| GO ID | GO name | Interaction type | Reference |
|---|---|---|---|
| GO:0000002 | Mitochondrial genome maintenance | Decreases phenotype | PMID:28460087 |
| GO:0000045 | Autophagosome assembly | Increases phenotype | PMID:34811946 |
| GO:0000084 | Mitotic s phase | Increases phenotype | PMID:30171970 |
| GO:0000423 | Mitophagy | Increases phenotype | PMID:30144575; PMID:33383311 |
| GO:0001510 | Rna methylation | Affects phenotype | PMID:34425375 |
| GO:0001662 | Behavioral fear response | Affects phenotype | PMID:33368748 |
| GO:0001774 | Microglial cell activation | Increases phenotype | PMID:24521700; PMID:28202386; PMID:29441825; PMID:29568078; PMID:32060784; PMID:32247534; PMID:32375810; PMID:34052309; PMID:34863858; PMID:38189626 |
| GO:0001775 | Cell activation | Increases phenotype | PMID:23562983 |
| GO:0001836 | Release of cytochrome c from mitochondria | Increases phenotype | PMID:18056701; PMID:18056701; PMID:18266926; PMID:30205152; PMID:18266926; PMID:30205152; PMID:32060784; PMID:33383311 |
| GO:0001837 | Epithelial to mesenchymal transition | Increases phenotype | PMID:25873302; PMID:34364922; PMID:34364922; PMID:38444083 |
| GO:0002232 | Leukocyte chemotaxis involved in inflammatory response | Increases phenotype | PMID:26345256 |
| GO:0002253 | Activation of immune response | Increases phenotype | PMID:24818613 |
| GO:0002523 | Leukocyte migration involved in inflammatory response | Increases phenotype | PMID:23603004; PMID:24523768; PMID:24818613; PMID:24963491; PMID:25215149; PMID:25338942; PMID:27993944; PMID:28696894; PMID:30025709; PMID:30036685; PMID:30088170; PMID:24963491; PMID:25215149; PMID:25338942; PMID:27375216; PMID:27375216; PMID:27890776; PMID:28131803; PMID:29273418; PMID:32462952; PMID:34455893; PMID:34463846; PMID:35430322; PMID:38763349; PMID:27890776; PMID:28696894; PMID:28921394; PMID:29273418; PMID:30025709; PMID:30036685; PMID:30088170; PMID:32064027; PMID:32462952; PMID:34455893 |
| GO:0002693 | Positive regulation of cellular extravasation | Increases phenotype | PMID:25815693; PMID:28936961; PMID:25891457 |
| GO:0003347 | Epicardial cell to mesenchymal cell transition | Increases phenotype | PMID:30317802 |
| GO:0003950 | Nad+ adp-ribosyltransferase activity | Decreases phenotype | PMID:31216030 |
| GO:0003994 | Aconitate hydratase activity | Decreases phenotype | PMID:28115273 |
| GO:0004069 | L-aspartate:2-oxoglutarate aminotransferase activity | Increases phenotype | PMID:28077425; PMID:34048864 |
| GO:0004129 | Cytochrome-c oxidase activity | Decreases phenotype | PMID:28090784; PMID:31348582 |
| GO:0004364 | Glutathione transferase activity | Decreases phenotype | PMID:28480221; PMID:34048864 |
| GO:0004457 | Lactate dehydrogenase activity | Increases phenotype | PMID:23546295; PMID:23649336; PMID:24818613; PMID:30797899; PMID:32306690; PMID:34021431; PMID:34048864; PMID:35236239 |
| GO:0004517 | Nitric-oxide synthase activity | Increases phenotype | PMID:19526292 |
| GO:0004565 | Beta-galactosidase activity | Increases phenotype | PMID:32540480 |
| GO:0004575 | Sucrose alpha-glucosidase activity | Decreases phenotype | PMID:34811946 |
| GO:0004602 | Glutathione peroxidase activity | Increases phenotype | PMID:21801858; PMID:21801858; PMID:28090784; PMID:24812154; PMID:24812154; PMID:33592258; PMID:25724285; PMID:28077425; PMID:28090784; PMID:28428137; PMID:30562684; PMID:33592258; PMID:34811946; PMID:39179512 |
| GO:0004697 | Protein kinase c activity | Increases phenotype | PMID:7662713 |
| GO:0004784 | Superoxide dismutase activity | Increases phenotype | PMID:24887138; PMID:25169090; PMID:25215149; PMID:25724285; PMID:26708779; PMID:26708779; PMID:26758514; PMID:27375216; PMID:28480221; PMID:29273418; PMID:26758514; PMID:26935021; PMID:27375216; PMID:28077425; PMID:28115273; PMID:28480221; PMID:28696894; PMID:28921394; PMID:28696894; PMID:28921394; PMID:30025709; PMID:30088170; PMID:33592258; PMID:28921394; PMID:29273418; PMID:30025709; PMID:30088170; PMID:30243747; PMID:30562684; PMID:31911963; PMID:32060784; PMID:33592258; PMID:34048864; PMID:34655599; PMID:34811946; PMID:35236239; PMID:39179512 |
| GO:0005776 | Autophagosome | Increases phenotype | PMID:30171970; PMID:30744607; PMID:34811946 |
| GO:0006089 | Lactate metabolic process | Affects phenotype | PMID:34811946 |
| GO:0006096 | Glycolytic process | Increases phenotype | PMID:38763349 |
| GO:0006264 | Mitochondrial dna replication | Increases phenotype | PMID:27993944 |
| GO:0006304 | Dna modification | Increases phenotype | PMID:26468117; PMID:29289706; PMID:30967525 |
| GO:0006309 | Apoptotic dna fragmentation | Increases phenotype | PMID:26074776 |
| GO:0006468 | Protein phosphorylation | Increases phenotype | PMID:7662713 |
| GO:0006508 | Proteolysis | Increases phenotype | PMID:22308036 |
