3-Chloro-1,2-dihydroxypropane


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0002248 Connective tissue replacement involved in inflammatory response wound healing Increases phenotype PMID:33187795
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:34915118; PMID:37162024
GO:0003016 Respiratory system process Increases phenotype PMID:33187795
GO:0005776 Autophagosome Increases phenotype PMID:32702505; PMID:34812491
GO:0006497 Protein lipidation Affects phenotype PMID:32702505; PMID:32702505; PMID:34812491; PMID:33187795; PMID:34812491; PMID:35149085
GO:0006606 Protein import into nucleus Affects phenotype PMID:34812491
GO:0006874 Cellular calcium ion homeostasis Affects phenotype PMID:33651226
GO:0006914 Autophagy Increases phenotype PMID:33187795; PMID:34812491
GO:0006915 Apoptotic process Increases phenotype PMID:33651226; PMID:34812491
GO:0006954 Inflammatory response Increases phenotype PMID:33187795
GO:0007006 Mitochondrial membrane organization Affects phenotype PMID:33651226
GO:0007042 Lysosomal lumen acidification Decreases phenotype PMID:32702505
GO:0007281 Germ cell development Decreases phenotype PMID:35063618
GO:0007283 Spermatogenesis Decreases phenotype PMID:35063618; PMID:35088268
GO:0008219 Cell death Increases phenotype PMID:17803981; PMID:33187795; PMID:35149085
GO:0008284 Positive regulation of cell population proliferation Decreases phenotype PMID:28070108
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:27884059
GO:0008343 Adult feeding behavior Affects phenotype PMID:30107153
GO:0010917 Negative regulation of mitochondrial membrane potential Increases phenotype PMID:38373586
GO:0010918 Positive regulation of mitochondrial membrane potential Decreases phenotype PMID:27732882
GO:0010942 Positive regulation of cell death Increases phenotype PMID:26025059
GO:0014904 Myotube cell development Decreases phenotype PMID:33171136
GO:0030262 Apoptotic nuclear changes Increases phenotype PMID:27732882
GO:0030263 Apoptotic chromosome condensation Decreases phenotype PMID:35063618
GO:0031987 Locomotion involved in locomotory behavior Increases phenotype PMID:33187795
GO:0035633 Maintenance of blood-brain barrier Decreases phenotype PMID:26025059
GO:0035752 Lysosomal lumen ph elevation Increases phenotype PMID:32702505
GO:0035914 Skeletal muscle cell differentiation Decreases phenotype PMID:33171136
GO:0035936 Testosterone secretion Affects phenotype PMID:35063618
GO:0042692 Muscle cell differentiation Decreases phenotype PMID:33171136
GO:0042755 Eating behavior Decreases phenotype PMID:33187795
GO:0042756 Drinking behavior Increases phenotype PMID:33187795
GO:0044237 Cellular metabolic process Decreases phenotype PMID:33187795; PMID:33651226; PMID:33651226; PMID:35149085; PMID:34812491; PMID:35149085
GO:0044754 Autolysosome Affects phenotype PMID:34812491
GO:0045454 Cell redox homeostasis Decreases phenotype PMID:35088268
GO:0046415 Urate metabolic process Affects phenotype PMID:30107153; PMID:33187795
GO:0046449 Creatinine metabolic process Affects phenotype PMID:29860048; PMID:30107153
GO:0050996 Positive regulation of lipid catabolic process Increases phenotype PMID:35088268
GO:0051726 Regulation of cell cycle Increases phenotype PMID:28070108
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:30107153; PMID:33187795; PMID:33651226
GO:0070265 Necrotic cell death Increases phenotype PMID:33187795; PMID:37162024
GO:0070266 Necroptotic process Increases phenotype PMID:29860048
GO:0070994 Detection of oxidative stress Increases phenotype PMID:32474023
GO:0090116 C-5 methylation of cytosine Decreases phenotype PMID:27884059
GO:0090200 Positive regulation of release of cytochrome c from mitochondria Increases phenotype PMID:27732882
GO:0090298 Negative regulation of mitochondrial dna replication Increases phenotype PMID:33913518
GO:0097195 Pilomotor reflex Increases phenotype PMID:33187795
GO:0097722 Sperm motility Decreases phenotype PMID:35063618; PMID:35088268
GO:0140639 Positive regulation of pyroptosis Increases phenotype PMID:38373586
GO:0160028 Negative regulation of pyroptosis Increases phenotype PMID:38373586
GO:1901526 Positive regulation of mitophagy Increases phenotype PMID:38373586
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:27732882; PMID:28070108; PMID:38373586
GO:2001171 Positive regulation of atp biosynthetic process Decreases phenotype PMID:27732882
GO:2001238 Positive regulation of extrinsic apoptotic signaling pathway Increases phenotype PMID:28070108
GO:2001244 Positive regulation of intrinsic apoptotic signaling pathway Increases phenotype PMID:28070108
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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.