Streptozocin


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000016 Lactase activity Decreases phenotype PMID:12428451
GO:0000050 Urea cycle Increases phenotype PMID:29614383; PMID:30927557
GO:0000104 Succinate dehydrogenase activity Decreases phenotype PMID:21799698
GO:0000165 Mapk cascade Increases phenotype PMID:21381899
GO:0000737 Dna catabolic process, endonucleolytic Increases phenotype PMID:32233808; PMID:32233808; PMID:38047382; PMID:38047382
GO:0001516 Prostaglandin biosynthetic process Increases phenotype PMID:30802477
GO:0001525 Angiogenesis Decreases phenotype PMID:35051763
GO:0001553 Luteinization Increases phenotype PMID:30421503
GO:0001780 Neutrophil homeostasis Affects phenotype PMID:33524429
GO:0001821 Histamine secretion Increases phenotype PMID:36547818
GO:0001836 Release of cytochrome c from mitochondria Affects phenotype PMID:21799698; PMID:25541178; PMID:31029786; PMID:34649470; PMID:37431890
GO:0001894 Tissue homeostasis Decreases phenotype PMID:35786680
GO:0001895 Retina homeostasis Affects phenotype PMID:37081038
GO:0002027 Regulation of heart rate Increases phenotype PMID:12477967; PMID:132978; PMID:16423284; PMID:26654777; PMID:29181404; PMID:35305976
GO:0002152 Bile acid conjugation Increases phenotype PMID:29382564
GO:0002158 Osteoclast proliferation Increases phenotype PMID:33450223
GO:0002286 T cell activation involved in immune response Increases phenotype PMID:33524429
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:29291386; PMID:29291386; PMID:29409856; PMID:29409856; PMID:33817209; PMID:34391751; PMID:34470562; PMID:34610774; PMID:34896238; PMID:34922902; PMID:34964214; PMID:36547818; PMID:38084638
GO:0002532 Production of molecular mediator involved in inflammatory response Increases phenotype PMID:37757635
GO:0002931 Response to ischemia Increases phenotype PMID:30611788
GO:0003015 Heart process Affects phenotype PMID:23500772
GO:0003085 Negative regulation of systemic arterial blood pressure Increases phenotype PMID:29274332
GO:0003093 Regulation of glomerular filtration Affects phenotype PMID:22116744
GO:0003094 Glomerular filtration Increases phenotype PMID:2819817; PMID:35243728; PMID:7589874
GO:0003954 Nadh dehydrogenase activity Decreases phenotype PMID:39299373
GO:0003993 Acid phosphatase activity Decreases phenotype PMID:31696645
GO:0003994 Aconitate hydratase activity Decreases phenotype PMID:22940631
GO:0004032 Alditol:nadp+ 1-oxidoreductase activity Increases phenotype PMID:30958922
GO:0004035 Alkaline phosphatase activity Increases phenotype PMID:27350165; PMID:28757134; PMID:28757134; PMID:30144451; PMID:29614383; PMID:29614383; PMID:36169646; PMID:30144451; PMID:31009641; PMID:36169646; PMID:37054934
GO:0004053 Arginase activity Increases phenotype PMID:29059224; PMID:32864810
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Increases phenotype PMID:27350165; PMID:29223569; PMID:29223569; PMID:30144451; PMID:36627075; PMID:29614383; PMID:29614383; PMID:31100278; PMID:36169646; PMID:31100278; PMID:32812462; PMID:33524429; PMID:34896238; PMID:36169646; PMID:36627075; PMID:37054934
GO:0004089 Carbonate dehydratase activity Decreases phenotype PMID:37354076
GO:0004111 Creatine kinase activity Increases phenotype PMID:36650709
GO:0004129 Cytochrome-c oxidase activity Decreases phenotype PMID:39265716; PMID:39299373
GO:0004175 Endopeptidase activity Increases phenotype PMID:30980806
GO:0004177 Aminopeptidase activity Decreases phenotype PMID:31009641
GO:0004340 Glucokinase activity Decreases phenotype PMID:10700396; PMID:10700396; PMID:11357483; PMID:27038876; PMID:11357483; PMID:27038876
GO:0004345 Glucose-6-phosphate dehydrogenase activity Decreases phenotype PMID:27038876; PMID:31606821; PMID:34470562
GO:0004346 Glucose-6-phosphatase activity Increases phenotype PMID:27038876; PMID:28330423; PMID:33823243; PMID:34470562; PMID:36169646
GO:0004364 Glutathione transferase activity Affects phenotype PMID:25905778; PMID:26748309; PMID:30144451; PMID:32812462; PMID:32864810; PMID:32864810; PMID:34477272; PMID:34477272; PMID:34610774; PMID:36650709; PMID:37354076; PMID:38602238
GO:0004373 Glycogen (starch) synthase activity Affects phenotype PMID:10700396; PMID:10700396; PMID:11357483; PMID:25641191; PMID:11357483; PMID:25641191; PMID:26616445
GO:0004396 Hexokinase activity Decreases phenotype PMID:25641191; PMID:34470562
GO:0004407 Histone deacetylase activity Increases phenotype PMID:27270450; PMID:37354076
GO:0004457 Lactate dehydrogenase activity Increases phenotype PMID:24954035; PMID:29409856; PMID:31696645; PMID:32812462; PMID:34656705; PMID:37054934; PMID:37354076
GO:0004575 Sucrose alpha-glucosidase activity Affects phenotype PMID:12428451
GO:0004602 Glutathione peroxidase activity Increases phenotype PMID:11424224; PMID:11424224; PMID:32812462; PMID:11424224; PMID:34039237; PMID:20828602; PMID:22476978; PMID:22476978; PMID:30817903; PMID:32864810; PMID:34477272; PMID:22940631; PMID:24001619; PMID:24001619; PMID:27350165; PMID:24740756; PMID:24854284; PMID:24877639; PMID:26286522; PMID:26341651; PMID:26499206; PMID:26511841; PMID:26748309; PMID:26748309; PMID:30817903; PMID:27350165; PMID:30817903; PMID:33639173; PMID:30958922; PMID:31009641; PMID:31833155; PMID:31833155; PMID:35414346; PMID:37354076; PMID:32202043; PMID:32202043; PMID:32662907; PMID:32303808; PMID:32662907; PMID:32864810; PMID:33484791; PMID:33639173; PMID:34477272; PMID:34610774; PMID:34896238; PMID:35414346; PMID:36169646; PMID:36510688; PMID:37354076
GO:0004611 Phosphoenolpyruvate carboxykinase activity Increases phenotype PMID:25641191
GO:0004674 Protein serine/threonine kinase activity Increases phenotype PMID:30607903
GO:0004679 Amp-activated protein kinase activity Decreases phenotype PMID:34428446
GO:0004697 Protein kinase c activity Increases phenotype PMID:12592403
GO:0004743 Pyruvate kinase activity Decreases phenotype PMID:10700396; PMID:10700396; PMID:11357483; PMID:11357483