| GO:0006520 | Amino acid metabolic process | Affects phenotype | PMID:32060784 |
| GO:0006537 | Glutamate biosynthetic process | Increases phenotype | PMID:28916328 |
| GO:0006606 | Protein import into nucleus | Increases phenotype | PMID:32060784; PMID:32064027; PMID:32763286 |
| GO:0006622 | Protein targeting to lysosome | Increases phenotype | PMID:28182653 |
| GO:0006672 | Ceramide metabolic process | Affects phenotype | PMID:36108500 |
| GO:0006693 | Prostaglandin metabolic process | Affects phenotype | PMID:32738378 |
| GO:0006694 | Steroid biosynthetic process | Increases phenotype | PMID:36108500 |
| GO:0006749 | Glutathione metabolic process | Increases phenotype | PMID:21801858; PMID:21801858; PMID:25579023; PMID:28090784; PMID:30744607; PMID:25579023; PMID:28090784; PMID:30744607; PMID:26598004; PMID:27788593; PMID:28090784; PMID:28467894; PMID:30403199; PMID:30562684; PMID:30744607; PMID:31381934; PMID:32064027; PMID:33592258; PMID:33838153; PMID:34021431; PMID:34048864; PMID:34214573; PMID:34655599 |
| GO:0006750 | Glutathione biosynthetic process | Increases phenotype | PMID:20600150; PMID:20600150; PMID:24812154; PMID:27993944; PMID:22996356; PMID:23546295; PMID:23546295; PMID:24812154; PMID:25545062; PMID:25724285; PMID:26708779; PMID:26708779; PMID:26758514; PMID:26758514; PMID:26935021; PMID:27014807; PMID:28428137; PMID:30797899 |
| GO:0006754 | Atp biosynthetic process | Decreases phenotype | PMID:24634145 |
| GO:0006809 | Nitric oxide biosynthetic process | Increases phenotype | PMID:19526292; PMID:20600150; PMID:27883937; PMID:30243747 |
| GO:0006874 | Cellular calcium ion homeostasis | Affects phenotype | PMID:27246695 |
| GO:0006879 | Cellular iron ion homeostasis | Affects phenotype | PMID:37507096 |
| GO:0006884 | Cell volume homeostasis | Affects phenotype | PMID:30280190 |
| GO:0006914 | Autophagy | Affects phenotype | PMID:27246695; PMID:30144575; PMID:30744607 |
| GO:0006915 | Apoptotic process | Increases phenotype | PMID:16213648; PMID:16310883; PMID:17324951; PMID:17324951; PMID:26887261; PMID:35236239; PMID:18056701; PMID:18056701; PMID:20594614; PMID:26074776; PMID:27793699; PMID:33383311; PMID:20594614; PMID:22987761; PMID:23620592; PMID:23807224; PMID:23985028; PMID:24060684; PMID:24130211; PMID:24290359; PMID:24530478; PMID:24887138; PMID:25314302; PMID:25628599; PMID:26074776; PMID:26447207; PMID:26935021; PMID:27793699; PMID:28480221; PMID:28480221; PMID:35430322; PMID:38763349; PMID:29071302; PMID:30112919; PMID:30144575; PMID:30144575; PMID:33592258; PMID:30171970; PMID:30698896; PMID:31400064; PMID:32741895; PMID:33383311; PMID:33592258; PMID:34811946; PMID:34863858; PMID:35236239; PMID:35430322; PMID:38763349; PMID:39059605 |
| GO:0006954 | Inflammatory response | Increases phenotype | PMID:31348582; PMID:31348582; PMID:32020686; PMID:32020686; PMID:33737140 |
| GO:0006974 | Cellular response to dna damage stimulus | Increases phenotype | PMID:19526292; PMID:24084170; PMID:27993944; PMID:28012437; PMID:30088170; PMID:31911963 |
| GO:0006979 | Response to oxidative stress | Increases phenotype | PMID:17107770; PMID:23603004; PMID:27788593 |
| GO:0006997 | Nucleus organization | Decreases phenotype | PMID:29071302 |
| GO:0007005 | Mitochondrion organization | Decreases phenotype | PMID:33368748 |
| GO:0007006 | Mitochondrial membrane organization | Affects phenotype | PMID:28090784 |
| GO:0007029 | Endoplasmic reticulum organization | Decreases phenotype | PMID:33368748 |
| GO:0007030 | Golgi organization | Decreases phenotype | PMID:33368748 |
| GO:0007040 | Lysosome organization | Increases phenotype | PMID:22982048 |
| GO:0007155 | Cell adhesion | Decreases phenotype | PMID:29495171 |
| GO:0007204 | Positive regulation of cytosolic calcium ion concentration | Increases phenotype | PMID:30185695; PMID:34897981 |
| GO:0007283 | Spermatogenesis | Decreases phenotype | PMID:31128353; PMID:31911963; PMID:39179512 |
| GO:0007566 | Embryo implantation | Affects phenotype | PMID:20713718 |
| GO:0007608 | Sensory perception of smell | Decreases phenotype | PMID:33372994 |
| GO:0007613 | Memory | Affects phenotype | PMID:33368748 |
| GO:0007626 | Locomotory behavior | Decreases phenotype | PMID:28090784 |
| GO:0007631 | Feeding behavior | Affects phenotype | PMID:34811946 |
| GO:0008121 | Ubiquinol-cytochrome-c reductase activity | Increases phenotype | PMID:34811946 |
| GO:0008137 | Nadh dehydrogenase (ubiquinone) activity | Affects phenotype | PMID:23562983; PMID:28090784; PMID:34811946 |
| GO:0008177 | Succinate dehydrogenase (ubiquinone) activity | Decreases phenotype | PMID:31348582 |
