DEDUCT | Database of Endocrine Disrupting chemicals and their Toxicity profiles

Mercuric chloride

Curated chemical-phenotype interactions from CTD

GO ID	GO name	Interaction type	Reference
GO:0000737	Dna catabolic process, endonucleolytic	Increases phenotype	PMID:39096083
GO:0001541	Ovarian follicle development	Affects phenotype	PMID:31071422
GO:0001820	Serotonin secretion	Increases phenotype	PMID:7664789; PMID:9022032; PMID:9022032
GO:0002000	Detection of renal blood flow	Affects phenotype	PMID:33476711
GO:0002381	Immunoglobulin production involved in immunoglobulin-mediated immune response	Increases phenotype	PMID:8102566
GO:0002523	Leukocyte migration involved in inflammatory response	Increases phenotype	PMID:39105374
GO:0002639	Positive regulation of immunoglobulin production	Increases phenotype	PMID:25237059
GO:0002718	Regulation of cytokine production involved in immune response	Increases phenotype	PMID:10886398
GO:0002830	Positive regulation of type 2 immune response	Affects phenotype	PMID:24089704; PMID:9931279
GO:0003084	Positive regulation of systemic arterial blood pressure	Increases phenotype	PMID:28987480
GO:0003094	Glomerular filtration	Affects phenotype	PMID:33476711
GO:0003993	Acid phosphatase activity	Increases phenotype	PMID:26215012
GO:0004035	Alkaline phosphatase activity	Affects phenotype	PMID:24485406; PMID:26215012
GO:0004096	Catalase activity	Affects phenotype	PMID:39096083
GO:0004129	Cytochrome-c oxidase activity	Decreases phenotype	PMID:31251452; PMID:33038468
GO:0004197	Cysteine-type endopeptidase activity	Affects phenotype	PMID:33497711
GO:0004364	Glutathione transferase activity	Affects phenotype	PMID:22416658; PMID:30359721; PMID:35066093
GO:0004457	Lactate dehydrogenase activity	Affects phenotype	PMID:22413763; PMID:24485406; PMID:27837179
GO:0004602	Glutathione peroxidase activity	Affects phenotype	PMID:17516994; PMID:20820944; PMID:23369933; PMID:33460233; PMID:39096083; PMID:22351102; PMID:23369933; PMID:23390552; PMID:24751971; PMID:24751971; PMID:24834726; PMID:24834726; PMID:25600690; PMID:25600690; PMID:33460233; PMID:39096083; PMID:39105374
GO:0004784	Superoxide dismutase activity	Decreases phenotype	PMID:17516994; PMID:17516994; PMID:22416658; PMID:24485406; PMID:24751971; PMID:20820944; PMID:23369933; PMID:25368988; PMID:32134168; PMID:33460233; PMID:39096083; PMID:22351102; PMID:22416658; PMID:24485406; PMID:23369933; PMID:23390552; PMID:24485406; PMID:24485406; PMID:24751971; PMID:24555655; PMID:24751971; PMID:25600690; PMID:26089086; PMID:32134168; PMID:33460233; PMID:39096083; PMID:39105374
GO:0006089	Lactate metabolic process	Affects phenotype	PMID:33038468
GO:0006457	Protein folding	Decreases phenotype	PMID:31251452
GO:0006695	Cholesterol biosynthetic process	Increases phenotype	PMID:24485406
GO:0006749	Glutathione metabolic process	Decreases phenotype	PMID:24970117; PMID:32134168; PMID:32134168; PMID:39096083; PMID:33497711; PMID:35066093; PMID:36646412; PMID:39096083; PMID:39105374
GO:0006750	Glutathione biosynthetic process	Affects phenotype	PMID:22416658; PMID:24485406; PMID:22416658; PMID:24485406; PMID:24751971; PMID:24039982; PMID:24485406; PMID:24485406; PMID:24751971; PMID:24751971; PMID:25600690; PMID:26215012; PMID:30359721
GO:0006809	Nitric oxide biosynthetic process	Increases phenotype	PMID:24751971; PMID:25600690; PMID:29981841
GO:0006813	Potassium ion transport	Affects phenotype	PMID:33038468
GO:0006816	Calcium ion transport	Increases phenotype	PMID:9405450
GO:0006826	Iron ion transport	Increases phenotype	PMID:9863766
