Doxorubicin


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000002 Mitochondrial genome maintenance Decreases phenotype PMID:34648132
GO:0000045 Autophagosome assembly Increases phenotype PMID:29729358; PMID:32652078; PMID:36639017
GO:0000050 Urea cycle Increases phenotype PMID:29481770; PMID:31100273; PMID:31830546
GO:0000080 Mitotic g1 phase Affects phenotype PMID:33331091; PMID:34856211; PMID:38423379
GO:0000084 Mitotic s phase Decreases phenotype PMID:30557669; PMID:31207347; PMID:32562081; PMID:33331091; PMID:34719826
GO:0000085 Mitotic g2 phase Increases phenotype PMID:22785532; PMID:31597699
GO:0000086 G2/m transition of mitotic cell cycle Increases phenotype PMID:30557669; PMID:31207345; PMID:31843629; PMID:32562081; PMID:33331091; PMID:34719826; PMID:34856211; PMID:38423379
GO:0000104 Succinate dehydrogenase activity Decreases phenotype PMID:34605098
GO:0000266 Mitochondrial fission Increases phenotype PMID:32434049
GO:0000278 Mitotic cell cycle Affects phenotype PMID:25543474; PMID:32562081; PMID:34126102
GO:0000422 Autophagy of mitochondrion Increases phenotype PMID:24675088; PMID:32434049
GO:0000737 Dna catabolic process, endonucleolytic Increases phenotype PMID:32335150; PMID:36634904; PMID:39427782
GO:0000902 Cell morphogenesis Decreases phenotype PMID:29385562
GO:0001510 Rna methylation Increases phenotype PMID:34648132
GO:0001525 Angiogenesis Decreases phenotype PMID:29775573; PMID:35524977
GO:0001541 Ovarian follicle development Decreases phenotype PMID:32666839; PMID:36572231
GO:0001545 Primary ovarian follicle growth Decreases phenotype PMID:36925030
GO:0001547 Antral ovarian follicle growth Decreases phenotype PMID:36925030
GO:0001551 Ovarian follicle endowment Decreases phenotype PMID:32666839
GO:0001552 Ovarian follicle atresia Increases phenotype PMID:32666839; PMID:36925030
GO:0001776 Leukocyte homeostasis Decreases phenotype PMID:29775573; PMID:38943348
GO:0001836 Release of cytochrome c from mitochondria Increases phenotype PMID:30928397; PMID:31843629; PMID:34126102; PMID:39043266
GO:0001906 Cell killing Increases phenotype PMID:21567185
GO:0001909 Leukocyte mediated cytotoxicity Increases phenotype PMID:17187072
GO:0001944 Vasculature development Increases phenotype PMID:36925030
GO:0001981 Baroreceptor detection of arterial stretch Increases phenotype PMID:34015281
GO:0002027 Regulation of heart rate Affects phenotype PMID:30342983; PMID:32691977; PMID:33704910; PMID:34343525; PMID:34369273; PMID:35137609; PMID:32691977; PMID:33704910; PMID:34343525; PMID:34369273; PMID:35137609
GO:0002281 Macrophage activation involved in immune response Increases phenotype PMID:32068018
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:29775573; PMID:29775573; PMID:37409694; PMID:31100273; PMID:31100273; PMID:33827303; PMID:33827303; PMID:33882726; PMID:33882726; PMID:34369273; PMID:38651543; PMID:34369273; PMID:34635025; PMID:37409694; PMID:37867446; PMID:38651543; PMID:39442788; PMID:40035845
GO:0002693 Positive regulation of cellular extravasation Increases phenotype PMID:26335259; PMID:31376360
GO:0003014 Renal system process Affects phenotype PMID:32812453
GO:0003073 Regulation of systemic arterial blood pressure Decreases phenotype PMID:26036690; PMID:32691977
GO:0003218 Cardiac left ventricle formation Decreases phenotype PMID:35524977
GO:0003300 Cardiac muscle hypertrophy Increases phenotype PMID:30557669
GO:0003810 Protein-glutamine gamma-glutamyltransferase activity Increases phenotype PMID:33827303
GO:0003954 Nadh dehydrogenase activity Decreases phenotype PMID:34605098
