DEDUCT | Database of Endocrine Disrupting chemicals and their Toxicity profiles

Cadmium

Curated chemical-phenotype interactions from CTD

GO ID	GO name	Interaction type	Reference
GO:0000045	Autophagosome assembly	Increases phenotype	PMID:23880342; PMID:27492225; PMID:31862506; PMID:34952138; PMID:32693121; PMID:34952138
GO:0000050	Urea cycle	Affects phenotype	PMID:31639282
GO:0000080	Mitotic g1 phase	Increases phenotype	PMID:28035397; PMID:31614173
GO:0000084	Mitotic s phase	Decreases phenotype	PMID:28035397; PMID:28176351; PMID:31468104; PMID:31614173; PMID:31689473
GO:0000085	Mitotic g2 phase	Affects phenotype	PMID:28035397
GO:0000086	G2/m transition of mitotic cell cycle	Affects phenotype	PMID:28176351; PMID:31468104
GO:0000104	Succinate dehydrogenase activity	Decreases phenotype	PMID:20143725; PMID:37342552
GO:0000278	Mitotic cell cycle	Affects phenotype	PMID:28176351; PMID:31689473
GO:0000422	Autophagy of mitochondrion	Increases phenotype	PMID:25464205
GO:0000423	Mitophagy	Increases phenotype	PMID:32142837
GO:0000723	Telomere maintenance	Decreases phenotype	PMID:30722777
GO:0000737	Dna catabolic process, endonucleolytic	Increases phenotype	PMID:26089033; PMID:33396178
GO:0001503	Ossification	Decreases phenotype	PMID:32522577
GO:0001510	Rna methylation	Increases phenotype	PMID:34488496
GO:0001525	Angiogenesis	Affects phenotype	PMID:21425301
GO:0001649	Osteoblast differentiation	Decreases phenotype	PMID:36453845
GO:0001662	Behavioral fear response	Affects phenotype	PMID:32617577; PMID:37047547
GO:0001776	Leukocyte homeostasis	Affects phenotype	PMID:27181932
GO:0001822	Kidney development	Increases phenotype	PMID:30629257
GO:0001836	Release of cytochrome c from mitochondria	Increases phenotype	PMID:21787653; PMID:24144892; PMID:29115570; PMID:29891925; PMID:33031904
GO:0001889	Liver development	Affects phenotype	PMID:35770551
GO:0001892	Embryonic placenta development	Decreases phenotype	PMID:37941438
GO:0001954	Positive regulation of cell-matrix adhesion	Decreases phenotype	PMID:28829631
GO:0002158	Osteoclast proliferation	Increases phenotype	PMID:38896780
GO:0002174	Mammary stem cell proliferation	Decreases phenotype	PMID:29741670
GO:0002246	Wound healing involved in inflammatory response	Decreases phenotype	PMID:28666365
GO:0002326	B cell lineage commitment	Decreases phenotype	PMID:29939372
GO:0002360	T cell lineage commitment	Decreases phenotype	PMID:29939372
GO:0002432	Granuloma formation	Increases phenotype	PMID:38712533
GO:0002523	Leukocyte migration involved in inflammatory response	Increases phenotype	PMID:33359024; PMID:34816377; PMID:35934034; PMID:36718047; PMID:36718047; PMID:38712533; PMID:37270049; PMID:37342552; PMID:37357614; PMID:38712533; PMID:38945390; PMID:39396604
GO:0003014	Renal system process	Decreases phenotype	PMID:16263522; PMID:16581550; PMID:20836141; PMID:25012790; PMID:26513915; PMID:22027495; PMID:33036323; PMID:25536107
GO:0003093	Regulation of glomerular filtration	Affects phenotype	PMID:37949422
GO:0003094	Glomerular filtration	Decreases phenotype	PMID:16263522; PMID:19700501; PMID:26852280; PMID:33603096; PMID:37949422
GO:0003104	Positive regulation of glomerular filtration	Increases phenotype	PMID:31326826
GO:0003105	Negative regulation of glomerular filtration	Increases phenotype	PMID:22033168; PMID:25042034; PMID:25042034
GO:0003700	Dna-binding transcription factor activity	Affects phenotype	PMID:33642518
GO:0003810	Protein-glutamine gamma-glutamyltransferase activity	Increases phenotype	PMID:36718047
GO:0003993	Acid phosphatase activity	Increases phenotype	PMID:26089033
GO:0004021	L-alanine:2-oxoglutarate aminotransferase activity	Increases phenotype	PMID:34673407; PMID:38238535
GO:0004035	Alkaline phosphatase activity	Affects phenotype	PMID:26089033; PMID:31639282; PMID:31639282; PMID:36718047; PMID:32522577; PMID:33396178; PMID:34673407; PMID:38238535; PMID:36718047; PMID:37148155; PMID:38238535
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	Affects phenotype	PMID:26089033; PMID:31390532; PMID:31390532; PMID:36718047; PMID:33359024; PMID:33642518; PMID:34673407; PMID:36718047; PMID:38238535
GO:0004096	Catalase activity	Decreases phenotype	PMID:32781062; PMID:34237468; PMID:35316447; PMID:38238535
GO:0004111	Creatine kinase activity	Increases phenotype	PMID:34237468; PMID:38712533
GO:0004129	Cytochrome-c oxidase activity	Decreases phenotype	PMID:33038468; PMID:37342552
GO:0004197	Cysteine-type endopeptidase activity	Increases phenotype	PMID:28413886; PMID:33497711
GO:0004357	Glutamate-cysteine ligase activity	Decreases phenotype	PMID:35384154
GO:0004364	Glutathione transferase activity	Affects phenotype	PMID:23543441; PMID:24952260; PMID:26089033; PMID:26363317; PMID:30359721; PMID:31639282; PMID:34237468; PMID:39270966
GO:0004448	Isocitrate dehydrogenase [nad(p)+] activity	Decreases phenotype	PMID:37342552
GO:0004457	Lactate dehydrogenase activity	Increases phenotype	PMID:20143725; PMID:26089033; PMID:30029485; PMID:30717178; PMID:31639282; PMID:38238535
GO:0004591	Oxoglutarate dehydrogenase (succinyl-transferring) activity	Decreases phenotype	PMID:37342552
GO:0004602	Glutathione peroxidase activity	Affects phenotype	PMID:15055539; PMID:32347499; PMID:19778222; PMID:21787725; PMID:22995158; PMID:23543441; PMID:22995158; PMID:23543441; PMID:23577223; PMID:26089033; PMID:30717178; PMID:31390532; PMID:31639282; PMID:31876186; PMID:32347499; PMID:33559965; PMID:34237468; PMID:34767868; PMID:34952138; PMID:35316447; PMID:35384154; PMID:35489423; PMID:37270049; PMID:39842396; PMID:37342552; PMID:37342552; PMID:37949422; PMID:37949422; PMID:38238535; PMID:38945390; PMID:39842396