| GO:0008219 | Cell death | Increases phenotype | PMID:18056701; PMID:18056701; PMID:19526292; PMID:21651901; PMID:24509835; PMID:28428137; PMID:30205152; PMID:19526292; PMID:21219333; PMID:21651901; PMID:21735318; PMID:22289031; PMID:22289031; PMID:22996356; PMID:23546295; PMID:24141985; PMID:27890776; PMID:22879928; PMID:22996356; PMID:23226354; PMID:23546295; PMID:23649336; PMID:23649336; PMID:24561720; PMID:24105845; PMID:24141985; PMID:24509835; PMID:24561720; PMID:24685904; PMID:24743698; PMID:25177032; PMID:25338942; PMID:25628599; PMID:26447207; PMID:26847702; PMID:27324791; PMID:27883937; PMID:27890776; PMID:28202386; PMID:28428137; PMID:28916328; PMID:28916328; PMID:31715309; PMID:30205152; PMID:30797899; PMID:31467635; PMID:31715309; PMID:32540480; PMID:33900547; PMID:3487318; PMID:7708768 |
| GO:0008283 | Cell population proliferation | Increases phenotype | PMID:19526292; PMID:23807224; PMID:24060684; PMID:24530478; PMID:24818613; PMID:24866057; PMID:24887138; PMID:25545062; PMID:26129822; PMID:26159257; PMID:26887261; PMID:28077425; PMID:29454966; PMID:29859004; PMID:30036685; PMID:30171970; PMID:34655599 |
| GO:0008284 | Positive regulation of cell population proliferation | Decreases phenotype | PMID:26674755; PMID:27220436 |
| GO:0008285 | Negative regulation of cell population proliferation | Increases phenotype | PMID:28474156; PMID:30185695; PMID:31381934; PMID:29289706; PMID:30185695; PMID:31189234; PMID:31294882; PMID:31368498; PMID:31368586; PMID:31381934; PMID:33838153 |
| GO:0008292 | Acetylcholine biosynthetic process | Affects phenotype | PMID:28916328 |
| GO:0008344 | Adult locomotory behavior | Affects phenotype | PMID:28428137 |
| GO:0008361 | Regulation of cell size | Affects phenotype | PMID:31610511 |
| GO:0008610 | Lipid biosynthetic process | Increases phenotype | PMID:24812154 |
| GO:0009060 | Aerobic respiration | Affects phenotype | PMID:26108578; PMID:27003823 |
| GO:0009247 | Glycolipid biosynthetic process | Increases phenotype | PMID:36108500 |
| GO:0009635 | Response to herbicide | Decreases phenotype | PMID:26099602 |
| GO:0010508 | Positive regulation of autophagy | Affects phenotype | PMID:25092649; PMID:26409479; PMID:27220436; PMID:31368586 |
| GO:0010718 | Positive regulation of epithelial to mesenchymal transition | Increases phenotype | PMID:28624451; PMID:30265375; PMID:30265375; PMID:37689312; PMID:30403199; PMID:35817254; PMID:37689312 |
| GO:0010729 | Positive regulation of hydrogen peroxide biosynthetic process | Increases phenotype | PMID:25947082 |
| GO:0010759 | Positive regulation of macrophage chemotaxis | Increases phenotype | PMID:25461551; PMID:25461551; PMID:25945502; PMID:25945502 |
| GO:0010882 | Regulation of cardiac muscle contraction by calcium ion signaling | Affects phenotype | PMID:25092649 |
| GO:0010917 | Negative regulation of mitochondrial membrane potential | Increases phenotype | PMID:25092649; PMID:28215578; PMID:31381934; PMID:32527420; PMID:33838153; PMID:34897981 |
| GO:0010918 | Positive regulation of mitochondrial membrane potential | Decreases phenotype | PMID:25947082; PMID:26686574; PMID:26686574; PMID:27003823; PMID:27003823; PMID:30185695 |
| GO:0010942 | Positive regulation of cell death | Increases phenotype | PMID:10464329; PMID:10464329; PMID:31669237; PMID:1850207; PMID:1850207; PMID:26597533; PMID:21215799; PMID:21215799; PMID:26409479; PMID:26498265; PMID:24376630; PMID:24462953; PMID:24486957; PMID:25015657; PMID:25092649; PMID:25461551; PMID:25693864; PMID:25947082; PMID:26111762; PMID:26196221; PMID:26355396; PMID:26409479; PMID:26597533; PMID:26598004; PMID:26649146; PMID:26674755; PMID:26686574; PMID:27682480; PMID:29058724; PMID:31669237; PMID:32527420; PMID:38237652; PMID:9038912 |
| GO:0014068 | Positive regulation of phosphatidylinositol 3-kinase signaling | Increases phenotype | PMID:30726711 |
| GO:0016042 | Lipid catabolic process | Increases phenotype | PMID:20600150; PMID:20600150; PMID:24812154; PMID:25338942; PMID:28921394; PMID:22289031; PMID:22736252; PMID:22736252; PMID:23546295; PMID:23546295; PMID:23649336; PMID:24523768; PMID:24523768; PMID:25215149; PMID:28696894; PMID:30088170; PMID:32020686; PMID:33592258; PMID:24523768; PMID:30088170; PMID:32020686; PMID:33592258; PMID:24523768; PMID:32064027; PMID:24586289; PMID:24812154; PMID:25177032; PMID:25215149; PMID:25724285; PMID:26708779; PMID:26708779; PMID:26758514; PMID:27375216; PMID:27890776; PMID:28480221; PMID:29273418; PMID:36031164; PMID:26758514; PMID:26935021; PMID:27375216; PMID:27890776; PMID:27919828; PMID:28090784; PMID:28090784; PMID:30571954; PMID:30744607; PMID:28115273; PMID:28480221; PMID:28696894; PMID:28921394; PMID:29273418; PMID:29568078; PMID:30088170; PMID:30243747; PMID:30562684; PMID:30571954; PMID:30744607; PMID:30797899; PMID:31715309; PMID:31911963; PMID:32020686; PMID:32064027; PMID:32375810; PMID:32738378; PMID:33592258; PMID:34048864; PMID:34052309; PMID:36031164 |
| GO:0016049 | Cell growth | Decreases phenotype | PMID:27793699; PMID:29454966; PMID:30144575; PMID:30171970; PMID:30243747; PMID:30797899 |
