein phosphorylation | Decreases phenotype | PMID:12168845; PMID:1812286 |
| GO:0006538 | Glutamate catabolic process | Decreases phenotype | PMID:35337893 |
| GO:0006629 | Lipid metabolic process | Increases phenotype | PMID:18586010; PMID:24025686 |
| GO:0006641 | Triglyceride metabolic process | Affects phenotype | PMID:33021114; PMID:37566541 |
| GO:0006695 | Cholesterol biosynthetic process | Increases phenotype | PMID:19605544; PMID:21775390; PMID:22447684; PMID:22869926; PMID:23543441; PMID:24017971; PMID:24319627; PMID:24746831; PMID:26690102 |
| GO:0006749 | Glutathione metabolic process | Increases phenotype | PMID:12242689; PMID:18547560; PMID:21462320; PMID:22830632; PMID:23758074; PMID:24316378; PMID:25411067; PMID:25471833; PMID:25537132; PMID:27527349; PMID:25882133; PMID:25929518; PMID:26286521; PMID:29667781; PMID:31201582; PMID:32034696; PMID:32530119; PMID:34748891; PMID:35122929; PMID:35876585; PMID:38447874; PMID:39053875 |
| GO:0006750 | Glutathione biosynthetic process | Increases phenotype | PMID:11424224; PMID:15053821; PMID:15198074; PMID:16758767; PMID:17211565; PMID:17265541; PMID:17433488; PMID:17433488; PMID:19325051; PMID:17927767; PMID:18057710; PMID:19325051; PMID:19723100; PMID:20554019; PMID:20600150; PMID:20804811; PMID:21284339; PMID:21337715; PMID:21775390; PMID:22257724; PMID:22391854; PMID:22467373; PMID:22870923; PMID:22897171; PMID:22902988; PMID:23265624; PMID:23265624; PMID:23994557; PMID:23357119; PMID:23534466; PMID:23543441; PMID:23994749; PMID:24946265; PMID:24952260; PMID:25046308; PMID:25108166; PMID:25204422; PMID:25714890; PMID:25926722; PMID:27050422; PMID:27111109; PMID:27260466; PMID:28040552; PMID:31332904; PMID:37419146; PMID:9528125; PMID:9920463 |
| GO:0006754 | Atp biosynthetic process | Decreases phenotype | PMID:22275840; PMID:24593786; PMID:24612139 |
| GO:0006790 | Sulfur compound metabolic process | Affects phenotype | PMID:11401418 |
| GO:0006801 | Superoxide metabolic process | Increases phenotype | PMID:16389571; PMID:27113704 |
| GO:0006805 | Xenobiotic metabolic process | Affects phenotype | PMID:35101544; PMID:9429083 |
| GO:0006809 | Nitric oxide biosynthetic process | Increases phenotype | PMID:15630180; PMID:22185406; PMID:23735482; PMID:24040572; PMID:18394220; PMID:19605544; PMID:20060843; PMID:20361964; PMID:20600150; PMID:21664865; PMID:22185406; PMID:22221676; PMID:22685622; PMID:23353651; PMID:24040572; PMID:24319627; PMID:24860958; PMID:26218279; PMID:26505893; PMID:26690102; PMID:27113704; PMID:28040552 |
| GO:0006816 | Calcium ion transport | Increases phenotype | PMID:23873842 |
| GO:0006821 | Chloride transport | Increases phenotype | PMID:19251944 |
| GO:0006855 | Xenobiotic transmembrane transport | Increases phenotype | PMID:21867607 |
| GO:0006874 | Cellular calcium ion homeostasis | Affects phenotype | PMID:26363153; PMID:33276066 |
| GO:0006884 | Cell volume homeostasis | Affects phenotype | PMID:36808657 |
| GO:0006887 | Exocytosis | Increases phenotype | PMID:23249183 |
| GO:0006914 | Autophagy | Increases phenotype | PMID:20654599; PMID:32902906; PMID:33021114 |
| GO:0006915 | Apoptotic process | Increases phenotype | PMID:12642403; PMID:14649542; PMID:14688022; PMID:14688022; PMID:22200874; PMID:23727915; PMID:25830055; PMID:15538571; PMID:15538571; PMID:24275163; PMID:15611226; PMID:15735102; PMID:15735102; PMID:27489195; PMID:30171828; PMID:8069862; PMID:16014620; PMID:16082193; PMID:16389571; PMID:16963249; PMID:18455702; PMID:20658310; PMID:23094058; PMID:26011145; PMID:28811126; PMID:18586010; PMID:19723100; PMID:25896587; PMID:26943884; PMID:34219513; PMID:20096292; PMID:20361964; PMID:20386985; PMID:20438634; PMID:21902895; PMID:25339540; PMID:8069862; PMID:20594614; PMID:20654599; PMID:20803121; PMID:22447039; PMID:24535669; PMID:21337715; PMID:21750559; PMID:21803128; PMID:21902895; PMID:21902895; PMID:22555976; PMID:24705122; PMID:21933852; PMID:22002103; PMID:22138401; PMID:22467373; PMID:22524206; PMID:22989100; PMID:23022152; PMID:23353698; PMID:23357119; PMID:23534466; PMID:23727915; PMID:23918355; PMID:24126416; PMID:24126416; PMID:24849437; PMID:26408079; PMID:24275163; PMID:30935903; PMID:24535669; PMID:24612139; PMID:25108166; PMID:25339540; PMID:25460361; PMID:25543474; PMID:25655047; PMID:25896587; PMID:26011145; PMID:26054880; PMID:26076811; PMID:26277538; PMID:26363153; PMID:26415619; PMID:26476374; PMID:26887929; PMID:26943884; PMID:26986492; PMID:26986492; PMID:8069862; PMID:27050144; PMID:27132804; PMID:27132804; PMID:27253410; PMID:33070227; PMID:27175602; PMID:27470402; PMID:27489195; PMID:27525270; PMID:28681665; PMID:30636491; PMID:30958996; PMID:31332904; PMID:32329368; PMID:32530119; PMID:34219513; PMID:34791735; PMID:8069862 |
| GO:0006954 | Inflammatory response | Increases phenotype | PMID:22728154; PMID:28681665; PMID:35510228 |
| GO:0006974 | Cellular response to dna damage stimulus | Increases phenotype | PMID:10693172; PMID:16970932; PMID:17045724; PMID:20386985; PMID:24946265; PMID:26493151; PMID:26739637; PMID:26943884; PMID:27252111; PMID:28315349; PMID:29710542; PMID:30935903; PMID:33038355 |
| GO:0006979 | Response to oxidative stress | Increases phenotype | PMID:14685008; PMID:21783994; PMID:30636491 |
| GO:0007005 | Mitochondrion organization | Decreases phenotype | PMID:22257724; PMID:27389774 |
| GO:0007033 | Vacuole organization | Increases phenotype | PMID:27923682 |
| GO:0007204 | Positive regulation of cytosolic calcium ion concentration | Increases phenotype | PMID:24368982; PMID:30152185 |
| GO:0007283 | Spermatogenesis | Decreases phenotype | PMID:24316378; PMID:25882133; PMID:26264430; PMID:32347499; PMID:38740240 |
| GO:0007346 | Regulation of mitotic cell cycle | Affects phenotype | PMID:28681665 |
| GO:0007420 | Brain development | Affects phenotype | PMID:32034696 |
| GO:0007566 | Embryo implantation | Decreases phenotype | PMID:28431985 |
| GO:0007588 | Excretion | Affects phenotype | PMID:12805248 |
| GO:0007605 | Sensory perception of sound | Affects phenotype | PMID:38490643 |
| GO:0007613 | Memory | Decreases phenotype | PMID:35822592; PMID:39613240 |
