DEDUCT | Database of Endocrine Disrupting chemicals and their Toxicity profiles

Tetradecanoylphorbol acetate

Curated chemical-phenotype interactions from CTD

GO ID	GO name	Interaction type	Reference
GO:0000086	G2/m transition of mitotic cell cycle	Decreases phenotype	PMID:26330309
GO:0000165	Mapk cascade	Increases phenotype	PMID:12376465
GO:0001516	Prostaglandin biosynthetic process	Increases phenotype	PMID:11164475; PMID:16552572; PMID:31351099
GO:0001530	Lipopolysaccharide binding	Increases phenotype	PMID:28720485
GO:0001787	Natural killer cell proliferation	Decreases phenotype	PMID:30171972
GO:0001819	Positive regulation of cytokine production	Increases phenotype	PMID:28463086
GO:0001912	Positive regulation of leukocyte mediated cytotoxicity	Increases phenotype	PMID:9576743
GO:0001934	Positive regulation of protein phosphorylation	Increases phenotype	PMID:8662792
GO:0001954	Positive regulation of cell-matrix adhesion	Increases phenotype	PMID:27475286
GO:0002092	Positive regulation of receptor internalization	Decreases phenotype	PMID:18313772
GO:0002149	Hypochlorous acid biosynthetic process	Increases phenotype	PMID:26187476; PMID:26187476; PMID:7772042; PMID:7772042
GO:0002523	Leukocyte migration involved in inflammatory response	Increases phenotype	PMID:22760862; PMID:22760862; PMID:29458014; PMID:26513295; PMID:27378624; PMID:29458014
GO:0002553	Histamine secretion by mast cell	Increases phenotype	PMID:23535185; PMID:23535185; PMID:27553716; PMID:30496664; PMID:24216625; PMID:27553716; PMID:30496664
GO:0002554	Serotonin secretion by platelet	Increases phenotype	PMID:8928743
GO:0002557	Histamine secretion by basophil	Increases phenotype	PMID:21331654
GO:0002726	Positive regulation of t cell cytokine production	Increases phenotype	PMID:20211254
GO:0003677	Dna binding	Increases phenotype	PMID:20438634
GO:0003756	Protein disulfide isomerase activity	Increases phenotype	PMID:28532685
GO:0003960	Nadph:quinone reductase activity	Decreases phenotype	PMID:23399806
GO:0004364	Glutathione transferase activity	Increases phenotype	PMID:22760862
GO:0004457	Lactate dehydrogenase activity	Decreases phenotype	PMID:33130239
GO:0004602	Glutathione peroxidase activity	Increases phenotype	PMID:22760862
GO:0004697	Protein kinase c activity	Increases phenotype	PMID:10484327; PMID:18436224; PMID:1932749
GO:0004784	Superoxide dismutase activity	Decreases phenotype	PMID:32662567
GO:0005243	Gap junction channel activity	Decreases phenotype	PMID:26023933; PMID:30668803
GO:0005391	P-type sodium:potassium-exchanging transporter activity	Decreases phenotype	PMID:35946054
GO:0005980	Glycogen catabolic process	Increases phenotype	PMID:3593207
GO:0006306	Dna methylation	Increases phenotype	PMID:23775084
GO:0006309	Apoptotic dna fragmentation	Affects phenotype	PMID:14978018; PMID:15538571; PMID:19723084; PMID:24814887; PMID:7481840; PMID:8219202; PMID:8231252; PMID:8376790
GO:0006468	Protein phosphorylation	Increases phenotype	PMID:23941771; PMID:7662713
GO:0006606	Protein import into nucleus	Affects phenotype	PMID:25114106
GO:0006695	Cholesterol biosynthetic process	Increases phenotype	PMID:29499335
GO:0006749	Glutathione metabolic process	Increases phenotype	PMID:23399806; PMID:32662567
GO:0006750	Glutathione biosynthetic process	Affects phenotype	PMID:22760862; PMID:24814887; PMID:28108223; PMID:29499335
GO:0006809	Nitric oxide biosynthetic process	Increases phenotype	PMID:31351099
GO:0006811	Monoatomic ion transport	Increases phenotype	PMID:2071675