| GO:0016477 | Cell migration | Increases phenotype | PMID:26129822; PMID:30317802 |
| GO:0016567 | Protein ubiquitination | Increases phenotype | PMID:26409479 |
| GO:0017148 | Negative regulation of translation | Decreases phenotype | PMID:28542246 |
| GO:0018158 | Protein oxidation | Increases phenotype | PMID:26409479; PMID:26468117; PMID:26686574; PMID:27788593; PMID:28921394; PMID:28921394; PMID:30036685; PMID:30036685; PMID:30243747; PMID:30562684; PMID:31715309; PMID:32738378; PMID:32060784; PMID:32738378 |
| GO:0019249 | Lactate biosynthetic process | Increases phenotype | PMID:27993944 |
| GO:0019432 | Triglyceride biosynthetic process | Decreases phenotype | PMID:28012437 |
| GO:0019471 | 4-hydroxyproline metabolic process | Increases phenotype | PMID:23590892; PMID:26860689; PMID:33737140 |
| GO:0019752 | Carboxylic acid metabolic process | Affects phenotype | PMID:32060784 |
| GO:0019835 | Cytolysis | Increases phenotype | PMID:34097952 |
| GO:0030070 | Insulin processing | Decreases phenotype | PMID:36394833 |
| GO:0030148 | Sphingolipid biosynthetic process | Increases phenotype | PMID:36108500 |
| GO:0030163 | Protein catabolic process | Affects phenotype | PMID:7836468 |
| GO:0030182 | Neuron differentiation | Decreases phenotype | PMID:31400064 |
| GO:0030199 | Collagen fibril organization | Increases phenotype | PMID:28116923; PMID:28696894; PMID:28921394; PMID:30744607; PMID:30744607; PMID:32462952; PMID:33737140; PMID:34364922; PMID:34463846; PMID:38460002; PMID:32462952; PMID:33737140; PMID:38460002 |
| GO:0030262 | Apoptotic nuclear changes | Increases phenotype | PMID:34897981 |
| GO:0030263 | Apoptotic chromosome condensation | Increases phenotype | PMID:29071302; PMID:33368748; PMID:34655599 |
| GO:0030308 | Negative regulation of cell growth | Increases phenotype | PMID:31128353 |
| GO:0030335 | Positive regulation of cell migration | Increases phenotype | PMID:30265375 |
| GO:0031175 | Neuron projection development | Decreases phenotype | PMID:26074776 |
| GO:0031398 | Positive regulation of protein ubiquitination | Decreases phenotype | PMID:26409479 |
| GO:0031987 | Locomotion involved in locomotory behavior | Decreases phenotype | PMID:32060784; PMID:32247534; PMID:34655599; PMID:38189626 |
| GO:0032148 | Activation of protein kinase b activity | Increases phenotype | PMID:27111068 |
| GO:0032287 | Peripheral nervous system myelin maintenance | Decreases phenotype | PMID:27788593 |
| GO:0032436 | Positive regulation of proteasomal ubiquitin-dependent protein catabolic process | Decreases phenotype | PMID:26598004 |
| GO:0032450 | Maltose alpha-glucosidase activity | Decreases phenotype | PMID:34811946 |
| GO:0032464 | Positive regulation of protein homooligomerization | Increases phenotype | PMID:27788593 |
| GO:0032790 | Ribosome disassembly | Affects phenotype | PMID:33368748 |
| GO:0032914 | Positive regulation of transforming growth factor beta1 production | Affects phenotype | PMID:23590892 |
| GO:0032930 | Positive regulation of superoxide anion generation | Increases phenotype | PMID:25947082; PMID:26108578; PMID:26468117; PMID:27788593; PMID:28215578; PMID:28542246; PMID:31385236 |
| GO:0032964 | Collagen biosynthetic process | Increases phenotype | PMID:27375216; PMID:28624451; PMID:28624451; PMID:30036685; PMID:28921394; PMID:29495171; PMID:30036685 |
| GO:0032967 | Positive regulation of collagen biosynthetic process | Increases phenotype | PMID:26345256; PMID:30403199; PMID:30726711; PMID:30726711; PMID:30797787; PMID:30797787 |
| GO:0033212 | Iron import into cell | Increases phenotype | PMID:30797899 |
| GO:0033327 | Leydig cell differentiation | Decreases phenotype | PMID:31128353; PMID:31911963 |
| GO:0033558 | Protein lysine deacetylase activity | Decreases phenotype | PMID:31216030 |
| GO:0034063 | Stress granule assembly | Increases phenotype | PMID:22879928 |
| GO:0034109 | Homotypic cell-cell adhesion | Decreases phenotype | PMID:30317802 |
| GO:0034440 | Lipid oxidation | Increases phenotype | PMID:24818613; PMID:25461551; PMID:25461551; PMID:25579023; PMID:34455893; PMID:25943564; PMID:25943564; PMID:34214573; PMID:26649146; PMID:26686574; PMID:27111068; PMID:27788593; PMID:28215578; PMID:29054699; PMID:30726711; PMID:30726711; PMID:30967525; PMID:31381934; PMID:31385236; PMID:32527420; PMID:33838153; PMID:34214573; PMID:34455893; PMID:34623211; PMID:34655599; PMID:39179512 |
| GO:0035640 | Exploration behavior | Affects phenotype | PMID:38189626 |
| GO:0035696 | Monocyte extravasation | Increases phenotype | PMID:36031164 |
| GO:0035752 | Lysosomal lumen ph elevation | Increases phenotype | PMID:28182653 |
| GO:0035794 | Positive regulation of mitochondrial membrane permeability | Increases phenotype | PMID:25943564; PMID:25947082 |
