Cisplatin


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000045 Autophagosome assembly Increases phenotype PMID:25979647; PMID:30550853; PMID:31220555; PMID:32562082
GO:0000080 Mitotic g1 phase Increases phenotype PMID:25979647
GO:0000084 Mitotic s phase Increases phenotype PMID:27840903; PMID:31255669; PMID:31303961; PMID:32562082; PMID:37760451; PMID:39461470
GO:0000086 G2/m transition of mitotic cell cycle Increases phenotype PMID:18468580; PMID:31303961; PMID:32562082; PMID:33522649; PMID:37760451; PMID:39461470
GO:0000104 Succinate dehydrogenase activity Decreases phenotype PMID:29471006
GO:0000165 Mapk cascade Affects phenotype PMID:18676776
GO:0000278 Mitotic cell cycle Affects phenotype PMID:33522649; PMID:34126102
GO:0000724 Double-strand break repair via homologous recombination Affects phenotype PMID:37802411
GO:0000737 Dna catabolic process, endonucleolytic Increases phenotype PMID:36425765; PMID:37802411; PMID:38830565; PMID:39461470
GO:0001541 Ovarian follicle development Decreases phenotype PMID:33031932; PMID:36567042
GO:0001547 Antral ovarian follicle growth Decreases phenotype PMID:31874189
GO:0001552 Ovarian follicle atresia Increases phenotype PMID:31874189; PMID:36567042
GO:0001774 Microglial cell activation Increases phenotype PMID:37769865
GO:0001836 Release of cytochrome c from mitochondria Affects phenotype PMID:16082193; PMID:25940438; PMID:29471006; PMID:33393703
GO:0001894 Tissue homeostasis Affects phenotype PMID:29191451
GO:0001906 Cell killing Increases phenotype PMID:21567185
GO:0001946 Lymphangiogenesis Increases phenotype PMID:34658261
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:28371137; PMID:28782499; PMID:34423507; PMID:32504734; PMID:32504734; PMID:32787450; PMID:39892498; PMID:32787450; PMID:34423507; PMID:39182635; PMID:39645019; PMID:39332792; PMID:39978533
GO:0002534 Cytokine production involved in inflammatory response Increases phenotype PMID:24975837
GO:0002693 Positive regulation of cellular extravasation Increases phenotype PMID:31926187
GO:0003093 Regulation of glomerular filtration Affects phenotype PMID:29852128; PMID:32856486; PMID:32856486; PMID:34658261; PMID:34658261
GO:0003094 Glomerular filtration Decreases phenotype PMID:27317936; PMID:32856486; PMID:39978533
GO:0003682 Chromatin binding Increases phenotype PMID:35842499
GO:0003810 Protein-glutamine gamma-glutamyltransferase activity Decreases phenotype PMID:33832332
GO:0003993 Acid phosphatase activity Increases phenotype PMID:33832332
GO:0004035 Alkaline phosphatase activity Affects phenotype PMID:28606469; PMID:28606469; PMID:28782499; PMID:33393703; PMID:33832332; PMID:36122812
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Increases phenotype PMID:28606469; PMID:30125553; PMID:32259551; PMID:32259551; PMID:33393703; PMID:33832332; PMID:36270770; PMID:32860823; PMID:33393703; PMID:33832332; PMID:36122812; PMID:36270770
GO:0004096 Catalase activity Decreases phenotype PMID:39978533
GO:0004129 Cytochrome-c oxidase activity Decreases phenotype PMID:33393703
GO:0004198 Calcium-dependent cysteine-type endopeptidase activity Increases phenotype PMID:35525317
GO:0004346 Glucose-6-phosphatase activity Decreases phenotype PMID:33832332
GO:0004364 Glutathione transferase activity Affects phenotype PMID:22987311; PMID:23229315; PMID:23229315; PMID:26612654; PMID:33522649; PMID:26612654; PMID:28606469; PMID:30125553; PMID:33832332; PMID:33522649; PMID:33832332; PMID:35243731
GO:0004396 Hexokinase activity Affects phenotype PMID:31149761; PMID:32860823
GO:0004457 Lactate dehydrogenase activity Increases phenotype PMID:26558470; PMID:28606469; PMID:29852128; PMID:33832332
GO:0004470 Malic enzyme activity Increases phenotype PMID:33832332
GO:0004602 Glutathione peroxidase activity Affects phenotype PMID:22987311; PMID:23229315; PMID:23229315; PMID:25737657; PMID:26612654; PMID:27616468; PMID:37561086; PMID:39978533; PMID:24113306; PMID:24239945; PMID:24291008; PMID:25737657; PMID:25776512; PMID:26612654; PMID:27616468; PMID:28371137; PMID:28371137; PMID:33832332; PMID:28606469; PMID:30125553; PMID:32565124; PMID:32565124; PMID:36122812; PMID:33393703; PMID:33587916; PMID:33832332; PMID:35243731; PMID:36122812; PMID:37561086; PMID:39978533
GO:0004679 Amp-activated protein kinase activity Increases phenotype PMID:29476062
GO:0004691 Camp-dependent protein kinase activity Increases phenotype PMID:33757793
GO:0004707 Map kinase activity Increases phenotype PMID:37087747
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:22987311; PMID:22987311; PMID:25308879; PMID:29471006; PMID:29752894; PMID:31306688; PMID:34560070; PMID:39892498; PMID:24113306; PMID:24239945; PMID:24291008; PMID:24632086; PMID:24632086; PMID:25737657; PMID:26612654; PMID:29852128; PMID:30452898; PMID:33522649; PMID:34569348; PMID:39102946; PMID:39645019; PMID:39978533; PMID:25308879; PMID:25737657; PMID:25776512; PMID:26612654; PMID:28371137; PMID:28371137; PMID:33832332; PMID:34151639; PMID:28606469; PMID:29471006; PMID:29752894; PMID:29852128; PMID:29962303; PMID:30452898; PMID:31306688; PMID:32565124; PMID:32565124; PMID:34047436; PMID:36122812; PMID:32567747; PMID:33393703; PMID:33522649; PMID:33587916; PMID:33634982; PMID:33832332; PMID:34047436; PMID:34151639; PMID:34533242; PMID:34560070; PMID:34569348; PMID:35243731; PMID:36122812; PMID:36270770; PMID:37497868; PMID:39102946; PMID:39645019; PMID:39892498; PMID:39978533
GO:0004791 Thioredoxin-disulfide reductase activity Decreases phenotype PMID:33832332
GO:0005776 Autophagosome Increases phenotype PMID:36070022
GO:0005975 Carbohydrate metabolic process Affects phenotype PMID:39182635
GO:0005977 Glycogen metabolic process Affects phenotype PMID:32860823
GO:0006082 Organic acid metabolic process Affects phenotype PMID:39182635
GO:0006106 Fumarate metabolic process Affects phenotype PMID:36100043
GO:0006264 Mitochondrial dna replication Decreases phenotype PMID:37497868
GO:0006304 Dna modification Affects phenotype PMID:24999622; PMID:26739623; PMID:27722009; PMID:39978533
GO:0006308 Dna catabolic process Increases phenotype PMID:34196753
GO:0006309 Apoptotic dna fragmentation Increases phenotype PMID:10665656; PMID:11592233; PMID:11592233; PMID:12709826; PMID:12709826; PMID:16357177; PMID:17320769; PMID:17399942; PMID:17574045; PMID:18383853; PMID:18676776; PMID:24291008; PMID:31493026; PMID:7728769; PMID:7841041; PMID:7861226; PMID:9098629; PMID:9921918