GO:0006874	Cellular calcium ion homeostasis	Affects phenotype	PMID:23535185; PMID:23535185; PMID:27553716; PMID:23898810; PMID:27553716; PMID:29233021; PMID:32314600; PMID:33906515
GO:0006909	Phagocytosis	Increases phenotype	PMID:39611946
GO:0006914	Autophagy	Increases phenotype	PMID:18823378
GO:0006915	Apoptotic process	Increases phenotype	PMID:11139146; PMID:11304686; PMID:14610070; PMID:11377554; PMID:12165276; PMID:12376465; PMID:14610070; PMID:14682396; PMID:14978018; PMID:15538571; PMID:16174796; PMID:17309078; PMID:20438634; PMID:25446327; PMID:36075570; PMID:7579353; PMID:7811993; PMID:8231252; PMID:8376790; PMID:8721951; PMID:9581819
GO:0006954	Inflammatory response	Increases phenotype	PMID:23835587; PMID:29458014; PMID:29458014; PMID:31351099; PMID:31351099
GO:0006971	Hypotonic response	Increases phenotype	PMID:11512036
GO:0006974	Cellular response to dna damage stimulus	Increases phenotype	PMID:26198647
GO:0006979	Response to oxidative stress	Increases phenotype	PMID:17309078; PMID:18154958; PMID:21146893; PMID:3037731
GO:0007049	Cell cycle	Decreases phenotype	PMID:11139146; PMID:7579353; PMID:9348195
GO:0007190	Activation of adenylate cyclase activity	Increases phenotype	PMID:2153673
GO:0007249	I-kappab kinase/nf-kappab signaling	Increases phenotype	PMID:22465218
GO:0007254	Jnk cascade	Increases phenotype	PMID:22465218; PMID:23941771
GO:0007268	Chemical synaptic transmission	Increases phenotype	PMID:15813995
GO:0007346	Regulation of mitotic cell cycle	Affects phenotype	PMID:26330309
GO:0007635	Chemosensory behavior	Increases phenotype	PMID:29669290
GO:0008219	Cell death	Increases phenotype	PMID:17053865; PMID:2153551; PMID:26343699; PMID:8207432
GO:0008283	Cell population proliferation	Increases phenotype	PMID:10524228; PMID:10528133; PMID:10528133; PMID:12421932; PMID:12165276; PMID:12421932; PMID:14729614; PMID:1624223; PMID:16832347; PMID:1705513; PMID:1846307; PMID:1932749; PMID:19723084; PMID:19723084; PMID:9348195; PMID:2071675; PMID:22039836; PMID:23680697; PMID:24814887; PMID:25446327; PMID:26100520; PMID:26330309; PMID:26513295; PMID:26537528; PMID:27432484; PMID:28108223; PMID:29458014; PMID:3097147; PMID:38299738; PMID:7579353; PMID:7826659; PMID:8384872; PMID:8586487
GO:0008284	Positive regulation of cell population proliferation	Increases phenotype	PMID:20206692; PMID:20523355; PMID:23835587; PMID:30133131
GO:0008285	Negative regulation of cell population proliferation	Increases phenotype	PMID:33268675
GO:0008610	Lipid biosynthetic process	Increases phenotype	PMID:29499335
GO:0009299	Mrna transcription	Affects phenotype	PMID:31068361
GO:0009636	Response to toxic substance	Affects phenotype	PMID:21319177; PMID:35364107
GO:0010575	Positive regulation of vascular endothelial growth factor production	Affects phenotype	PMID:8537383
GO:0010718	Positive regulation of epithelial to mesenchymal transition	Increases phenotype	PMID:25656647
GO:0010729	Positive regulation of hydrogen peroxide biosynthetic process	Increases phenotype	PMID:20238386; PMID:20238386; PMID:26187476; PMID:26187476
GO:0010800	Positive regulation of peptidyl-threonine phosphorylation	Increases phenotype	PMID:8662792
GO:0010811	Positive regulation of cell-substrate adhesion	Increases phenotype	PMID:28720485
GO:0010942	Positive regulation of cell death	Increases phenotype	PMID:25463304
GO:0010972	Negative regulation of g2/m transition of mitotic cell cycle	Increases phenotype	PMID:20206692
GO:0014004	Microglia differentiation	Increases phenotype	PMID:34774662
