DEDUCT | Database of Endocrine Disrupting chemicals and their Toxicity profiles

5-Fluorouracil

Curated chemical-phenotype interactions from CTD

GO ID	GO name	Interaction type	Reference
GO:0000052	Citrulline metabolic process	Decreases phenotype	PMID:36203040
GO:0000080	Mitotic g1 phase	Affects phenotype	PMID:38423379; PMID:39922517
GO:0000084	Mitotic s phase	Affects phenotype	PMID:32270916; PMID:39922517
GO:0000086	G2/m transition of mitotic cell cycle	Increases phenotype	PMID:31587439; PMID:39922517
GO:0000278	Mitotic cell cycle	Decreases phenotype	PMID:16709241; PMID:32270916
GO:0001552	Ovarian follicle atresia	Increases phenotype	PMID:30085306
GO:0001776	Leukocyte homeostasis	Decreases phenotype	PMID:29305999
GO:0001836	Release of cytochrome c from mitochondria	Increases phenotype	PMID:25940438; PMID:26544897
GO:0002027	Regulation of heart rate	Affects phenotype	PMID:32524861
GO:0002523	Leukocyte migration involved in inflammatory response	Increases phenotype	PMID:34665902; PMID:34794354; PMID:34800596; PMID:37335224; PMID:37338137
GO:0004035	Alkaline phosphatase activity	Increases phenotype	PMID:23108452; PMID:27836789
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	Increases phenotype	PMID:23108452; PMID:27836789; PMID:29678497
GO:0004197	Cysteine-type endopeptidase activity	Increases phenotype	PMID:34151400
GO:0004364	Glutathione transferase activity	Decreases phenotype	PMID:27836789
GO:0004402	Histone acetyltransferase activity	Increases phenotype	PMID:27194111
GO:0004457	Lactate dehydrogenase activity	Increases phenotype	PMID:27836789
GO:0004602	Glutathione peroxidase activity	Decreases phenotype	PMID:27836789; PMID:28025107; PMID:32752303
GO:0004705	Jun kinase activity	Increases phenotype	PMID:28025107
GO:0004784	Superoxide dismutase activity	Decreases phenotype	PMID:27836789; PMID:33634982; PMID:35235860
GO:0005911	Cell-cell junction	Decreases phenotype	PMID:26310874
GO:0006304	Dna modification	Increases phenotype	PMID:37335224
GO:0006308	Dna catabolic process	Increases phenotype	PMID:19115314; PMID:9379509
GO:0006309	Apoptotic dna fragmentation	Increases phenotype	PMID:11201380; PMID:17399942; PMID:19116755; PMID:2106500
GO:0006338	Chromatin remodeling	Increases phenotype	PMID:39922517
GO:0006412	Translation	Affects phenotype	PMID:15611226
GO:0006534	Cysteine metabolic process	Affects phenotype	PMID:34151400
GO:0006611	Protein export from nucleus	Affects phenotype	PMID:39922517
GO:0006693	Prostaglandin metabolic process	Affects phenotype	PMID:34665902
GO:0006695	Cholesterol biosynthetic process	Increases phenotype	PMID:31129132
GO:0006749	Glutathione metabolic process	Increases phenotype	PMID:31288002; PMID:33634982; PMID:34800596; PMID:35101590
GO:0006750	Glutathione biosynthetic process	Increases phenotype	PMID:31129132
GO:0006754	Atp biosynthetic process	Decreases phenotype	PMID:30518710
GO:0006874	Cellular calcium ion homeostasis	Affects phenotype	PMID:32270916; PMID:34748853
GO:0006879	Cellular iron ion homeostasis	Affects phenotype	PMID:35101590
GO:0006914	Autophagy	Increases phenotype	PMID:19116755; PMID:19816940