| GO:0007631 | Feeding behavior | Affects phenotype | PMID:27923682; PMID:37797956 |
| GO:0008137 | Nadh dehydrogenase (ubiquinone) activity | Affects phenotype | PMID:22257724; PMID:27389774 |
| GO:0008152 | Metabolic process | Affects phenotype | PMID:32537472; PMID:37797956 |
| GO:0008177 | Succinate dehydrogenase (ubiquinone) activity | Decreases phenotype | PMID:22257724 |
| GO:0008203 | Cholesterol metabolic process | Affects phenotype | PMID:33021114; PMID:37566541 |
| GO:0008210 | Estrogen metabolic process | Affects phenotype | PMID:32810592 |
| GO:0008217 | Regulation of blood pressure | Increases phenotype | PMID:23117658 |
| GO:0008219 | Cell death | Increases phenotype | PMID:11809906; PMID:12826665; PMID:16618767; PMID:16647178; PMID:18655187; PMID:19194971; PMID:20438634; PMID:20554019; PMID:20654599; PMID:21051700; PMID:22257724; PMID:22871832; PMID:22996356; PMID:23645742; PMID:23918355; PMID:24173369; PMID:25108166; PMID:25203460; PMID:25830055; PMID:25881548; PMID:26363153; PMID:26584763; PMID:26766292; PMID:27050422; PMID:27113704; PMID:27494022; PMID:30391638 |
| GO:0008283 | Cell population proliferation | Increases phenotype | PMID:10376965; PMID:10376965; PMID:10556937; PMID:20803121; PMID:22447039; PMID:24299158; PMID:10556937; PMID:10556937; PMID:12168845; PMID:27253410; PMID:10556937; PMID:19958256; PMID:25896587; PMID:10556937; PMID:24275163; PMID:11214823; PMID:11854699; PMID:12168845; PMID:12390030; PMID:22431435; PMID:23094058; PMID:24726691; PMID:26011145; PMID:12653748; PMID:12826665; PMID:14505808; PMID:14505808; PMID:17045724; PMID:14688022; PMID:22200874; PMID:23727915; PMID:17045724; PMID:17458902; PMID:18025287; PMID:18946510; PMID:19194971; PMID:19877526; PMID:19958256; PMID:20032413; PMID:22555976; PMID:24705122; PMID:20032413; PMID:25339540; PMID:20032413; PMID:27489195; PMID:20096292; PMID:20386985; PMID:21362404; PMID:21498710; PMID:21732360; PMID:22138401; PMID:22295890; PMID:22372587; PMID:22394507; PMID:22422628; PMID:22422628; PMID:33686878; PMID:22871832; PMID:23094058; PMID:23533474; PMID:23534466; PMID:23727915; PMID:24173369; PMID:24353828; PMID:24397597; PMID:24612139; PMID:24648896; PMID:25070040; PMID:25108166; PMID:25203460; PMID:25339540; PMID:25380086; PMID:25460361; PMID:25655047; PMID:25896587; PMID:26011145; PMID:26136938; PMID:26476374; PMID:26766292; PMID:27050144; PMID:27113704; PMID:27132804; PMID:27175602; PMID:9381980; PMID:27344173; PMID:27470402; PMID:27489195; PMID:27494022; PMID:27514524; PMID:27525270; PMID:28533128; PMID:28855101; PMID:3097147; PMID:32757775; PMID:36094770; PMID:38246289; PMID:39613240; PMID:7780149; PMID:8157359; PMID:8157359; PMID:9381980; PMID:9381980 |
| GO:0008284 | Positive regulation of cell population proliferation | Affects phenotype | PMID:12227197; PMID:12888923; PMID:12888923; PMID:20596804; PMID:26676551; PMID:19017364; PMID:19017364; PMID:19293639; PMID:23664836; PMID:19293639; PMID:19623560; PMID:22335904; PMID:21867607; PMID:21867678; PMID:22592909; PMID:23628706; PMID:25084985; PMID:25354548; PMID:25373458; PMID:25896339; PMID:26053266; PMID:26648539; PMID:26676551; PMID:30368985; PMID:9224209 |
| GO:0008285 | Negative regulation of cell population proliferation | Increases phenotype | PMID:28251795; PMID:30152185; PMID:30639267; PMID:37467934; PMID:38134066 |
| GO:0008610 | Lipid biosynthetic process | Increases phenotype | PMID:1324726; PMID:22447684; PMID:24648896 |
| GO:0008654 | Phospholipid biosynthetic process | Increases phenotype | PMID:23543441 |
| GO:0009060 | Aerobic respiration | Decreases phenotype | PMID:21775390 |
| GO:0009314 | Response to radiation | Increases phenotype | PMID:27041924 |
| GO:0009408 | Response to heat | Affects phenotype | PMID:27041924 |
| GO:0010189 | Vitamin e biosynthetic process | Affects phenotype | PMID:18057710; PMID:21284339; PMID:21565894; PMID:23543441; PMID:25737657 |
| GO:0010288 | Response to lead ion | Affects phenotype | PMID:23855546 |
| GO:0010459 | Negative regulation of heart rate | Increases phenotype | PMID:16331104 |
| GO:0010460 | Positive regulation of heart rate | Increases phenotype | PMID:25537132 |
| GO:0010498 | Proteasomal protein catabolic process | Decreases phenotype | PMID:18809656 |
| GO:0010694 | Positive regulation of alkaline phosphatase activity | Increases phenotype | PMID:24102669 |
| GO:0010729 | Positive regulation of hydrogen peroxide biosynthetic process | Increases phenotype | PMID:30821249 |
| GO:0010759 | Positive regulation of macrophage chemotaxis | Increases phenotype | PMID:25614714 |
| GO:0010829 | Negative regulation of glucose transmembrane transport | Affects phenotype | PMID:24432408; PMID:24513520 |
| GO:0010875 | Positive regulation of cholesterol efflux | Increases phenotype | PMID:22711909 |
| GO:0010884 | Positive regulation of lipid storage | Increases phenotype | PMID:25712622 |
| GO:0010890 | Positive regulation of sequestering of triglyceride | Increases phenotype | PMID:23647015 |
| GO:0010917 | Negative regulation of mitochondrial membrane potential | Increases phenotype | PMID:32527420; PMID:35122929; PMID:37098359; PMID:38490643 |
| GO:0010918 | Positive regulation of mitochondrial membrane potential | Decreases phenotype | PMID:22983795; PMID:23504962; PMID:24368982; PMID:24902966; PMID:25293876; PMID:30152185 |
| GO:0010940 | Positive regulation of necrotic cell death | Increases phenotype | PMID:19112469; PMID:27041924; PMID:37098359 |
| GO:0010942 | Positive regulation of cell death | Increases phenotype | PMID:15832817; PMID:16158945; PMID:16158945; PMID:24102669; PMID:17548900; PMID:17931660; PMID:18809656; PMID:21867607; PMID:22683914; PMID:22830632; PMID:22902249; PMID:23530649; PMID:23628706; PMID:23664836; PMID:23942037; PMID:24368982; PMID:24368982; PMID:25411067; PMID:25446499; PMID:24368982; PMID:25411067; PMID:26311153; PMID:9429083; PMID:24999622; PMID:25216733; PMID:25289772; PMID:25411067; PMID:25411067; PMID:25446499; PMID:25446499; PMID:25532488; PMID:25658812; PMID:25687049; PMID:26374991; PMID:32527420 |
| GO:0010971 | Positive regulation of g2/m transition of mitotic cell cycle | Decreases phenotype | PMID:11597122; PMID:25084985 |