| GO:0035936 | Testosterone secretion | Decreases phenotype | PMID:31610511 |
| GO:0036091 | Positive regulation of transcription from rna polymerase ii promoter in response to oxidative stress | Increases phenotype | PMID:26598004 |
| GO:0036211 | Protein modification process | Increases phenotype | PMID:19526292; PMID:32060784; PMID:34214573 |
| GO:0042053 | Regulation of dopamine metabolic process | Affects phenotype | PMID:25947082 |
| GO:0042102 | Positive regulation of t cell proliferation | Increases phenotype | PMID:26099602 |
| GO:0042127 | Regulation of cell population proliferation | Affects phenotype | PMID:31385236 |
| GO:0042246 | Tissue regeneration | Decreases phenotype | PMID:31128353 |
| GO:0042307 | Positive regulation of protein import into nucleus | Increases phenotype | PMID:26649146; PMID:27788593; PMID:30584891; PMID:30584891; PMID:31299241 |
| GO:0042311 | Vasodilation | Increases phenotype | PMID:26422756 |
| GO:0042382 | Paraspeckles | Increases phenotype | PMID:31311324 |
| GO:0042416 | Dopamine biosynthetic process | Affects phenotype | PMID:23562983; PMID:24743698 |
| GO:0042417 | Dopamine metabolic process | Affects phenotype | PMID:32060784 |
| GO:0042554 | Superoxide anion generation | Increases phenotype | PMID:19526292; PMID:22289031; PMID:25545062; PMID:28202386; PMID:29568078; PMID:30243747; PMID:30797899; PMID:31162603; PMID:33592258 |
| GO:0042743 | Hydrogen peroxide metabolic process | Affects phenotype | PMID:32738378 |
| GO:0042744 | Hydrogen peroxide catabolic process | Increases phenotype | PMID:20558743 |
| GO:0042755 | Eating behavior | Affects phenotype | PMID:33368748 |
| GO:0042776 | Proton motive force-driven mitochondrial atp synthesis | Decreases phenotype | PMID:26686574 |
| GO:0042908 | Xenobiotic transport | Increases phenotype | PMID:26358524 |
| GO:0043005 | Neuron projection | Increases phenotype | PMID:30280190 |
| GO:0043065 | Positive regulation of apoptotic process | Increases phenotype | PMID:25945502; PMID:25947082; PMID:26674755; PMID:27003823; PMID:27220436; PMID:28363843; PMID:28474156; PMID:28474156; PMID:30185695; PMID:31381934; PMID:29054699; PMID:30185695; PMID:30403199; PMID:31128353; PMID:31368498; PMID:31368586; PMID:31381934; PMID:31385236; PMID:33015978; PMID:33838153; PMID:37615264 |
| GO:0043433 | Negative regulation of dna-binding transcription factor activity | Increases phenotype | PMID:28542246 |
| GO:0043484 | Regulation of rna splicing | Affects phenotype | PMID:27111068 |
| GO:0043966 | Histone h3 acetylation | Affects phenotype | PMID:31216030 |
| GO:0044237 | Cellular metabolic process | Increases phenotype | PMID:22108603; PMID:23329662; PMID:25250048; PMID:25628599; PMID:26074776; PMID:26074776; PMID:31311324; PMID:31966674; PMID:32306690; PMID:32540480; PMID:33160981; PMID:33383311; PMID:34655599; PMID:26447207; PMID:30088170; PMID:30317802; PMID:30419666; PMID:30419666; PMID:33592258; PMID:35430322; PMID:37028639; PMID:37507096; PMID:31311324; PMID:31400064; PMID:31715309; PMID:31715309; PMID:32738378; PMID:31966674; PMID:32064027; PMID:32540480; PMID:32738378; PMID:32741895; PMID:33000210; PMID:33160981; PMID:33383311; PMID:33592258; PMID:33737140; PMID:34021431; PMID:34048864; PMID:34455893; PMID:34580234; PMID:34655599; PMID:34681664; PMID:34863858; PMID:35236239; PMID:37507096; PMID:39059605 |
| GO:0044319 | Wound healing, spreading of cells | Increases phenotype | PMID:25873302; PMID:34364922 |
| GO:0044403 | Biological process involved in symbiotic interaction | Affects phenotype | PMID:34863722 |
| GO:0044524 | Protein sulfhydration | Decreases phenotype | PMID:32064027 |
| GO:0044525 | Peptidyl-cystine sulfhydration | Increases phenotype | PMID:26409479 |
| GO:0044754 | Autolysosome | Decreases phenotype | PMID:30744607 |
| GO:0045123 | Cellular extravasation | Increases phenotype | PMID:36031164 |
| GO:0045429 | Positive regulation of nitric oxide biosynthetic process | Affects phenotype | PMID:25461551; PMID:26468117; PMID:26686574; PMID:30744883; PMID:34218561 |
| GO:0045454 | Cell redox homeostasis | Decreases phenotype | PMID:30726711; PMID:35707280 |
| GO:0045597 | Positive regulation of cell differentiation | Increases phenotype | PMID:20609355 |
| GO:0045919 | Positive regulation of cytolysis | Increases phenotype | PMID:30726711 |
| GO:0045930 | Negative regulation of mitotic cell cycle | Increases phenotype | PMID:26674755; PMID:26887261; PMID:29454966 |
| GO:0046034 | Atp metabolic process | Affects phenotype | PMID:34655599; PMID:34811946 |
| GO:0046058 | Camp metabolic process | Affects phenotype | PMID:27460631; PMID:33368748; PMID:33368748 |
| GO:0046209 | Nitric oxide metabolic process | Affects phenotype | PMID:21801858; PMID:24523768 |
| GO:0046323 | Glucose import | Affects phenotype | PMID:34048864 |