GO:0015884	Folic acid transport	Affects phenotype	PMID:18207340
GO:0016042	Lipid catabolic process	Increases phenotype	PMID:22760862; PMID:31351099; PMID:32662567
GO:0016049	Cell growth	Decreases phenotype	PMID:30797899
GO:0016301	Kinase activity	Increases phenotype	PMID:29183754
GO:0016477	Cell migration	Increases phenotype	PMID:16027158; PMID:24951586; PMID:24951586; PMID:32519806; PMID:36413041; PMID:25866363; PMID:25866363; PMID:26807887; PMID:28108223; PMID:28731287; PMID:32519806; PMID:32519806; PMID:36413041; PMID:36413041
GO:0016485	Protein processing	Increases phenotype	PMID:23430110
GO:0017121	Plasma membrane phospholipid scrambling	Increases phenotype	PMID:27771709
GO:0019046	Release from viral latency	Increases phenotype	PMID:25822022
GO:0019467	Ornithine catabolic process, by decarboxylation	Increases phenotype	PMID:2884032
GO:0019695	Choline metabolic process	Affects phenotype	PMID:8836877
GO:0019722	Calcium-mediated signaling	Increases phenotype	PMID:11516627; PMID:15006548
GO:0019852	L-ascorbic acid metabolic process	Affects phenotype	PMID:32662567
GO:0030032	Lamellipodium assembly	Increases phenotype	PMID:28108223
GO:0030099	Myeloid cell differentiation	Increases phenotype	PMID:26036281
GO:0030101	Natural killer cell activation	Increases phenotype	PMID:30171972; PMID:32702509
GO:0030154	Cell differentiation	Increases phenotype	PMID:10025902; PMID:11139146; PMID:16174796; PMID:18325031; PMID:11504768; PMID:11504768; PMID:30090394; PMID:18823378; PMID:2457505; PMID:30090394; PMID:32382956; PMID:38299738
GO:0030182	Neuron differentiation	Increases phenotype	PMID:24101030
GO:0030187	Melatonin biosynthetic process	Decreases phenotype	PMID:29528516
GO:0030218	Erythrocyte differentiation	Increases phenotype	PMID:35092719
GO:0030219	Megakaryocyte differentiation	Increases phenotype	PMID:35092719
GO:0030224	Monocyte differentiation	Increases phenotype	PMID:23680697; PMID:24849683; PMID:26036281; PMID:26330309; PMID:26330309
GO:0030225	Macrophage differentiation	Increases phenotype	PMID:24746987; PMID:24964617; PMID:29217270; PMID:25128825; PMID:25446327; PMID:26133781; PMID:25398544; PMID:29777723; PMID:30116142; PMID:30218697; PMID:30232031; PMID:30320338; PMID:30329025; PMID:30414920; PMID:30578886; PMID:30768972; PMID:30796934; PMID:30930231; PMID:31778932; PMID:32223187; PMID:32417575; PMID:32649966; PMID:33524445; PMID:34217685; PMID:34506768; PMID:34953976; PMID:35777529; PMID:36958387; PMID:38000456; PMID:39611946; PMID:26036281; PMID:26091108; PMID:26481333; PMID:29102675; PMID:34197882; PMID:34500009; PMID:27224998; PMID:29935159; PMID:30218697; PMID:30329025; PMID:34506768; PMID:35001170; PMID:36269090; PMID:35974258; PMID:36269090; PMID:39611946
GO:0030334	Regulation of cell migration	Affects phenotype	PMID:24211779
GO:0030335	Positive regulation of cell migration	Increases phenotype	PMID:20043135; PMID:20043135; PMID:25656647; PMID:30133131; PMID:22696189; PMID:24641402; PMID:25656647; PMID:30133131; PMID:30259628
GO:0030595	Leukocyte chemotaxis	Increases phenotype	PMID:1732379
GO:0031143	Pseudopodium	Increases phenotype	PMID:39611946
GO:0031394	Positive regulation of prostaglandin biosynthetic process	Increases phenotype	PMID:11458457
GO:0031589	Cell-substrate adhesion	Decreases phenotype	PMID:28108223
GO:0031669	Cellular response to nutrient levels	Increases phenotype	PMID:27278863
GO:0032088	Negative regulation of nf-kappab transcription factor activity	Increases phenotype	PMID:9837861
GO:0032125	Micronucleus organization	Increases phenotype	PMID:9057100