| GO:0012501 | Programmed cell death | Increases phenotype | PMID:22275840 |
| GO:0014002 | Astrocyte development | Increases phenotype | PMID:28984087 |
| GO:0014067 | Negative regulation of phosphatidylinositol 3-kinase signaling | Increases phenotype | PMID:20386467; PMID:38134066 |
| GO:0014068 | Positive regulation of phosphatidylinositol 3-kinase signaling | Decreases phenotype | PMID:25658812 |
| GO:0014850 | Response to muscle activity | Decreases phenotype | PMID:27583449 |
| GO:0015108 | Chloride transmembrane transporter activity | Decreases phenotype | PMID:12527479 |
| GO:0015267 | Channel activity | Affects phenotype | PMID:24026541 |
| GO:0015705 | Iodide transport | Affects phenotype | PMID:24447974 |
| GO:0016042 | Lipid catabolic process | Increases phenotype | PMID:11424224; PMID:1384499; PMID:15053821; PMID:15198074; PMID:16758767; PMID:17211565; PMID:17265541; PMID:17433488; PMID:17433488; PMID:19325051; PMID:17927767; PMID:18057710; PMID:18096136; PMID:19325051; PMID:19489629; PMID:20600150; PMID:20804811; PMID:21284339; PMID:21337715; PMID:21439094; PMID:21472459; PMID:21601209; PMID:21664865; PMID:22356231; PMID:22391854; PMID:22447684; PMID:22467373; PMID:22728154; PMID:22870923; PMID:22915297; PMID:23265624; PMID:23534466; PMID:23543441; PMID:23994749; PMID:24026541; PMID:24117263; PMID:24337353; PMID:24523661; PMID:24745150; PMID:24946265; PMID:25046308; PMID:25108166; PMID:25204422; PMID:25737657; PMID:25926722; PMID:25995762; PMID:26054880; PMID:26218279; PMID:26690102; PMID:26766292; PMID:26887929; PMID:27050422; PMID:27111109; PMID:27113704; PMID:27252111; PMID:27260466; PMID:27923682; PMID:28040552; PMID:28347707; PMID:28400101; PMID:28679351; PMID:28811126; PMID:29710542; PMID:32034696; PMID:34748891; PMID:8968052; PMID:9528125; PMID:9568736 |
| GO:0016049 | Cell growth | Decreases phenotype | PMID:30171828; PMID:30958996; PMID:33070227; PMID:34219513 |
| GO:0016174 | Nad(p)h oxidase h2o2-forming activity | Increases phenotype | PMID:22295890 |
| GO:0016209 | Antioxidant activity | Affects phenotype | PMID:25111660; PMID:30636491; PMID:37419146 |
| GO:0016477 | Cell migration | Affects phenotype | PMID:14593496; PMID:21308698; PMID:22295890; PMID:22394507; PMID:22422628; PMID:24001813; PMID:25655047; PMID:25971889; PMID:26408079; PMID:27470402; PMID:30016632 |
| GO:0016887 | Atp hydrolysis activity | Increases phenotype | PMID:21472459; PMID:27260466; PMID:34217736 |
| GO:0018108 | Peptidyl-tyrosine phosphorylation | Increases phenotype | PMID:10556937; PMID:19814731 |
| GO:0018158 | Protein oxidation | Increases phenotype | PMID:12818473; PMID:17211565; PMID:18506933; PMID:21472459; PMID:24593786; PMID:25532488; PMID:25737657; PMID:26766292; PMID:30821249; PMID:30990955; PMID:33439051 |
| GO:0019371 | Cyclooxygenase pathway | Decreases phenotype | PMID:20828867; PMID:25151738 |
| GO:0019432 | Triglyceride biosynthetic process | Increases phenotype | PMID:19605544; PMID:22447684; PMID:22535755; PMID:23543441; PMID:24017971; PMID:24319627; PMID:24648896; PMID:24746831; PMID:26690102 |
| GO:0019627 | Urea metabolic process | Affects phenotype | PMID:21284339; PMID:34922902; PMID:39053875 |
| GO:0019659 | Glucose catabolic process to lactate | Decreases phenotype | PMID:23664836 |
| GO:0019853 | L-ascorbic acid biosynthetic process | Affects phenotype | PMID:18057710; PMID:21284339; PMID:21565894; PMID:22897171; PMID:23543441; PMID:25737657 |
| GO:0022010 | Central nervous system myelination | Decreases phenotype | PMID:38823456 |
| GO:0030154 | Cell differentiation | Increases phenotype | PMID:11520601 |
| GO:0030199 | Collagen fibril organization | Increases phenotype | PMID:36808657 |
| GO:0030218 | Erythrocyte differentiation | Increases phenotype | PMID:21915944; PMID:9381980 |
| GO:0030263 | Apoptotic chromosome condensation | Increases phenotype | PMID:25882133; PMID:26944603; PMID:27923682; PMID:28251795; PMID:34922902; PMID:36808657; PMID:39988050 |
| GO:0030264 | Nuclear fragmentation involved in apoptotic nuclear change | Increases phenotype | PMID:28251795 |
| GO:0030282 | Bone mineralization | Increases phenotype | PMID:27028516 |
| GO:0030307 | Positive regulation of cell growth | Increases phenotype | PMID:24465016 |
| GO:0030317 | Flagellated sperm motility | Decreases phenotype | PMID:26264430 |
| GO:0030335 | Positive regulation of cell migration | Affects phenotype | PMID:19207037; PMID:25354548; PMID:25481090; PMID:27468969; PMID:26109002; PMID:26676551 |
| GO:0030391 | Fructosamine biosynthetic process | Affects phenotype | PMID:24338341 |
| GO:0030501 | Positive regulation of bone mineralization | Increases phenotype | PMID:26053266 |
| GO:0030887 | Positive regulation of myeloid dendritic cell activation | Increases phenotype | PMID:38823456 |
| GO:0031161 | Phosphatidylinositol catabolic process | Increases phenotype | PMID:9590266 |
| GO:0031175 | Neuron projection development | Decreases phenotype | PMID:35822592 |
| GO:0031324 | Negative regulation of cellular metabolic process | Increases phenotype | PMID:35122929 |
| GO:0031394 | Positive regulation of prostaglandin biosynthetic process | Decreases phenotype | PMID:22592909 |
| GO:0031642 | Negative regulation of myelination | Increases phenotype | PMID:37230155 |
| GO:0031987 | Locomotion involved in locomotory behavior | Decreases phenotype | PMID:23357119; PMID:35822592 |
| GO:0032000 | Positive regulation of fatty acid beta-oxidation | Decreases phenotype | PMID:24586721 |
| GO:0032006 | Regulation of tor signaling | Affects phenotype | PMID:24025686 |
| GO:0032023 | Trypsinogen activation | Affects phenotype | PMID:24593786 |
| GO:0032125 | Micronucleus organization | Increases phenotype | PMID:16758767; PMID:32910239 |
| GO:0032148 | Activation of protein kinase b activity | Increases phenotype | PMID:17548900; PMID:19138980; PMID:23099361; PMID:23504962; PMID:23855546; PMID:24465016; PMID:24491314; PMID:25293876; PMID:25481090; PMID:27468969; PMID:25712622; PMID:34726822 |
| GO:0032308 | Positive regulation of prostaglandin secretion | Increases phenotype | PMID:25687049; PMID:27257013 |
