Nickel Dichloride


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000045 Autophagosome assembly Affects phenotype PMID:35568058
GO:0000050 Urea cycle Affects phenotype PMID:31639282
GO:0000423 Mitophagy Increases phenotype PMID:36794572
GO:0000902 Cell morphogenesis Affects phenotype PMID:35568058
GO:0001837 Epithelial to mesenchymal transition Increases phenotype PMID:22648416; PMID:38488660
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:21544193; PMID:24670797; PMID:36794572; PMID:38488660
GO:0003994 Aconitate hydratase activity Decreases phenotype PMID:24577088
GO:0004035 Alkaline phosphatase activity Increases phenotype PMID:31639282
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Increases phenotype PMID:34921910
GO:0004364 Glutathione transferase activity Decreases phenotype PMID:31639282
GO:0004396 Hexokinase activity Increases phenotype PMID:24577088
GO:0004457 Lactate dehydrogenase activity Increases phenotype PMID:31639282
GO:0004602 Glutathione peroxidase activity Decreases phenotype PMID:25220231; PMID:30389395; PMID:31639282
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:25220231; PMID:30389395; PMID:31639282; PMID:38488660
GO:0005749 Mitochondrial respiratory chain complex ii, succinate dehydrogenase complex (ubiquinone) Decreases phenotype PMID:34921910
GO:0005750 Mitochondrial respiratory chain complex iii Decreases phenotype PMID:34921910
GO:0005776 Autophagosome Affects phenotype PMID:35568058
GO:0006281 Dna repair Decreases phenotype PMID:24711049
GO:0006497 Protein lipidation Increases phenotype PMID:35568058; PMID:36794572
GO:0006749 Glutathione metabolic process Increases phenotype PMID:34921910; PMID:36421005
GO:0006750 Glutathione biosynthetic process Affects phenotype PMID:31639282
GO:0006790 Sulfur compound metabolic process Increases phenotype PMID:30055191
GO:0006915 Apoptotic process Increases phenotype PMID:31943712
GO:0006979 Response to oxidative stress Affects phenotype PMID:24448832
GO:0007005 Mitochondrion organization Affects phenotype PMID:36794572
GO:0007254 Jnk cascade Decreases phenotype PMID:23536762
GO:0008137 Nadh dehydrogenase (ubiquinone) activity Decreases phenotype PMID:24577088
GO:0008219 Cell death Affects phenotype PMID:22172632; PMID:22770624; PMID:23828460; PMID:24080332; PMID:26865462; PMID:30724446
GO:0008283 Cell population proliferation Decreases phenotype PMID:22770624; PMID:24577088; PMID:25458486; PMID:26044615
GO:0008284 Positive regulation of cell population proliferation Affects phenotype PMID:25446860; PMID:28552779; PMID:30055191
GO:0009636 Response to toxic substance Affects phenotype PMID:24448832
GO:0010045 Response to nickel cation Decreases phenotype PMID:36421005
GO:0010424 Dna methylation on cytosine within a cg sequence Decreases phenotype PMID:34571076
GO:0010575 Positive regulation of vascular endothelial growth factor production Affects phenotype PMID:8537383
GO:0010942 Positive regulation of cell death Increases phenotype PMID:26026961; PMID:28472268; PMID:38104653
GO:0016042 Lipid catabolic process Increases phenotype PMID:25220231; PMID:25560666; PMID:28774209; PMID:30389395; PMID:31639282; PMID:34921910
GO:0016477 Cell migration Increases phenotype PMID:30016632
GO:0030218 Erythrocyte differentiation Affects phenotype PMID:21618677
GO:0030263 Apoptotic chromosome condensation Increases phenotype PMID:31943712
GO:0030335 Positive regulation of cell migration Increases phenotype PMID:26026961; PMID:30055191
GO:0030964 Nadh dehydrogenase complex Decreases phenotype PMID:34921910
GO:0031987 Locomotion involved in locomotory behavior Affects phenotype PMID:35568058
GO:0032088 Negative regulation of nf-kappab transcription factor activity Increases phenotype PMID:23844176
GO:0032125 Micronucleus organization Increases phenotype PMID:31639282
GO:0032148 Activation of protein kinase b activity Increases phenotype PMID:26026961
GO:0032631 Interleukin-27 production Increases phenotype PMID:30421605
GO:0033864 Positive regulation of nad(p)h oxidase activity Increases phenotype PMID:25446860
GO:0034440 Lipid oxidation Increases phenotype PMID:36421005
