Titanium dioxide


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000045 Autophagosome assembly Increases phenotype PMID:27226226; PMID:30273564
GO:0000086 G2/m transition of mitotic cell cycle Increases phenotype PMID:30910687
GO:0000165 Mapk cascade Affects phenotype PMID:39213753
GO:0000737 Dna catabolic process, endonucleolytic Increases phenotype PMID:39580016
GO:0001776 Leukocyte homeostasis Affects phenotype PMID:28646487
GO:0001890 Placenta development Increases phenotype PMID:30843041
GO:0002176 Male germ cell proliferation Affects phenotype PMID:39580016
GO:0002260 Lymphocyte homeostasis Affects phenotype PMID:28646487
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:17656681; PMID:28780322
GO:0003093 Regulation of glomerular filtration Affects phenotype PMID:25578686
GO:0003810 Protein-glutamine gamma-glutamyltransferase activity Increases phenotype PMID:28844848
GO:0004035 Alkaline phosphatase activity Increases phenotype PMID:23873220; PMID:29774637
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Increases phenotype PMID:23873220
GO:0004096 Catalase activity Increases phenotype PMID:25129858
GO:0004111 Creatine kinase activity Increases phenotype PMID:28780322
GO:0004364 Glutathione transferase activity Decreases phenotype PMID:34874108
GO:0004457 Lactate dehydrogenase activity Increases phenotype PMID:23873220; PMID:28780322; PMID:29774637
GO:0004602 Glutathione peroxidase activity Affects phenotype PMID:25016076; PMID:25129858; PMID:28780322; PMID:30738203
GO:0004784 Superoxide dismutase activity Affects phenotype PMID:25016076; PMID:25129858; PMID:28780322; PMID:30738203; PMID:39580016
GO:0006703 Estrogen biosynthetic process Increases phenotype PMID:28844848
GO:0006749 Glutathione metabolic process Increases phenotype PMID:26277626; PMID:26277626; PMID:34874108; PMID:33766574; PMID:34874108
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:28844848; PMID:30738203; PMID:31298478; PMID:31769605
GO:0006754 Atp biosynthetic process Increases phenotype PMID:25111187
GO:0006809 Nitric oxide biosynthetic process Increases phenotype PMID:25111187
GO:0006884 Cell volume homeostasis Affects phenotype PMID:28646487
GO:0006909 Phagocytosis Increases phenotype PMID:29774637
GO:0006914 Autophagy Increases phenotype PMID:29792337
GO:0006915 Apoptotic process Increases phenotype PMID:19156710; PMID:23111874; PMID:25016076; PMID:27225715; PMID:28646487; PMID:32333507
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:24594277; PMID:25224607; PMID:26028148; PMID:28780322; PMID:30626778
GO:0006979 Response to oxidative stress Increases phenotype PMID:20033351
GO:0007005 Mitochondrion organization Affects phenotype PMID:28400324
GO:0007009 Plasma membrane organization Decreases phenotype PMID:30738203
GO:0007029 Endoplasmic reticulum organization Affects phenotype PMID:39461655
GO:0007033 Vacuole organization Increases phenotype PMID:25111187
GO:0007204 Positive regulation of cytosolic calcium ion concentration Increases phenotype PMID:27939335
GO:0007283 Spermatogenesis Affects phenotype PMID:24241477; PMID:39580016
GO:0008219 Cell death Increases phenotype PMID:19783790; PMID:24717318; PMID:25224607; PMID:27060086; PMID:27216632; PMID:27226226
GO:0008233 Peptidase activity Decreases phenotype PMID:30273564
GO:0008283 Cell population proliferation Affects phenotype PMID:18805477; PMID:24594277; PMID:24717318; PMID:25111187
GO:0008284 Positive regulation of cell population proliferation Affects phenotype PMID:28606428; PMID:30012374
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:30098274; PMID:30126039; PMID:31927068; PMID:32224134; PMID:34730869; PMID:39213753
GO:0008360 Regulation of cell shape Affects phenotype PMID:23906720
GO:0010508 Positive regulation of autophagy Increases phenotype PMID:32004531
GO:0010759 Positive regulation of macrophage chemotaxis Increases phenotype PMID:30012374