GO:0004623	Phospholipase a2 activity	Increases phenotype	PMID:25808797
GO:0004705	Jun kinase activity	Increases phenotype	PMID:21425301; PMID:25069788
GO:0004707	Map kinase activity	Increases phenotype	PMID:21425301; PMID:25069788
GO:0004784	Superoxide dismutase activity	Increases phenotype	PMID:15055539; PMID:32347499; PMID:19778222; PMID:22995158; PMID:23543441; PMID:23577223; PMID:26051590; PMID:26089033; PMID:26363317; PMID:30029485; PMID:30717178; PMID:31639282; PMID:31639282; PMID:36718047; PMID:31876186; PMID:32347499; PMID:32735850; PMID:32781062; PMID:32781062; PMID:36356678; PMID:33404196; PMID:33559965; PMID:34237468; PMID:34510229; PMID:34952138; PMID:35316447; PMID:35489423; PMID:36356678; PMID:36718047; PMID:36918407; PMID:37022104; PMID:37342552; PMID:37342552; PMID:37949422; PMID:39197519; PMID:37949422; PMID:38238535; PMID:38289529; PMID:39197519; PMID:39725363; PMID:39842396
GO:0004791	Thioredoxin-disulfide reductase activity	Decreases phenotype	PMID:29975440
GO:0004833	Tryptophan 2,3-dioxygenase activity	Increases phenotype	PMID:35489423
GO:0005262	Calcium channel activity	Affects phenotype	PMID:29993192
GO:0005272	Sodium channel activity	Affects phenotype	PMID:29993192
GO:0005388	P-type calcium transporter activity	Decreases phenotype	PMID:26089033
GO:0005391	P-type sodium:potassium-exchanging transporter activity	Decreases phenotype	PMID:26089033
GO:0005506	Iron ion binding	Decreases phenotype	PMID:32645461
GO:0005776	Autophagosome	Increases phenotype	PMID:34673407; PMID:34952138; PMID:37270049
GO:0005884	Actin filament	Increases phenotype	PMID:30614199
GO:0005977	Glycogen metabolic process	Affects phenotype	PMID:37270049; PMID:38945390
GO:0005988	Lactose metabolic process	Affects phenotype	PMID:38945390
GO:0006006	Glucose metabolic process	Affects phenotype	PMID:25043455; PMID:36509832; PMID:37270049; PMID:38945390
GO:0006089	Lactate metabolic process	Affects phenotype	PMID:33038468; PMID:33404196; PMID:34481905
GO:0006090	Pyruvate metabolic process	Affects phenotype	PMID:33404196
GO:0006096	Glycolytic process	Affects phenotype	PMID:34481905
GO:0006099	Tricarboxylic acid cycle	Affects phenotype	PMID:37342552
GO:0006119	Oxidative phosphorylation	Increases phenotype	PMID:34481905
GO:0006163	Purine nucleotide metabolic process	Affects phenotype	PMID:35100813; PMID:39842396
GO:0006182	Cgmp biosynthetic process	Decreases phenotype	PMID:23703608
GO:0006264	Mitochondrial dna replication	Increases phenotype	PMID:25388156
GO:0006277	Dna amplification	Increases phenotype	PMID:2455903
GO:0006281	Dna repair	Affects phenotype	PMID:31769258
GO:0006304	Dna modification	Increases phenotype	PMID:35316447; PMID:3683394; PMID:38563870
GO:0006306	Dna methylation	Decreases phenotype	PMID:20137407; PMID:22382075; PMID:29529597; PMID:39119833
GO:0006308	Dna catabolic process	Increases phenotype	PMID:22677345; PMID:35384154
GO:0006309	Apoptotic dna fragmentation	Increases phenotype	PMID:10970901; PMID:15954739; PMID:25388156; PMID:29111403
GO:0006349	Regulation of gene expression by genomic imprinting	Affects phenotype	PMID:31082282
GO:0006490	Oligosaccharide-lipid intermediate biosynthetic process	Affects phenotype	PMID:3667605
GO:0006497	Protein lipidation	Increases phenotype	PMID:32142837; PMID:32693121; PMID:34481905; PMID:34481905; PMID:36336208; PMID:34695510; PMID:36336208; PMID:37148155
GO:0006520	Amino acid metabolic process	Affects phenotype	PMID:27401458; PMID:35301059
GO:0006522	Alanine metabolic process	Affects phenotype	PMID:32917723
GO:0006534	Cysteine metabolic process	Affects phenotype	PMID:32917723
GO:0006544	Glycine metabolic process	Affects phenotype	PMID:32917723
GO:0006606	Protein import into nucleus	Affects phenotype	PMID:37949422
GO:0006629	Lipid metabolic process	Affects phenotype	PMID:34237468; PMID:38712533; PMID:39842396
GO:0006631	Fatty acid metabolic process	Affects phenotype	PMID:28433638; PMID:35301059
GO:0006641	Triglyceride metabolic process	Affects phenotype	PMID:34516972; PMID:36718047; PMID:38945390
GO:0006644	Phospholipid metabolic process	Affects phenotype	PMID:35301059
GO:0006693	Prostaglandin metabolic process	Affects phenotype	PMID:35316447
GO:0006695	Cholesterol biosynthetic process	Increases phenotype	PMID:23543441; PMID:25240712
GO:0006703	Estrogen biosynthetic process	Affects phenotype	PMID:31793751
GO:0006739	Nadp metabolic process	Affects phenotype	PMID:38945390
GO:0006749	Glutathione metabolic process	Affects phenotype	PMID:24967604; PMID:26089033; PMID:26363317; PMID:30717178; PMID:30804470; PMID:31876186; PMID:32735850; PMID:33497711; PMID:33559965; PMID:34767868; PMID:35316447; PMID:35384154; PMID:36718047; PMID:36918407; PMID:37270049; PMID:37676925; PMID:37949422; PMID:39025289
GO:0006750	Glutathione biosynthetic process	Increases phenotype	PMID:18573614; PMID:21787725; PMID:22995158; PMID:23543441; PMID:22467032; PMID:22995158; PMID:23543441; PMID:24952260; PMID:25388156; PMID:30359721; PMID:31639282
GO:0006754	Atp biosynthetic process	Decreases phenotype	PMID:25388156; PMID:27289041
GO:0006772	Thiamine metabolic process	Affects phenotype	PMID:39842396
GO:0006778	Porphyrin-containing compound metabolic process	Affects phenotype	PMID:30529385; PMID:31491373
GO:0006811	Monoatomic ion transport	Decreases phenotype	PMID:8884763