GO:0032147	Activation of protein kinase activity	Increases phenotype	PMID:30696844
GO:0032148	Activation of protein kinase b activity	Increases phenotype	PMID:30133131; PMID:30696844
GO:0032310	Prostaglandin secretion	Increases phenotype	PMID:31506784
GO:0032430	Positive regulation of phospholipase a2 activity	Increases phenotype	PMID:8928743
GO:0032729	Positive regulation of type ii interferon production	Affects phenotype	PMID:22398747
GO:0032731	Positive regulation of interleukin-1 beta production	Affects phenotype	PMID:23535185
GO:0032733	Positive regulation of interleukin-10 production	Affects phenotype	PMID:22398747
GO:0032736	Positive regulation of interleukin-13 production	Affects phenotype	PMID:22398747
GO:0032743	Positive regulation of interleukin-2 production	Affects phenotype	PMID:22398747
GO:0032753	Positive regulation of interleukin-4 production	Affects phenotype	PMID:22398747
GO:0032755	Positive regulation of interleukin-6 production	Affects phenotype	PMID:22398747; PMID:23535185
GO:0032757	Positive regulation of interleukin-8 production	Affects phenotype	PMID:23426871; PMID:23426871; PMID:23535185; PMID:23535185
GO:0032760	Positive regulation of tumor necrosis factor production	Affects phenotype	PMID:22398747; PMID:23426871; PMID:23426871; PMID:23535185; PMID:23535185
GO:0032831	Positive regulation of cd4-positive, cd25-positive, alpha-beta regulatory t cell differentiation	Increases phenotype	PMID:27865421
GO:0032930	Positive regulation of superoxide anion generation	Increases phenotype	PMID:10027768; PMID:10517978; PMID:12388057; PMID:20238386; PMID:20238386; PMID:21457779; PMID:25980585; PMID:26187476; PMID:21457779; PMID:25980585; PMID:26187476; PMID:27159630; PMID:27816504; PMID:7537211
GO:0033173	Calcineurin-nfat signaling cascade	Increases phenotype	PMID:23941771
GO:0033554	Cellular response to stress	Affects phenotype	PMID:8836877
GO:0033861	Negative regulation of nad(p)h oxidase activity	Affects phenotype	PMID:23399806
GO:0034383	Low-density lipoprotein particle clearance	Increases phenotype	PMID:23386263
GO:0034440	Lipid oxidation	Increases phenotype	PMID:23399806
GO:0035855	Megakaryocyte development	Increases phenotype	PMID:33149232
GO:0035938	Estradiol secretion	Increases phenotype	PMID:31217279
GO:0035943	Estrone secretion	Increases phenotype	PMID:31217279
GO:0035976	Transcription factor ap-1 complex	Increases phenotype	PMID:10517978
GO:0036230	Granulocyte activation	Increases phenotype	PMID:37406967
GO:0038061	Nik/nf-kappab signaling	Increases phenotype	PMID:23941771
GO:0038066	P38mapk cascade	Increases phenotype	PMID:23941771
GO:0042102	Positive regulation of t cell proliferation	Increases phenotype	PMID:20634404
GO:0042110	T cell activation	Increases phenotype	PMID:23941771; PMID:25073960
GO:0042116	Macrophage activation	Increases phenotype	PMID:31351099
GO:0042117	Monocyte activation	Increases phenotype	PMID:19153980
GO:0042119	Neutrophil activation	Increases phenotype	PMID:12198030; PMID:29183754
GO:0042126	Nitrate metabolic process	Increases phenotype	PMID:17071120
GO:0042307	Positive regulation of protein import into nucleus	Increases phenotype	PMID:30133131; PMID:30254419
GO:0042310	Vasoconstriction	Increases phenotype	PMID:8764313; PMID:8932688
GO:0042311	Vasodilation	Increases phenotype	PMID:29458014
GO:0042360	Vitamin e metabolic process	Affects phenotype	PMID:32662567
GO:0042391	Regulation of membrane potential	Increases phenotype	PMID:6331525; PMID:9468117