GO:0006412 Translation Decreases phenotype PMID:25624349
GO:0006497 Protein lipidation Increases phenotype PMID:25979647; PMID:30550853; PMID:32562082
GO:0006506 Gpi anchor biosynthetic process Decreases phenotype PMID:27931811
GO:0006520 Amino acid metabolic process Affects phenotype PMID:39182635
GO:0006531 Aspartate metabolic process Affects phenotype PMID:36100043
GO:0006536 Glutamate metabolic process Affects phenotype PMID:35447140; PMID:35447140; PMID:36100043; PMID:36100043
GO:0006558 L-phenylalanine metabolic process Affects phenotype PMID:35447140
GO:0006568 Tryptophan metabolic process Affects phenotype PMID:35447140
GO:0006570 Tyrosine metabolic process Affects phenotype PMID:35447140; PMID:36100043
GO:0006601 Creatine biosynthetic process Increases phenotype PMID:25598344; PMID:30452898; PMID:37087747
GO:0006602 Creatinine catabolic process Decreases phenotype PMID:32742113
GO:0006606 Protein import into nucleus Increases phenotype PMID:26059411; PMID:32918990
GO:0006631 Fatty acid metabolic process Affects phenotype PMID:39182635
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:32860823
GO:0006644 Phospholipid metabolic process Affects phenotype PMID:33832332
GO:0006749 Glutathione metabolic process Increases phenotype PMID:22271272; PMID:25382014; PMID:25640527; PMID:25640527; PMID:33522649; PMID:34569348; PMID:39102946; PMID:39978533; PMID:26120027; PMID:27815112; PMID:29857117; PMID:32565124; PMID:32565124; PMID:33757793; PMID:34047436; PMID:32567747; PMID:32621855; PMID:33031932; PMID:33393703; PMID:33522649; PMID:33522649; PMID:34569348; PMID:39102946; PMID:39978533; PMID:33587916; PMID:33634982; PMID:33757793; PMID:33832332; PMID:34047436; PMID:34151639; PMID:34302894; PMID:34476871; PMID:34785303; PMID:38014886; PMID:34785303; PMID:35243731; PMID:35395232; PMID:36460226; PMID:37497868; PMID:38014886; PMID:39053794; PMID:39102946
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:17604343; PMID:22987311; PMID:22987311; PMID:25665769; PMID:29471006; PMID:29752894; PMID:31153982; PMID:23229315; PMID:23229315; PMID:25737657; PMID:26612654; PMID:27616468; PMID:29852128; PMID:30452898; PMID:31103702; PMID:24113306; PMID:24239945; PMID:24291008; PMID:25776512; PMID:26612654; PMID:26721606; PMID:27616468; PMID:28371137; PMID:28606469; PMID:29471006; PMID:29690507; PMID:29752894; PMID:29852128; PMID:30452898; PMID:31103702; PMID:31153982; PMID:31874189
GO:0006754 Atp biosynthetic process Decreases phenotype PMID:17604343; PMID:25806124; PMID:27989596; PMID:29471006
GO:0006771 Riboflavin metabolic process Affects phenotype PMID:35447140
GO:0006776 Vitamin a metabolic process Affects phenotype PMID:30368973
GO:0006809 Nitric oxide biosynthetic process Affects phenotype PMID:24632086; PMID:24632086; PMID:29852128; PMID:26612654; PMID:26612654; PMID:27616468; PMID:27616468; PMID:28371137; PMID:28606469; PMID:29191451; PMID:29752894; PMID:29852128; PMID:31874189
GO:0006855 Xenobiotic transmembrane transport Decreases phenotype PMID:28414026
GO:0006874 Cellular calcium ion homeostasis Affects phenotype PMID:31255669; PMID:35395232
GO:0006878 Cellular copper ion homeostasis Affects phenotype PMID:38462020
GO:0006879 Cellular iron ion homeostasis Affects phenotype PMID:34785303; PMID:39053794
GO:0006884 Cell volume homeostasis Affects phenotype PMID:35395232
GO:0006914 Autophagy Increases phenotype PMID:24799992; PMID:26201060; PMID:26763392; PMID:30550853; PMID:32562082; PMID:34990753; PMID:36070022; PMID:36336710; PMID:39182635
GO:0006915 Apoptotic process Increases phenotype PMID:10223459; PMID:10223459; PMID:35395232; PMID:10353256; PMID:10473109; PMID:10473109; PMID:18377724; PMID:10571245; PMID:10663630; PMID:10665656; PMID:31303961; PMID:33522649; PMID:10750663; PMID:10753191; PMID:10891466; PMID:10891466; PMID:12709826; PMID:16082193; PMID:10891529; PMID:10896673; PMID:10896673; PMID:12421819; PMID:15496615; PMID:15645133; PMID:18349320; PMID:18676776; PMID:19903766; PMID:22675468; PMID:25776512; PMID:25979647; PMID:29690507; PMID:34758370; PMID:11304686; PMID:11590323; PMID:12012012; PMID:12012012; PMID:14755253; PMID:15313391; PMID:17320769; PMID:7728769; PMID:9815594; PMID:12012012; PMID:9815594; PMID:12192598; PMID:12227071; PMID:12230498; PMID:12421819; PMID:12421819; PMID:18676776; PMID:19903766; PMID:12565868; PMID:12565868; PMID:12853972; PMID:14727531; PMID:18349320; PMID:18476001; PMID:9619762; PMID:12709826; PMID:12853972; PMID:12884094; PMID:12884094; PMID:35179410; PMID:14727531; PMID:14755253; PMID:15313391; PMID:15313391; PMID:15645133; PMID:15496615; PMID:15829011; PMID:19996588; PMID:32762018; PMID:37700640; PMID:15904426; PMID:15904426; PMID:39053794; PMID:16019139; PMID:17021654; PMID:18058806; PMID:36336213; PMID:16077963; PMID:16082193; PMID:16166447; PMID:16204029; PMID:16377638; PMID:16377638; PMID:18349320; PMID:16545138; PMID:16545138; PMID:18377724; PMID:37760451; PMID:37802411; PMID:16545138; PMID:29944906; PMID:16601104; PMID:17021654; PMID:17399942; PMID:29549912; PMID:33634982; PMID:17574045; PMID:17611077; PMID:17611077; PMID:30143678; PMID:18058806; PMID:18310471; PMID:18349320; PMID:18377724; PMID:18558085; PMID:18566236; PMID:18676776; PMID:18819900; PMID:19280190; PMID:19351772; PMID:19414349; PMID:19414349; PMID:9815594; PMID:19636294; PMID:19728331; PMID:19903766; PMID:19996588; PMID:20138251; PMID:20338106; PMID:20723315; PMID:21118639; PMID:22304828; PMID:22675468; PMID:23103224; PMID:23103562; PMID:23152886; PMID:23429292; PMID:23603837; PMID:23603837; PMID:39102946; PMID:23625948; PMID:23698071; PMID:24676941; PMID:24704392; PMID:24799992; PMID:24799992; PMID:27234046; PMID:36122806; PMID:39461470; PMID:25308879; PMID:25308879; PMID:29471006; PMID:32856486; PMID:35403300; PMID:25624349; PMID:25665769; PMID:25698245; PMID:25698245; PMID:27270317; PMID:29879412; PMID:32562082; PMID:34758370; PMID:37956922; PMID:25770930; PMID:25979647; PMID:26768586; PMID:26768586; PMID:39608515; PMID:26971374; PMID:27234046; PMID:27270317; PMID:27594783; PMID:33522649; PMID:7728769; PMID:27989596; PMID:28507149; PMID:28975372; PMID:29027213; PMID:29471006; PMID:29549912; PMID:29690507; PMID:29852128; PMID:29879412; PMID:29944906; PMID:29962303; PMID:30143678; PMID:30291867; PMID:30452898; PMID:30452898; PMID:34423507; PMID:30804470; PMID:31153982; PMID:31220555; PMID:31271808; PMID:31303961; PMID:32418911; PMID:32428544; PMID:32562082; PMID:32856486; PMID:32991863; PMID:32991863; PMID:35279909; PMID:33031932; PMID:33393703; PMID:33631298; PMID:33634982; PMID:34126102; PMID:34364923; PMID:34423507; PMID:34560070; PMID:34658261; PMID:34758370; PMID:34785303; PMID:34990753; PMID:35259468; PMID:35279909; PMID:35395232; PMID:35447140; PMID:36070022; PMID:36122812; PMID:36336213; PMID:36372261; PMID:36567042; PMID:36965608; PMID:37102204; PMID:37395757; PMID:37497868; PMID:37700640; PMID:37760451; PMID:37802411; PMID:38294069; PMID:38688426; PMID:39053794; PMID:39461470; PMID:39608515; PMID:7728769; PMID:7841041; PMID:7861226; PMID:9098629; PMID:9619762; PMID:9664115; PMID:9815594; PMID:9921918