GO:0006812	Monoatomic cation transport	Affects phenotype	PMID:32080757
GO:0006813	Potassium ion transport	Affects phenotype	PMID:33038468
GO:0006825	Copper ion transport	Affects phenotype	PMID:32879253
GO:0006874	Cellular calcium ion homeostasis	Affects phenotype	PMID:23902534; PMID:26089033; PMID:28176351; PMID:32080757; PMID:32599263; PMID:33559965; PMID:33617915; PMID:34516972; PMID:37300854
GO:0006875	Cellular metal ion homeostasis	Affects phenotype	PMID:35212737
GO:0006876	Cellular cadmium ion homeostasis	Increases phenotype	PMID:28464991; PMID:38195004
GO:0006879	Cellular iron ion homeostasis	Affects phenotype	PMID:26089033; PMID:39025289
GO:0006914	Autophagy	Affects phenotype	PMID:25955216; PMID:27492225; PMID:27658547; PMID:32693121; PMID:34673407; PMID:36336208
GO:0006915	Apoptotic process	Increases phenotype	PMID:15954739; PMID:17897638; PMID:20137407; PMID:21787653; PMID:22677345; PMID:23315796; PMID:23339468; PMID:23577223; PMID:23650964; PMID:23741317; PMID:23741317; PMID:29891925; PMID:23880342; PMID:24144892; PMID:24212999; PMID:25227780; PMID:25388156; PMID:39197519; PMID:25643798; PMID:27658547; PMID:28035397; PMID:28507149; PMID:28949029; PMID:29111403; PMID:29115570; PMID:29891925; PMID:29993192; PMID:30029485; PMID:30717178; PMID:30796935; PMID:30796935; PMID:32199951; PMID:30804470; PMID:31614173; PMID:32058163; PMID:32599263; PMID:32697411; PMID:33031904; PMID:33359024; PMID:33398418; PMID:33559965; PMID:33652105; PMID:33857584; PMID:34558789; PMID:34558789; PMID:34767868; PMID:34767868; PMID:34791780; PMID:34998821; PMID:35384129; PMID:35870590; PMID:35955783; PMID:36718047; PMID:36718047; PMID:38712533; PMID:37300854; PMID:38001299; PMID:39119833; PMID:39197519; PMID:39725363; PMID:39892737
GO:0006919	Activation of cysteine-type endopeptidase activity involved in apoptotic process	Increases phenotype	PMID:29982767
GO:0006935	Chemotaxis	Increases phenotype	PMID:32080757
GO:0006950	Response to stress	Affects phenotype	PMID:3667605
GO:0006954	Inflammatory response	Increases phenotype	PMID:23636881; PMID:31390532; PMID:37022104; PMID:38759447
GO:0006974	Cellular response to dna damage stimulus	Increases phenotype	PMID:23577223; PMID:33031904
GO:0006979	Response to oxidative stress	Increases phenotype	PMID:12927907; PMID:20399841; PMID:23578882; PMID:30529889
GO:0006997	Nucleus organization	Decreases phenotype	PMID:26165643; PMID:28949029; PMID:34952138
GO:0007005	Mitochondrion organization	Decreases phenotype	PMID:25159133; PMID:30614199; PMID:33559965; PMID:33617915; PMID:34481905; PMID:34673407; PMID:34952138; PMID:37022104; PMID:39025289
GO:0007006	Mitochondrial membrane organization	Affects phenotype	PMID:33038468
GO:0007009	Plasma membrane organization	Decreases phenotype	PMID:30614199
GO:0007033	Vacuole organization	Increases phenotype	PMID:27658547; PMID:33559965; PMID:33652105; PMID:34952138; PMID:35489423; PMID:37506864; PMID:38712533
GO:0007042	Lysosomal lumen acidification	Increases phenotype	PMID:22677345; PMID:31862506
GO:0007049	Cell cycle	Affects phenotype	PMID:23941782
GO:0007056	Spindle assembly involved in female meiosis	Decreases phenotype	PMID:29684212
GO:0007183	Smad protein complex assembly	Decreases phenotype	PMID:36453845
GO:0007204	Positive regulation of cytosolic calcium ion concentration	Increases phenotype	PMID:26165643
GO:0007267	Cell-cell signaling	Decreases phenotype	PMID:28176351
GO:0007283	Spermatogenesis	Decreases phenotype	PMID:20137407; PMID:29527696; PMID:31491373; PMID:31654709; PMID:32199951; PMID:35870590; PMID:32347499; PMID:32781062; PMID:32976933; PMID:33372294; PMID:34791780; PMID:35236366; PMID:37506864
GO:0007284	Spermatogonial cell division	Affects phenotype	PMID:37506864
GO:0007420	Brain development	Decreases phenotype	PMID:20829427; PMID:35770551
GO:0007601	Visual perception	Decreases phenotype	PMID:31666078
GO:0007610	Behavior	Affects phenotype	PMID:31491373
GO:0007611	Learning or memory	Decreases phenotype	PMID:23379984; PMID:29029324; PMID:38579196
GO:0007613	Memory	Decreases phenotype	PMID:29170048; PMID:30090589; PMID:31626305; PMID:32617577; PMID:35489423; PMID:38595292
GO:0007625	Grooming behavior	Increases phenotype	PMID:37047547
GO:0007631	Feeding behavior	Decreases phenotype	PMID:31390532; PMID:34237468; PMID:34237468; PMID:36278208; PMID:37676925
GO:0008121	Ubiquinol-cytochrome-c reductase activity	Decreases phenotype	PMID:33038468; PMID:37342552
GO:0008137	Nadh dehydrogenase (ubiquinone) activity	Decreases phenotype	PMID:33038468; PMID:37342552
GO:0008152	Metabolic process	Affects phenotype	PMID:29656123; PMID:35934034
GO:0008177	Succinate dehydrogenase (ubiquinone) activity	Decreases phenotype	PMID:33038468; PMID:37342552
GO:0008203	Cholesterol metabolic process	Affects phenotype	PMID:34998821; PMID:36718047; PMID:37236586; PMID:38945390
GO:0008206	Bile acid metabolic process	Affects phenotype	PMID:30090589; PMID:31491373; PMID:35934034; PMID:38945390
GO:0008210	Estrogen metabolic process	Affects phenotype	PMID:30478740; PMID:35236366
GO:0008217	Regulation of blood pressure	Affects phenotype	PMID:30477816
GO:0008219	Cell death	Increases phenotype	PMID:23578882; PMID:26537420; PMID:27005776; PMID:27658547; PMID:27871888; PMID:30614199; PMID:32735850; PMID:33497711