| GO:0046330 | Positive regulation of jnk cascade | Increases phenotype | PMID:31381934 |
| GO:0046415 | Urate metabolic process | Decreases phenotype | PMID:33838153 |
| GO:0046449 | Creatinine metabolic process | Decreases phenotype | PMID:30562684; PMID:32734364; PMID:33838153 |
| GO:0046466 | Membrane lipid catabolic process | Increases phenotype | PMID:3487318; PMID:7616398 |
| GO:0046474 | Glycerophospholipid biosynthetic process | Increases phenotype | PMID:36108500 |
| GO:0046621 | Negative regulation of organ growth | Increases phenotype | PMID:31174552 |
| GO:0046622 | Positive regulation of organ growth | Increases phenotype | PMID:31174552 |
| GO:0048143 | Astrocyte activation | Increases phenotype | PMID:24376630; PMID:30280190; PMID:34655599 |
| GO:0048146 | Positive regulation of fibroblast proliferation | Increases phenotype | PMID:25815693; PMID:26099602 |
| GO:0048247 | Lymphocyte chemotaxis | Increases phenotype | PMID:25461551; PMID:25461551; PMID:25945502; PMID:25945502 |
| GO:0048666 | Neuron development | Affects phenotype | PMID:28428137 |
| GO:0050665 | Hydrogen peroxide biosynthetic process | Increases phenotype | PMID:19344371; PMID:23226354; PMID:25545062; PMID:31715309 |
| GO:0050729 | Positive regulation of inflammatory response | Increases phenotype | PMID:30584891; PMID:33015978; PMID:34097952 |
| GO:0050766 | Positive regulation of phagocytosis | Increases phenotype | PMID:31299241 |
| GO:0050808 | Synapse organization | Decreases phenotype | PMID:33368748 |
| GO:0050885 | Neuromuscular process controlling balance | Decreases phenotype | PMID:27919828 |
| GO:0050900 | Leukocyte migration | Increases phenotype | PMID:30571954 |
| GO:0050996 | Positive regulation of lipid catabolic process | Increases phenotype | PMID:32734364; PMID:33015978; PMID:35707280 |
| GO:0051091 | Positive regulation of dna-binding transcription factor activity | Increases phenotype | PMID:28474156 |
| GO:0051092 | Positive regulation of nf-kappab transcription factor activity | Increases phenotype | PMID:28474156 |
| GO:0051209 | Release of sequestered calcium ion into cytosol | Increases phenotype | PMID:24060684 |
| GO:0051353 | Positive regulation of oxidoreductase activity | Increases phenotype | PMID:30726711 |
| GO:0051402 | Neuron apoptotic process | Increases phenotype | PMID:31966674 |
| GO:0051726 | Regulation of cell cycle | Increases phenotype | PMID:31368498 |
| GO:0051881 | Regulation of mitochondrial membrane potential | Affects phenotype | PMID:18056701; PMID:29287252; PMID:30144575; PMID:31467635; PMID:32540480; PMID:33383311; PMID:33592258; PMID:33592258; PMID:37507096; PMID:37507096 |
| GO:0051882 | Mitochondrial depolarization | Increases phenotype | PMID:31348582; PMID:34655599 |
| GO:0051897 | Positive regulation of protein kinase b signaling | Increases phenotype | PMID:30726711 |
| GO:0051901 | Positive regulation of mitochondrial depolarization | Increases phenotype | PMID:26108578 |
| GO:0051938 | L-glutamate import | Affects phenotype | PMID:34048864 |
| GO:0055074 | Calcium ion homeostasis | Affects phenotype | PMID:28115273 |
| GO:0055090 | Acylglycerol homeostasis | Decreases phenotype | PMID:36108500 |
| GO:0060011 | Sertoli cell proliferation | Decreases phenotype | PMID:31911963 |
| GO:0060047 | Heart contraction | Affects phenotype | PMID:28115273 |
| GO:0060452 | Positive regulation of cardiac muscle contraction | Decreases phenotype | PMID:27442881 |
| GO:0060586 | Multicellular organismal iron ion homeostasis | Affects phenotype | PMID:32294219 |
| GO:0061370 | Testosterone biosynthetic process | Affects phenotype | PMID:31610511; PMID:39179512 |
| GO:0061518 | Microglial cell proliferation | Affects phenotype | PMID:31299241 |
| GO:0061684 | Chaperone-mediated autophagy | Increases phenotype | PMID:29950142 |
| GO:0061692 | Cellular detoxification of hydrogen peroxide | Increases phenotype | PMID:22308036 |
| GO:0061744 | Motor behavior | Decreases phenotype | PMID:30726997; PMID:32247534 |
| GO:0061908 | Phagophore | Decreases phenotype | PMID:30744607 |
| GO:0070050 | Neuron cellular homeostasis | Affects phenotype | PMID:32375810 |
| GO:0070265 | Necrotic cell death | Increases phenotype | PMID:24523768; PMID:30562684 |
| GO:0070509 | Calcium ion import | Affects phenotype | PMID:34048864 |
| GO:0070842 | Aggresome assembly | Increases phenotype | PMID:26409479 |
| GO:0070994 | Detection of oxidative stress | Increases phenotype | PMID:26422756; PMID:32060784; PMID:32064027; PMID:34455893; PMID:34811946; PMID:35236239; PMID:37507096 |
| GO:0070997 | Neuron death | Increases phenotype | PMID:29568078; PMID:32247534; PMID:33368748; PMID:34052309; PMID:34623211; PMID:35511227; PMID:38189626 |
| GO:0072537 | Fibroblast activation | Increases phenotype | PMID:25945502 |