GO:0006919 Activation of cysteine-type endopeptidase activity involved in apoptotic process Increases phenotype PMID:29944906
GO:0006936 Muscle contraction Increases phenotype PMID:29852128
GO:0006954 Inflammatory response Increases phenotype PMID:29216766; PMID:32418911; PMID:31306688; PMID:32259551; PMID:32259551; PMID:33661552; PMID:36270770; PMID:32418911; PMID:32565124; PMID:33587916; PMID:33661552; PMID:36270770; PMID:37769865
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:23410825; PMID:23410825; PMID:25776512; PMID:23434506; PMID:24571982; PMID:24960055; PMID:25806124; PMID:25940438; PMID:26338418; PMID:26612654; PMID:28606469; PMID:29273566; PMID:30452898; PMID:33393703
GO:0006979 Response to oxidative stress Increases phenotype PMID:17320769; PMID:17574045; PMID:17886225; PMID:19351772
GO:0007005 Mitochondrion organization Decreases phenotype PMID:25598344; PMID:28698153; PMID:34785303; PMID:36070022; PMID:39053794; PMID:39182635
GO:0007006 Mitochondrial membrane organization Affects phenotype PMID:17604343
GO:0007033 Vacuole organization Increases phenotype PMID:32787450
GO:0007049 Cell cycle Decreases phenotype PMID:10571245; PMID:12012012; PMID:12709826; PMID:18819900; PMID:19351772; PMID:19996588; PMID:7841041; PMID:9098629
GO:0007095 Mitotic g2 dna damage checkpoint signaling Increases phenotype PMID:26739623
GO:0007254 Jnk cascade Decreases phenotype PMID:29148169
GO:0007283 Spermatogenesis Decreases phenotype PMID:31493026; PMID:32565124; PMID:32621855; PMID:32621855; PMID:36122812; PMID:32787450; PMID:33757793; PMID:33757793; PMID:34047436; PMID:34047436; PMID:36122812; PMID:37915485
GO:0007286 Spermatid development Decreases phenotype PMID:37915485
GO:0007585 Respiratory gaseous exchange by respiratory system Decreases phenotype PMID:37769865
GO:0007588 Excretion Increases phenotype PMID:31493026
GO:0007597 Blood coagulation, intrinsic pathway Increases phenotype PMID:31874189
GO:0007605 Sensory perception of sound Decreases phenotype PMID:32428544; PMID:37395757; PMID:38490643
GO:0007613 Memory Decreases phenotype PMID:32567747
GO:0007625 Grooming behavior Decreases phenotype PMID:38437957
GO:0007631 Feeding behavior Decreases phenotype PMID:36178099; PMID:37769865
GO:0007638 Mechanosensory behavior Affects phenotype PMID:28962077
GO:0008121 Ubiquinol-cytochrome-c reductase activity Decreases phenotype PMID:33393703
GO:0008137 Nadh dehydrogenase (ubiquinone) activity Decreases phenotype PMID:28698153; PMID:33393703
GO:0008152 Metabolic process Decreases phenotype PMID:24994473; PMID:28433571; PMID:36372261
GO:0008177 Succinate dehydrogenase (ubiquinone) activity Decreases phenotype PMID:33393703
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:32860823; PMID:33832332
GO:0008210 Estrogen metabolic process Affects phenotype PMID:33587916; PMID:33587916; PMID:36567042
GO:0008216 Spermidine metabolic process Affects phenotype PMID:35447140
GO:0008219 Cell death Affects phenotype PMID:10750663; PMID:11307620; PMID:11592233; PMID:17399942; PMID:18383853; PMID:18383853; PMID:19590723; PMID:19853261; PMID:20435919; PMID:20473330; PMID:26059411; PMID:28323900; PMID:20935474; PMID:23300844; PMID:24113306; PMID:24113306; PMID:27543423; PMID:28959534; PMID:24444656; PMID:24444656; PMID:26059411; PMID:24449132; PMID:24817946; PMID:25070243; PMID:25478571; PMID:25624349; PMID:25940438; PMID:26059411; PMID:26519223; PMID:26519223; PMID:26723870; PMID:26586936; PMID:26586936; PMID:27417252; PMID:26586936; PMID:27616468; PMID:34126102; PMID:26723870; PMID:27417252; PMID:27447558; PMID:27543423; PMID:27616468; PMID:28323900; PMID:28606469; PMID:28959534; PMID:28959534; PMID:29738843; PMID:29738843; PMID:29879412; PMID:29944906; PMID:30452898; PMID:31220555; PMID:32238696; PMID:32428544; PMID:34089817; PMID:34126102; PMID:35395232; PMID:8921280
GO:0008283 Cell population proliferation Increases phenotype PMID:11590323; PMID:12213288; PMID:12884094; PMID:15728126; PMID:16357177; PMID:17320769; PMID:24471873; PMID:24994473; PMID:25993309; PMID:26721606; PMID:17557286; PMID:17574045; PMID:18058806; PMID:18058806; PMID:25801007; PMID:18819900; PMID:19351772; PMID:19448140; PMID:19636294; PMID:19853261; PMID:19996588; PMID:20723315; PMID:21118639; PMID:22085405; PMID:22085405; PMID:22914438; PMID:32562082; PMID:36425765; PMID:22091836; PMID:24060681; PMID:25179160; PMID:22091836; PMID:25993309; PMID:30300626; PMID:22091836; PMID:30300626; PMID:37760451; PMID:37802411; PMID:22914438; PMID:23300844; PMID:23603837; PMID:23603837; PMID:25993309; PMID:23603837; PMID:27543423; PMID:24449132; PMID:24560772; PMID:24799992; PMID:24799992; PMID:24960055; PMID:24886082; PMID:24886082; PMID:25684395; PMID:24960055; PMID:24994473; PMID:25070243; PMID:25684395; PMID:25993309; PMID:26201060; PMID:26391003; PMID:26656794; PMID:26721606; PMID:26768586; PMID:2680578; PMID:27270317; PMID:27270317; PMID:32562082; PMID:36924737; PMID:37956922; PMID:27417252; PMID:27417252; PMID:35179410; PMID:27514524; PMID:27543423; PMID:27888128; PMID:28834734; PMID:30291867; PMID:30342059; PMID:32562082; PMID:32565124; PMID:33031932; PMID:34047436; PMID:36122812; PMID:36336710; PMID:36425765; PMID:36924737; PMID:37352108; PMID:37760451; PMID:37802411
GO:0008284 Positive regulation of cell population proliferation Affects phenotype PMID:15897250; PMID:22552402; PMID:22580740; PMID:23628706; PMID:24345465; PMID:24345465; PMID:28191284; PMID:27840903; PMID:28576465; PMID:29079042; PMID:34664776; PMID:35088190; PMID:36006825