GO:0004035 Alkaline phosphatase activity Affects phenotype PMID:29481770; PMID:32810592; PMID:33827303
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Affects phenotype PMID:29481770; PMID:31100273; PMID:31830546; PMID:33484087; PMID:33704910; PMID:33827303; PMID:34343525; PMID:39214269; PMID:33484087; PMID:33704910; PMID:33827303; PMID:34343525; PMID:39214269
GO:0004111 Creatine kinase activity Affects phenotype PMID:22666520; PMID:26721193; PMID:26818447; PMID:30928397; PMID:33484087; PMID:33704910; PMID:34343525; PMID:34427160; PMID:34605098; PMID:39214269; PMID:22666520; PMID:26818447; PMID:26818447; PMID:29775573; PMID:29775573; PMID:35134463; PMID:39089415; PMID:30928397; PMID:31830546; PMID:33484087; PMID:33704910; PMID:34343525; PMID:34358621; PMID:34427160; PMID:34605098; PMID:35134463; PMID:39089415; PMID:39214269
GO:0004129 Cytochrome-c oxidase activity Decreases phenotype PMID:34605098
GO:0004197 Cysteine-type endopeptidase activity Increases phenotype PMID:31307187; PMID:32185414
GO:0004362 Glutathione-disulfide reductase (nadph) activity Decreases phenotype PMID:38327044
GO:0004364 Glutathione transferase activity Affects phenotype PMID:17582587; PMID:17582587; PMID:33827303; PMID:25268985; PMID:29775573; PMID:33484087; PMID:33827303; PMID:34343525
GO:0004407 Histone deacetylase activity Increases phenotype PMID:28865727
GO:0004448 Isocitrate dehydrogenase [nad(p)+] activity Decreases phenotype PMID:34605098
GO:0004457 Lactate dehydrogenase activity Increases phenotype PMID:20666448; PMID:22666520; PMID:26818447; PMID:22666520; PMID:26818447; PMID:30928397; PMID:33484087; PMID:33704910; PMID:33827303; PMID:34343525; PMID:34427160; PMID:39214269; PMID:26818447; PMID:29133031; PMID:29481770; PMID:29481770; PMID:35134463; PMID:39089415; PMID:30928397; PMID:31830546; PMID:33484087; PMID:33704910; PMID:33827303; PMID:34047412; PMID:34343525; PMID:34427160; PMID:35134463; PMID:39089415; PMID:39214269
GO:0004517 Nitric-oxide synthase activity Affects phenotype PMID:17582587
GO:0004591 Oxoglutarate dehydrogenase (succinyl-transferring) activity Decreases phenotype PMID:34605098
GO:0004602 Glutathione peroxidase activity Increases phenotype PMID:20666448; PMID:24799355; PMID:26721193; PMID:28082111; PMID:28082111; PMID:31100273; PMID:39029857; PMID:29481770; PMID:29775573; PMID:31100273; PMID:31100273; PMID:38567888; PMID:32335150; PMID:33827303; PMID:34427160; PMID:34427160; PMID:35093381; PMID:39029857; PMID:34605098; PMID:35093381; PMID:39029857; PMID:39089415
GO:0004679 Amp-activated protein kinase activity Affects phenotype PMID:31563593; PMID:34296331
GO:0004784 Superoxide dismutase activity Affects phenotype PMID:17582587; PMID:17582587; PMID:25268985; PMID:28082111; PMID:31100273; PMID:33827303; PMID:37840533; PMID:39029857; PMID:17582587; PMID:31100273; PMID:33827303; PMID:38567888; PMID:24799355; PMID:25268985; PMID:26721193; PMID:33882726; PMID:38651543; PMID:26807765; PMID:26807765; PMID:30928397; PMID:33484087; PMID:34427160; PMID:34635025; PMID:38997059; PMID:39029857; PMID:27565713; PMID:28082111; PMID:28608983; PMID:28608983; PMID:29775573; PMID:35667395; PMID:37030624; PMID:29061315; PMID:29775573; PMID:29913208; PMID:30836069; PMID:30885636; PMID:30928397; PMID:31100273; PMID:32335150; PMID:32525084; PMID:33331091; PMID:33484087; PMID:33827303; PMID:33882726; PMID:34343525; PMID:34427160; PMID:34605098; PMID:34635025; PMID:34635025; PMID:38997059; PMID:39029857; PMID:37030624; PMID:37840533; PMID:37867446; PMID:38651543; PMID:38997059; PMID:39029857; PMID:39043266; PMID:39089415
