Deltamethrin


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000002 Mitochondrial genome maintenance Decreases phenotype PMID:34520793
GO:0000050 Urea cycle Affects phenotype PMID:31454128
GO:0001659 Temperature homeostasis Affects phenotype PMID:30009846
GO:0001774 Microglial cell activation Increases phenotype PMID:35741090
GO:0001836 Release of cytochrome c from mitochondria Increases phenotype PMID:27553674
GO:0001964 Startle response Affects phenotype PMID:30395337; PMID:30850843
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:25798648; PMID:28595958
GO:0004035 Alkaline phosphatase activity Increases phenotype PMID:28987327; PMID:33396045; PMID:35678313
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Increases phenotype PMID:33396045; PMID:35678313
GO:0004096 Catalase activity Affects phenotype PMID:33396045
GO:0004129 Cytochrome-c oxidase activity Decreases phenotype PMID:17304643
GO:0004175 Endopeptidase activity Decreases phenotype PMID:38040083
GO:0004197 Cysteine-type endopeptidase activity Decreases phenotype PMID:38040083
GO:0004303 Estradiol 17-beta-dehydrogenase activity Decreases phenotype PMID:34896426
GO:0004364 Glutathione transferase activity Increases phenotype PMID:30884102; PMID:33396045
GO:0004457 Lactate dehydrogenase activity Affects phenotype PMID:35678313
GO:0004602 Glutathione peroxidase activity Increases phenotype PMID:30884102; PMID:31454128; PMID:33396045; PMID:35678313; PMID:35678313
GO:0004784 Superoxide dismutase activity Affects phenotype PMID:28595958; PMID:28595958; PMID:31454128; PMID:30884102; PMID:31454128; PMID:35678313
GO:0006601 Creatine biosynthetic process Increases phenotype PMID:28595958
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:33396045; PMID:33396045; PMID:35678313; PMID:35678313
GO:0006750 Glutathione biosynthetic process Increases phenotype PMID:24217896; PMID:30884102; PMID:31454128
GO:0006754 Atp biosynthetic process Decreases phenotype PMID:27553674
GO:0006809 Nitric oxide biosynthetic process Increases phenotype PMID:25439240; PMID:31454128
GO:0006811 Monoatomic ion transport Increases phenotype PMID:2167745
GO:0006915 Apoptotic process Affects phenotype PMID:24217896; PMID:26588882; PMID:27553674
GO:0006919 Activation of cysteine-type endopeptidase activity involved in apoptotic process Increases phenotype PMID:30247739
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:25439240; PMID:28595958
GO:0007033 Vacuole organization Increases phenotype PMID:28595958
GO:0007283 Spermatogenesis Decreases phenotype PMID:25299849; PMID:34896426
GO:0007340 Acrosome reaction Decreases phenotype PMID:33396045; PMID:34896426
GO:0007611 Learning or memory Decreases phenotype PMID:30850843; PMID:32976580
GO:0007612 Learning Decreases phenotype PMID:25359175
GO:0007626 Locomotory behavior Increases phenotype PMID:25630971
GO:0008137 Nadh dehydrogenase (ubiquinone) activity Decreases phenotype PMID:27553674
GO:0008202 Steroid metabolic process Affects phenotype PMID:38176580
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:35678313
GO:0008219 Cell death Increases phenotype PMID:16644695; PMID:28595958
GO:0008283 Cell population proliferation Decreases phenotype PMID:26588882
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:32800223; PMID:32949729; PMID:34520793
GO:0010890 Positive regulation of sequestering of triglyceride Increases phenotype PMID:28119079; PMID:35715053
GO:0010917 Negative regulation of mitochondrial membrane potential Increases phenotype PMID:34520793; PMID:38040083
GO:0010940 Positive regulation of necrotic cell death Increases phenotype PMID:39971138
GO:0014046 Dopamine secretion Decreases phenotype PMID:30850843
GO:0016042 Lipid catabolic process Increases phenotype PMID:25439240; PMID:28595958; PMID:28595958; PMID:31454128; PMID:31454128; PMID:33396045; PMID:33396045; PMID:35678313; PMID:35678313; PMID:35741090
GO:0016049 Cell growth Decreases phenotype PMID:24217896
GO:0016209 Antioxidant activity Decreases phenotype PMID:25798648
GO:0021872 Forebrain generation of neurons Decreases phenotype PMID:25359175
GO:0030283 Testosterone dehydrogenase [nad(p)] activity Decreases phenotype PMID:33396045
GO:0030335 Positive regulation of cell migration Increases phenotype PMID:32800223
GO:0030534 Adult behavior Affects phenotype PMID:30009846
GO:0031223 Auditory behavior Affects phenotype PMID:30395337
GO:0031398 Positive regulation of protein ubiquitination Increases phenotype PMID:34520793
GO:0031987 Locomotion involved in locomotory behavior Increases phenotype PMID:31683416
GO:0032760 Positive regulation of tumor necrosis factor production Increases phenotype PMID:27655349
GO:0033148 Positive regulation of intracellular estrogen receptor signaling pathway Increases phenotype PMID:25449125
GO:0034101 Erythrocyte homeostasis Decreases phenotype PMID:33385678
GO:0034418 Urate biosynthetic process Affects phenotype PMID:31454128
GO:0034440 Lipid oxidation Increases phenotype PMID:26013673
GO:0035584 Calcium-mediated signaling using intracellular calcium source Decreases phenotype PMID:31166131