| GO:0032342 | Aldosterone biosynthetic process | Increases phenotype | PMID:24117263 |
| GO:0032430 | Positive regulation of phospholipase a2 activity | Increases phenotype | PMID:8928743 |
| GO:0032508 | Dna duplex unwinding | Increases phenotype | PMID:38740240 |
| GO:0032755 | Positive regulation of interleukin-6 production | Decreases phenotype | PMID:20828867 |
| GO:0032774 | Rna biosynthetic process | Decreases phenotype | PMID:22125951 |
| GO:0032930 | Positive regulation of superoxide anion generation | Affects phenotype | PMID:16331104; PMID:23647015; PMID:23758074 |
| GO:0032958 | Inositol phosphate biosynthetic process | Increases phenotype | PMID:23873842 |
| GO:0032964 | Collagen biosynthetic process | Increases phenotype | PMID:18341430; PMID:21216973; PMID:27028516 |
| GO:0032967 | Positive regulation of collagen biosynthetic process | Decreases phenotype | PMID:18547560 |
| GO:0033169 | Histone h3-k9 demethylation | Increases phenotype | PMID:28414027 |
| GO:0033212 | Iron import into cell | Affects phenotype | PMID:36584933; PMID:37230155 |
| GO:0033685 | Negative regulation of luteinizing hormone secretion | Increases phenotype | PMID:37098359 |
| GO:0033754 | Indoleamine 2,3-dioxygenase activity | Increases phenotype | PMID:34748891 |
| GO:0034101 | Erythrocyte homeostasis | Decreases phenotype | PMID:28679351 |
| GO:0034126 | Positive regulation of myd88-dependent toll-like receptor signaling pathway | Decreases phenotype | PMID:20828867 |
| GO:0034199 | Activation of protein kinase a activity | Decreases phenotype | PMID:23855546 |
| GO:0034374 | Low-density lipoprotein particle remodeling | Increases phenotype | PMID:19489629 |
| GO:0034389 | Lipid droplet organization | Increases phenotype | PMID:22869926 |
| GO:0034418 | Urate biosynthetic process | Affects phenotype | PMID:21284339; PMID:21909718 |
| GO:0034440 | Lipid oxidation | Affects phenotype | PMID:10647909; PMID:11401418; PMID:12738181; PMID:12818473; PMID:16177186; PMID:16177186; PMID:26286521; PMID:18404532; PMID:18506933; PMID:18547560; PMID:21462320; PMID:23758074; PMID:23855546; PMID:23997041; PMID:24316378; PMID:24613711; PMID:24902966; PMID:25339115; PMID:25411067; PMID:25471833; PMID:25532488; PMID:25537132; PMID:25537132; PMID:27527349; PMID:25539033; PMID:25712622; PMID:25882133; PMID:25929518; PMID:26286521; PMID:27527349; PMID:29667781; PMID:30372826; PMID:30821249; PMID:32527420; PMID:34751495; PMID:35876585; PMID:36808657; PMID:38387710; PMID:38447874; PMID:39053875; PMID:39613240; PMID:40009568 |
| GO:0034614 | Cellular response to reactive oxygen species | Decreases phenotype | PMID:22683914 |
| GO:0034644 | Cellular response to uv | Decreases phenotype | PMID:21282043 |
| GO:0034760 | Negative regulation of iron ion transmembrane transport | Increases phenotype | PMID:25058155 |
| GO:0034767 | Positive regulation of monoatomic ion transmembrane transport | Decreases phenotype | PMID:25967872 |
| GO:0035148 | Tube formation | Increases phenotype | PMID:23094058 |
| GO:0035640 | Exploration behavior | Decreases phenotype | PMID:35822592 |
| GO:0035641 | Locomotory exploration behavior | Decreases phenotype | PMID:39613240 |
| GO:0035809 | Regulation of urine volume | Affects phenotype | PMID:25578686 |
| GO:0036211 | Protein modification process | Increases phenotype | PMID:24337353; PMID:25108166 |
| GO:0036395 | Pancreatic amylase secretion | Increases phenotype | PMID:26873426 |
| GO:0038060 | Nitric oxide-cgmp-mediated signaling pathway | Increases phenotype | PMID:25967872 |
| GO:0042118 | Endothelial cell activation | Increases phenotype | PMID:17313705 |
| GO:0042132 | Fructose 1,6-bisphosphate 1-phosphatase activity | Increases phenotype | PMID:24946265 |
| GO:0042161 | Lipoprotein oxidation | Affects phenotype | PMID:10232833; PMID:11723413; PMID:17313705; PMID:9409251; PMID:9568736 |
| GO:0042178 | Xenobiotic catabolic process | Decreases phenotype | PMID:19138980; PMID:19215233; PMID:7908050 |
| GO:0042267 | Natural killer cell mediated cytotoxicity | Decreases phenotype | PMID:3081633 |
| GO:0042271 | Susceptibility to natural killer cell mediated cytotoxicity | Increases phenotype | PMID:20386467 |
| GO:0042307 | Positive regulation of protein import into nucleus | Affects phenotype | PMID:20728021; PMID:22711909; PMID:23099361; PMID:25896339; PMID:25957741 |
| GO:0042310 | Vasoconstriction | Increases phenotype | PMID:17374653; PMID:18436224; PMID:18801486; PMID:22535755; PMID:23873842 |
| GO:0042311 | Vasodilation | Increases phenotype | PMID:16331104; PMID:18436224; PMID:22535755; PMID:23873842 |
| GO:0042360 | Vitamin e metabolic process | Increases phenotype | PMID:19489629 |
| GO:0042403 | Thyroid hormone metabolic process | Affects phenotype | PMID:34748891 |
| GO:0042416 | Dopamine biosynthetic process | Decreases phenotype | PMID:23357119; PMID:27252111 |
| GO:0042417 | Dopamine metabolic process | Affects phenotype | PMID:32034696; PMID:35337893 |
| GO:0042428 | Serotonin metabolic process | Affects phenotype | PMID:32034696 |
| GO:0042438 | Melanin biosynthetic process | Affects phenotype | PMID:21290442 |
| GO:0042448 | Progesterone metabolic process | Affects phenotype | PMID:32810592 |
| GO:0042552 | Myelination | Decreases phenotype | PMID:33038355 |
| GO:0042554 | Superoxide anion generation | Affects phenotype | PMID:16389571; PMID:17374653; PMID:18436224; PMID:18801486; PMID:19903466; PMID:22524206; PMID:25562607; PMID:26584763; PMID:28315349; PMID:30171828 |
| GO:0042593 | Glucose homeostasis | Decreases phenotype | PMID:12242689 |
| GO:0042632 | Cholesterol homeostasis | Decreases phenotype | PMID:29474904 |
| GO:0043065 | Positive regulation of apoptotic process | Increases phenotype | PMID:12874837; PMID:14625852; PMID:16898267; PMID:17548900; PMID:19017364; PMID:19112469; PMID:19207037; PMID:19623560; PMID:19293639; PMID:19293639; PMID:20083342; PMID:20083342; PMID:21867607; PMID:22592909; PMID:23770986; PMID:23997041; PMID:24316378; PMID:24647664; PMID:24647664; PMID:30152185; PMID:24902966; PMID:24999622; PMID:25084985; PMID:25293876; PMID:25293876; PMID:25354548; PMID:25373458; PMID:25481090; PMID:26050647; PMID:26648539; PMID:28000380; PMID:32229109; PMID:35122929; PMID:37419146; PMID:38490643 |