GO:0035065 Regulation of histone acetylation Affects phenotype PMID:38050843
GO:0038066 P38mapk cascade Decreases phenotype PMID:23536762
GO:0042307 Positive regulation of protein import into nucleus Increases phenotype PMID:29355601
GO:0042391 Regulation of membrane potential Decreases phenotype PMID:28774209
GO:0042554 Superoxide anion generation Increases phenotype PMID:21797922
GO:0042755 Eating behavior Affects phenotype PMID:35568058
GO:0042756 Drinking behavior Affects phenotype PMID:35568058
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:24448832; PMID:36421005; PMID:38104653
GO:0043303 Mast cell degranulation Increases phenotype PMID:21544193
GO:0044237 Cellular metabolic process Decreases phenotype PMID:31943712; PMID:33774146
GO:0045089 Positive regulation of innate immune response Increases phenotype PMID:26456670
GO:0045277 Respiratory chain complex iv Decreases phenotype PMID:34921910
GO:0045454 Cell redox homeostasis Decreases phenotype PMID:28774209
GO:0045930 Negative regulation of mitotic cell cycle Increases phenotype PMID:29110037
GO:0046034 Atp metabolic process Affects phenotype PMID:34921910
GO:0046209 Nitric oxide metabolic process Affects phenotype PMID:31639282
GO:0046449 Creatinine metabolic process Affects phenotype PMID:31639282
GO:0046466 Membrane lipid catabolic process Increases phenotype PMID:9657286
GO:0046722 Lactic acid secretion Increases phenotype PMID:27452194; PMID:33596451
GO:0050679 Positive regulation of epithelial cell proliferation Decreases phenotype PMID:28472268
GO:0051092 Positive regulation of nf-kappab transcription factor activity Increases phenotype PMID:26026961
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:22648416; PMID:38552765
GO:0051882 Mitochondrial depolarization Increases phenotype PMID:34921910
GO:0051899 Membrane depolarization Affects phenotype PMID:28713246
GO:0070994 Detection of oxidative stress Increases phenotype PMID:34921910; PMID:35568058; PMID:38488660
GO:0071421 Manganese ion transmembrane transport Increases phenotype PMID:8549643
GO:0071481 Cellular response to x-ray Increases phenotype PMID:28472268
GO:0072537 Fibroblast activation Increases phenotype PMID:30055191
GO:0072576 Liver morphogenesis Affects phenotype PMID:21618677
GO:0072593 Reactive oxygen species metabolic process Affects phenotype PMID:24448832; PMID:31943712; PMID:34921910; PMID:35568058; PMID:38552765
GO:0097189 Apoptotic body Increases phenotype PMID:31943712
GO:0098703 Calcium ion import across plasma membrane Increases phenotype PMID:8549643
GO:0140888 Interferon-mediated signaling pathway Increases phenotype PMID:37951547
GO:1900227 Positive regulation of nlrp3 inflammasome complex assembly Increases phenotype PMID:24158569
GO:1901224 Positive regulation of nik/nf-kappab signaling Decreases phenotype PMID:23844176
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:36421005
GO:1902512 Positive regulation of apoptotic dna fragmentation Affects phenotype PMID:24448832
GO:1903409 Reactive oxygen species biosynthetic process Affects phenotype PMID:21797922; PMID:22172632; PMID:22648416; PMID:22770624; PMID:26962057; PMID:28774209; PMID:30389395
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:24158569; PMID:26026961; PMID:30055191
GO:1904827 Negative regulation of hydrogen sulfide biosynthetic process Increases phenotype PMID:30055191
GO:1905168 Positive regulation of double-strand break repair via homologous recombination Decreases phenotype PMID:28472268
GO:2000147 Positive regulation of cell motility Decreases phenotype PMID:23844176
GO:2000304 Positive regulation of ceramide biosynthetic process Affects phenotype PMID:24448832
GO:2000774 Positive regulation of cellular senescence Increases phenotype PMID:28552779
GO:2001034 Positive regulation of double-strand break repair via nonhomologous end joining Increases phenotype PMID:28472268
GO:2001057 Reactive nitrogen species metabolic process Affects phenotype PMID:31639282
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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.