GO:0004784 Superoxide dismutase activity Increases phenotype PMID:11424224; PMID:22116744; PMID:25617480; PMID:34039237; PMID:20828602; PMID:21439094; PMID:21664865; PMID:22116744; PMID:22476978; PMID:22476978; PMID:28757134; PMID:30144451; PMID:30817903; PMID:32864810; PMID:34477272; PMID:23406761; PMID:23677724; PMID:24001619; PMID:24001619; PMID:27350165; PMID:24854284; PMID:24877639; PMID:24946264; PMID:24946264; PMID:26748309; PMID:29233026; PMID:30817903; PMID:32710900; PMID:38084638; PMID:24954035; PMID:26286522; PMID:26341651; PMID:26499206; PMID:26499206; PMID:31696645; PMID:26511841; PMID:26511841; PMID:30481507; PMID:26690102; PMID:27350165; PMID:27769711; PMID:28757134; PMID:28757134; PMID:30817903; PMID:29233026; PMID:29247773; PMID:29331653; PMID:29331653; PMID:29409856; PMID:30817903; PMID:33639173; PMID:38602238; PMID:29409856; PMID:29441829; PMID:30481507; PMID:30817903; PMID:30958922; PMID:31009641; PMID:31682803; PMID:31696645; PMID:31833155; PMID:31833155; PMID:35414346; PMID:37354076; PMID:32202043; PMID:32202043; PMID:32662907; PMID:32303808; PMID:32662907; PMID:32812462; PMID:32864810; PMID:33484791; PMID:33639173; PMID:34352274; PMID:34477272; PMID:34610774; PMID:34649470; PMID:34896238; PMID:35414346; PMID:36169646; PMID:36510688; PMID:36650709; PMID:37354076; PMID:38084638; PMID:38602238
GO:0004791 Thioredoxin-disulfide reductase activity Decreases phenotype PMID:24752916
GO:0005391 P-type sodium:potassium-exchanging transporter activity Decreases phenotype PMID:32864810; PMID:37354076
GO:0005747 Mitochondrial respiratory chain complex i Decreases phenotype PMID:31029786
GO:0005749 Mitochondrial respiratory chain complex ii, succinate dehydrogenase complex (ubiquinone) Decreases phenotype PMID:31029786
GO:0005751 Mitochondrial respiratory chain complex iv Decreases phenotype PMID:31029786
GO:0005977 Glycogen metabolic process Increases phenotype PMID:30847815; PMID:31877369; PMID:33484791; PMID:33817209; PMID:33817209; PMID:36627075; PMID:33823243; PMID:34470562; PMID:34896238; PMID:35993117; PMID:36169646; PMID:36627075; PMID:37566541
GO:0005978 Glycogen biosynthetic process Decreases phenotype PMID:10700396; PMID:10700396; PMID:11357483; PMID:22116744; PMID:26616445; PMID:27038876; PMID:29223569; PMID:11357483; PMID:21439094; PMID:26616445; PMID:26616445; PMID:27038876; PMID:27350165; PMID:29223569
GO:0006004 Fucose metabolic process Affects phenotype PMID:32864810
GO:0006006 Glucose metabolic process Increases phenotype PMID:26286522; PMID:27350165; PMID:27350165; PMID:27566243; PMID:27566243; PMID:34391751; PMID:38084638; PMID:38602238; PMID:38602238; PMID:38706688; PMID:38706688
GO:0006054 N-acetylneuraminate metabolic process Affects phenotype PMID:32864810
GO:0006061 Sorbitol biosynthetic process Increases phenotype PMID:15298348; PMID:25986969
GO:0006085 Acetyl-coa biosynthetic process Increases phenotype PMID:22675305
GO:0006089 Lactate metabolic process Affects phenotype PMID:25050809; PMID:34656705; PMID:39922521
GO:0006090 Pyruvate metabolic process Affects phenotype PMID:25050809
GO:0006094 Gluconeogenesis Increases phenotype PMID:15298348; PMID:26071184; PMID:28757134; PMID:30927557
GO:0006101 Citrate metabolic process Affects phenotype PMID:25050809
GO:0006182 Cgmp biosynthetic process Decreases phenotype PMID:26006044
GO:0006304 Dna modification Increases phenotype PMID:23611540; PMID:24889822; PMID:32233808; PMID:34661493
GO:0006309 Apoptotic dna fragmentation Increases phenotype PMID:18721751
GO:0006468 Protein phosphorylation Increases phenotype PMID:24740756
GO:0006520 Amino acid metabolic process Affects phenotype PMID:25669659
GO:0006537 Glutamate biosynthetic process Increases phenotype PMID:15298348
GO:0006601 Creatine biosynthetic process Increases phenotype PMID:30927557
GO:0006631 Fatty acid metabolic process Affects phenotype PMID:33639173; PMID:33817209; PMID:33817209; PMID:35305976; PMID:34896238; PMID:35305976; PMID:37337224
GO:0006633 Fatty acid biosynthetic process Increases phenotype PMID:21439094; PMID:30817903; PMID:31009641
GO:0006635 Fatty acid beta-oxidation Affects phenotype PMID:25050809
GO:0006636 Unsaturated fatty acid biosynthetic process Affects phenotype PMID:31009641
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:29682576; PMID:31877369; PMID:32410268; PMID:33021114; PMID:33359794; PMID:33484791; PMID:33484791; PMID:34610774; PMID:37337224; PMID:39265716; PMID:39579577; PMID:33639173; PMID:33639173; PMID:34477272; PMID:36627075; PMID:36650709; PMID:33817209; PMID:33817209; PMID:35305976; PMID:37044004; PMID:34477272; PMID:34610774; PMID:34656705; PMID:34896238; PMID:35305976; PMID:36169646; PMID:36510688; PMID:36627075; PMID:36650709; PMID:36999408; PMID:37044004; PMID:37054934; PMID:37337224; PMID:37566541; PMID:39047806; PMID:39579577
GO:0006644 Phospholipid metabolic process Affects phenotype PMID:35305976
GO:0006672 Ceramide metabolic process Affects phenotype PMID:32481596
GO:0006684 Sphingomyelin metabolic process Affects phenotype PMID:32481596
GO:0006690 Icosanoid metabolic process Increases phenotype PMID:21832210
GO:0006695 Cholesterol biosynthetic process Increases phenotype PMID:24760747; PMID:24760747; PMID:28757134; PMID:28822685; PMID:25240712; PMID:26071184; PMID:29223569; PMID:26690102; PMID:26690102; PMID:30817903; PMID:27270450; PMID:27270450; PMID:31100278; PMID:27350165; PMID:27769711; PMID:28757134; PMID:28822685; PMID:29223569; PMID:29614383; PMID:30802477; PMID:30817903; PMID:30927557; PMID:31009641; PMID:31100278; PMID:31743741
GO:0006730 One-carbon metabolic process Affects phenotype PMID:29127188
GO:0006749 Glutathione metabolic process Increases phenotype PMID:12242689; PMID:12242689; PMID:21416479; PMID:26286521; PMID:21416479; PMID:21416479; PMID:33639173; PMID:34039237; PMID:34661493; PMID:23147376; PMID:23716880; PMID:23716880; PMID:26286522; PMID:33724628; PMID:24752916; PMID:25986969; PMID:26286521; PMID:26286522; PMID:26522834; PMID:28904557; PMID:29233026; PMID:29233026; PMID:32710900; PMID:33724628; PMID:38084638; PMID:30551545; PMID:30582900; PMID:32710900; PMID:33639173; PMID:33724628; PMID:33823243; PMID:34352274; PMID:34414639; PMID:34455488; PMID:34656705; PMID:34661493; PMID:34896238; PMID:35187753; PMID:35414346; PMID:35414346; PMID:37354076; PMID:36169646; PMID:37354076; PMID:38084638
GO:0006750 Glutathione biosynthetic process Increases phenotype PMID:11424224; PMID:11424224; PMID:28757134; PMID:29223569; PMID:30817903; PMID:15053821; PMID:15053821; PMID:24717679; PMID:29331653; PMID:29409856; PMID:30817903; PMID:20828602; PMID:22116744; PMID:22775417; PMID:22940631; PMID:24001619; PMID:24717679; PMID:24854284; PMID:24877639; PMID:24954035; PMID:25191525; PMID:25541178; PMID:25541178; PMID:26748309; PMID:25617480; PMID:25665769; PMID:26341651; PMID:26748309; PMID:28259689; PMID:28757134; PMID:28757134; PMID:29223569; PMID:29223569; PMID:29247773; PMID:29409856; PMID:30817903; PMID:30958922; PMID:31009641; PMID:31682803