GO:0006833	Water transport	Increases phenotype	PMID:19840149; PMID:20958918; PMID:22687538; PMID:7528928; PMID:9124401; PMID:9514918; PMID:9733774
GO:0006915	Apoptotic process	Increases phenotype	PMID:25953102; PMID:27714827; PMID:7867075; PMID:7867075; PMID:7867088
GO:0006954	Inflammatory response	Increases phenotype	PMID:31071422; PMID:37172713
GO:0006955	Immune response	Affects phenotype	PMID:3262595
GO:0007006	Mitochondrial membrane organization	Affects phenotype	PMID:33038468
GO:0007154	Cell communication	Decreases phenotype	PMID:12528335
GO:0007224	Smoothened signaling pathway	Decreases phenotype	PMID:31652400
GO:0007566	Embryo implantation	Affects phenotype	PMID:1238902
GO:0008121	Ubiquinol-cytochrome-c reductase activity	Decreases phenotype	PMID:33038468
GO:0008137	Nadh dehydrogenase (ubiquinone) activity	Decreases phenotype	PMID:33038468
GO:0008177	Succinate dehydrogenase (ubiquinone) activity	Decreases phenotype	PMID:31251452; PMID:33038468
GO:0008203	Cholesterol metabolic process	Affects phenotype	PMID:37172713
GO:0008219	Cell death	Increases phenotype	PMID:31404653; PMID:33497711; PMID:7867088
GO:0008241	Peptidyl-dipeptidase activity	Decreases phenotype	PMID:28987480
GO:0008283	Cell population proliferation	Decreases phenotype	PMID:25458486; PMID:25953102; PMID:27714827; PMID:27888128; PMID:29981841; PMID:8560497
GO:0008284	Positive regulation of cell population proliferation	Increases phenotype	PMID:10861847; PMID:25446860
GO:0008361	Regulation of cell size	Affects phenotype	PMID:30807803
GO:0010466	Negative regulation of peptidase activity	Affects phenotype	PMID:28987480
GO:0010729	Positive regulation of hydrogen peroxide biosynthetic process	Increases phenotype	PMID:8872981
GO:0010918	Positive regulation of mitochondrial membrane potential	Decreases phenotype	PMID:22910795
GO:0010942	Positive regulation of cell death	Increases phenotype	PMID:22910795; PMID:24816296; PMID:24973089; PMID:25849418; PMID:27720909
GO:0015694	Mercury ion transport	Increases phenotype	PMID:25145654; PMID:28536007
GO:0016042	Lipid catabolic process	Increases phenotype	PMID:17516994; PMID:17516994; PMID:22416658; PMID:24485406; PMID:24751971; PMID:24834726; PMID:20820944; PMID:23369933; PMID:25368988; PMID:21138989; PMID:22351102; PMID:26215012; PMID:22416658; PMID:24485406; PMID:22771764; PMID:23369933; PMID:23390552; PMID:24485406; PMID:24485406; PMID:24751971; PMID:24555655; PMID:24751971; PMID:24954677; PMID:25600690; PMID:25947387; PMID:26215012; PMID:32134168
GO:0016049	Cell growth	Affects phenotype	PMID:29981841
GO:0018158	Protein oxidation	Increases phenotype	PMID:22771764; PMID:22771764; PMID:23650045; PMID:23650045
GO:0019432	Triglyceride biosynthetic process	Increases phenotype	PMID:24485406; PMID:30807803
GO:0019627	Urea metabolic process	Affects phenotype	PMID:32599119
GO:0019722	Calcium-mediated signaling	Increases phenotype	PMID:9405450
GO:0022602	Ovulation cycle process	Affects phenotype	PMID:31071422
GO:0022904	Respiratory electron transport chain	Decreases phenotype	PMID:25926417
GO:0030073	Insulin secretion	Affects phenotype	PMID:23202902
GO:0030168	Platelet activation	Increases phenotype	PMID:30537864
GO:0030336	Negative regulation of cell migration	Increases phenotype	PMID:19539607
GO:0030890	Positive regulation of b cell proliferation	Affects phenotype	PMID:9693280
GO:0031143	Pseudopodium	Increases phenotype	PMID:30537864
GO:0031966	Mitochondrial membrane	Affects phenotype	PMID:33038468
GO:0032633	Interleukin-4 production	Increases phenotype	PMID:18432732