GO:0008283	Cell population proliferation	Increases phenotype	PMID:11749125; PMID:21787653; PMID:22634143; PMID:22677345; PMID:23548128; PMID:23577223; PMID:23880342; PMID:25343777; PMID:25388156; PMID:25643798; PMID:25955216; PMID:26006730; PMID:26006730; PMID:8207012; PMID:26537420; PMID:27071802; PMID:27658547; PMID:28315714; PMID:29111403; PMID:31614173; PMID:31689473; PMID:32781062; PMID:33857584; PMID:34816377; PMID:34952138; PMID:35934034; PMID:36602393; PMID:38563870; PMID:38712533; PMID:38944328
GO:0008284	Positive regulation of cell population proliferation	Increases phenotype	PMID:39191366
GO:0008285	Negative regulation of cell population proliferation	Increases phenotype	PMID:31271426; PMID:35134237
GO:0008355	Olfactory learning	Decreases phenotype	PMID:29029324; PMID:33039505
GO:0008361	Regulation of cell size	Affects phenotype	PMID:34875320
GO:0008584	Male gonad development	Decreases phenotype	PMID:32199951
GO:0008652	Amino acid biosynthetic process	Affects phenotype	PMID:28433638
GO:0008653	Lipopolysaccharide metabolic process	Affects phenotype	PMID:35934034
GO:0008654	Phospholipid biosynthetic process	Increases phenotype	PMID:23543441; PMID:25240712
GO:0009060	Aerobic respiration	Decreases phenotype	PMID:31756223
GO:0009116	Nucleoside metabolic process	Affects phenotype	PMID:35301059
GO:0009117	Nucleotide metabolic process	Affects phenotype	PMID:35301059
GO:0009308	Amine metabolic process	Affects phenotype	PMID:39842396
GO:0009435	Nad biosynthetic process	Decreases phenotype	PMID:27289041
GO:0009749	Response to glucose	Decreases phenotype	PMID:30629257; PMID:33259630
GO:0009790	Embryo development	Decreases phenotype	PMID:37941438
GO:0009812	Flavonoid metabolic process	Affects phenotype	PMID:39842396
GO:0010189	Vitamin e biosynthetic process	Decreases phenotype	PMID:23543441
GO:0010288	Response to lead ion	Affects phenotype	PMID:19938001
GO:0010424	Dna methylation on cytosine within a cg sequence	Affects phenotype	PMID:23644563; PMID:24169490; PMID:29373860; PMID:32484362
GO:0010467	Gene expression	Affects phenotype	PMID:24936443; PMID:28899425
GO:0010498	Proteasomal protein catabolic process	Decreases phenotype	PMID:22995398
GO:0010508	Positive regulation of autophagy	Increases phenotype	PMID:30985881
GO:0010659	Cardiac muscle cell apoptotic process	Increases phenotype	PMID:29982767
GO:0010729	Positive regulation of hydrogen peroxide biosynthetic process	Increases phenotype	PMID:37244046
GO:0010918	Positive regulation of mitochondrial membrane potential	Decreases phenotype	PMID:25981801
GO:0010940	Positive regulation of necrotic cell death	Increases phenotype	PMID:24824807; PMID:28587817
GO:0010942	Positive regulation of cell death	Increases phenotype	PMID:25159133; PMID:25981801; PMID:26165643; PMID:26259607
GO:0014002	Astrocyte development	Decreases phenotype	PMID:20829427
GO:0014047	Glutamate secretion	Decreases phenotype	PMID:30614199
GO:0015267	Channel activity	Increases phenotype	PMID:20133428
GO:0015444	P-type magnesium transporter activity	Decreases phenotype	PMID:26089033
GO:0015691	Cadmium ion transport	Increases phenotype	PMID:23238610
GO:0015727	Lactate transport	Increases phenotype	PMID:39427783
GO:0016042	Lipid catabolic process	Increases phenotype	PMID:22995158; PMID:22995158; PMID:23543441; PMID:23543441; PMID:23577223; PMID:31319114; PMID:31390532; PMID:31639282; PMID:32735850; PMID:33398418; PMID:33404196; PMID:33559965; PMID:34695510; PMID:35384154; PMID:35489423
GO:0016049	Cell growth	Affects phenotype	PMID:28507149
GO:0016160	Amylase activity	Decreases phenotype	PMID:38712533
GO:0016477	Cell migration	Affects phenotype	PMID:22884995; PMID:28315714; PMID:31437537; PMID:33559965; PMID:34488496; PMID:34687772
GO:0016567	Protein ubiquitination	Increases phenotype	PMID:29415948
GO:0016615	Malate dehydrogenase activity	Decreases phenotype	PMID:37342552
GO:0016887	Atp hydrolysis activity	Affects phenotype	PMID:34952138
GO:0017015	Regulation of transforming growth factor beta receptor signaling pathway	Affects phenotype	PMID:29408318
GO:0018158	Protein oxidation	Increases phenotype	PMID:22995158; PMID:26089033; PMID:35384154
GO:0018171	Peptidyl-cysteine oxidation	Increases phenotype	PMID:24077948
GO:0018345	Protein palmitoylation	Increases phenotype	PMID:38195004
GO:0018904	Ether metabolic process	Affects phenotype	PMID:39842396
GO:0019216	Regulation of lipid metabolic process	Affects phenotype	PMID:30529385; PMID:38382403
GO:0019432	Triglyceride biosynthetic process	Increases phenotype	PMID:23543441; PMID:25240712
GO:0019538	Protein metabolic process	Affects phenotype	PMID:31491373
GO:0019627	Urea metabolic process	Affects phenotype	PMID:37342552; PMID:37949422; PMID:38945390; PMID:39842396
GO:0019695	Choline metabolic process	Affects phenotype	PMID:27401458
GO:0019722	Calcium-mediated signaling	Affects phenotype	PMID:38579196
GO:0019752	Carboxylic acid metabolic process	Affects phenotype	PMID:32917723; PMID:39842396
GO:0019852	L-ascorbic acid metabolic process	Affects phenotype	PMID:26089033; PMID:34791780
GO:0019853	L-ascorbic acid biosynthetic process	Decreases phenotype	PMID:23543441
GO:0021953	Central nervous system neuron differentiation	Decreases phenotype	PMID:31271426
GO:0022008	Neurogenesis	Decreases phenotype	PMID:31271426; PMID:31626305; PMID:32617577
GO:0030001	Metal ion transport	Decreases phenotype	PMID:28721440
GO:0030097	Hemopoiesis	Decreases phenotype	PMID:38945390; PMID:39461408
GO:0030182	Neuron differentiation	Affects phenotype	PMID:31626305; PMID:33387572
GO:0030199	Collagen fibril organization	Increases phenotype	PMID:34875320; PMID:37022104; PMID:37270049; PMID:38712533
GO:0030220	Platelet formation	Decreases phenotype	PMID:31991237
