di-N-Octyl Phthalate


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0006699 Bile acid biosynthetic process Increases phenotype PMID:29128616
GO:0006750 Glutathione biosynthetic process Increases phenotype PMID:29128616
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:34822940
GO:0007005 Mitochondrion organization Affects phenotype PMID:34822940
GO:0007283 Spermatogenesis Decreases phenotype PMID:37364641
GO:0008283 Cell population proliferation Increases phenotype PMID:29128616
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:35739755
GO:0010906 Regulation of glucose metabolic process Affects phenotype PMID:35739755; PMID:37364641
GO:0033327 Leydig cell differentiation Decreases phenotype PMID:33075588
GO:0034599 Cellular response to oxidative stress Increases phenotype PMID:33052911
GO:0035360 Positive regulation of peroxisome proliferator activated receptor signaling pathway Increases phenotype PMID:26519955
GO:0042632 Cholesterol homeostasis Decreases phenotype PMID:35739755
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:35739755; PMID:37364641
GO:0044237 Cellular metabolic process Decreases phenotype PMID:34822940
GO:0046034 Atp metabolic process Affects phenotype PMID:34822940
GO:0046881 Positive regulation of follicle-stimulating hormone secretion Increases phenotype PMID:37364641
GO:0050890 Cognition Decreases phenotype PMID:32716663
GO:0070328 Triglyceride homeostasis Decreases phenotype PMID:35739755
GO:0070994 Detection of oxidative stress Increases phenotype PMID:34822940
GO:0072520 Seminiferous tubule development Affects phenotype PMID:37364641
GO:0072593 Reactive oxygen species metabolic process Affects phenotype PMID:34822940
GO:0140354 Lipid import into cell Increases phenotype PMID:35739755
GO:0160024 Leydig cell proliferation Decreases phenotype PMID:33075588
GO:1902884 Positive regulation of response to oxidative stress Increases phenotype PMID:35739755
GO:1904598 Positive regulation of connective tissue replacement involved in inflammatory response wound healing Increases phenotype PMID:35739755
GO:2000180 Negative regulation of androgen biosynthetic process Increases phenotype PMID:33075588
GO:2000844 Negative regulation of testosterone secretion Increases phenotype PMID:33075588
GO:2000845 Positive regulation of testosterone secretion Increases phenotype PMID:37364641
GO:2000866 Positive regulation of estradiol secretion Increases phenotype PMID:37364641
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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.