GO:0006754 Atp biosynthetic process Decreases phenotype PMID:21799698; PMID:22940631
GO:0006809 Nitric oxide biosynthetic process Affects phenotype PMID:21664865; PMID:24760747; PMID:26690102; PMID:29059224; PMID:29409856; PMID:29409856; PMID:29606028; PMID:29606028; PMID:30481507
GO:0006811 Monoatomic ion transport Increases phenotype PMID:2819817
GO:0006874 Cellular calcium ion homeostasis Affects phenotype PMID:37337224
GO:0006878 Cellular copper ion homeostasis Decreases phenotype PMID:24927960
GO:0006879 Cellular iron ion homeostasis Affects phenotype PMID:38483099
GO:0006914 Autophagy Affects phenotype PMID:33021114
GO:0006915 Apoptotic process Increases phenotype PMID:11801690; PMID:11801690; PMID:18669601; PMID:20446767; PMID:12540624; PMID:25191525; PMID:15056984; PMID:15056984; PMID:26614261; PMID:30847815; PMID:15964614; PMID:16293769; PMID:16293769; PMID:19626998; PMID:21139377; PMID:24530320; PMID:18669601; PMID:18721751; PMID:19626998; PMID:19840221; PMID:20446767; PMID:20650802; PMID:21139377; PMID:21163323; PMID:21599458; PMID:23406761; PMID:23499715; PMID:23677724; PMID:24530320; PMID:24707343; PMID:24810525; PMID:24880026; PMID:24946264; PMID:24946264; PMID:25541178; PMID:24967692; PMID:25191525; PMID:25541178; PMID:25665769; PMID:26474837; PMID:26614261; PMID:26887929; PMID:30980806; PMID:32233808; PMID:32233808; PMID:38047382; PMID:32554039; PMID:34610774; PMID:34964214; PMID:35187753; PMID:38047382; PMID:38049026; PMID:39579577; PMID:9826672; PMID:9879822
GO:0006939 Smooth muscle contraction Increases phenotype PMID:36547818
GO:0006954 Inflammatory response Affects phenotype PMID:31696645; PMID:31743741; PMID:31877369; PMID:32410268; PMID:33724628; PMID:34610774; PMID:36999408
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:22228707; PMID:22228707; PMID:31173751; PMID:31029786; PMID:31081965; PMID:31173751; PMID:31682803
GO:0006979 Response to oxidative stress Increases phenotype PMID:11589752; PMID:11711510; PMID:11711510; PMID:15957552; PMID:16289604; PMID:11711510; PMID:16289604; PMID:9522273; PMID:11711510; PMID:17589825; PMID:15720789; PMID:15957552; PMID:16752005; PMID:16841179; PMID:17270171; PMID:17270171; PMID:18549673; PMID:21139377; PMID:21163323; PMID:24140466; PMID:17279352; PMID:17589825; PMID:18549673; PMID:18647412; PMID:21381899; PMID:19840221; PMID:20446767; PMID:21139377; PMID:21163323; PMID:21381899; PMID:23147376; PMID:23499715; PMID:23786522; PMID:24140466; PMID:25050809; PMID:30318971; PMID:31400774; PMID:7797090; PMID:9522273
GO:0006996 Organelle organization Affects phenotype PMID:30365938
GO:0007005 Mitochondrion organization Affects phenotype PMID:31726037; PMID:37337224
GO:0007033 Vacuole organization Affects phenotype PMID:31682803; PMID:33817209; PMID:38084638
GO:0007049 Cell cycle Increases phenotype PMID:10887940
GO:0007204 Positive regulation of cytosolic calcium ion concentration Increases phenotype PMID:24333387; PMID:24752916
GO:0007283 Spermatogenesis Decreases phenotype PMID:31696645; PMID:32153207; PMID:32233808; PMID:32233808; PMID:38047382; PMID:38047382
GO:0007286 Spermatid development Decreases phenotype PMID:29953732
GO:0007612 Learning Decreases phenotype PMID:25037167; PMID:30120923; PMID:30481507
GO:0007613 Memory Decreases phenotype PMID:25037167; PMID:30481507; PMID:31833155; PMID:32805344
GO:0007614 Short-term memory Decreases phenotype PMID:24902786; PMID:30607903
GO:0007616 Long-term memory Decreases phenotype PMID:24902786; PMID:30607903
GO:0007617 Mating behavior Decreases phenotype PMID:8417201
GO:0007631 Feeding behavior Increases phenotype PMID:29266779; PMID:30802477; PMID:33817209
GO:0008088 Axo-dendritic transport Decreases phenotype PMID:11099694; PMID:12031555; PMID:20976160; PMID:2431858; PMID:2431858; PMID:2452237
GO:0008137 Nadh dehydrogenase (ubiquinone) activity Decreases phenotype PMID:39265716
GO:0008177 Succinate dehydrogenase (ubiquinone) activity Decreases phenotype PMID:39265716
GO:0008184 Glycogen phosphorylase activity Affects phenotype PMID:10700396; PMID:10700396; PMID:11357483; PMID:11357483; PMID:25641191; PMID:25641191; PMID:27038876; PMID:27038876; PMID:33823243; PMID:34470562
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:31877369; PMID:32410268; PMID:32410268; PMID:33484791; PMID:34610774; PMID:37337224; PMID:39265716; PMID:39579577; PMID:32410268; PMID:39265716; PMID:33021114; PMID:33359794; PMID:33484791; PMID:33484791; PMID:34610774; PMID:37337224; PMID:39265716; PMID:39579577; PMID:33484791; PMID:34610774; PMID:37337224; PMID:39579577; PMID:33639173; PMID:33639173; PMID:34477272; PMID:36627075; PMID:36650709; PMID:33639173; PMID:36627075; PMID:36650709; PMID:33817209; PMID:33817209; PMID:35305976; PMID:37044004; PMID:34477272; PMID:34610774; PMID:34656705; PMID:34896238; PMID:35305976; PMID:35305976; PMID:37044004; PMID:36169646; PMID:36510688; PMID:36627075; PMID:36627075; PMID:36650709; PMID:36650709; PMID:36999408; PMID:37044004; PMID:37054934; PMID:37337224; PMID:37566541; PMID:39579577
GO:0008210 Estrogen metabolic process Affects phenotype PMID:34656705; PMID:34964214
GO:0008217 Regulation of blood pressure Increases phenotype PMID:11240445; PMID:3525850; PMID:11711510; PMID:132978; PMID:17675792; PMID:3525850
GO:0008219 Cell death Increases phenotype PMID:27521901; PMID:30365938
GO:0008253 5'-nucleotidase activity Decreases phenotype PMID:33823243
GO:0008283 Cell population proliferation Affects phenotype PMID:10887940; PMID:12535201; PMID:24530320; PMID:24967692; PMID:25541178; PMID:30847815; PMID:31029786; PMID:37054934
GO:0008284 Positive regulation of cell population proliferation Increases phenotype PMID:33812996
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:32668280
GO:0008286 Insulin receptor signaling pathway Decreases phenotype PMID:23927877
GO:0008344 Adult locomotory behavior Decreases phenotype PMID:34352274
GO:0008361 Regulation of cell size Affects phenotype PMID:27270450
GO:0008584 Male gonad development Decreases phenotype PMID:31682803
GO:0008610 Lipid biosynthetic process Increases phenotype PMID:6337899
GO:0008654 Phospholipid biosynthetic process Increases phenotype PMID:25240712; PMID:30817903; PMID:31009641