GO:0006915	Apoptotic process	Increases phenotype	PMID:10473109; PMID:10473109; PMID:15986848; PMID:17461445; PMID:17461495; PMID:18377724; PMID:19116755; PMID:29879413; PMID:31587439; PMID:32752303; PMID:9192825; PMID:10611156; PMID:10611156; PMID:15904426; PMID:17461495; PMID:17632733; PMID:17704804; PMID:17914563; PMID:17996122; PMID:18075305; PMID:19115314; PMID:19618606; PMID:19816940; PMID:28599477; PMID:29879413; PMID:9379509; PMID:9388485; PMID:9792140; PMID:10611156; PMID:9050858; PMID:10745178; PMID:10891390; PMID:11166918; PMID:11300326; PMID:21594360; PMID:11196169; PMID:11201380; PMID:20682991; PMID:11478694; PMID:11750847; PMID:12150722; PMID:12150722; PMID:15908328; PMID:16027087; PMID:33634982; PMID:12442003; PMID:12442003; PMID:33630204; PMID:12692863; PMID:12792779; PMID:12884094; PMID:12884094; PMID:12941601; PMID:14646558; PMID:19764996; PMID:20188757; PMID:12934351; PMID:12935400; PMID:12935400; PMID:15534911; PMID:14607657; PMID:14607657; PMID:17399942; PMID:21474236; PMID:36122806; PMID:14646558; PMID:15087029; PMID:15124184; PMID:21036698; PMID:9619762; PMID:15282376; PMID:15485462; PMID:15534911; PMID:15534929; PMID:15611226; PMID:15709199; PMID:19097688; PMID:15754201; PMID:15886469; PMID:16491956; PMID:15896711; PMID:15904426; PMID:15908328; PMID:15986848; PMID:16077963; PMID:16377638; PMID:16491956; PMID:16709241; PMID:18497562; PMID:25824412; PMID:26310874; PMID:26544897; PMID:28599477; PMID:16888818; PMID:17207318; PMID:17219956; PMID:17219956; PMID:21461573; PMID:17461445; PMID:17461495; PMID:17632733; PMID:17704804; PMID:17914563; PMID:18074150; PMID:18075305; PMID:18304466; PMID:18320312; PMID:18377724; PMID:18377724; PMID:19885610; PMID:18497562; PMID:19097688; PMID:19116755; PMID:19618606; PMID:19764996; PMID:19816940; PMID:19885610; PMID:20178687; PMID:20188757; PMID:20367642; PMID:20682991; PMID:20844880; PMID:21461573; PMID:21461573; PMID:33630204; PMID:21474236; PMID:21594360; PMID:23941782; PMID:24095863; PMID:24095863; PMID:36861143; PMID:26310874; PMID:28599477; PMID:30871965; PMID:31587439; PMID:32270916; PMID:33630204; PMID:33634982; PMID:36203040; PMID:36861143; PMID:7654318; PMID:8554984; PMID:8917373; PMID:9050858; PMID:9359698; PMID:9379509; PMID:9478007; PMID:9619762
GO:0006974	Cellular response to dna damage stimulus	Increases phenotype	PMID:32270916
GO:0006979	Response to oxidative stress	Increases phenotype	PMID:15896711; PMID:20722640; PMID:21036698
GO:0007005	Mitochondrion organization	Decreases phenotype	PMID:30518710; PMID:35101590
GO:0007049	Cell cycle	Decreases phenotype	PMID:10611156; PMID:10745178; PMID:12792779; PMID:12935400; PMID:14673605; PMID:15043163; PMID:17461495; PMID:9192825; PMID:15754201; PMID:15908328; PMID:17207318; PMID:17461495; PMID:17461495; PMID:18075305; PMID:19115314; PMID:18075305; PMID:18497562; PMID:18834353; PMID:19706800; PMID:20632440; PMID:20632440; PMID:21474236; PMID:21474236; PMID:23941782; PMID:7579353; PMID:8917373; PMID:9299594; PMID:9930367
GO:0007616	Long-term memory	Decreases phenotype	PMID:31651976
GO:0008219	Cell death	Increases phenotype	PMID:10337531; PMID:17399942; PMID:18383853; PMID:18575591; PMID:24518598; PMID:24518598; PMID:30871965; PMID:24737281; PMID:25333773; PMID:26178269; PMID:26235807; PMID:27099147; PMID:30871965; PMID:34151400
GO:0008234	Cysteine-type peptidase activity	Increases phenotype	PMID:36203040