GO:0042554	Superoxide anion generation	Increases phenotype	PMID:12628514; PMID:17351912; PMID:18436224; PMID:19153980; PMID:22906169; PMID:22906169; PMID:34144024; PMID:28512001; PMID:34144024; PMID:36184561
GO:0042742	Defense response to bacterium	Increases phenotype	PMID:29183754; PMID:33063558
GO:0043065	Positive regulation of apoptotic process	Affects phenotype	PMID:20523355; PMID:25194819
GO:0043114	Regulation of vascular permeability	Affects phenotype	PMID:29458014
GO:0043315	Positive regulation of neutrophil degranulation	Increases phenotype	PMID:8549643
GO:0043408	Regulation of mapk cascade	Increases phenotype	PMID:31068361
GO:0043491	Protein kinase b signaling	Increases phenotype	PMID:22465218
GO:0043616	Keratinocyte proliferation	Decreases phenotype	PMID:38299738
GO:0043647	Inositol phosphate metabolic process	Affects phenotype	PMID:8836877
GO:0044237	Cellular metabolic process	Affects phenotype	PMID:24481452; PMID:30590137; PMID:33130239; PMID:35001170; PMID:35001170; PMID:36075570; PMID:36925031
GO:0044319	Wound healing, spreading of cells	Increases phenotype	PMID:24211529; PMID:30590137
GO:0045333	Cellular respiration	Increases phenotype	PMID:29183754; PMID:9468117
GO:0045429	Positive regulation of nitric oxide biosynthetic process	Increases phenotype	PMID:17071120; PMID:23399806
GO:0045576	Mast cell activation	Increases phenotype	PMID:27553716
GO:0045597	Positive regulation of cell differentiation	Increases phenotype	PMID:22614916; PMID:23725168; PMID:24584901
GO:0045618	Positive regulation of keratinocyte differentiation	Decreases phenotype	PMID:9219563
GO:0045639	Positive regulation of myeloid cell differentiation	Increases phenotype	PMID:24571310
GO:0045651	Positive regulation of macrophage differentiation	Increases phenotype	PMID:23386263; PMID:23840602; PMID:28720485; PMID:30978295; PMID:24760326; PMID:29960001; PMID:30502458; PMID:32721574; PMID:32739440; PMID:33012733; PMID:34189835; PMID:34398343; PMID:34529319; PMID:34599948; PMID:34677723; PMID:35537566; PMID:30502458; PMID:33268675; PMID:34673087; PMID:35537566
GO:0045654	Positive regulation of megakaryocyte differentiation	Increases phenotype	PMID:20523355
GO:0045730	Respiratory burst	Increases phenotype	PMID:19153980; PMID:36788734; PMID:39428054
GO:0045747	Positive regulation of notch signaling pathway	Increases phenotype	PMID:23134680
GO:0045907	Positive regulation of vasoconstriction	Increases phenotype	PMID:15278496
GO:0045930	Negative regulation of mitotic cell cycle	Increases phenotype	PMID:24814887; PMID:25446327; PMID:26198647
GO:0045944	Positive regulation of transcription by rna polymerase ii	Increases phenotype	PMID:27278863
GO:0046058	Camp metabolic process	Increases phenotype	PMID:29179997; PMID:8836877
GO:0046328	Regulation of jnk cascade	Affects phenotype	PMID:23426871; PMID:23774263
GO:0046330	Positive regulation of jnk cascade	Increases phenotype	PMID:24632454; PMID:25920576
GO:0046649	Lymphocyte activation	Affects phenotype	PMID:1371491; PMID:14978018
GO:0046847	Filopodium assembly	Increases phenotype	PMID:28108223
GO:0048102	Autophagic cell death	Increases phenotype	PMID:25446327
GO:0048469	Cell maturation	Increases phenotype	PMID:30171972
GO:0050665	Hydrogen peroxide biosynthetic process	Increases phenotype	PMID:19153980
GO:0050729	Positive regulation of inflammatory response	Increases phenotype	PMID:17071120
GO:0050731	Positive regulation of peptidyl-tyrosine phosphorylation	Increases phenotype	PMID:8662792
GO:0050766	Positive regulation of phagocytosis	Increases phenotype	PMID:33268675