GO:0005757 Mitochondrial permeability transition pore complex Affects phenotype PMID:34358621
GO:0005776 Autophagosome Increases phenotype PMID:22927544; PMID:36639017; PMID:38964637
GO:0005975 Carbohydrate metabolic process Affects phenotype PMID:36100043
GO:0005996 Monosaccharide metabolic process Affects phenotype PMID:36100043
GO:0006006 Glucose metabolic process Affects phenotype PMID:34273911; PMID:36805482
GO:0006012 Galactose metabolic process Affects phenotype PMID:34273911
GO:0006071 Glycerol metabolic process Affects phenotype PMID:39922518
GO:0006072 Glycerol-3-phosphate metabolic process Affects phenotype PMID:36100043
GO:0006089 Lactate metabolic process Affects phenotype PMID:34273911; PMID:34656704; PMID:36100043; PMID:36587877; PMID:36805482
GO:0006090 Pyruvate metabolic process Affects phenotype PMID:36100043; PMID:36587877
GO:0006096 Glycolytic process Decreases phenotype PMID:30557669
GO:0006101 Citrate metabolic process Affects phenotype PMID:36100043
GO:0006105 Succinate metabolic process Affects phenotype PMID:36100043; PMID:36587877
GO:0006106 Fumarate metabolic process Affects phenotype PMID:36100043
GO:0006108 Malate metabolic process Affects phenotype PMID:36100043
GO:0006121 Mitochondrial electron transport, succinate to ubiquinone Decreases phenotype PMID:28642010
GO:0006172 Adp biosynthetic process Decreases phenotype PMID:26721193
GO:0006259 Dna metabolic process Increases phenotype PMID:25781201
GO:0006260 Dna replication Decreases phenotype PMID:25124555
GO:0006264 Mitochondrial dna replication Decreases phenotype PMID:28456571; PMID:28865727; PMID:35093381; PMID:29729358; PMID:35093381
GO:0006303 Double-strand break repair via nonhomologous end joining Decreases phenotype PMID:21567185
GO:0006304 Dna modification Increases phenotype PMID:29315967; PMID:29315967; PMID:30588110; PMID:30588110; PMID:36925030
GO:0006306 Dna methylation Decreases phenotype PMID:28865727
GO:0006308 Dna catabolic process Increases phenotype PMID:34806536
GO:0006309 Apoptotic dna fragmentation Increases phenotype PMID:11502879; PMID:12370496; PMID:15380674; PMID:15538571; PMID:16044032; PMID:24998637; PMID:27780733; PMID:32075913; PMID:7688510
GO:0006338 Chromatin remodeling Increases phenotype PMID:28495616
GO:0006412 Translation Decreases phenotype PMID:29133031
GO:0006468 Protein phosphorylation Affects phenotype PMID:38367682
GO:0006473 Protein acetylation Affects phenotype PMID:28865727
GO:0006497 Protein lipidation Increases phenotype PMID:36639017; PMID:37062353; PMID:39725191
GO:0006520 Amino acid metabolic process Affects phenotype PMID:36100043; PMID:36587877
GO:0006531 Aspartate metabolic process Affects phenotype PMID:36100043
GO:0006536 Glutamate metabolic process Affects phenotype PMID:36100043
GO:0006560 Proline metabolic process Affects phenotype PMID:34273911
GO:0006570 Tyrosine metabolic process Affects phenotype PMID:36100043
GO:0006573 Valine metabolic process Affects phenotype PMID:34273911
GO:0006600 Creatine metabolic process Affects phenotype PMID:36100043
GO:0006601 Creatine biosynthetic process Increases phenotype PMID:31100273
GO:0006606 Protein import into nucleus Increases phenotype PMID:26025680; PMID:38964637; PMID:39631538
GO:0006631 Fatty acid metabolic process Affects phenotype PMID:34605098; PMID:36100043; PMID:36587877; PMID:39922518
GO:0006636 Unsaturated fatty acid biosynthetic process Affects phenotype PMID:34273911
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:34605098; PMID:34605098; PMID:38651543; PMID:38651543
GO:0006644 Phospholipid metabolic process Affects phenotype PMID:39922518
