Carbonyl cyanide (m-chlorophenyl)hydrazone


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000422 Autophagy of mitochondrion Increases phenotype PMID:22872702
GO:0000423 Mitophagy Increases phenotype PMID:28673964; PMID:30144575
GO:0005391 P-type sodium:potassium-exchanging transporter activity Decreases phenotype PMID:34170461
GO:0006119 Oxidative phosphorylation Decreases phenotype PMID:16787656
GO:0006497 Protein lipidation Increases phenotype PMID:32142837; PMID:34481905
GO:0006606 Protein import into nucleus Affects phenotype PMID:33524445
GO:0006839 Mitochondrial transport Decreases phenotype PMID:24315374
GO:0006874 Cellular calcium ion homeostasis Affects phenotype PMID:33524445
GO:0006915 Apoptotic process Increases phenotype PMID:28673964
GO:0006979 Response to oxidative stress Increases phenotype PMID:18676402
GO:0007005 Mitochondrion organization Decreases phenotype PMID:20307494
GO:0008104 Protein localization Affects phenotype PMID:24879156
GO:0008219 Cell death Increases phenotype PMID:11535817
GO:0008283 Cell population proliferation Decreases phenotype PMID:24189122
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:29241732
GO:0009060 Aerobic respiration Increases phenotype PMID:24658017; PMID:26187750; PMID:27554043
GO:0010917 Negative regulation of mitochondrial membrane potential Increases phenotype PMID:28112198; PMID:29203145; PMID:29371327; PMID:30673822; PMID:33161305; PMID:34089800; PMID:34560092; PMID:38040083
GO:0010918 Positive regulation of mitochondrial membrane potential Affects phenotype PMID:25160872; PMID:25446377; PMID:25446377; PMID:30576621; PMID:25451591; PMID:25462594; PMID:25686698; PMID:26070385; PMID:27554043; PMID:29241732; PMID:29288688; PMID:30009776; PMID:32587277
GO:0010942 Positive regulation of cell death Increases phenotype PMID:33161305
GO:0016049 Cell growth Decreases phenotype PMID:28688199
GO:0016567 Protein ubiquitination Increases phenotype PMID:39442788
GO:0042391 Regulation of membrane potential Affects phenotype PMID:24792648
GO:0042775 Mitochondrial atp synthesis coupled electron transport Decreases phenotype PMID:25746382
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:29241732; PMID:33161305
GO:0045333 Cellular respiration Affects phenotype PMID:28567457; PMID:31629068
GO:0045821 Positive regulation of glycolytic process Increases phenotype PMID:25746382
GO:0046034 Atp metabolic process Affects phenotype PMID:34170461
GO:0046466 Membrane lipid catabolic process Increases phenotype PMID:10967318
GO:0046902 Regulation of mitochondrial membrane permeability Affects phenotype PMID:31708537
GO:0051881 Regulation of mitochondrial membrane potential Decreases phenotype PMID:16753142; PMID:17912452; PMID:18172213; PMID:23266427; PMID:24189122; PMID:26260164; PMID:28673964; PMID:31639374; PMID:31708537; PMID:32652078; PMID:33592258; PMID:33630204; PMID:36336213; PMID:36460223; PMID:37268255; PMID:38748041
GO:0051882 Mitochondrial depolarization Increases phenotype PMID:18022205; PMID:31708537; PMID:31730886; PMID:34302491; PMID:35850439; PMID:35985368
GO:0051901 Positive regulation of mitochondrial depolarization Increases phenotype PMID:22509279; PMID:30502353
GO:0061739 Protein lipidation involved in autophagosome assembly Increases phenotype PMID:27318970
GO:0070265 Necrotic cell death Increases phenotype PMID:34170461
GO:0070370 Cellular heat acclimation Affects phenotype PMID:3487525
GO:0070585 Protein localization to mitochondrion Increases phenotype PMID:29241732; PMID:30734931
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:24140496; PMID:24189122; PMID:32652078; PMID:33630204
GO:0072655 Establishment of protein localization to mitochondrion Increases phenotype PMID:28673964
GO:0072656 Maintenance of protein location in mitochondrion Decreases phenotype PMID:28940366
GO:0099093 Calcium export from the mitochondrion Increases phenotype PMID:31708537
GO:1901524 Regulation of mitophagy Affects phenotype PMID:29241732
GO:1901526 Positive regulation of mitophagy Increases phenotype PMID:27318970; PMID:27629431; PMID:33161305; PMID:36078115
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:33161305
GO:1903862 Positive regulation of oxidative phosphorylation Increases phenotype PMID:25746382
GO:1905037 Autophagosome organization Increases phenotype PMID:39442788
GO:1905707 Negative regulation of mitochondrial atp synthesis coupled proton transport Increases phenotype PMID:34089800
GO:2001170 Negative regulation of atp biosynthetic process Increases phenotype PMID:29241732; PMID:30673822
GO:2001171 Positive regulation of atp biosynthetic process Decreases phenotype PMID:27554043
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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.