GO:0030223	Neutrophil differentiation	Decreases phenotype	PMID:29939372
GO:0030224	Monocyte differentiation	Decreases phenotype	PMID:29939372
GO:0030263	Apoptotic chromosome condensation	Increases phenotype	PMID:29170048; PMID:32735850; PMID:33559965; PMID:34673407; PMID:35100813; PMID:35489423; PMID:38595292
GO:0030282	Bone mineralization	Decreases phenotype	PMID:22151692
GO:0030308	Negative regulation of cell growth	Increases phenotype	PMID:27687512
GO:0030316	Osteoclast differentiation	Increases phenotype	PMID:23954550; PMID:31793751; PMID:32522522
GO:0031175	Neuron projection development	Decreases phenotype	PMID:36114956
GO:0031343	Positive regulation of cell killing	Affects phenotype	PMID:26165643
GO:0031589	Cell-substrate adhesion	Decreases phenotype	PMID:33422613; PMID:38563870
GO:0031966	Mitochondrial membrane	Affects phenotype	PMID:33038468
GO:0031987	Locomotion involved in locomotory behavior	Decreases phenotype	PMID:31166132; PMID:32735850; PMID:35489423; PMID:36918407
GO:0032060	Bleb assembly	Increases phenotype	PMID:37357614
GO:0032125	Micronucleus organization	Increases phenotype	PMID:31639282
GO:0032471	Negative regulation of endoplasmic reticulum calcium ion concentration	Increases phenotype	PMID:37300854
GO:0032680	Regulation of tumor necrosis factor production	Affects phenotype	PMID:31652851
GO:0032760	Positive regulation of tumor necrosis factor production	Increases phenotype	PMID:29028684; PMID:31652851
GO:0032868	Response to insulin	Affects phenotype	PMID:33259630
GO:0032941	Secretion by tissue	Increases phenotype	PMID:38759447
GO:0032964	Collagen biosynthetic process	Increases phenotype	PMID:30912652
GO:0033023	Mast cell homeostasis	Affects phenotype	PMID:38712533
GO:0033554	Cellular response to stress	Affects phenotype	PMID:3093479
GO:0033754	Indoleamine 2,3-dioxygenase activity	Increases phenotype	PMID:35489423
GO:0034101	Erythrocyte homeostasis	Affects phenotype	PMID:27181932
GO:0034440	Lipid oxidation	Increases phenotype	PMID:19778222; PMID:26089033; PMID:29408764; PMID:30717178; PMID:31876186; PMID:33372294; PMID:34237468; PMID:35316447; PMID:36356678; PMID:36718047; PMID:36868496; PMID:36918407; PMID:37342552; PMID:37676925; PMID:37949422; PMID:38289529; PMID:38595292; PMID:38945390; PMID:39025289; PMID:39842396
GO:0034504	Protein localization to nucleus	Increases phenotype	PMID:24077948
GO:0034599	Cellular response to oxidative stress	Increases phenotype	PMID:22713677
GO:0034720	Histone h3-k4 demethylation	Decreases phenotype	PMID:25673502
GO:0034757	Negative regulation of iron ion transport	Affects phenotype	PMID:32879253
GO:0035176	Social behavior	Decreases phenotype	PMID:37047547
GO:0035640	Exploration behavior	Affects phenotype	PMID:35489423
GO:0035641	Locomotory exploration behavior	Decreases phenotype	PMID:37047547
GO:0035752	Lysosomal lumen ph elevation	Increases phenotype	PMID:34516972
GO:0035855	Megakaryocyte development	Decreases phenotype	PMID:35134237
GO:0035934	Corticosterone secretion	Increases phenotype	PMID:35384129
GO:0035936	Testosterone secretion	Decreases phenotype	PMID:30717178; PMID:31654709; PMID:32199951
GO:0036123	Histone h3-k9 dimethylation	Increases phenotype	PMID:25673502
GO:0036211	Protein modification process	Increases phenotype	PMID:21787725; PMID:34875320
GO:0036499	Perk-mediated unfolded protein response	Increases phenotype	PMID:29373603
GO:0040007	Growth	Decreases phenotype	PMID:36918407
GO:0042110	T cell activation	Affects phenotype	PMID:39396604
GO:0042116	Macrophage activation	Increases phenotype	PMID:32917723; PMID:33359024
GO:0042158	Lipoprotein biosynthetic process	Affects phenotype	PMID:25240712
GO:0042214	Terpene metabolic process	Affects phenotype	PMID:39842396
GO:0042278	Purine nucleoside metabolic process	Affects phenotype	PMID:39842396
GO:0042304	Regulation of fatty acid biosynthetic process	Affects phenotype	PMID:26187450
GO:0042310	Vasoconstriction	Increases phenotype	PMID:11736687; PMID:23973752
GO:0042360	Vitamin e metabolic process	Affects phenotype	PMID:26089033
GO:0042403	Thyroid hormone metabolic process	Affects phenotype	PMID:30090589; PMID:38712533; PMID:38797200
GO:0042551	Neuron maturation	Decreases phenotype	PMID:36114956
GO:0042554	Superoxide anion generation	Affects phenotype	PMID:34952138
GO:0042573	Retinoic acid metabolic process	Affects phenotype	PMID:37506864
GO:0042593	Glucose homeostasis	Affects phenotype	PMID:27312901; PMID:30629257; PMID:33259630
GO:0042696	Menarche	Affects phenotype	PMID:36729392
GO:0042701	Progesterone secretion	Affects phenotype	PMID:31654709
GO:0042743	Hydrogen peroxide metabolic process	Increases phenotype	PMID:26089033; PMID:31876186
GO:0042756	Drinking behavior	Affects phenotype	PMID:34237468; PMID:34237468; PMID:36278208; PMID:34998821; PMID:37676925
GO:0042775	Mitochondrial atp synthesis coupled electron transport	Decreases phenotype	PMID:31756223
GO:0043029	T cell homeostasis	Affects phenotype	PMID:39396604
GO:0043046	Dna methylation involved in gamete generation	Affects phenotype	PMID:33483743
GO:0043065	Positive regulation of apoptotic process	Increases phenotype	PMID:20829427; PMID:27687512; PMID:28587817; PMID:30985881; PMID:37244046
GO:0043525	Positive regulation of neuron apoptotic process	Increases phenotype	PMID:24824807
GO:0043983	Histone h4-k12 acetylation	Affects phenotype	PMID:29684212
GO:0044062	Regulation of excretion	Increases phenotype	PMID:23806787
