Deoxynivalenol


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000084 Mitotic s phase Affects phenotype PMID:34677630
GO:0000086 G2/m transition of mitotic cell cycle Affects phenotype PMID:34677630
GO:0001819 Positive regulation of cytokine production Increases phenotype PMID:28935500
GO:0002377 Immunoglobulin production Affects phenotype PMID:38763499
GO:0002639 Positive regulation of immunoglobulin production Increases phenotype PMID:28935500; PMID:33170220
GO:0002693 Positive regulation of cellular extravasation Increases phenotype PMID:31034930
GO:0002866 Positive regulation of acute inflammatory response to antigenic stimulus Increases phenotype PMID:33170220
GO:0004035 Alkaline phosphatase activity Increases phenotype PMID:34400200
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Increases phenotype PMID:34400200; PMID:35925383; PMID:35925383
GO:0004602 Glutathione peroxidase activity Affects phenotype PMID:18636399; PMID:34400200; PMID:34673182; PMID:35090964
GO:0004784 Superoxide dismutase activity Affects phenotype PMID:34673182; PMID:35090964; PMID:37705238
GO:0006110 Regulation of glycolytic process Affects phenotype PMID:38040082
GO:0006111 Regulation of gluconeogenesis Affects phenotype PMID:38040082
GO:0006260 Dna replication Increases phenotype PMID:32416088
GO:0006304 Dna modification Increases phenotype PMID:35817260
GO:0006308 Dna catabolic process Increases phenotype PMID:34677630
GO:0006412 Translation Decreases phenotype PMID:37315771
GO:0006693 Prostaglandin metabolic process Affects phenotype PMID:32416088
GO:0006749 Glutathione metabolic process Increases phenotype PMID:30244016
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:18636399; PMID:26115597
GO:0006810 Transport Affects phenotype PMID:37315771
GO:0006874 Cellular calcium ion homeostasis Affects phenotype PMID:33309878
GO:0006879 Cellular iron ion homeostasis Affects phenotype PMID:39983889
GO:0006914 Autophagy Increases phenotype PMID:34677630
GO:0006915 Apoptotic process Increases phenotype PMID:20347963; PMID:20347963; PMID:33309878; PMID:27350164; PMID:27757495; PMID:33309878; PMID:34506767; PMID:34673182; PMID:34677630; PMID:35090964; PMID:35925383; PMID:37705238; PMID:38763499
GO:0006954 Inflammatory response Increases phenotype PMID:32416088; PMID:34400200; PMID:35090964
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:26115597; PMID:34677630
GO:0006979 Response to oxidative stress Increases phenotype PMID:20347963; PMID:24355168; PMID:30169763
GO:0007005 Mitochondrion organization Decreases phenotype PMID:34673182; PMID:35817260
GO:0008219 Cell death Increases phenotype PMID:18636399; PMID:27757495
GO:0008283 Cell population proliferation Affects phenotype PMID:24937323; PMID:24937323; PMID:32416088; PMID:26783879; PMID:27350164; PMID:32416088
GO:0008284 Positive regulation of cell population proliferation Affects phenotype PMID:28935499; PMID:35588983
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:30244016; PMID:30244016; PMID:35314294; PMID:37419272; PMID:32738333; PMID:35588983; PMID:37419272
GO:0008343 Adult feeding behavior Decreases phenotype PMID:34506767
GO:0010759 Positive regulation of macrophage chemotaxis Increases phenotype PMID:33170220
GO:0010942 Positive regulation of cell death Increases phenotype PMID:24355168; PMID:28013001; PMID:28865950; PMID:28935499; PMID:30169763
GO:0015707 Nitrite transport Increases phenotype PMID:21748807
GO:0015721 Bile acid and bile salt transport Affects phenotype PMID:35224661
GO:0016042 Lipid catabolic process Increases phenotype PMID:26115597; PMID:34673182
GO:0016049 Cell growth Decreases phenotype PMID:18636399; PMID:30668976; PMID:30716354
GO:0019369 Arachidonic acid metabolic process Affects phenotype PMID:38040082
GO:0019646 Aerobic electron transport chain Decreases phenotype PMID:28013001
GO:0030199 Collagen fibril organization Increases phenotype PMID:35925383
GO:0030263 Apoptotic chromosome condensation Increases phenotype PMID:38763499
GO:0030284 Nuclear estrogen receptor activity Increases phenotype PMID:27481073
GO:0030335 Positive regulation of cell migration Increases phenotype PMID:38432439
GO:0033212 Iron import into cell Increases phenotype PMID:37419272
GO:0034440 Lipid oxidation Increases phenotype PMID:35817260; PMID:39983889
GO:0035684 Helper t cell extravasation Increases phenotype PMID:33170220
GO:0035754 B cell chemotaxis Increases phenotype PMID:33170220
GO:0036146 Cellular response to mycotoxin Increases phenotype PMID:23719927; PMID:24355168
GO:0036335 Intestinal stem cell homeostasis Affects phenotype PMID:34506767
GO:0040015 Negative regulation of multicellular organism growth Increases phenotype PMID:35817260
GO:0043032 Positive regulation of macrophage activation Increases phenotype PMID:39725263
GO:0043065 Positive regulation of apoptotic process Affects phenotype PMID:30169763; PMID:32738333; PMID:35817260; PMID:39153657