GO:0032780	Negative regulation of atp-dependent activity	Affects phenotype	PMID:9243794
GO:0032930	Positive regulation of superoxide anion generation	Increases phenotype	PMID:28987480
GO:0033554	Cellular response to stress	Affects phenotype	PMID:24036268
GO:0033864	Positive regulation of nad(p)h oxidase activity	Increases phenotype	PMID:25446860
GO:0034440	Lipid oxidation	Increases phenotype	PMID:106178; PMID:23650045; PMID:24970117; PMID:33460233; PMID:39096083; PMID:39105374
GO:0035264	Multicellular organism growth	Decreases phenotype	PMID:28536007
GO:0035556	Intracellular signal transduction	Increases phenotype	PMID:7698341
GO:0035712	T-helper 2 cell activation	Increases phenotype	PMID:8258322
GO:0035812	Renal sodium excretion	Decreases phenotype	PMID:16189294
GO:0042092	Type 2 immune response	Increases phenotype	PMID:7589090; PMID:7657819; PMID:7664789
GO:0042102	Positive regulation of t cell proliferation	Decreases phenotype	PMID:22910795
GO:0042110	T cell activation	Increases phenotype	PMID:8102566; PMID:9766631
GO:0042113	B cell activation	Increases phenotype	PMID:7867088; PMID:8102566; PMID:8766555; PMID:8898950
GO:0042310	Vasoconstriction	Increases phenotype	PMID:10790511; PMID:31415774; PMID:33476711
GO:0042311	Vasodilation	Increases phenotype	PMID:10790511; PMID:28987480
GO:0042531	Positive regulation of tyrosine phosphorylation of stat protein	Increases phenotype	PMID:22910795
GO:0042554	Superoxide anion generation	Increases phenotype	PMID:31071422; PMID:31415774
GO:0042593	Glucose homeostasis	Decreases phenotype	PMID:23202902
GO:0043065	Positive regulation of apoptotic process	Affects phenotype	PMID:21435368; PMID:22785175; PMID:22910795; PMID:23202902; PMID:27837179; PMID:32879258
GO:0043410	Positive regulation of mapk cascade	Increases phenotype	PMID:10861847
GO:0044237	Cellular metabolic process	Decreases phenotype	PMID:29298499; PMID:37172713
GO:0045089	Positive regulation of innate immune response	Increases phenotype	PMID:26456670
GO:0045190	Isotype switching	Increases phenotype	PMID:8102566
GO:0045333	Cellular respiration	Decreases phenotype	PMID:33038468
GO:0045429	Positive regulation of nitric oxide biosynthetic process	Decreases phenotype	PMID:23650045
GO:0045907	Positive regulation of vasoconstriction	Increases phenotype	PMID:28987480
GO:0045931	Positive regulation of mitotic cell cycle	Increases phenotype	PMID:22910795
GO:0046034	Atp metabolic process	Affects phenotype	PMID:33038468; PMID:33497711
GO:0046330	Positive regulation of jnk cascade	Increases phenotype	PMID:10861847
GO:0046415	Urate metabolic process	Decreases phenotype	PMID:32879258
GO:0046449	Creatinine metabolic process	Decreases phenotype	PMID:17516994; PMID:32599119; PMID:32879258
GO:0046466	Membrane lipid catabolic process	Increases phenotype	PMID:27837179; PMID:39414706
GO:0046651	Lymphocyte proliferation	Increases phenotype	PMID:9376071
GO:0048246	Macrophage chemotaxis	Increases phenotype	PMID:12834626
GO:0048247	Lymphocyte chemotaxis	Increases phenotype	PMID:12834626
GO:0048874	Host-mediated regulation of intestinal microbiota composition	Increases phenotype	PMID:31175882
GO:0050729	Positive regulation of inflammatory response	Increases phenotype	PMID:22822941; PMID:39414706
GO:0050817	Coagulation	Increases phenotype	PMID:35022635
GO:0050861	Positive regulation of b cell receptor signaling pathway	Decreases phenotype	PMID:28668464
GO:0051881	Regulation of mitochondrial membrane potential	Affects phenotype	PMID:33038468; PMID:37172713
GO:0051882	Mitochondrial depolarization	Increases phenotype	PMID:31404653; PMID:33497711