GO:0050817	Coagulation	Increases phenotype	PMID:35022635
GO:0050870	Positive regulation of t cell activation	Increases phenotype	PMID:23134680; PMID:28463086; PMID:29317916
GO:0051027	Dna transport	Increases phenotype	PMID:33063558
GO:0051044	Positive regulation of membrane protein ectodomain proteolysis	Affects phenotype	PMID:23774263
GO:0051045	Negative regulation of membrane protein ectodomain proteolysis	Affects phenotype	PMID:23774263
GO:0051091	Positive regulation of dna-binding transcription factor activity	Increases phenotype	PMID:17475810; PMID:26022396; PMID:28572013; PMID:30696844
GO:0051092	Positive regulation of nf-kappab transcription factor activity	Increases phenotype	PMID:12076508; PMID:12086399; PMID:22387535; PMID:22696189; PMID:23134680; PMID:23288142; PMID:23535185; PMID:24836925; PMID:25073960; PMID:25656647; PMID:25656647; PMID:9582369; PMID:30796934; PMID:9582369
GO:0051281	Positive regulation of release of sequestered calcium ion into cytosol	Increases phenotype	PMID:2125206
GO:0051452	Intracellular ph reduction	Decreases phenotype	PMID:11304686
GO:0051881	Regulation of mitochondrial membrane potential	Decreases phenotype	PMID:14978018; PMID:15538571; PMID:17309078
GO:0051897	Positive regulation of protein kinase b signaling	Increases phenotype	PMID:23134680; PMID:23288142; PMID:25656647
GO:0055074	Calcium ion homeostasis	Affects phenotype	PMID:27771709; PMID:31709706
GO:0060242	Contact inhibition	Decreases phenotype	PMID:27432484
GO:0060267	Positive regulation of respiratory burst	Increases phenotype	PMID:28935932
GO:0060326	Cell chemotaxis	Increases phenotype	PMID:17114644; PMID:32519806; PMID:32519806; PMID:36413041; PMID:36413041
GO:0061951	Establishment of protein localization to plasma membrane	Increases phenotype	PMID:30133131
GO:0070371	Erk1 and erk2 cascade	Increases phenotype	PMID:22465218; PMID:23941771
GO:0070372	Regulation of erk1 and erk2 cascade	Affects phenotype	PMID:23426871; PMID:23774263
GO:0070374	Positive regulation of erk1 and erk2 cascade	Increases phenotype	PMID:20523355; PMID:23134680; PMID:23288142; PMID:24632454; PMID:25656647; PMID:25920576; PMID:28527916; PMID:34626302; PMID:35413382
GO:0070509	Calcium ion import	Increases phenotype	PMID:30394170
GO:0070836	Caveola assembly	Increases phenotype	PMID:15725944
GO:0070886	Positive regulation of calcineurin-nfat signaling cascade	Increases phenotype	PMID:17475810; PMID:17475810; PMID:23134680
GO:0071466	Cellular response to xenobiotic stimulus	Decreases phenotype	PMID:20206692
GO:0071542	Dopaminergic neuron differentiation	Increases phenotype	PMID:30529163
GO:0071897	Dna biosynthetic process	Increases phenotype	PMID:22760862
GO:0072089	Stem cell proliferation	Decreases phenotype	PMID:38299738
GO:0072593	Reactive oxygen species metabolic process	Increases phenotype	PMID:24038091; PMID:24814887; PMID:25446327; PMID:25843059; PMID:32357311; PMID:32712770; PMID:33063558; PMID:33063558; PMID:39428054; PMID:34302491; PMID:39428054
GO:0090023	Positive regulation of neutrophil chemotaxis	Increases phenotype	PMID:18670081
GO:0090037	Positive regulation of protein kinase c signaling	Affects phenotype	PMID:23288142
GO:0090150	Establishment of protein localization to membrane	Increases phenotype	PMID:28283350
GO:0090238	Positive regulation of arachidonic acid secretion	Affects phenotype	PMID:8836877
GO:0090280	Positive regulation of calcium ion import	Affects phenotype	PMID:23898810
GO:0097178	Ruffle assembly	Increases phenotype	PMID:16027158
