Paroxetine


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000165 Mapk cascade Increases phenotype PMID:17174998
GO:0001675 Acrosome assembly Affects phenotype PMID:36740106
GO:0001755 Neural crest cell migration Increases phenotype PMID:28844482
GO:0002027 Regulation of heart rate Affects phenotype PMID:9315988
GO:0004035 Alkaline phosphatase activity Increases phenotype PMID:36740106
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Increases phenotype PMID:36740106
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:36740106
GO:0006120 Mitochondrial electron transport, nadh to ubiquinone Decreases phenotype PMID:28482088
GO:0006122 Mitochondrial electron transport, ubiquinol to cytochrome c Decreases phenotype PMID:28482088
GO:0006749 Glutathione metabolic process Affects phenotype PMID:36460226; PMID:36740106
GO:0006915 Apoptotic process Increases phenotype PMID:17174998; PMID:36460226
GO:0006954 Inflammatory response Increases phenotype PMID:36740106
GO:0007283 Spermatogenesis Affects phenotype PMID:36740106
GO:0008283 Cell population proliferation Affects phenotype PMID:17473392; PMID:17473392; PMID:20955318; PMID:17612590; PMID:20529586; PMID:20955318
GO:0008284 Positive regulation of cell population proliferation Increases phenotype PMID:28844482
GO:0008344 Adult locomotory behavior Affects phenotype PMID:31344373
GO:0010942 Positive regulation of cell death Increases phenotype PMID:26162595
GO:0030073 Insulin secretion Decreases phenotype PMID:28482088
GO:0034440 Lipid oxidation Increases phenotype PMID:36460226; PMID:36740106
GO:0042755 Eating behavior Affects phenotype PMID:31344373
GO:0044237 Cellular metabolic process Decreases phenotype PMID:36460226
GO:0046209 Nitric oxide metabolic process Affects phenotype PMID:36740106
GO:0061370 Testosterone biosynthetic process Affects phenotype PMID:36740106
GO:0061951 Establishment of protein localization to plasma membrane Increases phenotype PMID:30591588
GO:0072593 Reactive oxygen species metabolic process Affects phenotype PMID:36460226
GO:0086003 Cardiac muscle cell contraction Increases phenotype PMID:26032411
GO:1904231 Positive regulation of succinate dehydrogenase activity Increases phenotype PMID:20347017
GO:2000845 Positive regulation of testosterone secretion Decreases phenotype PMID:26162595
GO:2000866 Positive regulation of estradiol secretion Increases phenotype PMID:26162595
GO:2000872 Positive regulation of progesterone secretion Increases phenotype PMID:26162595
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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.