Luteolin


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000045 Autophagosome assembly Increases phenotype PMID:32268164
GO:0000080 Mitotic g1 phase Affects phenotype PMID:33727136
GO:0000084 Mitotic s phase Affects phenotype PMID:33727136
GO:0001516 Prostaglandin biosynthetic process Increases phenotype PMID:24134915
GO:0001836 Release of cytochrome c from mitochondria Increases phenotype PMID:29115570
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:33827303
GO:0002693 Positive regulation of cellular extravasation Increases phenotype PMID:25450234
GO:0002863 Positive regulation of inflammatory response to antigenic stimulus Increases phenotype PMID:25450234
GO:0003810 Protein-glutamine gamma-glutamyltransferase activity Increases phenotype PMID:33827303
GO:0004035 Alkaline phosphatase activity Increases phenotype PMID:33827303
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Increases phenotype PMID:33827303
GO:0004364 Glutathione transferase activity Increases phenotype PMID:33827303
GO:0004457 Lactate dehydrogenase activity Increases phenotype PMID:33827303
GO:0004602 Glutathione peroxidase activity Affects phenotype PMID:26279214; PMID:33827303
GO:0004672 Protein kinase activity Decreases phenotype PMID:10556937
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:31362009; PMID:33675858; PMID:33827303
GO:0006309 Apoptotic dna fragmentation Increases phenotype PMID:10556937; PMID:12168845; PMID:32268164
GO:0006468 Protein phosphorylation Decreases phenotype PMID:12168845
GO:0006606 Protein import into nucleus Affects phenotype PMID:34217685
GO:0006695 Cholesterol biosynthetic process Increases phenotype PMID:25169908
GO:0006749 Glutathione metabolic process Increases phenotype PMID:31091348; PMID:31201582; PMID:31288002; PMID:33827303
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:25448439; PMID:25612170; PMID:26279214
GO:0006809 Nitric oxide biosynthetic process Increases phenotype PMID:31362009
GO:0006884 Cell volume homeostasis Affects phenotype PMID:34217685
GO:0006915 Apoptotic process Increases phenotype PMID:24525192; PMID:25612170; PMID:27474067; PMID:27489195; PMID:27525270; PMID:29115570; PMID:33727136; PMID:39216304
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:33727136
GO:0008283 Cell population proliferation Increases phenotype PMID:10556937; PMID:10556937; PMID:12168845; PMID:10556937; PMID:23994263; PMID:12168845; PMID:24525192; PMID:25058688; PMID:25448439; PMID:27474067; PMID:27489195; PMID:27525270; PMID:32268164
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:30207190; PMID:32259555; PMID:38134066; PMID:38230768
GO:0010917 Negative regulation of mitochondrial membrane potential Increases phenotype PMID:38103742
GO:0010918 Positive regulation of mitochondrial membrane potential Decreases phenotype PMID:28942281
GO:0010942 Positive regulation of cell death Decreases phenotype PMID:22683914
GO:0014067 Negative regulation of phosphatidylinositol 3-kinase signaling Increases phenotype PMID:38134066
GO:0016042 Lipid catabolic process Increases phenotype PMID:19489629; PMID:25448439; PMID:31091348; PMID:31362009
GO:0016049 Cell growth Decreases phenotype PMID:25612170
GO:0016174 Nad(p)h oxidase h2o2-forming activity Increases phenotype PMID:25448439
GO:0016477 Cell migration Increases phenotype PMID:30016632
GO:0016887 Atp hydrolysis activity Increases phenotype PMID:34217736
GO:0017148 Negative regulation of translation Increases phenotype PMID:32407927
GO:0018108 Peptidyl-tyrosine phosphorylation Increases phenotype PMID:10556937
GO:0018158 Protein oxidation Increases phenotype PMID:32407927
GO:0019627 Urea metabolic process Affects phenotype PMID:33827303
GO:0030335 Positive regulation of cell migration Increases phenotype PMID:30133131
GO:0032125 Micronucleus organization Increases phenotype PMID:33727136
GO:0032148 Activation of protein kinase b activity Increases phenotype PMID:29052401
GO:0033212 Iron import into cell Increases phenotype PMID:39231684
GO:0034374 Low-density lipoprotein particle remodeling Increases phenotype PMID:19489629
GO:0034440 Lipid oxidation Increases phenotype PMID:12738181; PMID:29115570; PMID:31288002; PMID:32407927; PMID:33827303
GO:0034614 Cellular response to reactive oxygen species Decreases phenotype PMID:22683914
GO:0035635 Entry of bacterium into host cell Decreases phenotype PMID:25051393
