Diisobutyl phthalate


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0001541 Ovarian follicle development Decreases phenotype PMID:34597818; PMID:35762964
GO:0001547 Antral ovarian follicle growth Decreases phenotype PMID:28013214
GO:0001568 Blood vessel development Increases phenotype PMID:37021957
GO:0003006 Developmental process involved in reproduction Affects phenotype PMID:37788136
GO:0004691 Camp-dependent protein kinase activity Increases phenotype PMID:33711355
GO:0006171 Camp biosynthetic process Increases phenotype PMID:37552060
GO:0006694 Steroid biosynthetic process Decreases phenotype PMID:35762964
GO:0007281 Germ cell development Decreases phenotype PMID:30802670; PMID:37788136
GO:0007283 Spermatogenesis Decreases phenotype PMID:30802670
GO:0007286 Spermatid development Decreases phenotype PMID:30802670
GO:0008210 Estrogen metabolic process Affects phenotype PMID:34597818
GO:0008219 Cell death Increases phenotype PMID:33711355
GO:0008283 Cell population proliferation Affects phenotype PMID:34428494; PMID:36708983
GO:0008584 Male gonad development Affects phenotype PMID:30802670
GO:0009566 Fertilization Decreases phenotype PMID:33711355
GO:0009790 Embryo development Decreases phenotype PMID:33711355
GO:0018108 Peptidyl-tyrosine phosphorylation Increases phenotype PMID:33711355
GO:0030728 Ovulation Increases phenotype PMID:33316053
GO:0030850 Prostate gland development Decreases phenotype PMID:30802670
GO:0032308 Positive regulation of prostaglandin secretion Increases phenotype PMID:33316053
GO:0034199 Activation of protein kinase a activity Increases phenotype PMID:37552060
GO:0035936 Testosterone secretion Decreases phenotype PMID:28013214; PMID:30802670; PMID:31199487
GO:0035938 Estradiol secretion Decreases phenotype PMID:28013214
GO:0035941 Androstenedione secretion Decreases phenotype PMID:28013214
GO:0035943 Estrone secretion Decreases phenotype PMID:28013214
GO:0042221 Response to chemical Increases phenotype PMID:34428494
GO:0042448 Progesterone metabolic process Affects phenotype PMID:34597818
GO:0042701 Progesterone secretion Affects phenotype PMID:33316053
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:33511402
GO:0044237 Cellular metabolic process Decreases phenotype PMID:36708983
GO:0044849 Estrous cycle Affects phenotype PMID:36929940
GO:0045444 Fat cell differentiation Increases phenotype PMID:24155963
GO:0046034 Atp metabolic process Affects phenotype PMID:33711355
GO:0048240 Sperm capacitation Increases phenotype PMID:33711355
GO:0048246 Macrophage chemotaxis Increases phenotype PMID:40323316
GO:0048599 Oocyte development Decreases phenotype PMID:28013214
GO:0050679 Positive regulation of epithelial cell proliferation Increases phenotype PMID:40323316
GO:0050729 Positive regulation of inflammatory response Increases phenotype PMID:31199487
GO:0060305 Regulation of cell diameter Affects phenotype PMID:37021957
GO:0060376 Positive regulation of mast cell differentiation Increases phenotype PMID:37021957
GO:0060512 Prostate gland morphogenesis Decreases phenotype PMID:31199487
GO:0060618 Nipple development Affects phenotype PMID:37788136
GO:0061107 Seminal vesicle development Decreases phenotype PMID:30802670
GO:0061370 Testosterone biosynthetic process Decreases phenotype PMID:28655647; PMID:33983380; PMID:34597818
GO:0061458 Reproductive system development Decreases phenotype PMID:37788136
GO:0072520 Seminiferous tubule development Decreases phenotype PMID:30802670
GO:0097722 Sperm motility Decreases phenotype PMID:30802670; PMID:33711355
GO:0098739 Import across plasma membrane Increases phenotype PMID:36708983
GO:1900015 Regulation of cytokine production involved in inflammatory response Affects phenotype PMID:38954831
GO:1900017 Positive regulation of cytokine production involved in inflammatory response Increases phenotype PMID:40323316
GO:1903456 Positive regulation of androst-4-ene-3,17-dione biosynthetic process Decreases phenotype PMID:28655647
GO:1904177 Regulation of adipose tissue development Affects phenotype PMID:37021957
GO:1905867 Epididymis development Affects phenotype PMID:30802670
GO:2000184 Positive regulation of progesterone biosynthetic process Increases phenotype PMID:37552060
GO:2000225 Negative regulation of testosterone biosynthetic process Increases phenotype PMID:37788136
GO:2000611 Positive regulation of thyroid hormone generation Increases phenotype PMID:29734584
GO:2000613 Negative regulation of thyroid-stimulating hormone secretion Increases phenotype PMID:29734584
GO:2000844 Negative regulation of testosterone secretion Increases phenotype PMID:37839492; PMID:39947446
GO:2000865 Negative regulation of estradiol secretion Increases phenotype PMID:37839492
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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.