GO:0010917 Negative regulation of mitochondrial membrane potential Increases phenotype PMID:31927068; PMID:32004531
GO:0010918 Positive regulation of mitochondrial membrane potential Decreases phenotype PMID:30098274
GO:0010942 Positive regulation of cell death Increases phenotype PMID:28606428; PMID:31927068
GO:0015692 Lead ion transport Increases phenotype PMID:30738203
GO:0016042 Lipid catabolic process Increases phenotype PMID:28780322; PMID:28780322; PMID:31298478; PMID:28844848; PMID:30738203; PMID:31298478; PMID:31769605
GO:0016049 Cell growth Decreases phenotype PMID:23873220; PMID:25224607; PMID:30626778
GO:0016209 Antioxidant activity Decreases phenotype PMID:39580016
GO:0030036 Actin cytoskeleton organization Decreases phenotype PMID:30711708
GO:0030336 Negative regulation of cell migration Increases phenotype PMID:32224134
GO:0030837 Negative regulation of actin filament polymerization Increases phenotype PMID:32224134
GO:0031115 Negative regulation of microtubule polymerization Increases phenotype PMID:32224134
GO:0031324 Negative regulation of cellular metabolic process Increases phenotype PMID:34973136
GO:0031589 Cell-substrate adhesion Decreases phenotype PMID:24717318
GO:0032148 Activation of protein kinase b activity Increases phenotype PMID:30098274
GO:0034101 Erythrocyte homeostasis Affects phenotype PMID:28646487
GO:0034116 Positive regulation of heterotypic cell-cell adhesion Increases phenotype PMID:29244817
GO:0034440 Lipid oxidation Increases phenotype PMID:30098274; PMID:34874108; PMID:39580016
GO:0035809 Regulation of urine volume Affects phenotype PMID:25578686
GO:0035937 Estrogen secretion Decreases phenotype PMID:30843041
GO:0042310 Vasoconstriction Affects phenotype PMID:20033351; PMID:30843041; PMID:35642938
GO:0042311 Vasodilation Increases phenotype PMID:20033351; PMID:35642938
GO:0042415 Norepinephrine metabolic process Increases phenotype PMID:34874108
GO:0042417 Dopamine metabolic process Increases phenotype PMID:34874108
GO:0042428 Serotonin metabolic process Increases phenotype PMID:34874108
GO:0042541 Hemoglobin biosynthetic process Decreases phenotype PMID:28646487
GO:0042554 Superoxide anion generation Increases phenotype PMID:19783790; PMID:33064449
GO:0043032 Positive regulation of macrophage activation Increases phenotype PMID:27760801
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:30098274; PMID:30126039; PMID:30711708; PMID:39213753
GO:0043123 Positive regulation of i-kappab kinase/nf-kappab signaling Increases phenotype PMID:30098274
GO:0043124 Negative regulation of i-kappab kinase/nf-kappab signaling Increases phenotype PMID:30098274
GO:0043313 Regulation of neutrophil degranulation Affects phenotype PMID:23726862
GO:0043525 Positive regulation of neuron apoptotic process Increases phenotype PMID:34874108
GO:0044237 Cellular metabolic process Decreases phenotype PMID:24717318; PMID:29792337; PMID:33766574; PMID:39547316; PMID:39580016
GO:0045023 G0 to g1 transition Decreases phenotype PMID:30910687
GO:0045792 Negative regulation of cell size Increases phenotype PMID:32224134
GO:0045907 Positive regulation of vasoconstriction Increases phenotype PMID:30033381
GO:0045930 Negative regulation of mitotic cell cycle Affects phenotype PMID:23873220; PMID:25111187; PMID:30738203; PMID:30910687; PMID:31927068
GO:0046034 Atp metabolic process Affects phenotype PMID:30098274
GO:0046330 Positive regulation of jnk cascade Increases phenotype PMID:34730869
GO:0048146 Positive regulation of fibroblast proliferation Increases phenotype PMID:27760801
GO:0048247 Lymphocyte chemotaxis Increases phenotype PMID:27760801
GO:0050665 Hydrogen peroxide biosynthetic process Increases phenotype PMID:19783790; PMID:27216632; PMID:30738203
GO:0050729 Positive regulation of inflammatory response Increases phenotype PMID:34874108
GO:0050764 Regulation of phagocytosis Affects phenotype PMID:29792337