GO:0006650 Glycerophospholipid metabolic process Affects phenotype PMID:36587877
GO:0006665 Sphingolipid metabolic process Affects phenotype PMID:39922518
GO:0006693 Prostaglandin metabolic process Affects phenotype PMID:36587877
GO:0006694 Steroid biosynthetic process Decreases phenotype PMID:24593989
GO:0006695 Cholesterol biosynthetic process Increases phenotype PMID:30928397; PMID:30928397; PMID:31830546; PMID:31830546
GO:0006739 Nadp metabolic process Affects phenotype PMID:36805482
GO:0006749 Glutathione metabolic process Increases phenotype PMID:25411067; PMID:25411067; PMID:33827303; PMID:26335259; PMID:26607004; PMID:26818447; PMID:26818447; PMID:33484087; PMID:33704910; PMID:34047412; PMID:34427160; PMID:28642010; PMID:28815802; PMID:29315967; PMID:29315967; PMID:30588110; PMID:30588110; PMID:31376360; PMID:32691977; PMID:33331091; PMID:33484087; PMID:33484087; PMID:33704910; PMID:34047412; PMID:34427160; PMID:33704910; PMID:33827303; PMID:33827303; PMID:38567888; PMID:34047412; PMID:34105389; PMID:34343525; PMID:34427160; PMID:34605098; PMID:34656704; PMID:34656704; PMID:39426736; PMID:35667395; PMID:36100043; PMID:37030624; PMID:38573338; PMID:35667395; PMID:37030624; PMID:38573338; PMID:35843304; PMID:36100043; PMID:36572231; PMID:36811345; PMID:36811345; PMID:37867446; PMID:37030624; PMID:37867446; PMID:38567888; PMID:38573338; PMID:39426736
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:17582587; PMID:17582587; PMID:28082111; PMID:31100273; PMID:17582587; PMID:31100273; PMID:24491677; PMID:24491677; PMID:29481770; PMID:24799355; PMID:28082111; PMID:29133031; PMID:29481770; PMID:29775573; PMID:30836069; PMID:30928397; PMID:31100273; PMID:31830546
GO:0006754 Atp biosynthetic process Decreases phenotype PMID:28456571; PMID:29803840; PMID:29913208; PMID:30840857
GO:0006769 Nicotinamide metabolic process Affects phenotype PMID:36100043
GO:0006771 Riboflavin metabolic process Affects phenotype PMID:36100043
GO:0006805 Xenobiotic metabolic process Increases phenotype PMID:33984456
GO:0006809 Nitric oxide biosynthetic process Increases phenotype PMID:17582587; PMID:29775573
GO:0006855 Xenobiotic transmembrane transport Increases phenotype PMID:21867607; PMID:24738333; PMID:35065085; PMID:35218280
GO:0006884 Cell volume homeostasis Affects phenotype PMID:33882726
GO:0006914 Autophagy Affects phenotype PMID:22927544; PMID:27666003; PMID:29191453; PMID:36639017
GO:0006915 Apoptotic process Increases phenotype PMID:10766178; PMID:10891466; PMID:10891466; PMID:10921050; PMID:11502879; PMID:11502879; PMID:15455384; PMID:16545138; PMID:18377724; PMID:29341321; PMID:33775688; PMID:34719826; PMID:34783124; PMID:34933054; PMID:12227071; PMID:12628736; PMID:12628736; PMID:12878482; PMID:27565713; PMID:30377735; PMID:36639017; PMID:12878482; PMID:12920203; PMID:12920203; PMID:27087047; PMID:28495616; PMID:30377735; PMID:30636491; PMID:35979984; PMID:12970750; PMID:18840609; PMID:7688510; PMID:14610070; PMID:14610070; PMID:8370474; PMID:14701702; PMID:16545138; PMID:15315341; PMID:15315341; PMID:17582587; PMID:31830546; PMID:15343345; PMID:15380674; PMID:15380674; PMID:19655762; PMID:30928397; PMID:35152301; PMID:38964637; PMID:39089415; PMID:15455384; PMID:15455384; PMID:18349320; PMID:15538571; PMID:15705788; PMID:15811867; PMID:15811867; PMID:22763982; PMID:28608983; PMID:32075913; PMID:35134463; PMID:36639017; PMID:39442788; PMID:15829011; PMID:24788927; PMID:15904426; PMID:16204029; PMID:16377638; PMID:16377638; PMID:18349320; PMID:16545138; PMID:16572199; PMID:17250809; PMID:17283156; PMID:17582587; PMID:17898295; PMID:18349320; PMID:18349320; PMID