GO:0009011 Starch synthase activity Decreases phenotype PMID:34470562
GO:0009100 Glycoprotein metabolic process Affects phenotype PMID:37354076
GO:0009103 Lipopolysaccharide biosynthetic process Affects phenotype PMID:34964214
GO:0009408 Response to heat Affects phenotype PMID:18229453; PMID:38865809
GO:0009448 Gamma-aminobutyric acid metabolic process Affects phenotype PMID:32303808
GO:0010189 Vitamin e biosynthetic process Affects phenotype PMID:22940631; PMID:26748309; PMID:30817903
GO:0010459 Negative regulation of heart rate Increases phenotype PMID:23500772; PMID:29274332
GO:0010666 Positive regulation of cardiac muscle cell apoptotic process Increases phenotype PMID:28856781
GO:0010729 Positive regulation of hydrogen peroxide biosynthetic process Increases phenotype PMID:27997345
GO:0010759 Positive regulation of macrophage chemotaxis Increases phenotype PMID:23611540; PMID:28700904
GO:0010867 Positive regulation of triglyceride biosynthetic process Increases phenotype PMID:30129056; PMID:31606821; PMID:37482253
GO:0010868 Negative regulation of triglyceride biosynthetic process Increases phenotype PMID:15066220
GO:0010890 Positive regulation of sequestering of triglyceride Increases phenotype PMID:23647015
GO:0010906 Regulation of glucose metabolic process Decreases phenotype PMID:30129056; PMID:37482253
GO:0010907 Positive regulation of glucose metabolic process Increases phenotype PMID:15066220; PMID:32810643
GO:0010922 Positive regulation of phosphatase activity Increases phenotype PMID:28330423
GO:0010923 Negative regulation of phosphatase activity Affects phenotype PMID:33823243
GO:0010942 Positive regulation of cell death Increases phenotype PMID:25446853; PMID:26700463; PMID:29953732
GO:0010983 Positive regulation of high-density lipoprotein particle clearance Increases phenotype PMID:31606821
GO:0010989 Negative regulation of low-density lipoprotein particle clearance Increases phenotype PMID:30129056; PMID:31606821
GO:0014067 Negative regulation of phosphatidylinositol 3-kinase signaling Increases phenotype PMID:29526571
GO:0016042 Lipid catabolic process Increases phenotype PMID:11424224; PMID:11424224; PMID:25905778; PMID:30144451; PMID:30817903; PMID:12234117; PMID:12477967; PMID:15053821; PMID:15053821; PMID:22116744; PMID:25617480; PMID:29331653; PMID:29409856; PMID:30817903; PMID:31173751; PMID:21439094; PMID:21664865; PMID:21799698; PMID:22116744; PMID:22675305; PMID:22940631; PMID:23406761; PMID:25541178; PMID:25541178; PMID:26748309; PMID:29223569; PMID:30817903; PMID:25665769; PMID:25905778; PMID:26341651; PMID:26343954; PMID:26499206; PMID:26690102; PMID:26748309; PMID:26748309; PMID:29223569; PMID:30817903; PMID:26887929; PMID:27488359; PMID:27769711; PMID:28259689; PMID:28259689; PMID:30481507; PMID:29059224; PMID:29181404; PMID:29181404; PMID:33639173; PMID:29223569; PMID:29233026; PMID:29233026; PMID:32710900; PMID:29233026; PMID:32710900; PMID:33724628; PMID:29247773; PMID:29331653; PMID:29409856; PMID:29441829; PMID:30120923; PMID:30144451; PMID:30481507; PMID:30817903; PMID:30847815; PMID:33639173; PMID:30927557; PMID:30958922; PMID:31009641; PMID:31029786; PMID:31081965; PMID:31100278; PMID:31173751; PMID:31682803; PMID:31696645; PMID:31726037; PMID:31833155; PMID:32202043; PMID:32202043; PMID:32662907; PMID:32662907; PMID:32710900; PMID:3277624; PMID:33484791; PMID:33639173; PMID:33724628; PMID:34352274; PMID:34414639; PMID:34477272; PMID:34656705; PMID:35702883
GO:0016160 Amylase activity Increases phenotype PMID:33823243
GO:0016477 Cell migration Increases phenotype PMID:30184259
GO:0016567 Protein ubiquitination Increases phenotype PMID:30980806
GO:0016570 Histone modification Affects phenotype PMID:39922521
GO:0016887 Atp hydrolysis activity Decreases phenotype PMID:30958922; PMID:31029786
GO:0017014 Protein nitrosylation Increases phenotype PMID:29059224
GO:0018158 Protein oxidation Affects phenotype PMID:21799698; PMID:24752916; PMID:24752916; PMID:37354076; PMID:25986969; PMID:26522834; PMID:28648635; PMID:28648635; PMID:31400774; PMID:29223569; PMID:29223569; PMID:33724628; PMID:29409856; PMID:30144451; PMID:30144451; PMID:32864810; PMID:31009641; PMID:31081965; PMID:31400774; PMID:32812462; PMID:32864810; PMID:33724628; PMID:34175429; PMID:34610774; PMID:35414346; PMID:35414346; PMID:37354076
GO:0018205 Peptidyl-lysine modification Affects phenotype PMID:39922521
GO:0018212 Peptidyl-tyrosine modification Increases phenotype PMID:12477967
GO:0019226 Transmission of nerve impulse Decreases phenotype PMID:20711301; PMID:24263156; PMID:2452237; PMID:39299373
GO:0019233 Sensory perception of pain Increases phenotype PMID:29606029; PMID:39299373
GO:0019249 Lactate biosynthetic process Increases phenotype PMID:15298348
GO:0019318 Hexose metabolic process Affects phenotype PMID:32864810
GO:0019432 Triglyceride biosynthetic process Increases phenotype PMID:24760747; PMID:24760747; PMID:25191525; PMID:26616445; PMID:27038876; PMID:28757134; PMID:28822685; PMID:25240712; PMID:26071184; PMID:28757134; PMID:29223569; PMID:26343954; PMID:26616445; PMID:26616445; PMID:27038876; PMID:26690102; PMID:26690102; PMID:26721197; PMID:30817903; PMID:26721197; PMID:27270450; PMID:27270450; PMID:27488359; PMID:31100278; PMID:27350165; PMID:27488359; PMID:27769711; PMID:28757134; PMID:28757134; PMID:29223569; PMID:28822685; PMID:29223569; PMID:29614383; PMID:30802477; PMID:30817903; PMID:30927557; PMID:31100278; PMID:31468622; PMID:31743741
GO:0019627 Urea metabolic process Affects phenotype PMID:29441829; PMID:29441829; PMID:34922902; PMID:30847815; PMID:34391751; PMID:34661493; PMID:34922902; PMID:36510688
GO:0019646 Aerobic electron transport chain Affects phenotype PMID:24752916
GO:0019852 L-ascorbic acid metabolic process Affects phenotype PMID:23716880; PMID:23716880; PMID:26286522; PMID:33724628; PMID:26286522; PMID:33724628
GO:0019853 L-ascorbic acid biosynthetic process Decreases phenotype PMID:26748309; PMID:30817903; PMID:31009641
GO:0020027 Hemoglobin metabolic process Affects phenotype PMID:23500772; PMID:35305976
GO:0030070 Insulin processing Increases phenotype PMID:33812996
GO:0030199 Collagen fibril organization Increases phenotype PMID:29266779; PMID:29682576; PMID:31726037; PMID:32410268; PMID:33631230; PMID:34391751; PMID:34414639; PMID:34470562; PMID:35051763; PMID:36510688; PMID:36547818; PMID:36650709; PMID:37352119; PMID:38047382; PMID:38483099; PMID:39265716; PMID:39265716