GO:0008283	Cell population proliferation	Decreases phenotype	PMID:10089915; PMID:10611156; PMID:10611156; PMID:17461495; PMID:17541943; PMID:18075305; PMID:19618606; PMID:19816940; PMID:23954321; PMID:24095863; PMID:28599477; PMID:29879413; PMID:7763285; PMID:9379509; PMID:11300326; PMID:11831116; PMID:11831116; PMID:19136700; PMID:12118325; PMID:17699714; PMID:12442003; PMID:12884094; PMID:12884094; PMID:19764996; PMID:20188757; PMID:22992727; PMID:14673605; PMID:14673605; PMID:24095863; PMID:15534911; PMID:15534929; PMID:15709199; PMID:15728126; PMID:15754201; PMID:15896711; PMID:15986848; PMID:15986848; PMID:17461445; PMID:17461495; PMID:29879413; PMID:32752303; PMID:16027087; PMID:28651835; PMID:16546719; PMID:16546719; PMID:17541943; PMID:18575591; PMID:19885610; PMID:25824412; PMID:27163855; PMID:16888818; PMID:17207318; PMID:17219956; PMID:17219956; PMID:21461573; PMID:27163855; PMID:17461445; PMID:17541943; PMID:18075305; PMID:18320312; PMID:18575591; PMID:18594983; PMID:19106745; PMID:19136700; PMID:19442486; PMID:19618606; PMID:19706800; PMID:19764996; PMID:19816940; PMID:19885610; PMID:19914299; PMID:20188757; PMID:20562578; PMID:20722640; PMID:20844880; PMID:21079960; PMID:21461573; PMID:21474236; PMID:21474236; PMID:25824412; PMID:22992727; PMID:23954321; PMID:24036456; PMID:24095863; PMID:25824412; PMID:25824412; PMID:26310874; PMID:28599477; PMID:25824412; PMID:27163855; PMID:25944804; PMID:26310874; PMID:27163855; PMID:28599477; PMID:29917191; PMID:31711903; PMID:36203040; PMID:36318118; PMID:7579353; PMID:8917373; PMID:9299594; PMID:9359698; PMID:9379509
GO:0008284	Positive regulation of cell population proliferation	Decreases phenotype	PMID:15897250; PMID:17912442; PMID:22316295; PMID:25190613; PMID:25936796; PMID:28249781; PMID:29258758
GO:0008285	Negative regulation of cell population proliferation	Affects phenotype	PMID:11961066; PMID:20865757; PMID:32856275; PMID:21371438; PMID:22678527; PMID:26385866; PMID:28906110; PMID:32856275; PMID:31563593; PMID:32294457; PMID:32634519; PMID:32856275; PMID:32949729; PMID:32800223; PMID:32856275; PMID:32949729; PMID:34427968; PMID:39949800
GO:0008361	Regulation of cell size	Affects phenotype	PMID:34151400
GO:0008384	Ikappab kinase activity	Increases phenotype	PMID:26310874
GO:0008610	Lipid biosynthetic process	Affects phenotype	PMID:32535746
GO:0009410	Response to xenobiotic stimulus	Affects phenotype	PMID:26310874
GO:0009790	Embryo development	Decreases phenotype	PMID:26178269
GO:0010918	Positive regulation of mitochondrial membrane potential	Decreases phenotype	PMID:28942281
GO:0010942	Positive regulation of cell death	Increases phenotype	PMID:11961066; PMID:24736981; PMID:24999622; PMID:25189999; PMID:25786529; PMID:29054700
GO:0016042	Lipid catabolic process	Increases phenotype	PMID:28025107; PMID:29117755; PMID:35101590; PMID:35235860
GO:0016049	Cell growth	Decreases phenotype	PMID:29678497; PMID:29879413
GO:0016477	Cell migration	Decreases phenotype	PMID:26310874
GO:0018158	Protein oxidation	Increases phenotype	PMID:32524861
GO:0019395	Fatty acid oxidation	Increases phenotype	PMID:32535746
GO:0019432	Triglyceride biosynthetic process	Increases phenotype	PMID:31129132