GO:0044237	Cellular metabolic process	Increases phenotype	PMID:23968883; PMID:26363317; PMID:28035397; PMID:28176351; PMID:28949029; PMID:29115570; PMID:29298499; PMID:29957541; PMID:29993192; PMID:30029485; PMID:30478740; PMID:30614199; PMID:30717178; PMID:30796935; PMID:30796935; PMID:32199951; PMID:30804470; PMID:31154059; PMID:31166132; PMID:31319114; PMID:31468104; PMID:31614173; PMID:31953414; PMID:32058163; PMID:32142837; PMID:32522522; PMID:33031904; PMID:33188856; PMID:33387572; PMID:33396178; PMID:33559965; PMID:33617915; PMID:33774064; PMID:37300869; PMID:33857584; PMID:33857584; PMID:35100813; PMID:34510229; PMID:34558789; PMID:34558789; PMID:34767868; PMID:36527706; PMID:34695510; PMID:34767868; PMID:34773240; PMID:34822840; PMID:34952138; PMID:35100813; PMID:35301059; PMID:35384129; PMID:35384129; PMID:35908931; PMID:36336208; PMID:36527706; PMID:36602393; PMID:37236586; PMID:37300854; PMID:37300869; PMID:37357614; PMID:37506864; PMID:38001299; PMID:38156290; PMID:38289529; PMID:38944328; PMID:39025289; PMID:39725363; PMID:39778647
GO:0044242	Cellular lipid catabolic process	Increases phenotype	PMID:21787725
GO:0044308	Axonal spine	Decreases phenotype	PMID:30614199
GO:0044319	Wound healing, spreading of cells	Increases phenotype	PMID:31319114; PMID:32080757; PMID:34481905; PMID:34481905; PMID:36336208; PMID:36336208
GO:0044754	Autolysosome	Increases phenotype	PMID:34481905
GO:0045023	G0 to g1 transition	Affects phenotype	PMID:28176351; PMID:31689473
GO:0045165	Cell fate commitment	Decreases phenotype	PMID:36114956
GO:0045214	Sarcomere organization	Decreases phenotype	PMID:29993192
GO:0045302	Choloylglycine hydrolase activity	Decreases phenotype	PMID:35934034
GO:0045329	Carnitine biosynthetic process	Increases phenotype	PMID:30529385
GO:0045333	Cellular respiration	Decreases phenotype	PMID:33038468
GO:0045444	Fat cell differentiation	Increases phenotype	PMID:31793751; PMID:36453845
GO:0045453	Bone resorption	Increases phenotype	PMID:18560534; PMID:22151692; PMID:23954550; PMID:31793751
GO:0045454	Cell redox homeostasis	Decreases phenotype	PMID:24496640; PMID:37244046
GO:0045653	Negative regulation of megakaryocyte differentiation	Increases phenotype	PMID:35134237
GO:0045792	Negative regulation of cell size	Increases phenotype	PMID:38712533
GO:0045795	Positive regulation of cell volume	Increases phenotype	PMID:37357614
GO:0045930	Negative regulation of mitotic cell cycle	Affects phenotype	PMID:27071802; PMID:31614173
GO:0045992	Negative regulation of embryonic development	Increases phenotype	PMID:29684212
GO:0046034	Atp metabolic process	Affects phenotype	PMID:33038468; PMID:33404196; PMID:33497711; PMID:34952138; PMID:36527706; PMID:39025289
GO:0046083	Adenine metabolic process	Affects phenotype	PMID:35301059
GO:0046209	Nitric oxide metabolic process	Affects phenotype	PMID:26089033; PMID:31639282; PMID:37676925
GO:0046323	Glucose import	Affects phenotype	PMID:34481905
GO:0046325	Negative regulation of glucose import	Increases phenotype	PMID:39191366
GO:0046330	Positive regulation of jnk cascade	Increases phenotype	PMID:24824807; PMID:26187450
GO:0046415	Urate metabolic process	Affects phenotype	PMID:39842396
GO:0046449	Creatinine metabolic process	Affects phenotype	PMID:31639282; PMID:31639282; PMID:35384154; PMID:35384154; PMID:37270049; PMID:37342552; PMID:37357614; PMID:37949422; PMID:37949422; PMID:39025289; PMID:39197519; PMID:38945390; PMID:39197519; PMID:39842396
GO:0046466	Membrane lipid catabolic process	Increases phenotype	PMID:12927907; PMID:32976933; PMID:37244046
GO:0046686	Response to cadmium ion	Increases phenotype	PMID:37941438
GO:0046697	Decidualization	Affects phenotype	PMID:39892737
GO:0046722	Lactic acid secretion	Increases phenotype	PMID:32917723
GO:0046849	Bone remodeling	Affects phenotype	PMID:30848671
GO:0048102	Autophagic cell death	Increases phenotype	PMID:27492225
GO:0048137	Spermatocyte division	Affects phenotype	PMID:37506864
GO:0048312	Intracellular distribution of mitochondria	Decreases phenotype	PMID:29684212
GO:0048589	Developmental growth	Decreases phenotype	PMID:35646058
GO:0048708	Astrocyte differentiation	Increases phenotype	PMID:33387572
GO:0048871	Multicellular organismal homeostasis	Decreases phenotype	PMID:31491373
GO:0048874	Host-mediated regulation of intestinal microbiota composition	Affects phenotype	PMID:35037767; PMID:35934034
GO:0050679	Positive regulation of epithelial cell proliferation	Increases phenotype	PMID:22884995
GO:0050729	Positive regulation of inflammatory response	Increases phenotype	PMID:25288670; PMID:30529385; PMID:31463135; PMID:37403423
GO:0050768	Negative regulation of neurogenesis	Increases phenotype	PMID:33039505
GO:0050801	Monoatomic ion homeostasis	Affects phenotype	PMID:30090589
GO:0050890	Cognition	Decreases phenotype	PMID:23379984; PMID:31666078; PMID:25288670; PMID:31626305; PMID:32735850
GO:0050892	Intestinal absorption	Affects phenotype	PMID:32879253
GO:0051238	Sequestering of metal ion	Increases phenotype	PMID:27984135
GO:0051280	Negative regulation of release of sequestered calcium ion into cytosol	Increases phenotype	PMID:28666365
GO:0051567	Histone h3-k9 methylation	Affects phenotype	PMID:29684212
GO:0051646	Mitochondrion localization	Affects phenotype	PMID:33617915
GO:0051881	Regulation of mitochondrial membrane potential	Affects phenotype	PMID:10970901; PMID:21787653; PMID:23741317; PMID:24144892; PMID:25159133; PMID:25464205; PMID:25643798; PMID:25808797; PMID:29891925; PMID:32142837; PMID:33038468; PMID:33559965; PMID:33617915; PMID:34558789; PMID:34558789; PMID:36527706; PMID:34952138; PMID:36527706; PMID:37342552; PMID:39025289