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:18695907; PMID:18695907; PMID:32634519; PMID:21371438; PMID:24196280; PMID:25987058; PMID:26318986; PMID:28117929; PMID:28914995; PMID:29857117; PMID:29857117; PMID:33785417; PMID:34157415; PMID:30368973; PMID:30506648; PMID:30506648; PMID:31101655; PMID:30871063; PMID:31133874; PMID:31563593; PMID:31586452; PMID:31586452; PMID:32800223; PMID:32800223; PMID:33148531; PMID:33148531; PMID:37689368; PMID:33520990; PMID:33785417; PMID:33952797; PMID:34157415; PMID:34196753; PMID:34291863; PMID:34524571; PMID:34822033; PMID:34826200; PMID:34858524; PMID:37689368
GO:0008291 Acetylcholine metabolic process Affects phenotype PMID:38437957
GO:0008347 Glial cell migration Increases phenotype PMID:38437957
GO:0008617 Guanosine metabolic process Affects phenotype PMID:35447140
GO:0008635 Activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c Increases phenotype PMID:22285227
GO:0009259 Ribonucleotide metabolic process Affects phenotype PMID:35447140
GO:0009314 Response to radiation Increases phenotype PMID:31586452
GO:0009408 Response to heat Decreases phenotype PMID:28962077
GO:0009437 Carnitine metabolic process Affects phenotype PMID:35447140; PMID:35788046; PMID:39182635; PMID:39182635
GO:0010189 Vitamin e biosynthetic process Decreases phenotype PMID:25737657
GO:0010389 Regulation of g2/m transition of mitotic cell cycle Affects phenotype PMID:36372261
GO:0010507 Negative regulation of autophagy Increases phenotype PMID:30291731
GO:0010637 Negative regulation of mitochondrial fusion Increases phenotype PMID:31133874
GO:0010890 Positive regulation of sequestering of triglyceride Increases phenotype PMID:36006825
GO:0010917 Negative regulation of mitochondrial membrane potential Increases phenotype PMID:28698153; PMID:33148531; PMID:37704181; PMID:38103742; PMID:38462020; PMID:38490643
GO:0010918 Positive regulation of mitochondrial membrane potential Affects phenotype PMID:25169008; PMID:27722009; PMID:31133874; PMID:33148531
GO:0010940 Positive regulation of necrotic cell death Increases phenotype PMID:24196280; PMID:27815112; PMID:40323313
GO:0010942 Positive regulation of cell death Increases phenotype PMID:19548002; PMID:20705681; PMID:20705681; PMID:22659117; PMID:23053666; PMID:24132751; PMID:24522273; PMID:22490514; PMID:22552402; PMID:22552402; PMID:22659117; PMID:24736981; PMID:22659117; PMID:22659117; PMID:28465190; PMID:23053666; PMID:23123662; PMID:23628706; PMID:23900706; PMID:23911960; PMID:23911960; PMID:31978392; PMID:24132751; PMID:24150977; PMID:24522273; PMID:24736981; PMID:24973089; PMID:25078587; PMID:25091475; PMID:25594011; PMID:25594011; PMID:27806920; PMID:25841332; PMID:25896339; PMID:26193055; PMID:27480280; PMID:27806920; PMID:27806920; PMID:31586452; PMID:31978392; PMID:28408137; PMID:28465190; PMID:28465190; PMID:31978392; PMID:29054700; PMID:29197217; PMID:29454061; PMID:29454061; PMID:30952644; PMID:29471073; PMID:30871063; PMID:30952644; PMID:31586452; PMID:31978392; PMID:34019859; PMID:40323313
GO:0010977 Negative regulation of neuron projection development Increases phenotype PMID:28115644
GO:0010996 Response to auditory stimulus Decreases phenotype PMID:33631298; PMID:39608515
GO:0014067 Negative regulation of phosphatidylinositol 3-kinase signaling Increases phenotype PMID:29148169
GO:0015879 Carnitine transport Affects phenotype PMID:35788046
GO:0015936 Coenzyme a metabolic process Affects phenotype PMID:35447140
GO:0015939 Pantothenate metabolic process Affects phenotype PMID:35447140
GO:0016042 Lipid catabolic process Increases phenotype PMID:17604343; PMID:25665769; PMID:25665769; PMID:29752894; PMID:31153982; PMID:31306688; PMID:25737657; PMID:25737657; PMID:26612654; PMID:26961486; PMID:27616468; PMID:29852128; PMID:30452898; PMID:31103702; PMID:25776512; PMID:25806124; PMID:26612654; PMID:26961486; PMID:27616468; PMID:28371137; PMID:28606469; PMID:29216766; PMID:29216766; PMID:33522649; PMID:29752894; PMID:29852128; PMID:29962303; PMID:30452898; PMID:30550853; PMID:31103702; PMID:31149761; PMID:31153982; PMID:31306688; PMID:32504734; PMID:32504734; PMID:32991863; PMID:34476871; PMID:34560070; PMID:32565124; PMID:32565124; PMID:33757793; PMID:34047436; PMID:32567747; PMID:32860823; PMID:32991863; PMID:33393703; PMID:33522649; PMID:33587916; PMID:33757793; PMID:33757793; PMID:34047436; PMID:34047436; PMID:34302894; PMID:34476871; PMID:34560070; PMID:34560070; PMID:35243731; PMID:35395232
GO:0016049 Cell growth Increases phenotype PMID:27270317; PMID:27270317; PMID:29690507; PMID:28073184; PMID:29273566; PMID:29471006; PMID:29690507; PMID:29852128; PMID:29890265; PMID:29944906; PMID:30291867; PMID:30365942; PMID:30452898; PMID:33244087; PMID:34687144; PMID:37956922
GO:0016174 Nad(p)h oxidase h2o2-forming activity Increases phenotype PMID:24291008
GO:0016477 Cell migration Decreases phenotype PMID:32918990; PMID:33164868; PMID:34990753; PMID:35279909; PMID:35569513
GO:0016505 Peptidase activator activity involved in apoptotic process Increases phenotype PMID:28699141; PMID:31586452
GO:0016567 Protein ubiquitination Decreases phenotype PMID:33631298
GO:0016615 Malate dehydrogenase activity Decreases phenotype PMID:33832332
GO:0018126 Protein hydroxylation Increases phenotype PMID:31612257
GO:0018158 Protein oxidation Increases phenotype PMID:17604343; PMID:33393703; PMID:25737657; PMID:25737657; PMID:26612654; PMID:30125553; PMID:26120027; PMID:26612654; PMID:30125553; PMID:32860823; PMID:32860823; PMID:33393703; PMID:33587916
GO:0019046 Release from viral latency Increases phenotype PMID:30550853
GO:0019222 Regulation of metabolic process Affects phenotype PMID:31926187
GO:0019233 Sensory perception of pain Decreases phenotype PMID:31493026
GO:0019249 Lactate biosynthetic process Decreases phenotype PMID:28073184
GO:0019627 Urea metabolic process Affects phenotype PMID:23229315; PMID:23229315; PMID:29599129; PMID:29599129; PMID:31612257; PMID:34476871
GO:0019628 Urate catabolic process Decreases phenotype PMID:32742113
GO:0019674 Nad metabolic process Increases phenotype PMID:27722009; PMID:34089817
GO:0019695 Choline metabolic process Affects phenotype PMID:35447140
GO:0019852 L-ascorbic acid metabolic process Affects phenotype PMID:26120027; PMID:35243731
GO:0019853 L-ascorbic acid biosynthetic process Decreases phenotype PMID:22987311; PMID:23229315; PMID:23229315; PMID:25737657; PMID:26612654; PMID:25737657; PMID:26612654