| GO:0043117 | Positive regulation of vascular permeability | Increases phenotype | PMID:22557973 |
| GO:0043123 | Positive regulation of i-kappab kinase/nf-kappab signaling | Increases phenotype | PMID:23504962 |
| GO:0043124 | Negative regulation of i-kappab kinase/nf-kappab signaling | Increases phenotype | PMID:20386467 |
| GO:0043217 | Myelin maintenance | Decreases phenotype | PMID:27389774 |
| GO:0043303 | Mast cell degranulation | Increases phenotype | PMID:27018130; PMID:31672514 |
| GO:0043408 | Regulation of mapk cascade | Affects phenotype | PMID:12653748; PMID:12888923; PMID:22711909 |
| GO:0043517 | Positive regulation of dna damage response, signal transduction by p53 class mediator | Increases phenotype | PMID:25078064 |
| GO:0043525 | Positive regulation of neuron apoptotic process | Increases phenotype | PMID:16806698; PMID:26944603 |
| GO:0043966 | Histone h3 acetylation | Affects phenotype | PMID:21165570; PMID:21857970; PMID:30958996 |
| GO:0043967 | Histone h4 acetylation | Increases phenotype | PMID:30958996 |
| GO:0044028 | Dna hypomethylation | Increases phenotype | PMID:27132804 |
| GO:0044237 | Cellular metabolic process | Increases phenotype | PMID:31201582; PMID:31332904; PMID:32120800; PMID:32329368; PMID:32530119; PMID:32530119; PMID:36893906; PMID:33021114; PMID:33070227; PMID:33276066; PMID:34219513; PMID:35510228; PMID:35945655; PMID:36044117; PMID:36584933; PMID:36870413; PMID:36893906; PMID:36982678; PMID:37115092; PMID:37147755; PMID:38740240; PMID:40009568 |
| GO:0044319 | Wound healing, spreading of cells | Decreases phenotype | PMID:22871832; PMID:23645742; PMID:24275163; PMID:25380086; PMID:25380086; PMID:28811126; PMID:27279714; PMID:32530119; PMID:33070227; PMID:36094770 |
| GO:0044849 | Estrous cycle | Affects phenotype | PMID:27634381 |
| GO:0044854 | Plasma membrane raft assembly | Increases phenotype | PMID:18720166 |
| GO:0045019 | Negative regulation of nitric oxide biosynthetic process | Increases phenotype | PMID:29474904 |
| GO:0045023 | G0 to g1 transition | Decreases phenotype | PMID:32530119; PMID:36982678 |
| GO:0045329 | Carnitine biosynthetic process | Decreases phenotype | PMID:22426011 |
| GO:0045333 | Cellular respiration | Decreases phenotype | PMID:26363153 |
| GO:0045429 | Positive regulation of nitric oxide biosynthetic process | Affects phenotype | PMID:11401418; PMID:15832817; PMID:18506933; PMID:18551111; PMID:22488414; PMID:23758074; PMID:23855546; PMID:25411067; PMID:25411067; PMID:29474904; PMID:27257013; PMID:37419146 |
| GO:0045444 | Fat cell differentiation | Increases phenotype | PMID:28854906 |
| GO:0045454 | Cell redox homeostasis | Affects phenotype | PMID:24316378; PMID:30821249; PMID:37230155; PMID:9429083 |
| GO:0045597 | Positive regulation of cell differentiation | Increases phenotype | PMID:12227197 |
| GO:0045599 | Negative regulation of fat cell differentiation | Increases phenotype | PMID:37467934 |
| GO:0045654 | Positive regulation of megakaryocyte differentiation | Increases phenotype | PMID:20523355 |
| GO:0045668 | Negative regulation of osteoblast differentiation | Increases phenotype | PMID:37467934 |
| GO:0045669 | Positive regulation of osteoblast differentiation | Increases phenotype | PMID:26053266; PMID:37690812 |
| GO:0045766 | Positive regulation of angiogenesis | Decreases phenotype | PMID:26676551 |
| GO:0045821 | Positive regulation of glycolytic process | Decreases phenotype | PMID:25658812 |
| GO:0045837 | Negative regulation of membrane potential | Increases phenotype | PMID:30636491 |
| GO:0045906 | Negative regulation of vasoconstriction | Increases phenotype | PMID:22488414; PMID:23758074 |
| GO:0045907 | Positive regulation of vasoconstriction | Increases phenotype | PMID:22488414; PMID:22557973; PMID:23758074 |
| GO:0045919 | Positive regulation of cytolysis | Increases phenotype | PMID:35122929 |
| GO:0045930 | Negative regulation of mitotic cell cycle | Increases phenotype | PMID:11854699; PMID:1581893; PMID:16618767; PMID:19194971; PMID:19293639; PMID:19293639; PMID:20803121; PMID:32530119; PMID:20386985; PMID:21732360; PMID:22230496; PMID:22431435; PMID:28811126; PMID:22555976; PMID:28251795; PMID:24173369; PMID:24368982; PMID:25655047; PMID:25830055; PMID:25896587; PMID:26623679; PMID:27470402; PMID:27514524; PMID:30171828; PMID:32530119; PMID:6828043 |
| GO:0045931 | Positive regulation of mitotic cell cycle | Decreases phenotype | PMID:25896339 |
| GO:0045944 | Positive regulation of transcription by rna polymerase ii | Increases phenotype | PMID:28668616 |
| GO:0046031 | Adp metabolic process | Increases phenotype | PMID:25064450 |
| GO:0046034 | Atp metabolic process | Increases phenotype | PMID:25064450 |
| GO:0046209 | Nitric oxide metabolic process | Increases phenotype | PMID:27224288; PMID:34748891; PMID:37390879; PMID:38447874; PMID:38447874 |
| GO:0046323 | Glucose import | Affects phenotype | PMID:35945655 |
| GO:0046326 | Positive regulation of glucose import | Decreases phenotype | PMID:23664836 |
| GO:0046330 | Positive regulation of jnk cascade | Increases phenotype | PMID:27257013 |
| GO:0046415 | Urate metabolic process | Decreases phenotype | PMID:22535755; PMID:25411067; PMID:34751495 |
| GO:0046449 | Creatinine metabolic process | Decreases phenotype | PMID:21284339; PMID:21909718; PMID:24946265; PMID:25411067; PMID:34751495; PMID:34922902; PMID:35510228; PMID:39053875 |
| GO:0046466 | Membrane lipid catabolic process | Increases phenotype | PMID:11350494; PMID:12669184; PMID:12763102; PMID:14685008; PMID:1756517; PMID:18980205; PMID:30636491; PMID:35337893; PMID:35906875; PMID:37419146; PMID:38490643 |
| GO:0046628 | Positive regulation of insulin receptor signaling pathway | Decreases phenotype | PMID:24491314 |
| GO:0046685 | Response to arsenic-containing substance | Affects phenotype | PMID:37797956 |
| GO:0046785 | Microtubule polymerization | Decreases phenotype | PMID:12390030 |
| GO:0046827 | Positive regulation of protein export from nucleus | Increases phenotype | PMID:21294050; PMID:27601294 |
