Perfluorohexanesulfonic acid


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000381 Regulation of alternative mrna splicing, via spliceosome Affects phenotype PMID:37995155
GO:0001556 Oocyte maturation Decreases phenotype PMID:36723383
GO:0002455 Humoral immune response mediated by circulating immunoglobulin Decreases phenotype PMID:26041029
GO:0003094 Glomerular filtration Decreases phenotype PMID:23482063
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:39933620
GO:0006119 Oxidative phosphorylation Decreases phenotype PMID:39933620
GO:0006590 Thyroid hormone generation Decreases phenotype PMID:29518214; PMID:34460931
GO:0006629 Lipid metabolic process Affects phenotype PMID:33113464
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:31931806; PMID:32991729; PMID:34464680; PMID:38117326
GO:0006650 Glycerophospholipid metabolic process Affects phenotype PMID:32991729
GO:0006684 Sphingomyelin metabolic process Affects phenotype PMID:32991729
GO:0006694 Steroid biosynthetic process Affects phenotype PMID:33991873
GO:0006695 Cholesterol biosynthetic process Decreases phenotype PMID:20123614
GO:0006699 Bile acid biosynthetic process Affects phenotype PMID:33991873
GO:0006954 Inflammatory response Decreases phenotype PMID:32916415
GO:0007346 Regulation of mitotic cell cycle Affects phenotype PMID:38603627
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:32971418; PMID:34464680; PMID:34500361
GO:0008219 Cell death Decreases phenotype PMID:26599974
GO:0008283 Cell population proliferation Affects phenotype PMID:23539207
GO:0008284 Positive regulation of cell population proliferation Increases phenotype PMID:35337807
GO:0010424 Dna methylation on cytosine within a cg sequence Affects phenotype PMID:33356526; PMID:35266797; PMID:39862910
GO:0010890 Positive regulation of sequestering of triglyceride Increases phenotype PMID:28049043
GO:0010917 Negative regulation of mitochondrial membrane potential Increases phenotype PMID:34843762
GO:0015171 Amino acid transmembrane transporter activity Decreases phenotype PMID:37995155
GO:0016049 Cell growth Decreases phenotype PMID:30144469
GO:0019369 Arachidonic acid metabolic process Affects phenotype PMID:33991873
GO:0030072 Peptide hormone secretion Decreases phenotype PMID:31216000
GO:0030282 Bone mineralization Affects phenotype PMID:35750749
GO:0030307 Positive regulation of cell growth Increases phenotype PMID:34843762
GO:0030308 Negative regulation of cell growth Increases phenotype PMID:36341878
GO:0030431 Sleep Decreases phenotype PMID:39512894
GO:0030520 Intracellular estrogen receptor signaling pathway Increases phenotype PMID:33111528
GO:0030889 Negative regulation of b cell proliferation Increases phenotype PMID:38458531
GO:0032818 Negative regulation of natural killer cell proliferation Increases phenotype PMID:38458531
GO:0032819 Positive regulation of natural killer cell proliferation Increases phenotype PMID:38458531
GO:0034440 Lipid oxidation Affects phenotype PMID:39933620
GO:0035937 Estrogen secretion Affects phenotype PMID:39933620
GO:0036109 Alpha-linolenic acid metabolic process Affects phenotype PMID:33991873
GO:0036343 Psychomotor behavior Affects phenotype PMID:32272335
GO:0040029 Epigenetic regulation of gene expression Affects phenotype PMID:39862910
GO:0042403 Thyroid hormone metabolic process Affects phenotype PMID:26517287
GO:0042572 Retinol metabolic process Affects phenotype PMID:33991873
GO:0042593 Glucose homeostasis Affects phenotype PMID:33984575
GO:0042632 Cholesterol homeostasis Affects phenotype PMID:23266098; PMID:29694846; PMID:32169067; PMID:36174755
GO:0042697 Menopause Increases phenotype PMID:39510233
GO:0042701 Progesterone secretion Affects phenotype PMID:39933620
GO:0043651 Linoleic acid metabolic process Affects phenotype PMID:33991873