GO:0019860 Uracil metabolic process Affects phenotype PMID:35447140
GO:0030199 Collagen fibril organization Increases phenotype PMID:29599129; PMID:32259551; PMID:32259551; PMID:33661552; PMID:33661552; PMID:34533242; PMID:38795875; PMID:38795875; PMID:39892498; PMID:39332792; PMID:39892498
GO:0030262 Apoptotic nuclear changes Increases phenotype PMID:29476062
GO:0030263 Apoptotic chromosome condensation Increases phenotype PMID:32856486; PMID:33393703; PMID:33393703; PMID:33832332; PMID:33832332; PMID:34560070; PMID:39645019
GO:0030264 Nuclear fragmentation involved in apoptotic nuclear change Increases phenotype PMID:31133874
GO:0030308 Negative regulation of cell growth Increases phenotype PMID:36341876; PMID:37087747
GO:0030335 Positive regulation of cell migration Affects phenotype PMID:32800223; PMID:34664776
GO:0030336 Negative regulation of cell migration Increases phenotype PMID:31586452; PMID:37659683
GO:0030899 Calcium-dependent atpase activity Decreases phenotype PMID:37179038
GO:0031175 Neuron projection development Increases phenotype PMID:23434506
GO:0031398 Positive regulation of protein ubiquitination Increases phenotype PMID:32738330
GO:0031987 Locomotion involved in locomotory behavior Decreases phenotype PMID:28962077; PMID:38437957
GO:0032049 Cardiolipin biosynthetic process Decreases phenotype PMID:17604343
GO:0032125 Micronucleus organization Affects phenotype PMID:24798381
GO:0032147 Activation of protein kinase activity Increases phenotype PMID:29476062
GO:0032148 Activation of protein kinase b activity Decreases phenotype PMID:29148169
GO:0032435 Negative regulation of proteasomal ubiquitin-dependent protein catabolic process Increases phenotype PMID:32738330
GO:0032731 Positive regulation of interleukin-1 beta production Increases phenotype PMID:24975837
GO:0032760 Positive regulation of tumor necrosis factor production Increases phenotype PMID:24975837
GO:0032781 Positive regulation of atp-dependent activity Decreases phenotype PMID:25640527
GO:0032930 Positive regulation of superoxide anion generation Increases phenotype PMID:32742113
GO:0033212 Iron import into cell Increases phenotype PMID:39353481
GO:0033554 Cellular response to stress Affects phenotype PMID:24036268
GO:0033685 Negative regulation of luteinizing hormone secretion Increases phenotype PMID:37915485
GO:0034109 Homotypic cell-cell adhesion Increases phenotype PMID:33969609
GO:0034440 Lipid oxidation Increases phenotype PMID:25382014; PMID:25382014; PMID:25640527; PMID:34569348; PMID:39102946; PMID:39978533; PMID:25382014; PMID:34569348; PMID:39102946; PMID:39978533; PMID:25640527; PMID:26120027; PMID:26165641; PMID:26165641; PMID:38014886; PMID:38795875; PMID:27722009; PMID:27815112; PMID:30368973; PMID:37102204; PMID:32621855; PMID:33832332; PMID:33832332; PMID:34151639; PMID:33952797; PMID:34151639; PMID:36460226; PMID:36567042; PMID:37102204; PMID:37395757; PMID:38014886; PMID:38014886; PMID:38795875; PMID:38056807; PMID:38795875; PMID:39102946; PMID:39332792; PMID:39978533
GO:0034504 Protein localization to nucleus Increases phenotype PMID:29191451
GO:0035265 Organ growth Increases phenotype PMID:28321044
GO:0035332 Positive regulation of hippo signaling Increases phenotype PMID:23671600
GO:0035377 Transepithelial water transport Decreases phenotype PMID:31076804
GO:0035498 Carnosine metabolic process Affects phenotype PMID:36100043
GO:0035640 Exploration behavior Decreases phenotype PMID:38437957
GO:0035809 Regulation of urine volume Affects phenotype PMID:35403300
GO:0035810 Positive regulation of urine volume Increases phenotype PMID:29599129
GO:0035815 Positive regulation of renal sodium excretion Decreases phenotype PMID:29599129
GO:0035825 Homologous recombination Decreases phenotype PMID:39461470
GO:0036123 Histone h3-k9 dimethylation Increases phenotype PMID:23429292
GO:0036126 Sperm flagellum Increases phenotype PMID:37915485
GO:0039693 Viral dna genome replication Increases phenotype PMID:30550853
GO:0040015 Negative regulation of multicellular organism growth Increases phenotype PMID:31926187
GO:0040018 Positive regulation of multicellular organism growth Decreases phenotype PMID:29148169
GO:0042078 Germ-line stem cell division Decreases phenotype PMID:29733421
GO:0042132 Fructose 1,6-bisphosphate 1-phosphatase activity Decreases phenotype PMID:33832332
GO:0042246 Tissue regeneration Increases phenotype PMID:28321044
GO:0042310 Vasoconstriction Increases phenotype PMID:19673932
GO:0042360 Vitamin e metabolic process Affects phenotype PMID:30368973; PMID:35243731
GO:0042428 Serotonin metabolic process Affects phenotype PMID:34560070; PMID:35447140
GO:0042448 Progesterone metabolic process Affects phenotype PMID:33587916
GO:0042537 Benzene-containing compound metabolic process Decreases phenotype PMID:29471073
GO:0042554 Superoxide anion generation Affects phenotype PMID:25940438; PMID:26768586; PMID:29191451; PMID:29879412; PMID:31874189
GO:0042572 Retinol metabolic process Affects phenotype PMID:35447140
GO:0042743 Hydrogen peroxide metabolic process Affects phenotype PMID:32565124
GO:0042756 Drinking behavior Affects phenotype PMID:29148169; PMID:29599129
GO:0042981 Regulation of apoptotic process Affects phenotype PMID:39179137
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:15703382; PMID:18483502; PMID:20477944; PMID:20798217; PMID:23041229; PMID:23482746; PMID:23482746; PMID:27392435; PMID:37689368; PMID:24130165; PMID:24563380; PMID:24563380; PMID:34822033; PMID:24973089; PMID:24973089; PMID:36006825; PMID:24980261; PMID:24999622; PMID:24999622; PMID:25159039; PMID:34931434; PMID:35622184; PMID:25159039; PMID:26739623; PMID:26739623; PMID:28119452; PMID:26739623; PMID:37087747; PMID:38462020; PMID:27392435; PMID:27815112; PMID:27840903; PMID:30871063; PMID:28119452; PMID:28624442; PMID:29733421; PMID:29857117; PMID:30871063; PMID:31133874; PMID:32621855; PMID:32800223; PMID:33148531; PMID:33952797; PMID:34822033; PMID:34826200; PMID:34931434; PMID:35304134; PMID:35367536; PMID:35622184; PMID:36006825; PMID:36800006; PMID:37087747; PMID:37179038; PMID:37659683; PMID:37689368; PMID:37863467; PMID:38053498; PMID:38056807; PMID:38059649; PMID:38103742; PMID:38253231; PMID:38490643
GO:0043066 Negative regulation of apoptotic process Affects phenotype PMID:33148531; PMID:34664776; PMID:35088190