| GO:0072593 | Reactive oxygen species metabolic process | Increases phenotype | PMID:21801858; PMID:21801858; PMID:30744607; PMID:32763286; PMID:23827392; PMID:24060684; PMID:24866057; PMID:24887138; PMID:25628599; PMID:25724285; PMID:26074776; PMID:26074776; PMID:32540480; PMID:26447207; PMID:29950142; PMID:30025709; PMID:30419666; PMID:30419666; PMID:33592258; PMID:30744607; PMID:31368586; PMID:31610511; PMID:32064027; PMID:32375810; PMID:32540480; PMID:32763286; PMID:33383311; PMID:33592258; PMID:34052309; PMID:34655599; PMID:34811946; PMID:34863858; PMID:38237652; PMID:39059605; PMID:39179512 |
| GO:0072676 | Lymphocyte migration | Increases phenotype | PMID:34811946 |
| GO:0072756 | Cellular response to paraquat | Increases phenotype | PMID:35430322; PMID:35511227; PMID:39059605 |
| GO:0080182 | Histone h3-k4 trimethylation | Increases phenotype | PMID:31216030 |
| GO:0086003 | Cardiac muscle cell contraction | Decreases phenotype | PMID:25092649 |
| GO:0090090 | Negative regulation of canonical wnt signaling pathway | Increases phenotype | PMID:27788593 |
| GO:0090141 | Positive regulation of mitochondrial fission | Increases phenotype | PMID:28215578 |
| GO:0090200 | Positive regulation of release of cytochrome c from mitochondria | Increases phenotype | PMID:25947082; PMID:26686574; PMID:33838153 |
| GO:0090327 | Negative regulation of locomotion involved in locomotory behavior | Increases phenotype | PMID:31174552 |
| GO:0090328 | Regulation of olfactory learning | Affects phenotype | PMID:33372994 |
| GO:0090398 | Cellular senescence | Increases phenotype | PMID:22982048; PMID:32540480 |
| GO:0090559 | Regulation of membrane permeability | Affects phenotype | PMID:21735318 |
| GO:0090659 | Walking behavior | Affects phenotype | PMID:29568078; PMID:30797899; PMID:34052309 |
| GO:0097202 | Activation of cysteine-type endopeptidase activity | Increases phenotype | PMID:32738378 |
| GO:0097212 | Lysosomal membrane organization | Decreases phenotype | PMID:32527420 |
| GO:0097214 | Positive regulation of lysosomal membrane permeability | Increases phenotype | PMID:28182653 |
| GO:0097707 | Ferroptosis | Increases phenotype | PMID:30797899; PMID:37507096 |
| GO:0097722 | Sperm motility | Decreases phenotype | PMID:39179512 |
| GO:0099558 | Maintenance of synapse structure | Decreases phenotype | PMID:32169474 |
| GO:0099610 | Action potential initiation | Affects phenotype | PMID:31467635 |
| GO:0106003 | Amyloid-beta complex | Increases phenotype | PMID:36394833 |
| GO:0110090 | Positive regulation of hippocampal neuron apoptotic process | Increases phenotype | PMID:36394833 |
| GO:0140112 | Extracellular vesicle biogenesis | Affects phenotype | PMID:34064677 |
| GO:0140639 | Positive regulation of pyroptosis | Increases phenotype | PMID:38237652 |
| GO:0140742 | Lncrna transcription | Affects phenotype | PMID:34425375 |
| GO:0150077 | Regulation of neuroinflammatory response | Increases phenotype | PMID:36108500 |
| GO:1900017 | Positive regulation of cytokine production involved in inflammatory response | Increases phenotype | PMID:36108500 |
| GO:1900020 | Positive regulation of protein kinase c activity | Increases phenotype | PMID:26649146 |
| GO:1900182 | Positive regulation of protein localization to nucleus | Increases phenotype | PMID:31162603 |
| GO:1900227 | Positive regulation of nlrp3 inflammasome complex assembly | Increases phenotype | PMID:29054699 |
| GO:1900409 | Positive regulation of cellular response to oxidative stress | Increases phenotype | PMID:30726997; PMID:37615264 |
| GO:1900535 | Palmitic acid biosynthetic process | Increases phenotype | PMID:28012437 |
| GO:1900745 | Positive regulation of p38mapk cascade | Increases phenotype | PMID:27442881; PMID:31381934 |
| GO:1901216 | Positive regulation of neuron death | Increases phenotype | PMID:28215578; PMID:30372676; PMID:32169474 |
| GO:1901224 | Positive regulation of nik/nf-kappab signaling | Increases phenotype | PMID:24060684; PMID:24609059 |
| GO:1901670 | Negative regulation of superoxide dismutase activity | Increases phenotype | PMID:29054699; PMID:29058724; PMID:30403199; PMID:30726711; PMID:30726711; PMID:30967525; PMID:30744883; PMID:33838153; PMID:37615264 |
| GO:1901671 | Positive regulation of superoxide dismutase activity | Affects phenotype | PMID:25461551; PMID:25579023; PMID:25943564; PMID:26649146 |
| GO:1901676 | Positive regulation of histone h3-k27 acetylation | Increases phenotype | PMID:31216030 |
| GO:1901800 | Positive regulation of proteasomal protein catabolic process | Affects phenotype | PMID:26409479 |
| GO:1901991 | Negative regulation of mitotic cell cycle phase transition | Increases phenotype | PMID:26358524 |
| GO:1902043 | Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors | Increases phenotype | PMID:28414160 |
| GO:1902108 | Regulation of mitochondrial membrane permeability involved in apoptotic process | Affects phenotype | PMID:24799198 |
