Biochanin A


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000737 Dna catabolic process, endonucleolytic Increases phenotype PMID:35547012; PMID:39177155
GO:0004096 Catalase activity Increases phenotype PMID:39177155
GO:0004364 Glutathione transferase activity Affects phenotype PMID:33410021; PMID:39177155
GO:0004691 Camp-dependent protein kinase activity Decreases phenotype PMID:9115691
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:33410021; PMID:35547012; PMID:38764152; PMID:39177155
GO:0006309 Apoptotic dna fragmentation Increases phenotype PMID:12791511
GO:0006711 Estrogen catabolic process Increases phenotype PMID:28985473
GO:0006749 Glutathione metabolic process Affects phenotype PMID:33410021; PMID:35547012; PMID:37016276; PMID:38764152; PMID:39177155
GO:0006915 Apoptotic process Increases phenotype PMID:12791511
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:33410021
GO:0008283 Cell population proliferation Decreases phenotype PMID:12791511
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:32259555
GO:0016042 Lipid catabolic process Affects phenotype PMID:33410021
GO:0018158 Protein oxidation Affects phenotype PMID:33410021; PMID:39177155
GO:0030336 Negative regulation of cell migration Increases phenotype PMID:38266663
GO:0032963 Collagen metabolic process Affects phenotype PMID:37016276
GO:0034440 Lipid oxidation Increases phenotype PMID:35547012; PMID:37016276; PMID:38764152; PMID:39177155
GO:0036211 Protein modification process Increases phenotype PMID:35547012
GO:0043123 Positive regulation of i-kappab kinase/nf-kappab signaling Increases phenotype PMID:22387535
GO:0046209 Nitric oxide metabolic process Affects phenotype PMID:38764152
GO:0046449 Creatinine metabolic process Affects phenotype PMID:37057715
GO:0046961 Proton-transporting atpase activity, rotational mechanism Decreases phenotype PMID:10882397
GO:0051091 Positive regulation of dna-binding transcription factor activity Increases phenotype PMID:22387535
GO:0051092 Positive regulation of nf-kappab transcription factor activity Increases phenotype PMID:22387535
GO:0070265 Necrotic cell death Increases phenotype PMID:38764152; PMID:39177155
GO:0071243 Cellular response to arsenic-containing substance Affects phenotype PMID:35547012
GO:0071247 Cellular response to chromate Affects phenotype PMID:35547012
GO:0071674 Mononuclear cell migration Increases phenotype PMID:39177155
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:38764152
GO:0097722 Sperm motility Decreases phenotype PMID:33410021
GO:0098759 Cellular response to interleukin-8 Decreases phenotype PMID:22387535
GO:1900086 Positive regulation of peptidyl-tyrosine autophosphorylation Increases phenotype PMID:22387535
GO:1901224 Positive regulation of nik/nf-kappab signaling Increases phenotype PMID:22387535
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.