GO:0030263 Apoptotic chromosome condensation Increases phenotype PMID:31029786; PMID:34922902; PMID:35414346; PMID:37352119; PMID:38084638
GO:0030282 Bone mineralization Decreases phenotype PMID:33450223
GO:0030316 Osteoclast differentiation Increases phenotype PMID:35315182
GO:0031987 Locomotion involved in locomotory behavior Decreases phenotype PMID:32805344; PMID:32805344; PMID:38865809; PMID:35702883; PMID:38865809
GO:0031999 Negative regulation of fatty acid beta-oxidation Increases phenotype PMID:29988851
GO:0032024 Positive regulation of insulin secretion Affects phenotype PMID:25446853; PMID:33812996; PMID:37482253
GO:0032114 Regulation of glucose-6-phosphatase activity Increases phenotype PMID:33823243
GO:0032148 Activation of protein kinase b activity Affects phenotype PMID:25808216; PMID:26522834; PMID:28856781; PMID:29274332; PMID:29526571; PMID:33812996; PMID:34428446; PMID:34455488
GO:0032450 Maltose alpha-glucosidase activity Affects phenotype PMID:12428451
GO:0032528 Microvillus organization Decreases phenotype PMID:31009641
GO:0032760 Positive regulation of tumor necrosis factor production Affects phenotype PMID:23147376; PMID:24513509
GO:0032776 Dna methylation on cytosine Decreases phenotype PMID:29127188
GO:0032781 Positive regulation of atp-dependent activity Increases phenotype PMID:33823243
GO:0032836 Glomerular basement membrane development Affects phenotype PMID:31726037
GO:0032868 Response to insulin Decreases phenotype PMID:25808216; PMID:25849131
GO:0032869 Cellular response to insulin stimulus Affects phenotype PMID:29935216
GO:0032930 Positive regulation of superoxide anion generation Increases phenotype PMID:23647015
GO:0032964 Collagen biosynthetic process Increases phenotype PMID:29331653; PMID:29331653; PMID:29409856; PMID:29409856
GO:0032967 Positive regulation of collagen biosynthetic process Increases phenotype PMID:21416479; PMID:28700904; PMID:28946194; PMID:30551545; PMID:30611788
GO:0033132 Negative regulation of glucokinase activity Increases phenotype PMID:31606821
GO:0033327 Leydig cell differentiation Affects phenotype PMID:32233808
GO:0033861 Negative regulation of nad(p)h oxidase activity Affects phenotype PMID:24752916
GO:0034377 Plasma lipoprotein particle assembly Increases phenotype PMID:31400774
GO:0034418 Urate biosynthetic process Affects phenotype PMID:36510688
GO:0034440 Lipid oxidation Increases phenotype PMID:16177186; PMID:16177186; PMID:21416479; PMID:26286521; PMID:30657622; PMID:16177186; PMID:26286521; PMID:16177186; PMID:30657622; PMID:21416479; PMID:21416479; PMID:22733486; PMID:24413998; PMID:34661493; PMID:38602238; PMID:21416479; PMID:26286521; PMID:21416479; PMID:28648635; PMID:31323227; PMID:21416479; PMID:31323227; PMID:21832210; PMID:22733486; PMID:24413998; PMID:24752916; PMID:24752916; PMID:37354076; PMID:24889822; PMID:25057273; PMID:25446853; PMID:25503068; PMID:25503068; PMID:31323227; PMID:37352119; PMID:25986969; PMID:26286521; PMID:26286522; PMID:26522834; PMID:28178614; PMID:28648635; PMID:28904557; PMID:29274332; PMID:29988851; PMID:30551545; PMID:30611788; PMID:30657622; PMID:30657622; PMID:37354076; PMID:31323227; PMID:31323227; PMID:37352119; PMID:33823243; PMID:34039237; PMID:34455488; PMID:34455488; PMID:38084638; PMID:34661493; PMID:35414346; PMID:36169646; PMID:37352119; PMID:37354076; PMID:38084638; PMID:38602238; PMID:39299373
GO:0035629 N-terminal protein amino acid n-linked glycosylation Increases phenotype PMID:30582900
GO:0035640 Exploration behavior Decreases phenotype PMID:38865809
GO:0035641 Locomotory exploration behavior Decreases phenotype PMID:34352274
GO:0035702 Monocyte homeostasis Affects phenotype PMID:33524429
GO:0035809 Regulation of urine volume Affects phenotype PMID:33639173; PMID:37054934
GO:0035810 Positive regulation of urine volume Increases phenotype PMID:1999276; PMID:29291386; PMID:8371420
GO:0035812 Renal sodium excretion Increases phenotype PMID:1999276; PMID:2819817
GO:0035936 Testosterone secretion Decreases phenotype PMID:8417201
GO:0036211 Protein modification process Increases phenotype PMID:25541178; PMID:26616445
GO:0036269 Swimming behavior Decreases phenotype PMID:25037167; PMID:25037167; PMID:34352274; PMID:34352274
GO:0036343 Psychomotor behavior Decreases phenotype PMID:32062618
GO:0036440 Citrate synthase activity Decreases phenotype PMID:39299373
GO:0040015 Negative regulation of multicellular organism growth Increases phenotype PMID:28904557; PMID:35993117
GO:0040018 Positive regulation of multicellular organism growth Decreases phenotype PMID:22733486; PMID:24413998; PMID:27542954; PMID:28700904
GO:0042060 Wound healing Decreases phenotype PMID:27288104
GO:0042132 Fructose 1,6-bisphosphate 1-phosphatase activity Increases phenotype PMID:25641191; PMID:34470562; PMID:36169646
GO:0042158 Lipoprotein biosynthetic process Affects phenotype PMID:25240712
GO:0042310 Vasoconstriction Affects phenotype PMID:11240445; PMID:19673932; PMID:29059224; PMID:29181404
GO:0042311 Vasodilation Increases phenotype PMID:12477967; PMID:17675792; PMID:23884884; PMID:29181404
GO:0042360 Vitamin e metabolic process Affects phenotype PMID:23716880; PMID:23716880; PMID:26286522; PMID:33724628; PMID:26286522; PMID:26286522; PMID:33724628; PMID:33724628
GO:0042415 Norepinephrine metabolic process Affects phenotype PMID:25669659; PMID:35085591
GO:0042416 Dopamine biosynthetic process Decreases phenotype PMID:27566243
GO:0042417 Dopamine metabolic process Increases phenotype PMID:24752916; PMID:25669659
GO:0042421 Norepinephrine biosynthetic process Increases phenotype PMID:27566243
GO:0042427 Serotonin biosynthetic process Decreases phenotype PMID:27566243; PMID:32303808
GO:0042554 Superoxide anion generation Increases phenotype PMID:26006044; PMID:29059224; PMID:35085591
GO:0042593 Glucose homeostasis Decreases phenotype PMID:21416479; PMID:21416479; PMID:30421503; PMID:35786680; PMID:23458895; PMID:23500772; PMID:24781736; PMID:25050809; PMID:25503068; PMID:29953732; PMID:30582900; PMID:30657622; PMID:25849131; PMID:27542954; PMID:27609014; PMID:28946194; PMID:29382564; PMID:29526571; PMID:29935216; PMID:29953732; PMID:30582900; PMID:30657622; PMID:30551545; PMID:30582900; PMID:30657622; PMID:31400774; PMID:33812996; PMID:35786680