GO:0050766 Positive regulation of phagocytosis Increases phenotype PMID:30012374
GO:0051091 Positive regulation of dna-binding transcription factor activity Increases phenotype PMID:34730869
GO:0051092 Positive regulation of nf-kappab transcription factor activity Increases phenotype PMID:32004531
GO:0051348 Negative regulation of transferase activity Affects phenotype PMID:34874108
GO:0051494 Negative regulation of cytoskeleton organization Increases phenotype PMID:32224134
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:30273564; PMID:30738203
GO:0060075 Regulation of resting membrane potential Affects phenotype PMID:25487314
GO:0061024 Membrane organization Decreases phenotype PMID:39547316
GO:0061370 Testosterone biosynthetic process Decreases phenotype PMID:28844848; PMID:39580016
GO:0070265 Necrotic cell death Increases phenotype PMID:23873220; PMID:28646487
GO:0070374 Positive regulation of erk1 and erk2 cascade Increases phenotype PMID:34730869
GO:0070994 Detection of oxidative stress Increases phenotype PMID:23111874; PMID:25016076; PMID:25578686; PMID:29774637; PMID:30273564
GO:0071624 Positive regulation of granulocyte chemotaxis Increases phenotype PMID:25406100
GO:0071763 Nuclear membrane organization Affects phenotype PMID:28400324
GO:0072593 Reactive oxygen species metabolic process Affects phenotype PMID:33766574
GO:0086004 Regulation of cardiac muscle cell contraction Affects phenotype PMID:25487314
GO:0090200 Positive regulation of release of cytochrome c from mitochondria Increases phenotype PMID:30098274
GO:0097722 Sperm motility Decreases phenotype PMID:39580016
GO:0098742 Cell-cell adhesion via plasma-membrane adhesion molecules Increases phenotype PMID:29244817
GO:0098911 Regulation of ventricular cardiac muscle cell action potential Affects phenotype PMID:25487314
GO:1900101 Regulation of endoplasmic reticulum unfolded protein response Increases phenotype PMID:39461655
GO:1900745 Positive regulation of p38mapk cascade Increases phenotype PMID:30098274; PMID:34730869
GO:1901671 Positive regulation of superoxide dismutase activity Increases phenotype PMID:26277626
GO:1903047 Mitotic cell cycle process Decreases phenotype PMID:24717318
GO:1903283 Negative regulation of glutathione peroxidase activity Increases phenotype PMID:34874108
GO:1903284 Positive regulation of glutathione peroxidase activity Decreases phenotype PMID:26277626
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:27216632; PMID:27225715; PMID:28780322; PMID:30626778; PMID:30738203; PMID:31068539
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:25406100; PMID:28606428; PMID:30098274; PMID:30711708; PMID:31927068; PMID:32004531; PMID:34730869; PMID:35973603; PMID:39213753
GO:1903779 Regulation of cardiac conduction Affects phenotype PMID:25487314
GO:1904989 Positive regulation of endothelial cell activation Increases phenotype PMID:29244817
GO:1905517 Macrophage migration Increases phenotype PMID:29774637
GO:1905898 Positive regulation of response to endoplasmic reticulum stress Increases phenotype PMID:39461655
GO:1990266 Neutrophil migration Increases phenotype PMID:29766753
GO:2000225 Negative regulation of testosterone biosynthetic process Affects phenotype PMID:24241477
GO:2000391 Positive regulation of neutrophil extravasation Increases phenotype PMID:27760801; PMID:30012374
GO:2000786 Positive regulation of autophagosome assembly Increases phenotype PMID:31927068
GO:2000839 Positive regulation of androstenedione secretion Increases phenotype PMID:39661493
GO:2000845 Positive regulation of testosterone secretion Increases phenotype PMID:39661493
GO:2001020 Regulation of response to dna damage stimulus Increases phenotype PMID:35973603
GO:2001248 Regulation of ammonia assimilation cycle Affects phenotype PMID:25411160
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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.