GO:0019722	Calcium-mediated signaling	Increases phenotype	PMID:21474236
GO:0021779	Oligodendrocyte cell fate commitment	Decreases phenotype	PMID:25178657
GO:0021915	Neural tube development	Decreases phenotype	PMID:29258758
GO:0030154	Cell differentiation	Affects phenotype	PMID:31711903
GO:0030199	Collagen fibril organization	Increases phenotype	PMID:35101590
GO:0030263	Apoptotic chromosome condensation	Increases phenotype	PMID:34794354
GO:0030335	Positive regulation of cell migration	Affects phenotype	PMID:25936796; PMID:32800223
GO:0030336	Negative regulation of cell migration	Increases phenotype	PMID:37625625
GO:0032125	Micronucleus organization	Affects phenotype	PMID:18621143
GO:0032148	Activation of protein kinase b activity	Decreases phenotype	PMID:29054700
GO:0034101	Erythrocyte homeostasis	Decreases phenotype	PMID:29305999
GO:0034440	Lipid oxidation	Increases phenotype	PMID:31288002; PMID:37335224
GO:0035726	Common myeloid progenitor cell proliferation	Decreases phenotype	PMID:29305999
GO:0042307	Positive regulation of protein import into nucleus	Affects phenotype	PMID:24154490; PMID:28785074
GO:0042552	Myelination	Decreases phenotype	PMID:25178657
GO:0042640	Anagen	Affects phenotype	PMID:39922517
GO:0042756	Drinking behavior	Affects phenotype	PMID:34665902
GO:0043065	Positive regulation of apoptotic process	Increases phenotype	PMID:22316295; PMID:25190613; PMID:25936796; PMID:28249781; PMID:32275922; PMID:32314717; PMID:32800223; PMID:35608750; PMID:37625625
GO:0044237	Cellular metabolic process	Decreases phenotype	PMID:31152734; PMID:31587439; PMID:31587439; PMID:31747558; PMID:32752303; PMID:31747558; PMID:31747558; PMID:33630204; PMID:33880675; PMID:35427566; PMID:36122806; PMID:37934567; PMID:32024692; PMID:32270916; PMID:32535746; PMID:33634982; PMID:35427566; PMID:33030807; PMID:33630204; PMID:33244087; PMID:33630204; PMID:33634982; PMID:33880675; PMID:34151400; PMID:34748853; PMID:34856211; PMID:35101590; PMID:35235860; PMID:35427566; PMID:35690101; PMID:36203040; PMID:36639866; PMID:36639866; PMID:37934567; PMID:38908813; PMID:39334374; PMID:39922517
GO:0044319	Wound healing, spreading of cells	Decreases phenotype	PMID:27163855; PMID:35235860
GO:0045023	G0 to g1 transition	Increases phenotype	PMID:31587439; PMID:32270916; PMID:35235860
GO:0045454	Cell redox homeostasis	Decreases phenotype	PMID:29117755
GO:0045851	Ph reduction	Increases phenotype	PMID:32524861
GO:0045930	Negative regulation of mitotic cell cycle	Increases phenotype	PMID:22316295; PMID:23941782; PMID:24368982; PMID:25824412; PMID:26544897; PMID:27268964; PMID:31587439
GO:0046034	Atp metabolic process	Affects phenotype	PMID:32535746; PMID:32949729; PMID:36203040
GO:0046110	Xanthine metabolic process	Affects phenotype	PMID:34151400
GO:0046460	Neutral lipid biosynthetic process	Increases phenotype	PMID:32535746
GO:0046466	Membrane lipid catabolic process	Increases phenotype	PMID:26921358
GO:0046620	Regulation of organ growth	Decreases phenotype	PMID:20844880
GO:0048598	Embryonic morphogenesis	Decreases phenotype	PMID:26385866
GO:0050665	Hydrogen peroxide biosynthetic process	Increases phenotype	PMID:29117755
GO:0050729	Positive regulation of inflammatory response	Increases phenotype	PMID:30125396