GO:0042632 Cholesterol homeostasis Decreases phenotype PMID:28946194; PMID:29382564; PMID:29988851; PMID:30582900; PMID:31400774
GO:0042713 Sperm ejaculation Decreases phenotype PMID:8417201
GO:0042743 Hydrogen peroxide metabolic process Affects phenotype PMID:34039237
GO:0042755 Eating behavior Increases phenotype PMID:28330423; PMID:34414639; PMID:34414639; PMID:35072544; PMID:35305976; PMID:35072544; PMID:35305976; PMID:39675543
GO:0042756 Drinking behavior Increases phenotype PMID:28330423; PMID:28330423; PMID:32233808; PMID:29181404; PMID:29181404; PMID:33817209; PMID:35305976; PMID:29526571; PMID:30802477; PMID:33817209; PMID:34470562; PMID:35305976; PMID:36510688; PMID:39675543
GO:0043029 T cell homeostasis Affects phenotype PMID:33524429
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:23147376; PMID:23458895; PMID:23792339; PMID:24333387; PMID:24889822; PMID:25301743; PMID:27609014; PMID:30611788; PMID:33812996; PMID:34455488; PMID:35442559; PMID:39719253
GO:0043303 Mast cell degranulation Increases phenotype PMID:36547818
GO:0043525 Positive regulation of neuron apoptotic process Increases phenotype PMID:27702591
GO:0043553 Negative regulation of phosphatidylinositol 3-kinase activity Increases phenotype PMID:36462176
GO:0043687 Post-translational protein modification Increases phenotype PMID:31499052
GO:0043966 Histone h3 acetylation Decreases phenotype PMID:27270450
GO:0043970 Histone h3-k9 acetylation Decreases phenotype PMID:21778425
GO:0044237 Cellular metabolic process Decreases phenotype PMID:30607903
GO:0044242 Cellular lipid catabolic process Increases phenotype PMID:22476978; PMID:24954035
GO:0044319 Wound healing, spreading of cells Decreases phenotype PMID:35051763
GO:0044342 Type b pancreatic cell proliferation Decreases phenotype PMID:28625491
GO:0044403 Biological process involved in symbiotic interaction Affects phenotype PMID:31743741
GO:0045019 Negative regulation of nitric oxide biosynthetic process Increases phenotype PMID:29274332; PMID:29274332; PMID:30657622; PMID:30657622
GO:0045333 Cellular respiration Decreases phenotype PMID:39299373
GO:0045429 Positive regulation of nitric oxide biosynthetic process Increases phenotype PMID:24752916; PMID:28648635; PMID:33823243; PMID:34175429
GO:0045454 Cell redox homeostasis Decreases phenotype PMID:15298348; PMID:29606029; PMID:37120126
GO:0045541 Negative regulation of cholesterol biosynthetic process Increases phenotype PMID:15066220
GO:0045542 Positive regulation of cholesterol biosynthetic process Increases phenotype PMID:31606821; PMID:37482253
GO:0045766 Positive regulation of angiogenesis Increases phenotype PMID:39719253
GO:0045822 Negative regulation of heart contraction Increases phenotype PMID:29274332
GO:0045859 Regulation of protein kinase activity Affects phenotype PMID:23786522
GO:0045907 Positive regulation of vasoconstriction Increases phenotype PMID:21832210; PMID:27131411; PMID:28299329; PMID:28946194
GO:0045919 Positive regulation of cytolysis Increases phenotype PMID:31400774
GO:0046034 Atp metabolic process Affects phenotype PMID:37337224
GO:0046058 Camp metabolic process Affects phenotype PMID:32303808; PMID:37431890
GO:0046068 Cgmp metabolic process Increases phenotype PMID:28299329; PMID:34428446
GO:0046086 Adenosine biosynthetic process Increases phenotype PMID:27087133
GO:0046173 Polyol biosynthetic process Increases phenotype PMID:30958922
GO:0046209 Nitric oxide metabolic process Increases phenotype PMID:19000375; PMID:29181404; PMID:29181404; PMID:33639173; PMID:30607903; PMID:33639173; PMID:33639173; PMID:34039237; PMID:34414639; PMID:35305976; PMID:37354076
GO:0046314 Phosphocreatine biosynthetic process Increases phenotype PMID:15298348
GO:0046323 Glucose import Affects phenotype PMID:27087133; PMID:30721768
GO:0046326 Positive regulation of glucose import Decreases phenotype PMID:29526571
GO:0046370 Fructose biosynthetic process Increases phenotype PMID:15298348
GO:0046415 Urate metabolic process Decreases phenotype PMID:22733486; PMID:22733486; PMID:24413998; PMID:24413998; PMID:28700904; PMID:29988851; PMID:39265716
GO:0046430 Non-phosphorylated glucose metabolic process Increases phenotype PMID:25986969
GO:0046449 Creatinine metabolic process Decreases phenotype PMID:22116744; PMID:22733486; PMID:24413998; PMID:28700904; PMID:29331653; PMID:29409856; PMID:29409856; PMID:33639173; PMID:34661493; PMID:35072544; PMID:37352119; PMID:29441829; PMID:29441829; PMID:34922902; PMID:37054934; PMID:29614383; PMID:29614383; PMID:34391751; PMID:29988851; PMID:30551545; PMID:30847815; PMID:33631230; PMID:33631230; PMID:34212273; PMID:34649470; PMID:33639173; PMID:33639173; PMID:34661493; PMID:35072544; PMID:37352119; PMID:34391751; PMID:34649470; PMID:34661493; PMID:34922902; PMID:34922902; PMID:37054934; PMID:35072544; PMID:36510688; PMID:37352119; PMID:37482253; PMID:38483099; PMID:39265716; PMID:39922521
GO:0046466 Membrane lipid catabolic process Affects phenotype PMID:10624784; PMID:11216864; PMID:11589752; PMID:15957552; PMID:16289604; PMID:29606028; PMID:16289604; PMID:16289604; PMID:30371987; PMID:16752005; PMID:17589825; PMID:18291360; PMID:18549673; PMID:18549673; PMID:21163323; PMID:19840221; PMID:27609014; PMID:29606028; PMID:29606029; PMID:30318971; PMID:30371987; PMID:9522273
GO:0046620 Regulation of organ growth Affects phenotype PMID:10862828; PMID:18229453; PMID:18549673; PMID:21215763; PMID:2452237; PMID:8371420; PMID:9522273
GO:0046621 Negative regulation of organ growth Increases phenotype PMID:12242689
GO:0046622 Positive regulation of organ growth Increases phenotype PMID:29988851; PMID:35786680; PMID:35993117
GO:0046627 Negative regulation of insulin receptor signaling pathway Increases phenotype PMID:29526571
GO:0046649 Lymphocyte activation Increases phenotype PMID:11801690
GO:0046676 Negative regulation of insulin secretion Increases phenotype PMID:28946194; PMID:31499052; PMID:32810643
GO:0046685 Response to arsenic-containing substance Increases phenotype PMID:39675543
GO:0047429 Nucleoside triphosphate diphosphatase activity Decreases phenotype PMID:33823243
GO:0047823 D-glutamyltransferase activity Affects phenotype PMID:31009641; PMID:31696645
GO:0048143 Astrocyte activation Increases phenotype PMID:24333387; PMID:35085591
GO:0048266 Behavioral response to pain Affects phenotype PMID:37431890; PMID:38865809
