Gossypol


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000212 Meiotic spindle organization Decreases phenotype PMID:34509492
GO:0004784 Superoxide dismutase activity Increases phenotype PMID:34699866
GO:0006309 Apoptotic dna fragmentation Increases phenotype PMID:18840529
GO:0006914 Autophagy Increases phenotype PMID:20587533
GO:0006915 Apoptotic process Increases phenotype PMID:18840529; PMID:21750559; PMID:34509492
GO:0007005 Mitochondrion organization Decreases phenotype PMID:34509492
GO:0008283 Cell population proliferation Affects phenotype PMID:18840529; PMID:3097147
GO:0016049 Cell growth Decreases phenotype PMID:39263880
GO:0016477 Cell migration Increases phenotype PMID:39263880
GO:0031941 Filamentous actin Increases phenotype PMID:39263880
GO:0040038 Polar body extrusion after meiotic divisions Decreases phenotype PMID:34509492
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:35872041
GO:0044237 Cellular metabolic process Decreases phenotype PMID:39263880
GO:0044319 Wound healing, spreading of cells Decreases phenotype PMID:39263880
GO:0046034 Atp metabolic process Affects phenotype PMID:34509492
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:21750559; PMID:34509492
GO:0060326 Cell chemotaxis Affects phenotype PMID:39263880
GO:0070192 Chromosome organization involved in meiotic cell cycle Decreases phenotype PMID:34509492
GO:0070265 Necrotic cell death Increases phenotype PMID:34699866
GO:0070994 Detection of oxidative stress Affects phenotype PMID:34699866
GO:0072593 Reactive oxygen species metabolic process Affects phenotype PMID:34509492
GO:1903047 Mitotic cell cycle process Decreases phenotype PMID:34699866
GO:1903537 Meiotic cell cycle process involved in oocyte maturation Affects phenotype PMID:34509492
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.