| GO:0046882 | Negative regulation of follicle-stimulating hormone secretion | Increases phenotype | PMID:37098359 |
| GO:0046961 | Proton-transporting atpase activity, rotational mechanism | Decreases phenotype | PMID:10882397 |
| GO:0047498 | Calcium-dependent phospholipase a2 activity | Decreases phenotype | PMID:3218613 |
| GO:0048023 | Positive regulation of melanin biosynthetic process | Increases phenotype | PMID:24318284 |
| GO:0048143 | Astrocyte activation | Affects phenotype | PMID:27583449; PMID:35822592 |
| GO:0048286 | Lung alveolus development | Decreases phenotype | PMID:29432836 |
| GO:0048385 | Regulation of retinoic acid receptor signaling pathway | Affects phenotype | PMID:25151738 |
| GO:0048874 | Host-mediated regulation of intestinal microbiota composition | Affects phenotype | PMID:37797956 |
| GO:0050665 | Hydrogen peroxide biosynthetic process | Affects phenotype | PMID:18394220; PMID:21337715; PMID:21472459; PMID:22356231; PMID:22467373; PMID:26054880; PMID:27344173; PMID:28040552; PMID:30171828 |
| GO:0050729 | Positive regulation of inflammatory response | Affects phenotype | PMID:26066604; PMID:26873426; PMID:32537472; PMID:37419146; PMID:38823456 |
| GO:0050746 | Regulation of lipoprotein metabolic process | Affects phenotype | PMID:21250691 |
| GO:0050766 | Positive regulation of phagocytosis | Decreases phenotype | PMID:17958546 |
| GO:0050801 | Monoatomic ion homeostasis | Affects phenotype | PMID:34922902 |
| GO:0050878 | Regulation of body fluid levels | Increases phenotype | PMID:28341573 |
| GO:0050890 | Cognition | Decreases phenotype | PMID:38246289 |
| GO:0050996 | Positive regulation of lipid catabolic process | Increases phenotype | PMID:25345581; PMID:37098359 |
| GO:0051091 | Positive regulation of dna-binding transcription factor activity | Increases phenotype | PMID:15832817 |
| GO:0051092 | Positive regulation of nf-kappab transcription factor activity | Affects phenotype | PMID:16177186; PMID:18404532; PMID:21282043; PMID:21867678; PMID:22683914; PMID:27166148; PMID:27583449 |
| GO:0051209 | Release of sequestered calcium ion into cytosol | Increases phenotype | PMID:19814731 |
| GO:0051281 | Positive regulation of release of sequestered calcium ion into cytosol | Increases phenotype | PMID:23022152; PMID:26341291; PMID:9590266 |
| GO:0051348 | Negative regulation of transferase activity | Affects phenotype | PMID:35122929 |
| GO:0051482 | Positive regulation of cytosolic calcium ion concentration involved in phospholipase c-activating g protein-coupled signaling pathway | Increases phenotype | PMID:26341291 |
| GO:0051881 | Regulation of mitochondrial membrane potential | Decreases phenotype | PMID:14505808; PMID:15538571; PMID:20386985; PMID:20654599; PMID:20658310; PMID:22431435; PMID:20803121; PMID:21750559; PMID:22257724; PMID:22275840; PMID:23534466; PMID:24126416; PMID:24535669; PMID:24612139; PMID:25339540; PMID:25830055; PMID:26277538; PMID:26363153; PMID:26584763; PMID:27050144; PMID:27050422; PMID:27132804; PMID:27389774; PMID:31332904; PMID:32530119; PMID:35510228 |
| GO:0051897 | Positive regulation of protein kinase b signaling | Affects phenotype | PMID:25658812; PMID:28000380 |
| GO:0051901 | Positive regulation of mitochondrial depolarization | Increases phenotype | PMID:24647664 |
| GO:0055072 | Iron ion homeostasis | Affects phenotype | PMID:39053875 |
| GO:0055074 | Calcium ion homeostasis | Affects phenotype | PMID:23530660 |
| GO:0055088 | Lipid homeostasis | Affects phenotype | PMID:18551111; PMID:21462320; PMID:23647015; PMID:24491314; PMID:25712622 |
| GO:0055091 | Phospholipid homeostasis | Decreases phenotype | PMID:11401418 |
| GO:0060326 | Cell chemotaxis | Decreases phenotype | PMID:32530119; PMID:33070227; PMID:33686878; PMID:34219513 |
| GO:0060402 | Calcium ion transport into cytosol | Increases phenotype | PMID:23530660 |
| GO:0060454 | Positive regulation of gastric acid secretion | Decreases phenotype | PMID:18547560 |
| GO:0060612 | Adipose tissue development | Increases phenotype | PMID:24025686 |
| GO:0060707 | Trophoblast giant cell differentiation | Affects phenotype | PMID:38387710 |
| GO:0061370 | Testosterone biosynthetic process | Decreases phenotype | PMID:22356231; PMID:24316378; PMID:25046308; PMID:25882133; PMID:27111109; PMID:28040552; PMID:29710542; PMID:32232643; PMID:38740240 |
| GO:0061408 | Positive regulation of transcription from rna polymerase ii promoter in response to heat stress | Decreases phenotype | PMID:21798748 |
| GO:0061436 | Establishment of skin barrier | Decreases phenotype | PMID:23668856 |
| GO:0061518 | Microglial cell proliferation | Increases phenotype | PMID:38246289 |
| GO:0061951 | Establishment of protein localization to plasma membrane | Increases phenotype | PMID:30591588 |
| GO:0070265 | Necrotic cell death | Increases phenotype | PMID:22275840; PMID:25882133; PMID:25929518; PMID:26986492; PMID:28679351; PMID:32757775; PMID:33070227; PMID:39053875 |
| GO:0070267 | Oncosis | Increases phenotype | PMID:26766292 |
| GO:0070269 | Pyroptosis | Increases phenotype | PMID:34791735 |
| GO:0070328 | Triglyceride homeostasis | Decreases phenotype | PMID:29474904 |
| GO:0070346 | Positive regulation of fat cell proliferation | Increases phenotype | PMID:24586721 |
| GO:0070365 | Hepatocyte differentiation | Increases phenotype | PMID:26739637 |
| GO:0070374 | Positive regulation of erk1 and erk2 cascade | Affects phenotype | PMID:25481090; PMID:27257013 |
| GO:0070509 | Calcium ion import | Increases phenotype | PMID:31672514 |
| GO:0070527 | Platelet aggregation | Increases phenotype | PMID:19814731; PMID:23249183 |
| GO:0070585 | Protein localization to mitochondrion | Decreases phenotype | PMID:26944603 |
| GO:0070633 | Transepithelial transport | Increases phenotype | PMID:33276066 |
| GO:0070994 | Detection of oxidative stress | Increases phenotype | PMID:23543441; PMID:25578686; PMID:26887929; PMID:27113704; PMID:32347499; PMID:33439051; PMID:34791735; PMID:34922902; PMID:35510228; PMID:36808657; PMID:37566541; PMID:38447874; PMID:38740240; PMID:39988050 |
| GO:0071222 | Cellular response to lipopolysaccharide | Decreases phenotype | PMID:28984087 |