GO:0051897	Positive regulation of protein kinase b signaling	Increases phenotype	PMID:22910795
GO:0055074	Calcium ion homeostasis	Affects phenotype	PMID:29981841
GO:0060073	Micturition	Increases phenotype	PMID:33476711
GO:0060208	Proestrus	Affects phenotype	PMID:31071422
GO:0061045	Negative regulation of wound healing	Increases phenotype	PMID:19539607
GO:0061098	Positive regulation of protein tyrosine kinase activity	Increases phenotype	PMID:10092522; PMID:10092522; PMID:7698341; PMID:7698341
GO:0061370	Testosterone biosynthetic process	Affects phenotype	PMID:32134168; PMID:32134168; PMID:33460233; PMID:33460233
GO:0070265	Necrotic cell death	Increases phenotype	PMID:17516994; PMID:29045746
GO:0070266	Necroptotic process	Increases phenotype	PMID:21435368
GO:0070374	Positive regulation of erk1 and erk2 cascade	Affects phenotype	PMID:22910795; PMID:28668464
GO:0070527	Platelet aggregation	Increases phenotype	PMID:30537864
GO:0070994	Detection of oxidative stress	Increases phenotype	PMID:24555655; PMID:33460233; PMID:33460233; PMID:39096083; PMID:36646412; PMID:37172713; PMID:39096083
GO:0071674	Mononuclear cell migration	Increases phenotype	PMID:8538927
GO:0072378	Blood coagulation, fibrin clot formation	Increases phenotype	PMID:30537864
GO:0072593	Reactive oxygen species metabolic process	Affects phenotype	PMID:33497711
GO:0072678	T cell migration	Increases phenotype	PMID:7763084
GO:0090322	Regulation of superoxide metabolic process	Increases phenotype	PMID:9863766
GO:0097722	Sperm motility	Decreases phenotype	PMID:39096083
GO:0098508	Endothelial to hematopoietic transition	Increases phenotype	PMID:31404653
GO:0140042	Lipid droplet formation	Increases phenotype	PMID:31071422
GO:1900017	Positive regulation of cytokine production involved in inflammatory response	Increases phenotype	PMID:25237059
GO:1901670	Negative regulation of superoxide dismutase activity	Increases phenotype	PMID:26825963; PMID:27837179; PMID:39414706
GO:1901671	Positive regulation of superoxide dismutase activity	Decreases phenotype	PMID:24970117
GO:1902552	Negative regulation of catalase activity	Increases phenotype	PMID:26825963; PMID:39414706
GO:1902600	Proton transmembrane transport	Affects phenotype	PMID:33038468
GO:1903283	Negative regulation of glutathione peroxidase activity	Increases phenotype	PMID:26825963; PMID:27837179
GO:1903284	Positive regulation of glutathione peroxidase activity	Affects phenotype	PMID:23650045; PMID:24970117
GO:1903409	Reactive oxygen species biosynthetic process	Increases phenotype	PMID:22240155; PMID:30359721
GO:1903428	Positive regulation of reactive oxygen species biosynthetic process	Increases phenotype	PMID:22910795; PMID:24970117; PMID:27837179
GO:1903787	Negative regulation of glutathione biosynthetic process	Increases phenotype	PMID:39414706
GO:1904480	Positive regulation of intestinal absorption	Increases phenotype	PMID:31175882
GO:1905898	Positive regulation of response to endoplasmic reticulum stress	Increases phenotype	PMID:32879258
GO:1990051	Activation of protein kinase c activity	Increases phenotype	PMID:9405450
GO:2000379	Positive regulation of reactive oxygen species metabolic process	Increases phenotype	PMID:18409822; PMID:23202902; PMID:9022032
GO:2000516	Positive regulation of cd4-positive, alpha-beta t cell activation	Increases phenotype	PMID:25237059
GO:2000573	Positive regulation of dna biosynthetic process	Increases phenotype	PMID:10861847
GO:2001151	Regulation of renal water transport	Affects phenotype	PMID:15462210

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.