GO:0097202	Activation of cysteine-type endopeptidase activity	Increases phenotype	PMID:23535185
GO:0097280	Histamine secretion mediated by immunoglobulin	Increases phenotype	PMID:11516627; PMID:11788349; PMID:6180017; PMID:6206106; PMID:8689388; PMID:9372312
GO:0097707	Ferroptosis	Increases phenotype	PMID:30797899
GO:0140354	Lipid import into cell	Increases phenotype	PMID:37055963
GO:0140644	Neutrophil extracellular trap	Increases phenotype	PMID:33063558; PMID:38341106; PMID:39428054
GO:0140645	Neutrophic extracellular trap formation	Increases phenotype	PMID:39428054
GO:1900017	Positive regulation of cytokine production involved in inflammatory response	Increases phenotype	PMID:23535185
GO:1900020	Positive regulation of protein kinase c activity	Increases phenotype	PMID:18313772; PMID:25980585
GO:1900182	Positive regulation of protein localization to nucleus	Increases phenotype	PMID:31545954
GO:1900447	Regulation of cell morphogenesis involved in phenotypic switching	Increases phenotype	PMID:15781058
GO:1900744	Regulation of p38mapk cascade	Affects phenotype	PMID:23426871; PMID:23774263
GO:1900745	Positive regulation of p38mapk cascade	Increases phenotype	PMID:23399806; PMID:24632454; PMID:25818598; PMID:25920576; PMID:30133131; PMID:30254419; PMID:30259628; PMID:31545954
GO:1901216	Positive regulation of neuron death	Increases phenotype	PMID:17561261
GO:1901224	Positive regulation of nik/nf-kappab signaling	Increases phenotype	PMID:19509257; PMID:20206692; PMID:23535185
GO:1901670	Negative regulation of superoxide dismutase activity	Increases phenotype	PMID:23399806
GO:1903078	Positive regulation of protein localization to plasma membrane	Increases phenotype	PMID:8662792
GO:1903283	Negative regulation of glutathione peroxidase activity	Increases phenotype	PMID:23399806
GO:1903409	Reactive oxygen species biosynthetic process	Increases phenotype	PMID:10865939; PMID:27989599; PMID:28108223; PMID:31351099
GO:1903428	Positive regulation of reactive oxygen species biosynthetic process	Increases phenotype	PMID:16724856; PMID:16724856; PMID:17109845; PMID:17109845; PMID:20523355; PMID:22696189; PMID:24158569; PMID:26162596; PMID:27737899; PMID:32587277; PMID:35395341
GO:1903451	Negative regulation of g1 to g0 transition	Increases phenotype	PMID:20206692
GO:1903583	Positive regulation of basophil degranulation	Increases phenotype	PMID:9590266
GO:1903595	Positive regulation of histamine secretion by mast cell	Increases phenotype	PMID:23426871; PMID:30254419
GO:1903753	Negative regulation of p38mapk cascade	Increases phenotype	PMID:35413382
GO:1903936	Cellular response to sodium arsenite	Affects phenotype	PMID:8836877
GO:1904007	Positive regulation of phospholipase d activity	Increases phenotype	PMID:8928743
GO:1904628	Cellular response to phorbol 13-acetate 12-myristate	Increases phenotype	PMID:27278863
GO:1904996	Positive regulation of leukocyte adhesion to vascular endothelial cell	Increases phenotype	PMID:26824242
GO:1905477	Positive regulation of protein localization to membrane	Increases phenotype	PMID:16532021
GO:1990051	Activation of protein kinase c activity	Increases phenotype	PMID:17561261; PMID:31068361; PMID:9852137
GO:1990349	Gap junction-mediated intercellular transport	Decreases phenotype	PMID:35413382
GO:2000045	Regulation of g1/s transition of mitotic cell cycle	Affects phenotype	PMID:26330309
GO:2000391	Positive regulation of neutrophil extravasation	Increases phenotype	PMID:23399806

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.