| GO:0071493 | Cellular response to uv-b | Affects phenotype | PMID:19138980 |
| GO:0071897 | Dna biosynthetic process | Affects phenotype | PMID:22125951; PMID:26476374 |
| GO:0071902 | Positive regulation of protein serine/threonine kinase activity | Increases phenotype | PMID:24491314 |
| GO:0072175 | Epithelial tube formation | Increases phenotype | PMID:21857970 |
| GO:0072593 | Reactive oxygen species metabolic process | Increases phenotype | PMID:23530649; PMID:23607047; PMID:24952260; PMID:25111660; PMID:26277538; PMID:32530119; PMID:32902906; PMID:34791735; PMID:36584933; PMID:39127184; PMID:40009568 |
| GO:0072676 | Lymphocyte migration | Decreases phenotype | PMID:27525872 |
| GO:0072678 | T cell migration | Increases phenotype | PMID:22728078 |
| GO:0090181 | Regulation of cholesterol metabolic process | Affects phenotype | PMID:21250691 |
| GO:0090200 | Positive regulation of release of cytochrome c from mitochondria | Increases phenotype | PMID:22983795; PMID:25293876; PMID:26944603 |
| GO:0090559 | Regulation of membrane permeability | Affects phenotype | PMID:24593786 |
| GO:0090668 | Endothelial cell chemotaxis to vascular endothelial growth factor | Increases phenotype | PMID:23094058 |
| GO:0097188 | Dentin mineralization | Increases phenotype | PMID:24102669 |
| GO:0097212 | Lysosomal membrane organization | Decreases phenotype | PMID:32527420 |
| GO:0097237 | Cellular response to toxic substance | Decreases phenotype | PMID:35122929 |
| GO:0097280 | Histamine secretion mediated by immunoglobulin | Decreases phenotype | PMID:2448357 |
| GO:0097327 | Response to antineoplastic agent | Affects phenotype | PMID:24999622; PMID:26050647 |
| GO:0097503 | Sialylation | Affects phenotype | PMID:17931660 |
| GO:0097531 | Mast cell migration | Increases phenotype | PMID:24465016 |
| GO:0097707 | Ferroptosis | Increases phenotype | PMID:36584933 |
| GO:0097722 | Sperm motility | Decreases phenotype | PMID:25882133; PMID:28040552; PMID:37098359; PMID:38740240 |
| GO:0098706 | Iron ion import across cell outer membrane | Increases phenotype | PMID:24746831 |
| GO:0106292 | Superoxide-generating nadph oxidase activity | Increases phenotype | PMID:27344173 |
| GO:0120039 | Plasma membrane bounded cell projection morphogenesis | Decreases phenotype | PMID:28431985 |
| GO:0140042 | Lipid droplet formation | Increases phenotype | PMID:30445784; PMID:33021114 |
| GO:0160020 | Positive regulation of ferroptosis | Increases phenotype | PMID:37230155 |
| GO:1900086 | Positive regulation of peptidyl-tyrosine autophosphorylation | Increases phenotype | PMID:22387535 |
| GO:1900087 | Positive regulation of g1/s transition of mitotic cell cycle | Decreases phenotype | PMID:16898267; PMID:19623560; PMID:24647664; PMID:25293876; PMID:25354548 |
| GO:1900111 | Positive regulation of histone h3-k9 dimethylation | Decreases phenotype | PMID:28414027 |
| GO:1900114 | Positive regulation of histone h3-k9 trimethylation | Decreases phenotype | PMID:28414027 |
| GO:1900181 | Negative regulation of protein localization to nucleus | Increases phenotype | PMID:35122929 |
| GO:1900409 | Positive regulation of cellular response to oxidative stress | Increases phenotype | PMID:32537472 |
| GO:1900745 | Positive regulation of p38mapk cascade | Affects phenotype | PMID:11597122; PMID:16532021; PMID:20083342; PMID:22592909; PMID:22683914; PMID:22711909; PMID:24647664; PMID:25614714; PMID:25957741; PMID:26053266; PMID:26586997; PMID:27257013; PMID:27454768 |
| GO:1901165 | Positive regulation of trophoblast cell migration | Decreases phenotype | PMID:25354548 |
| GO:1901224 | Positive regulation of nik/nf-kappab signaling | Affects phenotype | PMID:18404532; PMID:20828867; PMID:21282043; PMID:22452660; PMID:22683914; PMID:25957741; PMID:26873426; PMID:27601294 |
| GO:1901656 | Glycoside transport | Affects phenotype | PMID:33184029 |
| GO:1901670 | Negative regulation of superoxide dismutase activity | Increases phenotype | PMID:24569067; PMID:29667781; PMID:30372826; PMID:30821249; PMID:34726822; PMID:34751495; PMID:35122929; PMID:35876585; PMID:38490643 |
| GO:1901671 | Positive regulation of superoxide dismutase activity | Affects phenotype | PMID:12242689; PMID:16177186; PMID:18547560; PMID:23758074; PMID:23997041; PMID:24316378; PMID:24902966; PMID:25532488; PMID:25537132; PMID:27527349; PMID:25539033 |
| GO:1901687 | Glutathione derivative biosynthetic process | Affects phenotype | PMID:11424224; PMID:19838946; PMID:22830632; PMID:23357119; PMID:24316378 |
| GO:1901992 | Positive regulation of mitotic cell cycle phase transition | Decreases phenotype | PMID:11597122 |
| GO:1902174 | Positive regulation of keratinocyte apoptotic process | Increases phenotype | PMID:19138980 |
| GO:1902237 | Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | Increases phenotype | PMID:24368982 |
| GO:1902459 | Positive regulation of stem cell population maintenance | Decreases phenotype | PMID:27468969 |
| GO:1902512 | Positive regulation of apoptotic dna fragmentation | Increases phenotype | PMID:12874837; PMID:16158945; PMID:28251795; PMID:16806698; PMID:22983795; PMID:25289772; PMID:26944603; PMID:28251795; PMID:30639267 |
| GO:1903038 | Negative regulation of leukocyte cell-cell adhesion | Increases phenotype | PMID:29740324 |
| GO:1903047 | Mitotic cell cycle process | Affects phenotype | PMID:36982678 |
| GO:1903078 | Positive regulation of protein localization to plasma membrane | Affects phenotype | PMID:24465016 |
| GO:1903223 | Positive regulation of oxidative stress-induced neuron death | Increases phenotype | PMID:37419146 |
| GO:1903283 | Negative regulation of glutathione peroxidase activity | Increases phenotype | PMID:29667781; PMID:30821249; PMID:34726822; PMID:35122929; PMID:35876585 |
| GO:1903284 | Positive regulation of glutathione peroxidase activity | Decreases phenotype | PMID:10647909; PMID:12242689; PMID:23997041; PMID:25532488; PMID:25537132 |
| GO:1903348 | Positive regulation of bicellular tight junction assembly | Decreases phenotype | PMID:28431985 |