GO:0051490	Negative regulation of filopodium assembly	Increases phenotype	PMID:37625625
GO:0051881	Regulation of mitochondrial membrane potential	Increases phenotype	PMID:15754201; PMID:16491956; PMID:18834353; PMID:19097688; PMID:26544897; PMID:28599477; PMID:27268964; PMID:28599477; PMID:28599477; PMID:29879413; PMID:29879413; PMID:30518710
GO:0051884	Regulation of timing of anagen	Affects phenotype	PMID:39922517
GO:0055007	Cardiac muscle cell differentiation	Affects phenotype	PMID:24704097
GO:0061003	Positive regulation of dendritic spine morphogenesis	Increases phenotype	PMID:31651976
GO:0061739	Protein lipidation involved in autophagosome assembly	Increases phenotype	PMID:31563593
GO:0070265	Necrotic cell death	Increases phenotype	PMID:29678497; PMID:32752303; PMID:34794354; PMID:35101590; PMID:35235860; PMID:39334374
GO:0070365	Hepatocyte differentiation	Increases phenotype	PMID:23108452
GO:0070661	Leukocyte proliferation	Decreases phenotype	PMID:17541943
GO:0070782	Phosphatidylserine exposure on apoptotic cell surface	Increases phenotype	PMID:17097791
GO:0070994	Detection of oxidative stress	Increases phenotype	PMID:32524861; PMID:34665902; PMID:34794354; PMID:34800596; PMID:37338137
GO:0072593	Reactive oxygen species metabolic process	Affects phenotype	PMID:33634982; PMID:34748853; PMID:35101590; PMID:35235860
GO:0097189	Apoptotic body	Increases phenotype	PMID:39922517
GO:0097327	Response to antineoplastic agent	Affects phenotype	PMID:11961066; PMID:21371438; PMID:24736981; PMID:24999622; PMID:32275922
GO:0098508	Endothelial to hematopoietic transition	Increases phenotype	PMID:31404653
GO:0150020	Basal dendrite arborization	Decreases phenotype	PMID:31651976
GO:0150023	Apical dendrite arborization	Decreases phenotype	PMID:31651976
GO:1901222	Regulation of nik/nf-kappab signaling	Increases phenotype	PMID:32314717
GO:1901670	Negative regulation of superoxide dismutase activity	Increases phenotype	PMID:31288002
GO:1902520	Response to doxorubicin	Decreases phenotype	PMID:31563593
GO:1902807	Negative regulation of cell cycle g1/s phase transition	Increases phenotype	PMID:35608750
GO:1903047	Mitotic cell cycle process	Affects phenotype	PMID:35235860; PMID:38423379; PMID:39922517
GO:1903428	Positive regulation of reactive oxygen species biosynthetic process	Increases phenotype	PMID:32800223
GO:1903707	Negative regulation of hemopoiesis	Increases phenotype	PMID:29305999
GO:1904673	Negative regulation of somatic stem cell population maintenance	Increases phenotype	PMID:29305999
GO:1905220	Negative regulation of platelet formation	Increases phenotype	PMID:29305999
GO:1905395	Response to flavonoid	Increases phenotype	PMID:31288002
GO:1905457	Negative regulation of lymphoid progenitor cell differentiation	Increases phenotype	PMID:29305999
GO:2000738	Positive regulation of stem cell differentiation	Decreases phenotype	PMID:25786529
GO:2001040	Positive regulation of cellular response to drug	Increases phenotype	PMID:15294447
GO:2001057	Reactive nitrogen species metabolic process	Affects phenotype	PMID:35235860
GO:2001170	Negative regulation of atp biosynthetic process	Increases phenotype	PMID:28942281

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.