Coumestrol


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0004035 Alkaline phosphatase activity Increases phenotype PMID:31843813
GO:0006915 Apoptotic process Increases phenotype PMID:20623010
GO:0007049 Cell cycle Decreases phenotype PMID:20623010
GO:0008283 Cell population proliferation Affects phenotype PMID:20623010; PMID:24213142
GO:0008284 Positive regulation of cell population proliferation Increases phenotype PMID:28396216; PMID:35307500
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:23526725; PMID:28986287
GO:0008637 Apoptotic mitochondrial changes Increases phenotype PMID:28986287
GO:0010918 Positive regulation of mitochondrial membrane potential Decreases phenotype PMID:28986287
GO:0010976 Positive regulation of neuron projection development Increases phenotype PMID:28396216
GO:0030262 Apoptotic nuclear changes Increases phenotype PMID:28986287
GO:0033148 Positive regulation of intracellular estrogen receptor signaling pathway Increases phenotype PMID:28396216
GO:0036474 Cell death in response to hydrogen peroxide Affects phenotype PMID:23526725
GO:0044819 Mitotic g1/s transition checkpoint signaling Increases phenotype PMID:28986287
GO:0045931 Positive regulation of mitotic cell cycle Increases phenotype PMID:35307500
GO:0098869 Cellular oxidant detoxification Increases phenotype PMID:28986287
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:28986287
GO:1904172 Positive regulation of bleb assembly Increases phenotype PMID:28986287
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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.