GO:0048874 Host-mediated regulation of intestinal microbiota composition Decreases phenotype PMID:29382564
GO:0050665 Hydrogen peroxide biosynthetic process Increases phenotype PMID:25905778
GO:0050729 Positive regulation of inflammatory response Increases phenotype PMID:39719253
GO:0050801 Monoatomic ion homeostasis Affects phenotype PMID:34922902
GO:0050808 Synapse organization Decreases phenotype PMID:22062134
GO:0050885 Neuromuscular process controlling balance Decreases phenotype PMID:38865809
GO:0050965 Detection of temperature stimulus involved in sensory perception of pain Increases phenotype PMID:39299373
GO:0050966 Detection of mechanical stimulus involved in sensory perception of pain Increases phenotype PMID:39299373
GO:0050996 Positive regulation of lipid catabolic process Increases phenotype PMID:31606821; PMID:37120126; PMID:37224990; PMID:37482253; PMID:39719253
GO:0051092 Positive regulation of nf-kappab transcription factor activity Increases phenotype PMID:16177186
GO:0051343 Positive regulation of cyclic-nucleotide phosphodiesterase activity Increases phenotype PMID:28299329
GO:0051345 Positive regulation of hydrolase activity Increases phenotype PMID:33823243
GO:0051347 Positive regulation of transferase activity Increases phenotype PMID:33823243
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:21799698; PMID:22940631; PMID:25541178; PMID:31029786; PMID:37337224; PMID:37431890; PMID:39265716
GO:0051882 Mitochondrial depolarization Increases phenotype PMID:39265716
GO:0051896 Regulation of protein kinase b signaling Affects phenotype PMID:23786522
GO:0051898 Negative regulation of protein kinase b signaling Increases phenotype PMID:36462176
GO:0051899 Membrane depolarization Increases phenotype PMID:30721768
GO:0055069 Zinc ion homeostasis Affects phenotype PMID:32233808
GO:0055072 Iron ion homeostasis Decreases phenotype PMID:39719253
GO:0055074 Calcium ion homeostasis Affects phenotype PMID:29935216; PMID:32303808; PMID:35315182
GO:0055078 Sodium ion homeostasis Affects phenotype PMID:36510688
GO:0055088 Lipid homeostasis Decreases phenotype PMID:23647015
GO:0055089 Fatty acid homeostasis Decreases phenotype PMID:25050809; PMID:33812996
GO:0060008 Sertoli cell differentiation Affects phenotype PMID:32233808
GO:0060048 Cardiac muscle contraction Increases phenotype PMID:132978
GO:0060073 Micturition Increases phenotype PMID:29526571
GO:0060193 Positive regulation of lipase activity Increases phenotype PMID:33823243
GO:0060346 Bone trabecula formation Affects phenotype PMID:33450223
GO:0060421 Positive regulation of heart growth Increases phenotype PMID:12242689
GO:0060550 Positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity Increases phenotype PMID:28330423; PMID:33823243
GO:0060740 Prostate gland epithelium morphogenesis Decreases phenotype PMID:28904557
GO:0061113 Pancreas morphogenesis Affects phenotype PMID:29223569
GO:0061370 Testosterone biosynthetic process Decreases phenotype PMID:26006044; PMID:30365938; PMID:31696645; PMID:31696645; PMID:32153207; PMID:32233808; PMID:35187753; PMID:38047382; PMID:32153207; PMID:35187753
GO:0061518 Microglial cell proliferation Increases phenotype PMID:30682331
GO:0070085 Glycosylation Increases phenotype PMID:10623569
GO:0070091 Glucagon secretion Affects phenotype PMID:32710900
GO:0070212 Protein poly-adp-ribosylation Increases phenotype PMID:15298348; PMID:27288104
GO:0070265 Necrotic cell death Increases phenotype PMID:32710900; PMID:33724628; PMID:34470562; PMID:34610774; PMID:35702883; PMID:37352119; PMID:38084638
GO:0070328 Triglyceride homeostasis Decreases phenotype PMID:28946194; PMID:29382564; PMID:29988851; PMID:29988851; PMID:33812996; PMID:30582900; PMID:31400774; PMID:33812996; PMID:35786680
GO:0070343 White fat cell proliferation Increases phenotype PMID:37337224
GO:0070640 Vitamin d3 metabolic process Affects phenotype PMID:29953732
GO:0070994 Detection of oxidative stress Increases phenotype PMID:21799698; PMID:24440807; PMID:24740756; PMID:25541178; PMID:25669659; PMID:26887929; PMID:27109771; PMID:29420703; PMID:29420703; PMID:34649470; PMID:30120923; PMID:32495657; PMID:32812462; PMID:34610774; PMID:34649470; PMID:34896238; PMID:34922902; PMID:35187753; PMID:35187753; PMID:38047382; PMID:36510688; PMID:36650709; PMID:37566541; PMID:38047382; PMID:38602238; PMID:39299373; PMID:39579577
GO:0070997 Neuron death Increases phenotype PMID:35702883
GO:0071639 Positive regulation of monocyte chemotactic protein-1 production Affects phenotype PMID:24513509
GO:0071674 Mononuclear cell migration Increases phenotype PMID:32710900
GO:0071711 Basement membrane organization Decreases phenotype PMID:31682803
GO:0071894 Histone h2b conserved c-terminal lysine ubiquitination Increases phenotype PMID:28946194
GO:0071902 Positive regulation of protein serine/threonine kinase activity Decreases phenotype PMID:34428446
GO:0072520 Seminiferous tubule development Affects phenotype PMID:31696645; PMID:32233808
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:20976160; PMID:23458895; PMID:24717679; PMID:29682576; PMID:34039237; PMID:35702883; PMID:37354076; PMID:37354076; PMID:38706688; PMID:39265716; PMID:39299373; PMID:39675543
GO:0080182 Histone h3-k4 trimethylation Increases phenotype PMID:27652271
GO:0085029 Extracellular matrix assembly Affects phenotype PMID:31726037
GO:0086001 Cardiac muscle cell action potential Affects phenotype PMID:29181404
GO:0090398 Cellular senescence Increases phenotype PMID:23859249; PMID:32473187; PMID:38483099
GO:0090400 Stress-induced premature senescence Increases phenotype PMID:29673160
GO:0090648 Response to environmental enrichment Affects phenotype PMID:32805344
GO:0097176 Epoxide metabolic process Increases phenotype PMID:21832210
GO:0097368 Establishment of sertoli cell barrier Decreases phenotype PMID:31682803
GO:0097601 Retina blood vessel maintenance Decreases phenotype PMID:12592403
GO:0097692 Histone h3-k4 monomethylation Increases phenotype PMID:27652271
GO:0097722 Sperm motility Decreases phenotype PMID:30365938; PMID:30365938; PMID:31682803; PMID:38047382
GO:0098727 Maintenance of cell number Decreases phenotype PMID:34455488; PMID:34455488; PMID:35786680
GO:0140042 Lipid droplet formation Increases phenotype PMID:30129056; PMID:30129056; PMID:33812996; PMID:36933875; PMID:31726037; PMID:31743741; PMID:32410268; PMID:33021114; PMID:33812996; PMID:33817209; PMID:34896238; PMID:35786680; PMID:36933875; PMID:37337224; PMID:39047806
