t-Butyl hydroquinone


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0001525 Angiogenesis Decreases phenotype PMID:36206955
GO:0001787 Natural killer cell proliferation Decreases phenotype PMID:30171972
GO:0001836 Release of cytochrome c from mitochondria Increases phenotype PMID:26878773
GO:0002503 Peptide antigen assembly with mhc class ii protein complex Increases phenotype PMID:30021835
GO:0002539 Prostaglandin production involved in inflammatory response Increases phenotype PMID:23942037
GO:0004602 Glutathione peroxidase activity Decreases phenotype PMID:32565124
GO:0004784 Superoxide dismutase activity Affects phenotype PMID:26878773; PMID:32565124; PMID:37075934; PMID:37393915
GO:0006749 Glutathione metabolic process Increases phenotype PMID:27774770; PMID:29857117; PMID:30244016; PMID:30547568; PMID:32565124; PMID:37716422
GO:0006750 Glutathione biosynthetic process Affects phenotype PMID:24970285; PMID:25305463; PMID:27178040
GO:0006915 Apoptotic process Increases phenotype PMID:26878773; PMID:28583816; PMID:32428544; PMID:37075934
GO:0006954 Inflammatory response Increases phenotype PMID:32565124
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:28583816
GO:0007005 Mitochondrion organization Decreases phenotype PMID:31726083
GO:0007283 Spermatogenesis Affects phenotype PMID:32565124
GO:0007605 Sensory perception of sound Affects phenotype PMID:32428544
GO:0008219 Cell death Increases phenotype PMID:32428544
GO:0008283 Cell population proliferation Decreases phenotype PMID:24970285; PMID:32565124
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:29966676; PMID:30547568
GO:0009410 Response to xenobiotic stimulus Affects phenotype PMID:33148531
GO:0010460 Positive regulation of heart rate Increases phenotype PMID:28844481
GO:0010701 Positive regulation of norepinephrine secretion Increases phenotype PMID:28844481
GO:0010917 Negative regulation of mitochondrial membrane potential Increases phenotype PMID:31423616; PMID:37393915
GO:0010940 Positive regulation of necrotic cell death Increases phenotype PMID:35724838
GO:0010942 Positive regulation of cell death Increases phenotype PMID:22466069; PMID:23942037; PMID:26879219
GO:0014068 Positive regulation of phosphatidylinositol 3-kinase signaling Affects phenotype PMID:23829535
GO:0016042 Lipid catabolic process Increases phenotype PMID:24970285; PMID:26878773; PMID:28583816; PMID:32565124
GO:0030101 Natural killer cell activation Increases phenotype PMID:30171972; PMID:32702509
GO:0030316 Osteoclast differentiation Increases phenotype PMID:23112101
GO:0032689 Negative regulation of type ii interferon production Affects phenotype PMID:22250088
GO:0032736 Positive regulation of interleukin-13 production Affects phenotype PMID:22250088
GO:0032753 Positive regulation of interleukin-4 production Affects phenotype PMID:22250088
GO:0032754 Positive regulation of interleukin-5 production Affects phenotype PMID:22250088
GO:0033212 Iron import into cell Increases phenotype PMID:37393915
GO:0034440 Lipid oxidation Increases phenotype PMID:27774770; PMID:37716422
GO:0035148 Tube formation Decreases phenotype PMID:36206955
GO:0036091 Positive regulation of transcription from rna polymerase ii promoter in response to oxidative stress Increases phenotype PMID:27473261; PMID:33838154
GO:0042167 Heme catabolic process Increases phenotype PMID:23942037
GO:0042743 Hydrogen peroxide metabolic process Affects phenotype PMID:32565124
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:25341683; PMID:25645596; PMID:29857117; PMID:31423616; PMID:35724838
GO:0043388 Positive regulation of dna binding Affects phenotype PMID:22250088
GO:0043392 Negative regulation of dna binding Affects phenotype PMID:22250088
GO:0044237 Cellular metabolic process Decreases phenotype PMID:31311324; PMID:31726083; PMID:32334435; PMID:32428544; PMID:37075934; PMID:37716422
GO:0044319 Wound healing, spreading of cells Decreases phenotype PMID:36206955
GO:0045429 Positive regulation of nitric oxide biosynthetic process Increases phenotype PMID:23942037
GO:0045453 Bone resorption Increases phenotype PMID:23112101
GO:0045454 Cell redox homeostasis Affects phenotype PMID:37393915
GO:0045581 Negative regulation of t cell differentiation Affects phenotype PMID:22250088
GO:0045582 Positive regulation of t cell differentiation Affects phenotype PMID:22250088
GO:0045930 Negative regulation of mitotic cell cycle Increases phenotype PMID:26878773
GO:0048469 Cell maturation Increases phenotype PMID:30171972
GO:0050996 Positive regulation of lipid catabolic process Increases phenotype PMID:37393915
GO:0051092 Positive regulation of nf-kappab transcription factor activity Increases phenotype PMID:28844481
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:26878773; PMID:37716422
GO:0051899 Membrane depolarization Increases phenotype PMID:37075934
GO:0060326 Cell chemotaxis Decreases phenotype PMID:36206955
GO:0061370 Testosterone biosynthetic process Affects phenotype PMID:32565124
GO:0070994 Detection of oxidative stress Increases phenotype PMID:37075934
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:31423616; PMID:32428544; PMID:36343453; PMID:36786954; PMID:37716422
GO:0090200 Positive regulation of release of cytochrome c from mitochondria Increases phenotype PMID:31423616
GO:0097722 Sperm motility Decreases phenotype PMID:32565124
GO:0098683 Cochlear hair cell ribbon synapse Decreases phenotype PMID:32428544
GO:0140042 Lipid droplet formation Increases phenotype PMID:24484068
GO:1900181 Negative regulation of protein localization to nucleus Increases phenotype PMID:33148531; PMID:35122929
GO:1900182 Positive regulation of protein localization to nucleus Increases phenotype PMID:29788535; PMID:30965670; PMID:33148531; PMID:35724838
GO:1900409 Positive regulation of cellular response to oxidative stress Increases phenotype PMID:37393915
GO:1901098 Positive regulation of autophagosome maturation Decreases phenotype PMID:23589329
GO:1901671 Positive regulation of superoxide dismutase activity Decreases phenotype PMID:27774770
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:24970285; PMID:26878773; PMID:28583816; PMID:30476502; PMID:31726083
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:27774770; PMID:28844481; PMID:29857117; PMID:35122929; PMID:37393915
GO:2000481 Positive regulation of camp-dependent protein kinase activity Affects phenotype PMID:23829535
GO:2000553 Positive regulation of t-helper 2 cell cytokine production Affects phenotype PMID:22250088
GO:2000786 Positive regulation of autophagosome assembly Increases phenotype PMID:23589329
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.