Permethrin


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000089 Mitotic metaphase Affects phenotype PMID:29741206
GO:0000105 Histidine biosynthetic process Decreases phenotype PMID:29477483
GO:0000723 Telomere maintenance Affects phenotype PMID:23774483
GO:0000737 Dna catabolic process, endonucleolytic Increases phenotype PMID:34224971
GO:0001774 Microglial cell activation Increases phenotype PMID:32832901
GO:0002027 Regulation of heart rate Affects phenotype PMID:34224971
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:34224971
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Increases phenotype PMID:28456543; PMID:34224971
GO:0004457 Lactate dehydrogenase activity Increases phenotype PMID:34224971
GO:0004602 Glutathione peroxidase activity Decreases phenotype PMID:31621018; PMID:34224971
GO:0004679 Amp-activated protein kinase activity Decreases phenotype PMID:28866332
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:28456543; PMID:34224971
GO:0006007 Glucose catabolic process Decreases phenotype PMID:29477483
GO:0006021 Inositol biosynthetic process Decreases phenotype PMID:29477483
GO:0006094 Gluconeogenesis Decreases phenotype PMID:29477483
GO:0006096 Glycolytic process Affects phenotype PMID:27984134
GO:0006099 Tricarboxylic acid cycle Affects phenotype PMID:27984134
GO:0006114 Glycerol biosynthetic process Decreases phenotype PMID:29477483
GO:0006306 Dna methylation Decreases phenotype PMID:33865946
GO:0006338 Chromatin remodeling Increases phenotype PMID:31175960
GO:0006529 Asparagine biosynthetic process Decreases phenotype PMID:29477483
GO:0006532 Aspartate biosynthetic process Decreases phenotype PMID:29477483
GO:0006545 Glycine biosynthetic process Decreases phenotype PMID:29477483
GO:0006561 Proline biosynthetic process Decreases phenotype PMID:29477483
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:34224971
GO:0006749 Glutathione metabolic process Increases phenotype PMID:32911180
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:19153980; PMID:29741206; PMID:31621018
GO:0006979 Response to oxidative stress Increases phenotype PMID:18692543
GO:0007283 Spermatogenesis Affects phenotype PMID:31621018
GO:0007420 Brain development Affects phenotype PMID:31175960
GO:0007610 Behavior Affects phenotype PMID:31175960
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:34224971
GO:0008219 Cell death Increases phenotype PMID:27502151
GO:0008283 Cell population proliferation Affects phenotype PMID:16326432; PMID:27502151
GO:0008284 Positive regulation of cell population proliferation Increases phenotype PMID:28431163; PMID:34427685
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:29149346; PMID:32949729
GO:0009088 Threonine biosynthetic process Decreases phenotype PMID:29477483
GO:0009097 Isoleucine biosynthetic process Decreases phenotype PMID:29477483
GO:0009098 Leucine biosynthetic process Decreases phenotype PMID:29477483
GO:0009099 Valine biosynthetic process Decreases phenotype PMID:29477483
GO:0010468 Regulation of gene expression Affects phenotype PMID:31175960
GO:0010917 Negative regulation of mitochondrial membrane potential Increases phenotype PMID:38040083
GO:0016042 Lipid catabolic process Increases phenotype PMID:28456543; PMID:31621018
GO:0018158 Protein oxidation Affects phenotype PMID:31175960; PMID:32911180; PMID:34224971
GO:0019226 Transmission of nerve impulse Increases phenotype PMID:38599286
GO:0019344 Cysteine biosynthetic process Decreases phenotype PMID:29477483
GO:0019432 Triglyceride biosynthetic process Increases phenotype PMID:24911977; PMID:30738135; PMID:31199990
GO:0030199 Collagen fibril organization Increases phenotype PMID:34224971
GO:0031959 Mineralocorticoid receptor signaling pathway Increases phenotype PMID:29149346
GO:0031987 Locomotion involved in locomotory behavior Decreases phenotype PMID:29803855
GO:0032147 Activation of protein kinase activity Decreases phenotype PMID:28866332
GO:0032148 Activation of protein kinase b activity Increases phenotype PMID:28866332
GO:0032760 Positive regulation of tumor necrosis factor production Increases phenotype PMID:27655349
GO:0032776 Dna methylation on cytosine Affects phenotype PMID:33148267
GO:0033148 Positive regulation of intracellular estrogen receptor signaling pathway Increases phenotype PMID:25449125
GO:0033610 Oxalate biosynthetic process Decreases phenotype PMID:29477483
GO:0034440 Lipid oxidation Affects phenotype PMID:28659758; PMID:31175960; PMID:32911180
GO:0034441 Plasma lipoprotein particle oxidation Increases phenotype PMID:32911180