:27780733; PMID:18371937; PMID:18377724; PMID:18840609; PMID:20298590; PMID:20298590; PMID:27780733; PMID:34856211; PMID:20333787; PMID:20543097; PMID:20666448; PMID:20957741; PMID:21911303; PMID:22763982; PMID:23848338; PMID:23848338; PMID:27780733; PMID:31645432; PMID:32335150; PMID:36122806; PMID:24593989; PMID:32394736; PMID:24788927; PMID:24812279; PMID:24998637; PMID:25339540; PMID:26317544; PMID:26416351; PMID:26450947; PMID:26519223; PMID:26701723; PMID:26775663; PMID:26807765; PMID:26807765; PMID:34358621; PMID:27087047; PMID:27163855; PMID:31207345; PMID:27666003; PMID:28495616; PMID:28507149; PMID:28608983; PMID:28987325; PMID:29061315; PMID:29141199; PMID:29341321; PMID:29549912; PMID:29549912; PMID:31976328; PMID:29655913; PMID:29775573; PMID:29913208; PMID:29913208; PMID:31570982; PMID:30377735; PMID:30636491; PMID:30885636; PMID:30928397; PMID:31207347; PMID:31843629; PMID:31570982; PMID:31570982; PMID:31830546; PMID:33882726; PMID:35152301; PMID:31597699; PMID:31629898; PMID:31645432; PMID:31843629; PMID:31976328; PMID:32075913; PMID:32173973; PMID:32173973; PMID:33331091; PMID:32335150; PMID:32394736; PMID:32434049; PMID:32434049; PMID:39631538; PMID:32846153; PMID:33507000; PMID:33775688; PMID:33882726; PMID:34358621; PMID:34719826; PMID:34783124; PMID:34933054; PMID:35134463; PMID:35152301; PMID:35218280; PMID:35979984; PMID:35979984; PMID:36805482; PMID:39089415; PMID:36639017; PMID:36805482; PMID:36805482; PMID:38573338; PMID:36811345; PMID:36925030; PMID:37345903; PMID:38573338; PMID:38964637; PMID:39089415; PMID:39442788; PMID:39631538; PMID:39725191; PMID:39922518; PMID:7517174; PMID:7688510; PMID:7969078; PMID:8370474; PMID:9359698
GO:0006919 Activation of cysteine-type endopeptidase activity involved in apoptotic process Increases phenotype PMID:24480152; PMID:26822305
GO:0006954 Inflammatory response Increases phenotype PMID:34358621; PMID:39214269
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:26317544; PMID:27565713; PMID:29775573; PMID:29913208; PMID:30107152; PMID:30107152; PMID:31207347; PMID:30769864; PMID:31207347; PMID:32107588; PMID:32335150; PMID:32562081; PMID:32846153; PMID:34047412
GO:0006979 Response to oxidative stress Increases phenotype PMID:12628736; PMID:15380674; PMID:17542780; PMID:18006777; PMID:19342159; PMID:20543097; PMID:21104935; PMID:24211725; PMID:30636491; PMID:7744298
GO:0006997 Nucleus organization Decreases phenotype PMID:36587877
GO:0007005 Mitochondrion organization Decreases phenotype PMID:22666520; PMID:24727461; PMID:28608983; PMID:29729358; PMID:30836069; PMID:34105389; PMID:34246718; PMID:35093381; PMID:37030624; PMID:39442788
GO:0007006 Mitochondrial membrane organization Decreases phenotype PMID:30377735
GO:0007033 Vacuole organization Increases phenotype PMID:28495616; PMID:31570982; PMID:35134463; PMID:35137609; PMID:36587877
GO:0007040 Lysosome organization Increases phenotype PMID:34246718
GO:0007041 Lysosomal transport Affects phenotype PMID:34105389
GO:0007042 Lysosomal lumen acidification Decreases phenotype PMID:34296331
GO:0007049 Cell cycle Decreases phenotype PMID:11502879; PMID:3107574; PMID:3756902; PMID:6449284; PMID:6449284; PMID:7688510; PMID:7579561
GO:0007095 Mitotic g2 dna damage checkpoint signaling Increases phenotype PMID:34519926
GO:0007137 Meiotic metaphase ii Affects phenotype PMID:31368505
GO:0007204 Positive regulation of cytosolic calcium ion concentration Increases phenotype PMID:30543781
GO:0007254 Jnk cascade Increases phenotype PMID:29087013
GO:0007283 Spermatogenesis Decreases phenotype PMID:24593989