| GO:1903409 | Reactive oxygen species biosynthetic process | Increases phenotype | PMID:10865939; PMID:14505808; PMID:14505808; PMID:17045724; PMID:15735102; PMID:16647178; PMID:17458902; PMID:19194971; PMID:19723100; PMID:19958256; PMID:21775390; PMID:22002103; PMID:22257724; PMID:22295890; PMID:22482891; PMID:22685622; PMID:22728154; PMID:23265624; PMID:24173369; PMID:24337353; PMID:24535669; PMID:24593786; PMID:24612139; PMID:25108166; PMID:25203460; PMID:25204422; PMID:26076811; PMID:26218279; PMID:26493151; PMID:26584763; PMID:27050144; PMID:27050422; PMID:27113704; PMID:27260466; PMID:27389774; PMID:27494022; PMID:27525270; PMID:28533128; PMID:28811126; PMID:28881718; PMID:30636491 |
| GO:1903428 | Positive regulation of reactive oxygen species biosynthetic process | Affects phenotype | PMID:12874837; PMID:19138980; PMID:19293639; PMID:20083342; PMID:20083342; PMID:20523355; PMID:20705415; PMID:22452660; PMID:22902249; PMID:23504962; PMID:23647015; PMID:23770986; PMID:23855546; PMID:23997041; PMID:24902966; PMID:24999622; PMID:25293876; PMID:25354548; PMID:25712622; PMID:26066604; PMID:26311153; PMID:26374991; PMID:26944603; PMID:27454768; PMID:30152185; PMID:32527420; PMID:35122929; PMID:37230155; PMID:37419146; PMID:38490643 |
| GO:1903573 | Negative regulation of response to endoplasmic reticulum stress | Increases phenotype | PMID:30368985 |
| GO:1903583 | Positive regulation of basophil degranulation | Increases phenotype | PMID:31751647; PMID:9590266 |
| GO:1903607 | Cytochrome c biosynthetic process | Increases phenotype | PMID:20658310 |
| GO:1903626 | Positive regulation of dna catabolic process | Increases phenotype | PMID:30821249; PMID:32229109 |
| GO:1903787 | Negative regulation of glutathione biosynthetic process | Increases phenotype | PMID:37098359 |
| GO:1903935 | Response to sodium arsenite | Affects phenotype | PMID:17931660 |
| GO:1903980 | Positive regulation of microglial cell activation | Increases phenotype | PMID:28984087 |
| GO:1904007 | Positive regulation of phospholipase d activity | Increases phenotype | PMID:8928743 |
| GO:1904011 | Cellular response to aroclor 1254 | Affects phenotype | PMID:21472459 |
| GO:1904063 | Negative regulation of cation transmembrane transport | Increases phenotype | PMID:24647664 |
| GO:1904064 | Positive regulation of cation transmembrane transport | Increases phenotype | PMID:24647664 |
| GO:1904094 | Positive regulation of autophagic cell death | Increases phenotype | PMID:28251795 |
| GO:1904179 | Positive regulation of adipose tissue development | Increases phenotype | PMID:21462320; PMID:24465016; PMID:24491314 |
| GO:1904180 | Negative regulation of membrane depolarization | Increases phenotype | PMID:25967872 |
| GO:1904305 | Negative regulation of gastro-intestinal system smooth muscle contraction | Increases phenotype | PMID:25967872 |
| GO:1904480 | Positive regulation of intestinal absorption | Decreases phenotype | PMID:12663055 |
| GO:1904659 | Glucose transmembrane transport | Increases phenotype | PMID:220448 |
| GO:1904738 | Vascular associated smooth muscle cell migration | Affects phenotype | PMID:11854699; PMID:26476374 |
| GO:1904833 | Positive regulation of removal of superoxide radicals | Increases phenotype | PMID:25354548 |
| GO:1904996 | Positive regulation of leukocyte adhesion to vascular endothelial cell | Increases phenotype | PMID:22557973 |
| GO:1905523 | Positive regulation of macrophage migration | Increases phenotype | PMID:24465016 |
| GO:1905628 | Negative regulation of serotonin biosynthetic process | Increases phenotype | PMID:37419146 |
| GO:1905844 | Negative regulation of cellular response to gamma radiation | Increases phenotype | PMID:30368985 |
| GO:1990051 | Activation of protein kinase c activity | Affects phenotype | PMID:26311153; PMID:3089985 |
| GO:2000193 | Positive regulation of fatty acid transport | Increases phenotype | PMID:25712622 |
| GO:2000224 | Regulation of testosterone biosynthetic process | Affects phenotype | PMID:25539033 |
| GO:2000379 | Positive regulation of reactive oxygen species metabolic process | Increases phenotype | PMID:24569067 |
| GO:2000391 | Positive regulation of neutrophil extravasation | Decreases phenotype | PMID:27525872 |
| GO:2000439 | Positive regulation of monocyte extravasation | Increases phenotype | PMID:38823456 |
| GO:2000491 | Positive regulation of hepatic stellate cell activation | Affects phenotype | PMID:27601294 |
| GO:2000519 | Positive regulation of t-helper 1 cell activation | Increases phenotype | PMID:38823456 |
| GO:2000609 | Regulation of thyroid hormone generation | Affects phenotype | PMID:25151738 |
| GO:2000617 | Positive regulation of histone h3-k9 acetylation | Increases phenotype | PMID:20705415 |
| GO:2000648 | Positive regulation of stem cell proliferation | Decreases phenotype | PMID:27468969 |
| GO:2000685 | Positive regulation of cellular response to x-ray | Decreases phenotype | PMID:25339115 |
| GO:2000774 | Positive regulation of cellular senescence | Increases phenotype | PMID:25481090 |
| GO:2000786 | Positive regulation of autophagosome assembly | Increases phenotype | PMID:25293876; PMID:28251795 |
| GO:2000844 | Negative regulation of testosterone secretion | Increases phenotype | PMID:37098359 |
| GO:2000845 | Positive regulation of testosterone secretion | Decreases phenotype | PMID:24316378; PMID:26264430 |
| GO:2000866 | Positive regulation of estradiol secretion | Increases phenotype | PMID:28431985 |
| GO:2000872 | Positive regulation of progesterone secretion | Decreases phenotype | PMID:28431985 |
| GO:2001038 | Regulation of cellular response to drug | Affects phenotype | PMID:38401715 |
| GO:2001057 | Reactive nitrogen species metabolic process | Increases phenotype | PMID:22524206; PMID:26887929; PMID:27527349 |
| GO:2001244 | Positive regulation of intrinsic apoptotic signaling pathway | Increases phenotype | PMID:30639267 |
| GO:2001250 | Positive regulation of ammonia assimilation cycle | Decreases phenotype | PMID:24491314 |
| GO:2001272 | Positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis | Increases phenotype | PMID:25896339 |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.