Diazepam


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0001659 Temperature homeostasis Affects phenotype PMID:19767791
GO:0001774 Microglial cell activation Increases phenotype PMID:25448683
GO:0002027 Regulation of heart rate Increases phenotype PMID:1206211; PMID:1206211; PMID:7189484; PMID:3775101; PMID:9101342
GO:0004602 Glutathione peroxidase activity Affects phenotype PMID:27111380
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:27111380
GO:0006457 Protein folding Affects phenotype PMID:32450180
GO:0006811 Monoatomic ion transport Increases phenotype PMID:2167745
GO:0006915 Apoptotic process Increases phenotype PMID:16059654; PMID:19056468
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:32450180
GO:0007268 Chemical synaptic transmission Affects phenotype PMID:12694808
GO:0007625 Grooming behavior Increases phenotype PMID:31075342
GO:0008217 Regulation of blood pressure Decreases phenotype PMID:14729239; PMID:3775101
GO:0008219 Cell death Increases phenotype PMID:23313729
GO:0008283 Cell population proliferation Increases phenotype PMID:16059654; PMID:19782064; PMID:25448683
GO:0009410 Response to xenobiotic stimulus Increases phenotype PMID:30682440
GO:0014049 Positive regulation of glutamate secretion Increases phenotype PMID:28174044
GO:0016042 Lipid catabolic process Increases phenotype PMID:27111380; PMID:29572072; PMID:32450180
GO:0018158 Protein oxidation Increases phenotype PMID:27111380
GO:0030431 Sleep Increases phenotype PMID:27641627
GO:0031644 Regulation of nervous system process Affects phenotype PMID:11027839
GO:0031987 Locomotion involved in locomotory behavior Decreases phenotype PMID:28559105; PMID:28733205
GO:0035640 Exploration behavior Increases phenotype PMID:31075342
GO:0042178 Xenobiotic catabolic process Affects phenotype PMID:27641627
GO:0046209 Nitric oxide metabolic process Affects phenotype PMID:32450180
GO:0050885 Neuromuscular process controlling balance Decreases phenotype PMID:12818372
GO:0051899 Membrane depolarization Increases phenotype PMID:28733205
GO:0051970 Negative regulation of transmission of nerve impulse Increases phenotype PMID:14729239
GO:0060080 Inhibitory postsynaptic potential Increases phenotype PMID:14654092; PMID:19589347
GO:0060081 Membrane hyperpolarization Increases phenotype PMID:28733205; PMID:31075342
GO:0060326 Cell chemotaxis Increases phenotype PMID:2994216
GO:0060856 Establishment of blood-brain barrier Affects phenotype PMID:32450180
GO:0090075 Relaxation of muscle Increases phenotype PMID:12818372
GO:1901216 Positive regulation of neuron death Increases phenotype PMID:28174044
GO:1904457 Positive regulation of neuronal action potential Increases phenotype PMID:28174044
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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.