GO:0036124 Histone h3-k9 trimethylation Decreases phenotype PMID:31175960
GO:0042307 Positive regulation of protein import into nucleus Increases phenotype PMID:28659758
GO:0042417 Dopamine metabolic process Affects phenotype PMID:31175960
GO:0042554 Superoxide anion generation Increases phenotype PMID:19153980
GO:0042632 Cholesterol homeostasis Decreases phenotype PMID:32911180
GO:0043651 Linoleic acid metabolic process Decreases phenotype PMID:29477483
GO:0044255 Cellular lipid metabolic process Affects phenotype PMID:27984134
GO:0044546 Nlrp3 inflammasome complex assembly Increases phenotype PMID:32832901
GO:0044860 Protein localization to plasma membrane raft Increases phenotype PMID:29751049
GO:0046034 Atp metabolic process Affects phenotype PMID:32949729
GO:0046167 Glycerol-3-phosphate biosynthetic process Decreases phenotype PMID:29477483
GO:0046295 Glycolate biosynthetic process Decreases phenotype PMID:29477483
GO:0046323 Glucose import Increases phenotype PMID:24911977
GO:0046335 Ethanolamine biosynthetic process Decreases phenotype PMID:29477483
GO:0046369 Galactose biosynthetic process Decreases phenotype PMID:29477483
GO:0046370 Fructose biosynthetic process Affects phenotype PMID:29477483
GO:0046399 Glucuronate biosynthetic process Decreases phenotype PMID:29477483
GO:0048143 Astrocyte activation Increases phenotype PMID:27984134
GO:0048266 Behavioral response to pain Increases phenotype PMID:26409647
GO:0048874 Host-mediated regulation of intestinal microbiota composition Decreases phenotype PMID:29751049
GO:0050665 Hydrogen peroxide biosynthetic process Increases phenotype PMID:19153980
GO:0051276 Chromosome organization Affects phenotype PMID:29741206
GO:0051602 Response to electrical stimulus Affects phenotype PMID:26409647
GO:0051899 Membrane depolarization Increases phenotype PMID:30205134
GO:0055064 Chloride ion homeostasis Affects phenotype PMID:34224971
GO:0055074 Calcium ion homeostasis Affects phenotype PMID:30056177; PMID:30205134; PMID:34224971
GO:0055075 Potassium ion homeostasis Affects phenotype PMID:34224971
GO:0055078 Sodium ion homeostasis Affects phenotype PMID:34224971
GO:0061370 Testosterone biosynthetic process Affects phenotype PMID:31621018
GO:0070265 Necrotic cell death Increases phenotype PMID:28456543; PMID:34224971
GO:0070328 Triglyceride homeostasis Decreases phenotype PMID:29751049
GO:0070994 Detection of oxidative stress Increases phenotype PMID:34224971
GO:0072520 Seminiferous tubule development Affects phenotype PMID:31621018
GO:0072593 Reactive oxygen species metabolic process Affects phenotype PMID:32832901
GO:0072659 Protein localization to plasma membrane Increases phenotype PMID:28866332
GO:0080182 Histone h3-k4 trimethylation Increases phenotype PMID:31175960
GO:0090116 C-5 methylation of cytosine Increases phenotype PMID:31175960
GO:0090592 Dna synthesis involved in dna replication Increases phenotype PMID:32040184; PMID:34427685
GO:0097006 Regulation of plasma lipoprotein particle levels Decreases phenotype PMID:32911180
GO:0098874 Spike train Increases phenotype PMID:26409647
GO:0140042 Lipid droplet formation Increases phenotype PMID:34224971
GO:1900535 Palmitic acid biosynthetic process Affects phenotype PMID:29477483
GO:1901203 Positive regulation of extracellular matrix assembly Increases phenotype PMID:32911180
GO:1901660 Calcium ion export Increases phenotype PMID:30205134
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:32911180
GO:1902259 Regulation of delayed rectifier potassium channel activity Affects phenotype PMID:26409647
GO:1902632 Positive regulation of membrane hyperpolarization Increases phenotype PMID:26409647
GO:1903283 Negative regulation of glutathione peroxidase activity Increases phenotype PMID:32911180
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:30205134
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:28866332; PMID:32911180
GO:1903784 Positive regulation of sodium ion import across plasma membrane Increases phenotype PMID:27655349
GO:1903980 Positive regulation of microglial cell activation Increases phenotype PMID:27984134
GO:1904457 Positive regulation of neuronal action potential Increases phenotype PMID:26409647
GO:1905605 Positive regulation of blood-brain barrier permeability Increases phenotype PMID:36167171
GO:1905642 Negative regulation of dna methylation Increases phenotype PMID:29051472
GO:1990962 Xenobiotic transport across blood-brain barrier Increases phenotype PMID:36167171
GO:2000347 Positive regulation of hepatocyte proliferation Increases phenotype PMID:30629241
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.