Cadmium acetate


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000045 Autophagosome assembly Increases phenotype PMID:29870746
GO:0000226 Microtubule cytoskeleton organization Decreases phenotype PMID:29870746
GO:0001836 Release of cytochrome c from mitochondria Increases phenotype PMID:24577723; PMID:25043952; PMID:27717697
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:37128655
GO:0004602 Glutathione peroxidase activity Decreases phenotype PMID:23534466; PMID:8951241
GO:0004679 Amp-activated protein kinase activity Decreases phenotype PMID:34897960
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:23534466; PMID:33404196
GO:0006006 Glucose metabolic process Affects phenotype PMID:37128655
GO:0006089 Lactate metabolic process Affects phenotype PMID:33404196
GO:0006090 Pyruvate metabolic process Affects phenotype PMID:33404196
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:23534466; PMID:8951241
GO:0006754 Atp biosynthetic process Decreases phenotype PMID:27717697
GO:0006915 Apoptotic process Increases phenotype PMID:23534466; PMID:23534466; PMID:27717697; PMID:29870746; PMID:24577723; PMID:25043952; PMID:27717697; PMID:29870746; PMID:29883672
GO:0007005 Mitochondrion organization Decreases phenotype PMID:27717697
GO:0008283 Cell population proliferation Decreases phenotype PMID:21787718; PMID:23534466; PMID:24577723; PMID:25043952; PMID:29883672; PMID:8951241
GO:0010823 Negative regulation of mitochondrion organization Increases phenotype PMID:30605698
GO:0016042 Lipid catabolic process Increases phenotype PMID:23534466; PMID:23534466; PMID:27717697; PMID:27717697; PMID:33404196
GO:0019627 Urea metabolic process Affects phenotype PMID:37128655
GO:0030262 Apoptotic nuclear changes Increases phenotype PMID:30605698
GO:0030263 Apoptotic chromosome condensation Increases phenotype PMID:30605698; PMID:37128655
GO:0032148 Activation of protein kinase b activity Decreases phenotype PMID:34897960
GO:0034440 Lipid oxidation Increases phenotype PMID:34897960; PMID:38294748
GO:0036091 Positive regulation of transcription from rna polymerase ii promoter in response to oxidative stress Increases phenotype PMID:29140578
GO:0040018 Positive regulation of multicellular organism growth Decreases phenotype PMID:21360559
GO:0042307 Positive regulation of protein import into nucleus Increases phenotype PMID:29140578
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:38294748
GO:0043525 Positive regulation of neuron apoptotic process Increases phenotype PMID:30605698
GO:0044319 Wound healing, spreading of cells Decreases phenotype PMID:29870746
GO:0045454 Cell redox homeostasis Decreases phenotype PMID:34897960
GO:0045930 Negative regulation of mitotic cell cycle Increases phenotype PMID:29870746
GO:0046034 Atp metabolic process Affects phenotype PMID:33404196
GO:0046415 Urate metabolic process Affects phenotype PMID:37128655
GO:0046621 Negative regulation of organ growth Increases phenotype PMID:30605698
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:23534466; PMID:23534466; PMID:27717697; PMID:27717697
GO:0055069 Zinc ion homeostasis Decreases phenotype PMID:21360559
GO:0055074 Calcium ion homeostasis Affects phenotype PMID:28347754; PMID:29883672
GO:0061370 Testosterone biosynthetic process Affects phenotype PMID:33404196
GO:0070265 Necrotic cell death Increases phenotype PMID:37128655
GO:0071901 Negative regulation of protein serine/threonine kinase activity Affects phenotype PMID:34897960
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:21787718; PMID:23534466; PMID:24933620
GO:0097352 Autophagosome maturation Decreases phenotype PMID:28347754
GO:0140639 Positive regulation of pyroptosis Increases phenotype PMID:36347317
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:34897960
GO:1901671 Positive regulation of superoxide dismutase activity Increases phenotype PMID:38294748
GO:1902237 Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Increases phenotype PMID:30605698
GO:1903283 Negative regulation of glutathione peroxidase activity Increases phenotype PMID:34897960
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:27717697; PMID:27717697; PMID:28347754; PMID:28347754
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:36347317; PMID:38294748
GO:1903917 Positive regulation of endoplasmic reticulum stress-induced eif2 alpha dephosphorylation Increases phenotype PMID:30605698
GO:1905898 Positive regulation of response to endoplasmic reticulum stress Increases phenotype PMID:30605698
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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.