| GO:1902237 | Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | Increases phenotype | PMID:28986289 |
| GO:1902512 | Positive regulation of apoptotic dna fragmentation | Increases phenotype | PMID:26358524; PMID:26686574 |
| GO:1902552 | Negative regulation of catalase activity | Increases phenotype | PMID:37615264 |
| GO:1902624 | Positive regulation of neutrophil migration | Affects phenotype | PMID:23603004 |
| GO:1902824 | Positive regulation of late endosome to lysosome transport | Increases phenotype | PMID:28182653 |
| GO:1902958 | Positive regulation of mitochondrial electron transport, nadh to ubiquinone | Decreases phenotype | PMID:26686574 |
| GO:1903074 | Trail death-inducing signaling complex assembly | Increases phenotype | PMID:28414160 |
| GO:1903078 | Positive regulation of protein localization to plasma membrane | Increases phenotype | PMID:28414160 |
| GO:1903209 | Positive regulation of oxidative stress-induced cell death | Increases phenotype | PMID:27788593 |
| GO:1903283 | Negative regulation of glutathione peroxidase activity | Increases phenotype | PMID:29054699; PMID:30967525; PMID:31368586 |
| GO:1903284 | Positive regulation of glutathione peroxidase activity | Affects phenotype | PMID:26468117; PMID:28467894 |
| GO:1903409 | Reactive oxygen species biosynthetic process | Increases phenotype | PMID:22289031; PMID:23546295; PMID:23546295; PMID:24141985; PMID:23649336; PMID:23649336; PMID:24561720; PMID:24141985; PMID:24561720; PMID:25177032; PMID:26758514; PMID:27793699; PMID:29287252; PMID:29859004; PMID:30171970; PMID:30243747; PMID:31348582 |
| GO:1903428 | Positive regulation of reactive oxygen species biosynthetic process | Increases phenotype | PMID:24609059; PMID:25693864; PMID:25947082; PMID:26597533; PMID:26686574; PMID:27788593; PMID:28474156; PMID:28474156; PMID:29058724; PMID:30185695; PMID:31381934; PMID:28474156; PMID:33015978; PMID:29054699; PMID:29058724; PMID:29289706; PMID:30185695; PMID:30403199; PMID:31128353; PMID:31381934; PMID:32527420; PMID:33015978; PMID:33838153; PMID:34897981; PMID:35707280 |
| GO:1903899 | Positive regulation of perk-mediated unfolded protein response | Increases phenotype | PMID:28986289 |
| GO:1903941 | Negative regulation of respiratory gaseous exchange | Increases phenotype | PMID:30797787 |
| GO:1903978 | Regulation of microglial cell activation | Affects phenotype | PMID:28467894 |
| GO:1903980 | Positive regulation of microglial cell activation | Increases phenotype | PMID:30726997; PMID:31299241; PMID:32169474 |
| GO:1904053 | Positive regulation of protein targeting to vacuole involved in autophagy | Increases phenotype | PMID:28182653 |
| GO:1904141 | Positive regulation of microglial cell migration | Increases phenotype | PMID:31299241 |
| GO:1904233 | Negative regulation of aconitate hydratase activity | Increases phenotype | PMID:28542246 |
| GO:1904654 | Negative regulation of lung alveolus development | Increases phenotype | PMID:36462643 |
| GO:1904762 | Positive regulation of myofibroblast differentiation | Increases phenotype | PMID:25945502 |
| GO:1905037 | Autophagosome organization | Increases phenotype | PMID:22982048; PMID:28012437 |
| GO:1905447 | Negative regulation of mitochondrial atp synthesis coupled electron transport | Increases phenotype | PMID:28460087 |
| GO:1905517 | Macrophage migration | Increases phenotype | PMID:30571954 |
| GO:1905642 | Negative regulation of dna methylation | Increases phenotype | PMID:31189234 |
| GO:1905809 | Negative regulation of synapse organization | Increases phenotype | PMID:32169474 |
| GO:1990266 | Neutrophil migration | Increases phenotype | PMID:30562684 |
| GO:2000083 | Negative regulation of l-ascorbic acid biosynthetic process | Increases phenotype | PMID:32734364 |
| GO:2000370 | Positive regulation of clathrin-dependent endocytosis | Increases phenotype | PMID:28182653 |
| GO:2000391 | Positive regulation of neutrophil extravasation | Increases phenotype | PMID:25461551; PMID:25461551; PMID:28600744; PMID:28600744; PMID:30967525; PMID:35707280 |
| GO:2000406 | Positive regulation of t cell migration | Increases phenotype | PMID:32734364 |
| GO:2000611 | Positive regulation of thyroid hormone generation | Increases phenotype | PMID:31362416 |
| GO:2000844 | Negative regulation of testosterone secretion | Increases phenotype | PMID:31128353 |
| GO:2000854 | Positive regulation of corticosterone secretion | Increases phenotype | PMID:30744883; PMID:31174552 |
| GO:2001171 | Positive regulation of atp biosynthetic process | Decreases phenotype | PMID:25943564 |
| GO:2001238 | Positive regulation of extrinsic apoptotic signaling pathway | Increases phenotype | PMID:28414160 |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.