GO:0043525 Positive regulation of neuron apoptotic process Increases phenotype PMID:18809400
GO:0044237 Cellular metabolic process Increases phenotype PMID:18468580; PMID:18468580; PMID:31303961; PMID:31306688; PMID:33421460; PMID:33522649; PMID:35569513; PMID:18468580; PMID:36460226; PMID:23410825; PMID:23410825; PMID:25979647; PMID:28302721; PMID:32461103; PMID:32562082; PMID:33164868; PMID:35259468; PMID:35833306; PMID:36460226; PMID:37956922; PMID:25979647; PMID:25979647; PMID:28302721; PMID:32562082; PMID:33465425; PMID:35259468; PMID:35833306; PMID:36070022; PMID:36425765; PMID:28302721; PMID:28960945; PMID:29298499; PMID:29552305; PMID:29567272; PMID:29940172; PMID:29940172; PMID:32024692; PMID:36893906; PMID:37760451; PMID:37802411; PMID:37920924; PMID:29962303; PMID:30804470; PMID:30804470; PMID:31076804; PMID:39182635; PMID:31077746; PMID:36893906; PMID:37802411; PMID:38437957; PMID:31149761; PMID:31152734; PMID:31220555; PMID:31255669; PMID:31256211; PMID:31303961; PMID:31306688; PMID:31594641; PMID:32024692; PMID:32238696; PMID:32418911; PMID:32428544; PMID:32461103; PMID:32562082; PMID:32751388; PMID:32762018; PMID:37700640; PMID:32856486; PMID:32918990; PMID:32918990; PMID:36122806; PMID:39461470; PMID:33031932; PMID:33164868; PMID:33244087; PMID:33465425; PMID:33522649; PMID:33631298; PMID:33634982; PMID:33757793; PMID:34047436; PMID:34182011; PMID:34302894; PMID:34423507; PMID:34533242; PMID:34533242; PMID:39182635; PMID:34560070; PMID:34560070; PMID:35279909; PMID:34785303; PMID:34990753; PMID:35179410; PMID:35219798; PMID:35259468; PMID:35395232; PMID:35525317; PMID:35569513; PMID:36336213; PMID:36070022; PMID:36122806; PMID:36336213; PMID:36336710; PMID:36425765; PMID:37399938; PMID:37497868; PMID:37700640; PMID:37760451; PMID:37769865; PMID:37802411; PMID:37956922; PMID:38219984; PMID:38294069; PMID:38437957; PMID:38830565; PMID:39053794; PMID:39461470; PMID:39608515; PMID:39608515; PMID:39947413; PMID:39828184; PMID:39947413
GO:0044242 Cellular lipid catabolic process Increases phenotype PMID:24239945; PMID:24865317
GO:0044319 Wound healing, spreading of cells Decreases phenotype PMID:31303961; PMID:32418911; PMID:32762018; PMID:32918990; PMID:39053794
GO:0044754 Autolysosome Increases phenotype PMID:30550853; PMID:32562082
GO:0044843 Cell cycle g1/s phase transition Decreases phenotype PMID:28323900
GO:0044849 Estrous cycle Affects phenotype PMID:36567042; PMID:38056807
GO:0045023 G0 to g1 transition Decreases phenotype PMID:32562082; PMID:33522649; PMID:34126102; PMID:37760451; PMID:39461470
GO:0045429 Positive regulation of nitric oxide biosynthetic process Increases phenotype PMID:25640527; PMID:25640527; PMID:28902463; PMID:27815112; PMID:28902463; PMID:32621855; PMID:37179038
GO:0045454 Cell redox homeostasis Decreases phenotype PMID:22271272; PMID:37179038
GO:0045919 Positive regulation of cytolysis Increases phenotype PMID:33952797
GO:0045930 Negative regulation of mitotic cell cycle Increases phenotype PMID:18468580; PMID:19548002; PMID:24799992; PMID:24994473; PMID:25776512; PMID:25979647; PMID:25940438; PMID:25979647; PMID:26193055; PMID:26201060; PMID:26201060; PMID:31303961; PMID:27514524; PMID:27594783; PMID:28027876; PMID:29944906; PMID:30291867; PMID:31303961; PMID:32562082; PMID:34822033
GO:0045931 Positive regulation of mitotic cell cycle Decreases phenotype PMID:18483502; PMID:28576465
GO:0046034 Atp metabolic process Affects phenotype PMID:34762139; PMID:36567042; PMID:37497868
GO:0046058 Camp metabolic process Affects phenotype PMID:33757793
GO:0046110 Xanthine metabolic process Affects phenotype PMID:35447140
GO:0046209 Nitric oxide metabolic process Increases phenotype PMID:26120027; PMID:32860823; PMID:33393703; PMID:33757793; PMID:39102946; PMID:39332792
GO:0046323 Glucose import Decreases phenotype PMID:28073184
GO:0046325 Negative regulation of glucose import Increases phenotype PMID:36800006
GO:0046330 Positive regulation of jnk cascade Increases phenotype PMID:18483502
GO:0046415 Urate metabolic process Decreases phenotype PMID:23649842; PMID:30125553; PMID:24975837; PMID:28119452; PMID:29476062; PMID:35367536; PMID:28414026; PMID:28414026; PMID:30682439; PMID:28902463; PMID:28902463; PMID:31926187; PMID:32777238; PMID:29476062; PMID:30291731; PMID:32777238; PMID:33522649; PMID:33522649; PMID:34569348; PMID:34569348; PMID:35367536
GO:0046449 Creatinine metabolic process Decreases phenotype PMID:23229315; PMID:23229315; PMID:23649842; PMID:29599129; PMID:37561086; PMID:24975837; PMID:24975837; PMID:29752894; PMID:32787450; PMID:34423507; PMID:34476871; PMID:34533242; PMID:34560070; PMID:34658261; PMID:35403300; PMID:37057715; PMID:37956922; PMID:38795875; PMID:39892498; PMID:28073184; PMID:28119452; PMID:29476062; PMID:35367536; PMID:28414026; PMID:28414026; PMID:30682439; PMID:28902463; PMID:28902463; PMID:31926187; PMID:32777238; PMID:33965372; PMID:29216766; PMID:29216766; PMID:29852128; PMID:31103702; PMID:31612257; PMID:33522649; PMID:34569348; PMID:39102946; PMID:39182635; PMID:39645019; PMID:39978533; PMID:29216766; PMID:31612257; PMID:33522649; PMID:34569348; PMID:39102946; PMID:39182635; PMID:39645019; PMID:39978533; PMID:29476062; PMID:29599129; PMID:29599129; PMID:37561086; PMID:29752894; PMID:29752894; PMID:34533242; PMID:29852128; PMID:30291731; PMID:31103702; PMID:31612257; PMID:31612257; PMID:37102204; PMID:32777238; PMID:32787450; PMID:32787450; PMID:34423507; PMID:34476871; PMID:34533242; PMID:34560070; PMID:34658261; PMID:35403300; PMID:37057715; PMID:37956922; PMID:38795875; PMID:39892498; PMID:33522649; PMID:34423507; PMID:34476871; PMID:34533242; PMID:34560070; PMID:34658261; PMID:35367536; PMID:37057715; PMID:37102204; PMID:37561086; PMID:38795875; PMID:39102946; PMID:39332792; PMID:39645019; PMID:39892498; PMID:39978533
GO:0046466 Membrane lipid catabolic process Increases phenotype PMID:12815610; PMID:12815610; PMID:15027813; PMID:15027813; PMID:17886225; PMID:1812305; PMID:38056807; PMID:38490643
GO:0046618 Xenobiotic export from cell Decreases phenotype PMID:25841332
GO:0046620 Regulation of organ growth Affects phenotype PMID:12815610; PMID:17886225
GO:0046621 Negative regulation of organ growth Increases phenotype PMID:32621855
GO:0046882 Negative regulation of follicle-stimulating hormone secretion Increases phenotype PMID:37915485
GO:0048266 Behavioral response to pain Increases phenotype PMID:28962077