GO:0140131 Positive regulation of lymphocyte chemotaxis Increases phenotype PMID:29526571
GO:0140657 Atp-dependent activity Increases phenotype PMID:34039237
GO:0160020 Positive regulation of ferroptosis Increases phenotype PMID:39719253
GO:1900017 Positive regulation of cytokine production involved in inflammatory response Increases phenotype PMID:27664441
GO:1900110 Negative regulation of histone h3-k9 dimethylation Increases phenotype PMID:27652271
GO:1900135 Positive regulation of renin secretion into blood stream Increases phenotype PMID:27542954
GO:1900227 Positive regulation of nlrp3 inflammasome complex assembly Increases phenotype PMID:27783111
GO:1900409 Positive regulation of cellular response to oxidative stress Increases phenotype PMID:35961541
GO:1900535 Palmitic acid biosynthetic process Increases phenotype PMID:31009641
GO:1900745 Positive regulation of p38mapk cascade Increases phenotype PMID:28299329; PMID:29673160; PMID:34310909
GO:1901098 Positive regulation of autophagosome maturation Decreases phenotype PMID:24889822
GO:1901142 Insulin metabolic process Decreases phenotype PMID:23458895; PMID:24781736; PMID:31606821
GO:1901203 Positive regulation of extracellular matrix assembly Increases phenotype PMID:25057273; PMID:25057273; PMID:27997345; PMID:27997345
GO:1901224 Positive regulation of nik/nf-kappab signaling Increases phenotype PMID:23677724
GO:1901318 Negative regulation of flagellated sperm motility Increases phenotype PMID:29953732
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:19000375; PMID:23147376; PMID:23500772; PMID:23792339; PMID:25037167; PMID:29988851; PMID:30551545; PMID:30582900; PMID:30611788; PMID:31323227; PMID:33823243; PMID:34455488
GO:1901671 Positive regulation of superoxide dismutase activity Affects phenotype PMID:12242689; PMID:26286521; PMID:16177186; PMID:22733486; PMID:23716880; PMID:24752916; PMID:25057273; PMID:25503068; PMID:25986969; PMID:28178614; PMID:31400774; PMID:31400774
GO:1901676 Positive regulation of histone h3-k27 acetylation Increases phenotype PMID:27997345
GO:1901687 Glutathione derivative biosynthetic process Affects phenotype PMID:11424224; PMID:23716880; PMID:24752916
GO:1901799 Negative regulation of proteasomal protein catabolic process Increases phenotype PMID:38049026
GO:1901875 Positive regulation of post-translational protein modification Increases phenotype PMID:19833897
GO:1901896 Positive regulation of atpase-coupled calcium transmembrane transporter activity Decreases phenotype PMID:23716880
GO:1902466 Positive regulation of histone h3-k27 trimethylation Increases phenotype PMID:29127188
GO:1902512 Positive regulation of apoptotic dna fragmentation Increases phenotype PMID:21416479; PMID:21416479; PMID:31323227; PMID:31323227
GO:1903283 Negative regulation of glutathione peroxidase activity Increases phenotype PMID:19000375
GO:1903284 Positive regulation of glutathione peroxidase activity Affects phenotype PMID:12242689; PMID:23716880; PMID:25057273; PMID:25503068; PMID:25986969; PMID:26522834
GO:1903300 Negative regulation of hexokinase activity Increases phenotype PMID:28330423
GO:1903408 Positive regulation of p-type sodium:potassium-exchanging transporter activity Decreases phenotype PMID:23716880
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:21799698; PMID:26006044; PMID:26511841; PMID:27939242; PMID:29606029; PMID:30802477; PMID:31009641; PMID:31029786; PMID:31682803
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:16478977; PMID:24333387; PMID:24752916; PMID:26700463; PMID:30611788
GO:1903626 Positive regulation of dna catabolic process Increases phenotype PMID:21416479
GO:1903709 Uterine gland development Increases phenotype PMID:30421503
GO:1903721 Positive regulation of i-kappab phosphorylation Increases phenotype PMID:21832210
GO:1903787 Negative regulation of glutathione biosynthetic process Increases phenotype PMID:39719253
GO:1903830 Magnesium ion transmembrane transport Decreases phenotype PMID:23716880
GO:1903966 Monounsaturated fatty acid biosynthetic process Affects phenotype PMID:31009641
GO:1903982 Negative regulation of microvillus length Increases phenotype PMID:31009641
GO:1904141 Positive regulation of microglial cell migration Increases phenotype PMID:30682331
GO:1904178 Negative regulation of adipose tissue development Increases phenotype PMID:35786680
GO:1904230 Negative regulation of succinate dehydrogenase activity Increases phenotype PMID:24752916
GO:1904231 Positive regulation of succinate dehydrogenase activity Decreases phenotype PMID:24333387
GO:1904251 Regulation of bile acid metabolic process Decreases phenotype PMID:29382564
GO:1904996 Positive regulation of leukocyte adhesion to vascular endothelial cell Increases phenotype PMID:15370362
GO:1905075 Positive regulation of tight junction disassembly Increases phenotype PMID:27783111
GO:1905517 Macrophage migration Increases phenotype PMID:30184259; PMID:32710900
GO:1905867 Epididymis development Affects phenotype PMID:31696645
GO:1990009 Retinal cell apoptotic process Increases phenotype PMID:20654064
GO:1990266 Neutrophil migration Increases phenotype PMID:33524429
GO:1990678 Histone h4-k16 deacetylation Increases phenotype PMID:29127188
GO:2000252 Negative regulation of feeding behavior Increases phenotype PMID:32233808
GO:2000253 Positive regulation of feeding behavior Increases phenotype PMID:29614383; PMID:29614383; PMID:34470562; PMID:34470562; PMID:36510688; PMID:38049026; PMID:39299373
GO:2000255 Negative regulation of male germ cell proliferation Increases phenotype PMID:29953732
GO:2000374 Regulation of oxygen metabolic process Affects phenotype PMID:25050809
GO:2000617 Positive regulation of histone h3-k9 acetylation Increases phenotype PMID:24889822
GO:2000786 Positive regulation of autophagosome assembly Increases phenotype PMID:35786680
GO:2000844 Negative regulation of testosterone secretion Increases phenotype PMID:28904557; PMID:29953732; PMID:29953732
GO:2000984 Negative regulation of atp citrate synthase activity Increases phenotype PMID:24752916
GO:2001057 Reactive nitrogen species metabolic process Increases phenotype PMID:26887929
GO:2001295 Malonyl-coa biosynthetic process Decreases phenotype PMID:22675305
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.