GO:0043066 Negative regulation of apoptotic process Increases phenotype PMID:32738333
GO:0044237 Cellular metabolic process Decreases phenotype PMID:21748807; PMID:30251759; PMID:32065293; PMID:33309878; PMID:34673182; PMID:34677630; PMID:35090964; PMID:35925383; PMID:37705238; PMID:38549690
GO:0044256 Protein digestion Affects phenotype PMID:38040082
GO:0044319 Wound healing, spreading of cells Decreases phenotype PMID:30854615
GO:0045023 G0 to g1 transition Affects phenotype PMID:34677630
GO:0045454 Cell redox homeostasis Decreases phenotype PMID:35817260; PMID:37419272; PMID:38040082
GO:0045627 Positive regulation of t-helper 1 cell differentiation Increases phenotype PMID:28935500
GO:0045738 Negative regulation of dna repair Affects phenotype PMID:24355168
GO:0045930 Negative regulation of mitotic cell cycle Increases phenotype PMID:30169763; PMID:30286430
GO:0046209 Nitric oxide metabolic process Affects phenotype PMID:34673182
GO:0046330 Positive regulation of jnk cascade Increases phenotype PMID:30169763
GO:0046466 Membrane lipid catabolic process Affects phenotype PMID:24355168
GO:0048863 Stem cell differentiation Decreases phenotype PMID:34506767
GO:0048874 Host-mediated regulation of intestinal microbiota composition Increases phenotype PMID:30981666; PMID:31034930
GO:0050729 Positive regulation of inflammatory response Increases phenotype PMID:35314294
GO:0050766 Positive regulation of phagocytosis Increases phenotype PMID:38432439
GO:0050995 Negative regulation of lipid catabolic process Increases phenotype PMID:38040082
GO:0050996 Positive regulation of lipid catabolic process Increases phenotype PMID:37419272
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:33309878; PMID:34673182; PMID:37705238
GO:0051882 Mitochondrial depolarization Increases phenotype PMID:34677630
GO:0051899 Membrane depolarization Increases phenotype PMID:37705238
GO:0051938 L-glutamate import Affects phenotype PMID:21748807
GO:0060729 Intestinal epithelial structure maintenance Decreases phenotype PMID:35817260
GO:0061024 Membrane organization Affects phenotype PMID:33890134
GO:0070265 Necrotic cell death Increases phenotype PMID:38763499
GO:0070269 Pyroptosis Increases phenotype PMID:35925383
GO:0070633 Transepithelial transport Decreases phenotype PMID:35817260
GO:0070994 Detection of oxidative stress Increases phenotype PMID:34677630
GO:0071736 Igg immunoglobulin complex, circulating Affects phenotype PMID:38763499
GO:0071746 Iga immunoglobulin complex, circulating Affects phenotype PMID:38763499
GO:0072593 Reactive oxygen species metabolic process Affects phenotype PMID:33309878; PMID:35090964; PMID:37705238
GO:0072683 T cell extravasation Increases phenotype PMID:36602574
GO:0090136 Epithelial cell-cell adhesion Decreases phenotype PMID:35817260
GO:0090200 Positive regulation of release of cytochrome c from mitochondria Increases phenotype PMID:35817260
GO:0090557 Establishment of endothelial intestinal barrier Decreases phenotype PMID:34506767
GO:0097212 Lysosomal membrane organization Decreases phenotype PMID:29174985
GO:0120193 Tight junction organization Decreases phenotype PMID:35817260
GO:0140042 Lipid droplet formation Increases phenotype PMID:35925383
GO:0140354 Lipid import into cell Increases phenotype PMID:38040082
GO:0140911 Pore-forming activity Increases phenotype PMID:35925383
GO:0160020 Positive regulation of ferroptosis Increases phenotype PMID:37419272
GO:1900017 Positive regulation of cytokine production involved in inflammatory response Increases phenotype PMID:33170220
GO:1900181 Negative regulation of protein localization to nucleus Increases phenotype PMID:35817260
GO:1900182 Positive regulation of protein localization to nucleus Increases phenotype PMID:35817260
GO:1903047 Mitotic cell cycle process Affects phenotype PMID:34677630
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:18636399; PMID:26783879
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Affects phenotype PMID:28013001; PMID:30169763; PMID:35817260; PMID:37419272; PMID:37419272; PMID:39147090; PMID:39153657
GO:1903999 Negative regulation of eating behavior Increases phenotype PMID:25787141; PMID:35817260
GO:1905448 Positive regulation of mitochondrial atp synthesis coupled electron transport Decreases phenotype PMID:28013001
GO:1905517 Macrophage migration Increases phenotype PMID:35925383
GO:2000321 Positive regulation of t-helper 17 cell differentiation Increases phenotype PMID:28935500
GO:2000391 Positive regulation of neutrophil extravasation Increases phenotype PMID:33170220
GO:2000421 Positive regulation of eosinophil extravasation Increases phenotype PMID:33170220
GO:2000510 Positive regulation of dendritic cell chemotaxis Increases phenotype PMID:33170220
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.