GO:0048675 Axon extension Decreases phenotype PMID:18809400
GO:0048812 Neuron projection morphogenesis Decreases phenotype PMID:37395757
GO:0050665 Hydrogen peroxide biosynthetic process Increases phenotype PMID:26612654; PMID:28698153
GO:0050729 Positive regulation of inflammatory response Increases phenotype PMID:32621855; PMID:37087747
GO:0050885 Neuromuscular process controlling balance Affects phenotype PMID:28962077
GO:0050996 Positive regulation of lipid catabolic process Increases phenotype PMID:32742113; PMID:37179038; PMID:38522819
GO:0051092 Positive regulation of nf-kappab transcription factor activity Increases phenotype PMID:25184746; PMID:28119452
GO:0051402 Neuron apoptotic process Increases phenotype PMID:37395757
GO:0051726 Regulation of cell cycle Affects phenotype PMID:33520990
GO:0051881 Regulation of mitochondrial membrane potential Decreases phenotype PMID:17574045; PMID:18676776; PMID:18809400; PMID:24291008; PMID:24994473; PMID:24994473; PMID:26721606; PMID:26721606; PMID:26768586; PMID:29549912; PMID:29890265; PMID:29944906; PMID:30452898; PMID:31255669; PMID:34423507; PMID:35395232; PMID:37395757; PMID:37497868; PMID:39053794
GO:0051882 Mitochondrial depolarization Increases phenotype PMID:32762018; PMID:33393703
GO:0051899 Membrane depolarization Increases phenotype PMID:37497868; PMID:39053794
GO:0055069 Zinc ion homeostasis Decreases phenotype PMID:25382014
GO:0055070 Copper ion homeostasis Decreases phenotype PMID:25382014
GO:0055072 Iron ion homeostasis Affects phenotype PMID:33969609; PMID:34302894; PMID:38014886; PMID:38056807
GO:0055078 Sodium ion homeostasis Affects phenotype PMID:29599129
GO:0060073 Micturition Affects phenotype PMID:35403300
GO:0060112 Generation of ovulation cycle rhythm Affects phenotype PMID:31874189
GO:0060117 Auditory receptor cell development Decreases phenotype PMID:34302894
GO:0060326 Cell chemotaxis Decreases phenotype PMID:32619082; PMID:32918990; PMID:35279909; PMID:39053794
GO:0060547 Negative regulation of necrotic cell death Increases phenotype PMID:27722009
GO:0061333 Renal tubule morphogenesis Affects phenotype PMID:37087747
GO:0061370 Testosterone biosynthetic process Affects phenotype PMID:32565124; PMID:33757793; PMID:33757793; PMID:34047436; PMID:36122812; PMID:34047436; PMID:36122812
GO:0061739 Protein lipidation involved in autophagosome assembly Affects phenotype PMID:25987058; PMID:28408137; PMID:29454061; PMID:30291731; PMID:31563593
GO:0061827 Sperm head Increases phenotype PMID:37915485
GO:0070212 Protein poly-adp-ribosylation Affects phenotype PMID:18468580; PMID:23410825
GO:0070265 Necrotic cell death Affects phenotype PMID:24975837; PMID:25806124; PMID:27397436; PMID:27397436; PMID:29216766; PMID:39978533; PMID:29216766; PMID:29471006; PMID:29471006; PMID:29752894; PMID:32856486; PMID:29752894; PMID:29852128; PMID:29879412; PMID:31271808; PMID:32856486; PMID:32888910; PMID:33393703; PMID:33393703; PMID:33661552; PMID:33832332; PMID:33661552; PMID:33832332; PMID:34151639; PMID:34560070; PMID:34569348; PMID:36336213; PMID:39102946; PMID:39892498; PMID:39978533
GO:0070269 Pyroptosis Affects phenotype PMID:31518571; PMID:35525317
GO:0070301 Cellular response to hydrogen peroxide Increases phenotype PMID:26519223
GO:0070328 Triglyceride homeostasis Decreases phenotype PMID:35367536
GO:0070373 Negative regulation of erk1 and erk2 cascade Increases phenotype PMID:29148169
GO:0070374 Positive regulation of erk1 and erk2 cascade Increases phenotype PMID:16386719
GO:0070584 Mitochondrion morphogenesis Decreases phenotype PMID:18809400
GO:0070782 Phosphatidylserine exposure on apoptotic cell surface Increases phenotype PMID:17097791
GO:0070994 Detection of oxidative stress Affects phenotype PMID:23384965; PMID:24113306; PMID:24113306; PMID:34533242; PMID:24291008; PMID:25043994; PMID:25043994; PMID:34476871; PMID:39892498; PMID:34151639; PMID:34151639; PMID:36270770; PMID:34476871; PMID:34476871; PMID:39892498; PMID:34533242; PMID:34569348; PMID:34569348; PMID:37561086; PMID:39645019; PMID:34785303; PMID:36122812; PMID:36270770; PMID:37561086; PMID:39645019; PMID:39608515; PMID:39645019; PMID:39892498
GO:0071169 Establishment of protein localization to chromatin Increases phenotype PMID:35842499
GO:0071466 Cellular response to xenobiotic stimulus Increases phenotype PMID:27417252; PMID:30550853
GO:0071674 Mononuclear cell migration Increases phenotype PMID:38795875
GO:0072520 Seminiferous tubule development Decreases phenotype PMID:37915485
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:29962303; PMID:31255669; PMID:32428544; PMID:32428544; PMID:36965608; PMID:32860823; PMID:33031932; PMID:33393703; PMID:33634982; PMID:34089817; PMID:34302894; PMID:34560070; PMID:34560070; PMID:38462020; PMID:35395232; PMID:36070022; PMID:36460226; PMID:36460226; PMID:37956922; PMID:36965608; PMID:37395757; PMID:37497868; PMID:37956922; PMID:38056807; PMID:38462020; PMID:39053794
GO:0072676 Lymphocyte migration Increases phenotype PMID:31493026
GO:0072718 Response to cisplatin Decreases phenotype PMID:31563593; PMID:34524571; PMID:34664776
GO:0072719 Cellular response to cisplatin Increases phenotype PMID:21696631; PMID:23434506; PMID:27994509; PMID:27994509; PMID:35088190; PMID:30506648; PMID:30871063; PMID:31255669; PMID:33785417; PMID:35088190
GO:0090200 Positive regulation of release of cytochrome c from mitochondria Increases phenotype PMID:25184746
GO:0090298 Negative regulation of mitochondrial dna replication Increases phenotype PMID:37179038
GO:0090324 Negative regulation of oxidative phosphorylation Increases phenotype PMID:38522819
GO:0090398 Cellular senescence Increases phenotype PMID:33491125; PMID:36372261
GO:0090659 Walking behavior Affects phenotype PMID:28962077
GO:0097189 Apoptotic body Increases phenotype PMID:24676941; PMID:39053794
GO:0097225 Sperm midpiece Increases phenotype PMID:37915485
GO:0097298 Regulation of nucleus size Affects phenotype PMID:39102946
GO:0097327 Response to antineoplastic agent Increases phenotype PMID:20705681; PMID:20798217; PMID:21371438; PMID:24130165; PMID:24345465; PMID:24736981; PMID:24999622; PMID:25351371; PMID:27736728; PMID:28408137; PMID:28576465; PMID:28624442; PMID:29476062; PMID:31133874; PMID:33148531
GO:0097531 Mast cell migration Increases phenotype PMID:37352108