GO:0051882	Mitochondrial depolarization	Increases phenotype	PMID:23315796; PMID:29115570; PMID:33497711; PMID:34481905; PMID:34767868; PMID:36527706
GO:0051899	Membrane depolarization	Increases phenotype	PMID:36527706; PMID:37342552
GO:0055065	Metal ion homeostasis	Decreases phenotype	PMID:19847775
GO:0055069	Zinc ion homeostasis	Decreases phenotype	PMID:21328412
GO:0055070	Copper ion homeostasis	Affects phenotype	PMID:37022104
GO:0055071	Manganese ion homeostasis	Affects phenotype	PMID:37022104
GO:0055072	Iron ion homeostasis	Affects phenotype	PMID:34558789; PMID:37022104
GO:0055073	Cadmium ion homeostasis	Affects phenotype	PMID:37022104
GO:0055074	Calcium ion homeostasis	Affects phenotype	PMID:23497059; PMID:23741317; PMID:32522522; PMID:37148155
GO:0055088	Lipid homeostasis	Affects phenotype	PMID:30529385
GO:0055089	Fatty acid homeostasis	Affects phenotype	PMID:30529385; PMID:32007690
GO:0060047	Heart contraction	Affects phenotype	PMID:23902534
GO:0060079	Excitatory postsynaptic potential	Decreases phenotype	PMID:8884763
GO:0060135	Maternal process involved in female pregnancy	Affects phenotype	PMID:38759447
GO:0060218	Hematopoietic stem cell differentiation	Decreases phenotype	PMID:29939372
GO:0060326	Cell chemotaxis	Affects phenotype	PMID:31319114; PMID:33188856; PMID:33422613; PMID:33559965; PMID:34488496; PMID:34687772
GO:0060348	Bone development	Decreases phenotype	PMID:31793751
GO:0060419	Heart growth	Affects phenotype	PMID:35770551
GO:0060437	Lung growth	Affects phenotype	PMID:35770551
GO:0060444	Branching involved in mammary gland duct morphogenesis	Decreases phenotype	PMID:29741670
GO:0060612	Adipose tissue development	Increases phenotype	PMID:30629257
GO:0060674	Placenta blood vessel development	Decreases phenotype	PMID:35384129; PMID:37941438
GO:0060711	Labyrinthine layer development	Increases phenotype	PMID:35770551
GO:0060718	Chorionic trophoblast cell differentiation	Decreases phenotype	PMID:36370079
GO:0060723	Regulation of cell proliferation involved in embryonic placenta development	Affects phenotype	PMID:29373603
GO:0061007	Hepaticobiliary system process	Affects phenotype	PMID:25424620
GO:0061370	Testosterone biosynthetic process	Decreases phenotype	PMID:29527696; PMID:29527696; PMID:31654709; PMID:36356678; PMID:29527696; PMID:36356678; PMID:31654709; PMID:32781062; PMID:33372294; PMID:33404196; PMID:35236366; PMID:35870590; PMID:36356678
GO:0061739	Protein lipidation involved in autophagosome assembly	Increases phenotype	PMID:34673407
GO:0061909	Autophagosome-lysosome fusion	Affects phenotype	PMID:31862506; PMID:34481905; PMID:34695510
GO:0070265	Necrotic cell death	Increases phenotype	PMID:23636881; PMID:28949029; PMID:33372294; PMID:35934034; PMID:36868496
GO:0070266	Necroptotic process	Increases phenotype	PMID:37357614
GO:0070269	Pyroptosis	Increases phenotype	PMID:37300869
GO:0070328	Triglyceride homeostasis	Affects phenotype	PMID:26187450; PMID:33259630
GO:0070341	Fat cell proliferation	Decreases phenotype	PMID:38712533
GO:0070374	Positive regulation of erk1 and erk2 cascade	Increases phenotype	PMID:24824807; PMID:25343777
GO:0070994	Detection of oxidative stress	Increases phenotype	PMID:16507456; PMID:24936443; PMID:23193971; PMID:23193971; PMID:32347499; PMID:23543441; PMID:26089033; PMID:28433638; PMID:29527696; PMID:29527696; PMID:38712533; PMID:32347499; PMID:32781062; PMID:34767868; PMID:34816377; PMID:34875320; PMID:34998821; PMID:35384154; PMID:35870590; PMID:36527706; PMID:36918407; PMID:37022104; PMID:37300854; PMID:37357614; PMID:38238535; PMID:38289529; PMID:38712533; PMID:39197519; PMID:39725363
GO:0070997	Neuron death	Increases phenotype	PMID:25461191
GO:0071276	Cellular response to cadmium ion	Increases phenotype	PMID:25294218; PMID:8108390
GO:0071461	Cellular response to redox state	Increases phenotype	PMID:31756223
GO:0071480	Cellular response to gamma radiation	Affects phenotype	PMID:31769258
GO:0072520	Seminiferous tubule development	Affects phenotype	PMID:35236366
GO:0072593	Reactive oxygen species metabolic process	Increases phenotype	PMID:15055539; PMID:15055539; PMID:33372294; PMID:20090884; PMID:23339468; PMID:23577223; PMID:23741317; PMID:24952260; PMID:28035397; PMID:29993192; PMID:30717178; PMID:31860779; PMID:32058163; PMID:32142837; PMID:32917723; PMID:33031904; PMID:33372294; PMID:33497711; PMID:33559965; PMID:34510229; PMID:34558789; PMID:34558789; PMID:34767868; PMID:34687772; PMID:34695510; PMID:34767868; PMID:35100813; PMID:36602393; PMID:36602393; PMID:37300854; PMID:36868496; PMID:36918407; PMID:37300854; PMID:37300869; PMID:37342552; PMID:38001299; PMID:38896780; PMID:38944328; PMID:39025289; PMID:8123758
GO:0072674	Multinuclear osteoclast differentiation	Increases phenotype	PMID:38896780
GO:0072677	Eosinophil migration	Increases phenotype	PMID:39396604
GO:0080009	Mrna methylation	Decreases phenotype	PMID:37236586; PMID:39725363
GO:0080020	Regulation of coenzyme a biosynthetic process	Increases phenotype	PMID:30529385
GO:0080182	Histone h3-k4 trimethylation	Increases phenotype	PMID:25673502
GO:0086001	Cardiac muscle cell action potential	Affects phenotype	PMID:29993192
GO:0086004	Regulation of cardiac muscle cell contraction	Affects phenotype	PMID:29982767
GO:0090024	Negative regulation of neutrophil chemotaxis	Increases phenotype	PMID:28666365
GO:0090207	Regulation of triglyceride metabolic process	Affects phenotype	PMID:26187450