GO:0044237 Cellular metabolic process Affects phenotype PMID:36326898; PMID:38117326; PMID:38549690
GO:0044255 Cellular lipid metabolic process Affects phenotype PMID:34464680
GO:0045444 Fat cell differentiation Increases phenotype PMID:34800597; PMID:39111555
GO:0045540 Regulation of cholesterol biosynthetic process Affects phenotype PMID:32169067
GO:0045793 Positive regulation of cell size Increases phenotype PMID:28049043; PMID:29694846
GO:0046034 Atp metabolic process Affects phenotype PMID:39933620
GO:0046337 Phosphatidylethanolamine metabolic process Affects phenotype PMID:32991729
GO:0046470 Phosphatidylcholine metabolic process Affects phenotype PMID:32991729
GO:0046486 Glycerolipid metabolic process Decreases phenotype PMID:37315490
GO:0046890 Regulation of lipid biosynthetic process Affects phenotype PMID:34500360
GO:0050890 Cognition Affects phenotype PMID:32272335
GO:0051572 Negative regulation of histone h3-k4 methylation Increases phenotype PMID:34843762
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:35548680; PMID:39933620
GO:0051882 Mitochondrial depolarization Increases phenotype PMID:39933620
GO:0055088 Lipid homeostasis Decreases phenotype PMID:37315490
GO:0060612 Adipose tissue development Increases phenotype PMID:27352404
GO:0060613 Fat pad development Increases phenotype PMID:33387635
GO:0060669 Embryonic placenta morphogenesis Affects phenotype PMID:33677611
GO:0060711 Labyrinthine layer development Decreases phenotype PMID:37315490
GO:0070162 Adiponectin secretion Decreases phenotype PMID:31216000
GO:0070316 Regulation of g0 to g1 transition Affects phenotype PMID:38603627
GO:0070460 Thyroid-stimulating hormone secretion Affects phenotype PMID:24577800
GO:0071736 Igg immunoglobulin complex, circulating Decreases phenotype PMID:27501995
GO:0072576 Liver morphogenesis Affects phenotype PMID:29518214
GO:0072593 Reactive oxygen species metabolic process Affects phenotype PMID:39933620
GO:0140042 Lipid droplet formation Increases phenotype PMID:34464680
GO:1901676 Positive regulation of histone h3-k27 acetylation Increases phenotype PMID:34843762
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:36075290
GO:1903691 Positive regulation of wound healing, spreading of epidermal cells Increases phenotype PMID:34843762
GO:1903725 Regulation of phospholipid metabolic process Affects phenotype PMID:37315490
GO:1904179 Positive regulation of adipose tissue development Increases phenotype PMID:32991729; PMID:33387635
GO:1904197 Positive regulation of granulosa cell proliferation Increases phenotype PMID:38603627
GO:1904203 Positive regulation of iodide transport Increases phenotype PMID:32065294
GO:1904358 Positive regulation of telomere maintenance via telomere lengthening Increases phenotype PMID:34193151
GO:2000391 Positive regulation of neutrophil extravasation Increases phenotype PMID:38458531
GO:2000409 Positive regulation of t cell extravasation Increases phenotype PMID:38458531
GO:2000421 Positive regulation of eosinophil extravasation Increases phenotype PMID:38458531
GO:2000439 Positive regulation of monocyte extravasation Increases phenotype PMID:38458531
GO:2000609 Regulation of thyroid hormone generation Affects phenotype PMID:29488882; PMID:32311629
GO:2000611 Positive regulation of thyroid hormone generation Increases phenotype PMID:31518930
GO:2000614 Positive regulation of thyroid-stimulating hormone secretion Increases phenotype PMID:26517287
GO:2000616 Negative regulation of histone h3-k9 acetylation Increases phenotype PMID:34843762
GO:2000865 Negative regulation of estradiol secretion Increases phenotype PMID:38603627
GO:2000872 Positive regulation of progesterone secretion Increases phenotype PMID:38603627
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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.