Fenitrothion


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0001894 Tissue homeostasis Decreases phenotype PMID:31173782
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:34968465
GO:0002638 Negative regulation of immunoglobulin production Increases phenotype PMID:31173782
GO:0003300 Cardiac muscle hypertrophy Increases phenotype PMID:32572764; PMID:34968465
GO:0004111 Creatine kinase activity Increases phenotype PMID:34968465
GO:0004364 Glutathione transferase activity Decreases phenotype PMID:30578656; PMID:32034696; PMID:33393722; PMID:33439051; PMID:34802538
GO:0004457 Lactate dehydrogenase activity Increases phenotype PMID:34968465
GO:0004602 Glutathione peroxidase activity Decreases phenotype PMID:33393722; PMID:34802538
GO:0004784 Superoxide dismutase activity Affects phenotype PMID:32034696; PMID:32572764; PMID:33393722; PMID:33439051; PMID:34802538; PMID:34968465
GO:0006304 Dna modification Increases phenotype PMID:31173782
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:34968465
GO:0006749 Glutathione metabolic process Increases phenotype PMID:30578656; PMID:30639957; PMID:31173782; PMID:32034696; PMID:33393722; PMID:34968465
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:19591892; PMID:32572764; PMID:33393722
GO:0007283 Spermatogenesis Decreases phenotype PMID:26264430; PMID:26264430; PMID:30578656; PMID:30578656
GO:0007286 Spermatid development Decreases phenotype PMID:29292090
GO:0007420 Brain development Affects phenotype PMID:32034696
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:34968465
GO:0008483 Transaminase activity Affects phenotype PMID:30578656
GO:0009395 Phospholipid catabolic process Decreases phenotype PMID:29292090
GO:0009448 Gamma-aminobutyric acid metabolic process Increases phenotype PMID:31173782
GO:0010729 Positive regulation of hydrogen peroxide biosynthetic process Increases phenotype PMID:30578656
GO:0010923 Negative regulation of phosphatase activity Increases phenotype PMID:30578656
GO:0016042 Lipid catabolic process Affects phenotype PMID:32034696; PMID:33393722
GO:0018158 Protein oxidation Increases phenotype PMID:32572764; PMID:33439051
GO:0019432 Triglyceride biosynthetic process Increases phenotype PMID:24361246
GO:0019627 Urea metabolic process Affects phenotype PMID:34802538
GO:0030263 Apoptotic chromosome condensation Increases phenotype PMID:31173782
GO:0030317 Flagellated sperm motility Decreases phenotype PMID:26264430
GO:0034440 Lipid oxidation Increases phenotype PMID:30578656; PMID:30639957; PMID:30639957; PMID:34802538; PMID:31173782; PMID:34802538; PMID:34968465
GO:0040015 Negative regulation of multicellular organism growth Increases phenotype PMID:29292090; PMID:30639957; PMID:30639957
GO:0042417 Dopamine metabolic process Increases phenotype PMID:31173782; PMID:32034696
GO:0042428 Serotonin metabolic process Increases phenotype PMID:31173782; PMID:32034696
GO:0042756 Drinking behavior Decreases phenotype PMID:30639957
GO:0046209 Nitric oxide metabolic process Affects phenotype PMID:33393722
GO:0046415 Urate metabolic process Decreases phenotype PMID:30639957
GO:0046449 Creatinine metabolic process Decreases phenotype PMID:30639957; PMID:34802538
GO:0046621 Negative regulation of organ growth Increases phenotype PMID:29292090
GO:0046622 Positive regulation of organ growth Increases phenotype PMID:29292090
GO:0046661 Male sex differentiation Affects phenotype PMID:17582585
GO:0051348 Negative regulation of transferase activity Affects phenotype PMID:30578656
GO:0060765 Regulation of androgen receptor signaling pathway Affects phenotype PMID:35951760
GO:0061069 Male urethra development Increases phenotype PMID:35951760
GO:0070075 Tear secretion Decreases phenotype PMID:17582585
GO:0070994 Detection of oxidative stress Increases phenotype PMID:33439051
GO:0110090 Positive regulation of hippocampal neuron apoptotic process Increases phenotype PMID:31173782
GO:1900138 Negative regulation of phospholipase a2 activity Increases phenotype PMID:29292090
GO:1901318 Negative regulation of flagellated sperm motility Increases phenotype PMID:29292090
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:30578656; PMID:30639957; PMID:31173782
GO:1903283 Negative regulation of glutathione peroxidase activity Increases phenotype PMID:30578656; PMID:30639957
GO:1903725 Regulation of phospholipid metabolic process Decreases phenotype PMID:29292090
GO:1903999 Negative regulation of eating behavior Increases phenotype PMID:30639957; PMID:31173782
GO:2000844 Negative regulation of testosterone secretion Increases phenotype PMID:30578656
GO:2000845 Positive regulation of testosterone secretion Decreases phenotype PMID:26264430
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.