GO:0036269 Swimming behavior Affects phenotype PMID:31683416
GO:0042403 Thyroid hormone metabolic process Affects phenotype PMID:31683416
GO:0042416 Dopamine biosynthetic process Affects phenotype PMID:26588882; PMID:30884102
GO:0042421 Norepinephrine biosynthetic process Affects phenotype PMID:30850843; PMID:30884102
GO:0042427 Serotonin biosynthetic process Affects phenotype PMID:30884102
GO:0042554 Superoxide anion generation Increases phenotype PMID:28987327
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:25299849; PMID:32800223; PMID:33385678; PMID:34520793; PMID:39971138
GO:0045429 Positive regulation of nitric oxide biosynthetic process Increases phenotype PMID:26013673
GO:0045454 Cell redox homeostasis Decreases phenotype PMID:26013673; PMID:35741090
GO:0045773 Positive regulation of axon extension Increases phenotype PMID:31166131
GO:0046034 Atp metabolic process Affects phenotype PMID:32949729
GO:0046209 Nitric oxide metabolic process Affects phenotype PMID:35678313
GO:0046323 Glucose import Affects phenotype PMID:29380240
GO:0046415 Urate metabolic process Affects phenotype PMID:28595958
GO:0046449 Creatinine metabolic process Affects phenotype PMID:31454128
GO:0046878 Positive regulation of saliva secretion Increases phenotype PMID:30395337
GO:0048102 Autophagic cell death Affects phenotype PMID:26588882
GO:0048240 Sperm capacitation Decreases phenotype PMID:33396045; PMID:34896426
GO:0050729 Positive regulation of inflammatory response Increases phenotype PMID:39971138
GO:0050768 Negative regulation of neurogenesis Decreases phenotype PMID:32976580
GO:0050890 Cognition Decreases phenotype PMID:30850843
GO:0050996 Positive regulation of lipid catabolic process Increases phenotype PMID:33385678; PMID:39971138
GO:0051646 Mitochondrion localization Affects phenotype PMID:34520793
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:17304643; PMID:27553674
GO:0060291 Long-term synaptic potentiation Increases phenotype PMID:30850843
GO:0061370 Testosterone biosynthetic process Affects phenotype PMID:34896426; PMID:36053783
GO:0061739 Protein lipidation involved in autophagosome assembly Increases phenotype PMID:34520793
GO:0070059 Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Increases phenotype PMID:31841155
GO:0070585 Protein localization to mitochondrion Increases phenotype PMID:28987327
GO:0071211 Protein targeting to vacuole involved in autophagy Affects phenotype PMID:34520793
GO:0071902 Positive regulation of protein serine/threonine kinase activity Increases phenotype PMID:28119079
GO:0102727 3beta-hydroxysteroid dehydrogenase activity Decreases phenotype PMID:33396045; PMID:34896426; PMID:36053783
GO:0140059 Dendrite arborization Increases phenotype PMID:31166131
GO:0150078 Positive regulation of neuroinflammatory response Increases phenotype PMID:35741090
GO:1900825 Regulation of membrane depolarization during cardiac muscle cell action potential Decreases phenotype PMID:30868487
GO:1901216 Positive regulation of neuron death Increases phenotype PMID:25630971
GO:1901526 Positive regulation of mitophagy Increases phenotype PMID:34520793
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:39971138
GO:1901799 Negative regulation of proteasomal protein catabolic process Increases phenotype PMID:34520793
GO:1902237 Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Increases phenotype PMID:25359175
GO:1902512 Positive regulation of apoptotic dna fragmentation Increases phenotype PMID:26013673
GO:1902552 Negative regulation of catalase activity Increases phenotype PMID:39971138
GO:1903223 Positive regulation of oxidative stress-induced neuron death Increases phenotype PMID:26013673
GO:1903381 Regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway Increases phenotype PMID:25359175
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:24217896; PMID:26588882; PMID:28987327
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:25798648; PMID:32800223; PMID:35741090; PMID:39971138
GO:1903607 Cytochrome c biosynthetic process Decreases phenotype PMID:17304643
GO:1903779 Regulation of cardiac conduction Affects phenotype PMID:25798648
GO:1903784 Positive regulation of sodium ion import across plasma membrane Increases phenotype PMID:27655349
GO:1903787 Negative regulation of glutathione biosynthetic process Increases phenotype PMID:33385678; PMID:39971138
GO:1904179 Positive regulation of adipose tissue development Increases phenotype PMID:35715053
GO:1904456 Negative regulation of neuronal action potential Increases phenotype PMID:31166131
GO:1905629 Positive regulation of serotonin biosynthetic process Increases phenotype PMID:33385678
GO:1990138 Neuron projection extension Increases phenotype PMID:28943602
GO:2000748 Positive regulation of defecation rhythm Increases phenotype PMID:33385678
GO:2000786 Positive regulation of autophagosome assembly Increases phenotype PMID:34520793
GO:2000854 Positive regulation of corticosterone secretion Increases phenotype PMID:33385678
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.