GO:0090303	Positive regulation of wound healing	Increases phenotype	PMID:39032683
GO:0090557	Establishment of endothelial intestinal barrier	Decreases phenotype	PMID:35934034
GO:0097169	Aim2 inflammasome complex	Affects phenotype	PMID:31463135
GO:0097189	Apoptotic body	Increases phenotype	PMID:33652105
GO:0097205	Renal filtration	Affects phenotype	PMID:25424620
GO:0097212	Lysosomal membrane organization	Affects phenotype	PMID:34695510
GO:0097213	Regulation of lysosomal membrane permeability	Affects phenotype	PMID:34695510
GO:0097298	Regulation of nucleus size	Affects phenotype	PMID:38712533
GO:0097502	Mannosylation	Affects phenotype	PMID:3667605
GO:0097621	Monoamine oxidase activity	Increases phenotype	PMID:29170048
GO:0097707	Ferroptosis	Increases phenotype	PMID:34558789
GO:0097722	Sperm motility	Decreases phenotype	PMID:29527696; PMID:32781062; PMID:34791780; PMID:35236366; PMID:35236366; PMID:38944328; PMID:35870590; PMID:37506864; PMID:38944328
GO:0097746	Blood vessel diameter maintenance	Affects phenotype	PMID:29685964
GO:0098659	Inorganic cation import across plasma membrane	Increases phenotype	PMID:27114535
GO:0098868	Bone growth	Decreases phenotype	PMID:38896780
GO:0110081	Negative regulation of placenta blood vessel development	Increases phenotype	PMID:29373603
GO:0110090	Positive regulation of hippocampal neuron apoptotic process	Increases phenotype	PMID:31271426
GO:0120193	Tight junction organization	Decreases phenotype	PMID:31390532
GO:0140042	Lipid droplet formation	Increases phenotype	PMID:36602393; PMID:36918407; PMID:37236586; PMID:39778647
GO:0150078	Positive regulation of neuroinflammatory response	Increases phenotype	PMID:38595292
GO:0150104	Transport across blood-brain barrier	Affects phenotype	PMID:36641952
GO:1900227	Positive regulation of nlrp3 inflammasome complex assembly	Affects phenotype	PMID:31463135
GO:1900409	Positive regulation of cellular response to oxidative stress	Increases phenotype	PMID:29170048; PMID:31078004
GO:1900745	Positive regulation of p38mapk cascade	Increases phenotype	PMID:24824807
GO:1901142	Insulin metabolic process	Affects phenotype	PMID:25867198
GO:1901216	Positive regulation of neuron death	Increases phenotype	PMID:24824807
GO:1901318	Negative regulation of flagellated sperm motility	Affects phenotype	PMID:32976933
GO:1901386	Negative regulation of voltage-gated calcium channel activity	Increases phenotype	PMID:27114535
GO:1901670	Negative regulation of superoxide dismutase activity	Increases phenotype	PMID:31756223; PMID:38595292
GO:1901671	Positive regulation of superoxide dismutase activity	Increases phenotype	PMID:32976933
GO:1902071	Regulation of hypoxia-inducible factor-1alpha signaling pathway	Affects phenotype	PMID:29408318
GO:1902237	Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	Increases phenotype	PMID:37261864
GO:1902552	Negative regulation of catalase activity	Increases phenotype	PMID:31756223; PMID:37244046
GO:1902600	Proton transmembrane transport	Affects phenotype	PMID:33038468
GO:1902882	Regulation of response to oxidative stress	Affects phenotype	PMID:23479318
GO:1903047	Mitotic cell cycle process	Affects phenotype	PMID:28035397; PMID:31468104
GO:1903283	Negative regulation of glutathione peroxidase activity	Increases phenotype	PMID:37244046
GO:1903409	Reactive oxygen species biosynthetic process	Increases phenotype	PMID:23548128; PMID:25464205; PMID:26514923; PMID:27071802; PMID:29111403; PMID:30359721; PMID:30796935
GO:1903428	Positive regulation of reactive oxygen species biosynthetic process	Increases phenotype	PMID:27687512; PMID:29408318; PMID:37403423; PMID:38595292; PMID:39191366
GO:1903561	Extracellular vesicle	Increases phenotype	PMID:34044057
GO:1903597	Negative regulation of gap junction assembly	Increases phenotype	PMID:26165643
GO:1903703	Enterocyte differentiation	Affects phenotype	PMID:38563870
GO:1903787	Negative regulation of glutathione biosynthetic process	Increases phenotype	PMID:38595292
GO:1904141	Positive regulation of microglial cell migration	Increases phenotype	PMID:38595292
GO:1904145	Negative regulation of meiotic cell cycle process involved in oocyte maturation	Increases phenotype	PMID:29684212
GO:1904659	Glucose transmembrane transport	Increases phenotype	PMID:39427783
GO:1905037	Autophagosome organization	Increases phenotype	PMID:34695510
GO:1905146	Lysosomal protein catabolic process	Decreases phenotype	PMID:34695510
GO:1905220	Negative regulation of platelet formation	Increases phenotype	PMID:35134237
GO:1905517	Macrophage migration	Increases phenotype	PMID:39396604
GO:1905603	Regulation of blood-brain barrier permeability	Decreases phenotype	PMID:20829427
GO:1905898	Positive regulation of response to endoplasmic reticulum stress	Increases phenotype	PMID:37261864
GO:1990266	Neutrophil migration	Increases phenotype	PMID:39396604
GO:1990349	Gap junction-mediated intercellular transport	Decreases phenotype	PMID:26165643
GO:2000052	Positive regulation of non-canonical wnt signaling pathway	Affects phenotype	PMID:29939372
GO:2000390	Negative regulation of neutrophil extravasation	Increases phenotype	PMID:28666365
GO:2000726	Negative regulation of cardiac muscle cell differentiation	Increases phenotype	PMID:36321828
GO:2000872	Positive regulation of progesterone secretion	Decreases phenotype	PMID:25981801
GO:2001057	Reactive nitrogen species metabolic process	Affects phenotype	PMID:31639282

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.