GO:0035640 Exploration behavior Decreases phenotype PMID:31362009
GO:0035936 Testosterone secretion Affects phenotype PMID:31201582
GO:0036275 Response to 5-fluorouracil Increases phenotype PMID:31288002
GO:0042118 Endothelial cell activation Increases phenotype PMID:17313705
GO:0042161 Lipoprotein oxidation Increases phenotype PMID:17313705
GO:0042307 Positive regulation of protein import into nucleus Increases phenotype PMID:30133131
GO:0042310 Vasoconstriction Increases phenotype PMID:25169908
GO:0042360 Vitamin e metabolic process Increases phenotype PMID:19489629
GO:0042701 Progesterone secretion Affects phenotype PMID:31201582
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:38103742
GO:0044237 Cellular metabolic process Affects phenotype PMID:29115570; PMID:32268164; PMID:33727136; PMID:34217685; PMID:37115092; PMID:37308028; PMID:39216304
GO:0044319 Wound healing, spreading of cells Decreases phenotype PMID:27474067; PMID:37379125
GO:0044854 Plasma membrane raft assembly Increases phenotype PMID:18720166
GO:0045023 G0 to g1 transition Affects phenotype PMID:33727136
GO:0045429 Positive regulation of nitric oxide biosynthetic process Increases phenotype PMID:18448292
GO:0045907 Positive regulation of vasoconstriction Increases phenotype PMID:29052401
GO:0045919 Positive regulation of cytolysis Increases phenotype PMID:30207190
GO:0046034 Atp metabolic process Decreases phenotype PMID:29115570; PMID:33727136
GO:0046209 Nitric oxide metabolic process Increases phenotype PMID:33827303; PMID:37390879
GO:0046415 Urate metabolic process Affects phenotype PMID:31091348
GO:0046449 Creatinine metabolic process Affects phenotype PMID:31091348; PMID:33827303; PMID:37057715
GO:0050665 Hydrogen peroxide biosynthetic process Increases phenotype PMID:31362009
GO:0050728 Negative regulation of inflammatory response Increases phenotype PMID:37563784
GO:0050996 Positive regulation of lipid catabolic process Increases phenotype PMID:39231684
GO:0051092 Positive regulation of nf-kappab transcription factor activity Decreases phenotype PMID:22683914
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:34217685; PMID:39216304
GO:0051882 Mitochondrial depolarization Increases phenotype PMID:29115570
GO:0060047 Heart contraction Affects phenotype PMID:28115273
GO:0061951 Establishment of protein localization to plasma membrane Increases phenotype PMID:30133131; PMID:30591588
GO:0071466 Cellular response to xenobiotic stimulus Decreases phenotype PMID:38175295
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:25448439; PMID:29115570; PMID:33675858; PMID:34217685; PMID:34699766; PMID:39105397
GO:0090557 Establishment of endothelial intestinal barrier Decreases phenotype PMID:33675858
GO:0097153 Cysteine-type endopeptidase activity involved in apoptotic process Increases phenotype PMID:33727136
GO:0098609 Cell-cell adhesion Increases phenotype PMID:17313705
GO:0120189 Positive regulation of bile acid secretion Increases phenotype PMID:32259555
GO:0160020 Positive regulation of ferroptosis Increases phenotype PMID:39231684
GO:1900103 Positive regulation of endoplasmic reticulum unfolded protein response Increases phenotype PMID:32407927
GO:1900182 Positive regulation of protein localization to nucleus Increases phenotype PMID:32407927
GO:1900745 Positive regulation of p38mapk cascade Decreases phenotype PMID:22683914
GO:1901224 Positive regulation of nik/nf-kappab signaling Decreases phenotype PMID:22683914
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:31288002
GO:1901671 Positive regulation of superoxide dismutase activity Increases phenotype PMID:39231684
GO:1903047 Mitotic cell cycle process Affects phenotype PMID:33727136
GO:1903409 Reactive oxygen species biosynthetic process Affects phenotype PMID:19958256; PMID:25169908; PMID:27525270
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:38103742
GO:1903583 Positive regulation of basophil degranulation Increases phenotype PMID:31751647
GO:1903787 Negative regulation of glutathione biosynthetic process Increases phenotype PMID:39231684
GO:1905395 Response to flavonoid Increases phenotype PMID:31288002
GO:1990051 Activation of protein kinase c activity Increases phenotype PMID:3089985
GO:2001170 Negative regulation of atp biosynthetic process Increases phenotype PMID:28942281
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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.