GO:0097707 Ferroptosis Affects phenotype PMID:34302894; PMID:34785303; PMID:38014886
GO:0097722 Sperm motility Decreases phenotype PMID:28606469; PMID:32565124; PMID:33757793
GO:0098609 Cell-cell adhesion Decreases phenotype PMID:23625948; PMID:32562082
GO:0098657 Import into cell Affects phenotype PMID:31255669
GO:0098683 Cochlear hair cell ribbon synapse Decreases phenotype PMID:32428544
GO:0098743 Cell aggregation Affects phenotype PMID:30143678; PMID:33785417
GO:0098808 Mrna cap binding Increases phenotype PMID:25624349
GO:0099156 Cell-cell signaling via exosome Increases phenotype PMID:35088190
GO:0140042 Lipid droplet formation Increases phenotype PMID:35367536
GO:0140639 Positive regulation of pyroptosis Increases phenotype PMID:36341876
GO:0160020 Positive regulation of ferroptosis Increases phenotype PMID:38056807; PMID:38670420; PMID:39353481
GO:1900408 Negative regulation of cellular response to oxidative stress Increases phenotype PMID:25184746
GO:1900409 Positive regulation of cellular response to oxidative stress Increases phenotype PMID:37987512
GO:1900745 Positive regulation of p38mapk cascade Increases phenotype PMID:16386719; PMID:26739623
GO:1901098 Positive regulation of autophagosome maturation Increases phenotype PMID:29476062
GO:1901224 Positive regulation of nik/nf-kappab signaling Increases phenotype PMID:25184746; PMID:28119452
GO:1901318 Negative regulation of flagellated sperm motility Increases phenotype PMID:32621855; PMID:37915485
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:22271272; PMID:27722009; PMID:33952797; PMID:37915485; PMID:38462020; PMID:38490643
GO:1901671 Positive regulation of superoxide dismutase activity Affects phenotype PMID:25382014; PMID:25382014; PMID:25640527; PMID:25640527; PMID:26120027; PMID:29148169
GO:1901687 Glutathione derivative biosynthetic process Decreases phenotype PMID:22271272; PMID:25640527
GO:1901713 Negative regulation of urea catabolic process Increases phenotype PMID:32742113
GO:1901896 Positive regulation of atpase-coupled calcium transmembrane transporter activity Decreases phenotype PMID:26120027
GO:1901988 Negative regulation of cell cycle phase transition Increases phenotype PMID:38253231
GO:1901990 Regulation of mitotic cell cycle phase transition Increases phenotype PMID:38053498
GO:1901992 Positive regulation of mitotic cell cycle phase transition Decreases phenotype PMID:27840903; PMID:28414026
GO:1902110 Positive regulation of mitochondrial membrane permeability involved in apoptotic process Increases phenotype PMID:22285227
GO:1902459 Positive regulation of stem cell population maintenance Increases phenotype PMID:20705681
GO:1902512 Positive regulation of apoptotic dna fragmentation Increases phenotype PMID:25640527; PMID:26120027; PMID:26193055; PMID:9751194
GO:1902520 Response to doxorubicin Decreases phenotype PMID:31563593
GO:1902552 Negative regulation of catalase activity Increases phenotype PMID:37915485
GO:1902806 Regulation of cell cycle g1/s phase transition Affects phenotype PMID:28323900
GO:1902807 Negative regulation of cell cycle g1/s phase transition Increases phenotype PMID:35567596
GO:1903047 Mitotic cell cycle process Affects phenotype PMID:28371273; PMID:31255669; PMID:36425765; PMID:37760451; PMID:39461470
GO:1903283 Negative regulation of glutathione peroxidase activity Increases phenotype PMID:22271272; PMID:27722009; PMID:37915485
GO:1903284 Positive regulation of glutathione peroxidase activity Decreases phenotype PMID:25382014; PMID:25382014; PMID:25640527; PMID:25640527; PMID:26120027
GO:1903408 Positive regulation of p-type sodium:potassium-exchanging transporter activity Decreases phenotype PMID:26120027
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:24799992; PMID:24799992; PMID:29890265; PMID:30550853; PMID:26612654; PMID:29471006; PMID:29690507; PMID:29879412; PMID:30452898; PMID:30550853; PMID:31153982; PMID:36372261
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Affects phenotype PMID:22147442; PMID:22147442; PMID:29454061; PMID:24999622; PMID:25896339; PMID:26120027; PMID:26193055; PMID:28624442; PMID:29454061; PMID:29857117; PMID:32800223; PMID:34822033; PMID:37087747; PMID:37179038; PMID:37689368; PMID:37915485; PMID:37987512; PMID:38059649; PMID:38103742; PMID:38490643; PMID:39353481
GO:1903430 Negative regulation of cell maturation Increases phenotype PMID:34437932
GO:1903599 Positive regulation of autophagy of mitochondrion Decreases phenotype PMID:25598344
GO:1903753 Negative regulation of p38mapk cascade Increases phenotype PMID:29148169
GO:1903787 Negative regulation of glutathione biosynthetic process Increases phenotype PMID:32742113; PMID:33520990
GO:1903999 Negative regulation of eating behavior Increases phenotype PMID:31926187
GO:1904037 Positive regulation of epithelial cell apoptotic process Increases phenotype PMID:22147442
GO:1904479 Negative regulation of intestinal absorption Increases phenotype PMID:33965372
GO:1905037 Autophagosome organization Increases phenotype PMID:36070022
GO:1905517 Macrophage migration Increases phenotype PMID:32888910
GO:1990266 Neutrophil migration Increases phenotype PMID:32888910
GO:1990349 Gap junction-mediated intercellular transport Increases phenotype PMID:23900706
GO:2000255 Negative regulation of male germ cell proliferation Increases phenotype PMID:29733421
GO:2000648 Positive regulation of stem cell proliferation Increases phenotype PMID:20705681; PMID:34437932
GO:2000737 Negative regulation of stem cell differentiation Increases phenotype PMID:35894553
GO:2000774 Positive regulation of cellular senescence Increases phenotype PMID:24130165
GO:2000786 Positive regulation of autophagosome assembly Increases phenotype PMID:29454061; PMID:29476062
GO:2000844 Negative regulation of testosterone secretion Increases phenotype PMID:32621855; PMID:37915485
GO:2000845 Positive regulation of testosterone secretion Decreases phenotype PMID:27815112
GO:2001025 Positive regulation of response to drug Increases phenotype PMID:34135758
GO:2001040 Positive regulation of cellular response to drug Increases phenotype PMID:15294447
GO:2001057 Reactive nitrogen species metabolic process Increases phenotype PMID:26193055
GO:2001170 Negative regulation of atp biosynthetic process Increases phenotype PMID:37179038; PMID:37660997
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.