GO:0007631 Feeding behavior Affects phenotype PMID:36805482; PMID:36805482; PMID:39706312
GO:0008152 Metabolic process Decreases phenotype PMID:29141199
GO:0008177 Succinate dehydrogenase (ubiquinone) activity Decreases phenotype PMID:34105389
GO:0008202 Steroid metabolic process Affects phenotype PMID:36587877
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:34605098
GO:0008210 Estrogen metabolic process Affects phenotype PMID:32810592
GO:0008217 Regulation of blood pressure Affects phenotype PMID:33882726
GO:0008219 Cell death Affects phenotype PMID:10766178; PMID:12370496; PMID:12370496; PMID:21882827; PMID:27368152; PMID:17187072; PMID:17542780; PMID:18655187; PMID:18655187; PMID:24444656; PMID:20438634; PMID:20543097; PMID:2159380; PMID:21882827; PMID:23671600; PMID:23671600; PMID:25333773; PMID:24444656; PMID:24518598; PMID:24518598; PMID:8794900; PMID:25333773; PMID:25373508; PMID:25373508; PMID:26564229; PMID:27099147; PMID:38042493; PMID:25478571; PMID:26416351; PMID:26519223; PMID:26537877; PMID:26564229; PMID:26842497; PMID:28456571; PMID:27079618; PMID:27099147; PMID:27155237; PMID:27368152; PMID:27378523; PMID:28323900; PMID:28456571; PMID:28987325; PMID:29141199; PMID:29968951; PMID:30831132; PMID:3107574; PMID:31533062; PMID:34126102; PMID:35134463; PMID:3756902; PMID:38042493; PMID:7579561; PMID:8794900; PMID:9131769
GO:0008283 Cell population proliferation Increases phenotype PMID:15705602; PMID:15728126; PMID:16044032; PMID:22751436; PMID:24161697; PMID:24291741; PMID:27163855; PMID:28756149; PMID:16891467; PMID:16891467; PMID:24161697; PMID:24975222; PMID:27163855; PMID:17542780; PMID:18371937; PMID:19174558; PMID:20193325; PMID:20298590; PMID:20333787; PMID:20666448; PMID:21882827; PMID:21882827; PMID:21911303; PMID:27368152; PMID:28756149; PMID:21911303; PMID:22751436; PMID:22992727; PMID:22992727; PMID:28756149; PMID:23293585; PMID:23794209; PMID:23794209; PMID:27769712; PMID:24161697; PMID:24211423; PMID:24892553; PMID:24892553; PMID:28099878; PMID:24975222; PMID:24998637; PMID:25056133; PMID:25339540; PMID:25605917; PMID:28756149; PMID:25824409; PMID:25944566; PMID:26025680; PMID:26025680; PMID:28756149; PMID:26170237; PMID:26170237; PMID:28756149; PMID:26519223; PMID:27163855; PMID:27163855; PMID:28756149; PMID:27368152; PMID:2758416; PMID:27769712; PMID:27780733; PMID:28756149; PMID:28082111; PMID:28756149; PMID:29112301; PMID:29481770; PMID:29775573; PMID:30482226; PMID:30517846; PMID:3107574; PMID:31570982; PMID:32360864; PMID:34801851; PMID:35186504; PMID:36572231; PMID:36634904; PMID:36925030; PMID:39214269; PMID:40035845; PMID:9359698
GO:0008284 Positive regulation of cell population proliferation Affects phenotype PMID:15897250; PMID:22580740; PMID:25912555; PMID:26821882; PMID:26969377; PMID:26969377; PMID:27423937; PMID:27423937; PMID:27807322; PMID:28191284; PMID:28710503
GO:0008285 Negative regulation of cell population proliferation Affects phenotype PMID:21371438; PMID:25887995; PMID:28534845; PMID:29087013; PMID:29966675; PMID:29105997; PMID:29555536; PMID:29966675; PMID:30611789; PMID:30703373; PMID:31101655; PMID:31226464; PMID:31563593; PMID:32217108; PMID:32289291; PMID:32505695; PMID:32634519; PMID:33984456; PMID:34296331; PMID:34296331; PMID:35438302; PMID:34519926; PMID:34524571; PMID:34648132; PMID:35213076; PMID:35438302; PMID:35710092; PMID:38943348
GO:0008344 Adult locomotory behavior Affects phenotype PMID:26678157
GO:0008361 Regulation of cell size Affects phenotype PMID:35093381; PMID:39097071; PMID:39725191
GO:0008610 Lipid biosynthetic process Increases phenotype PMID:29481770
GO:0009060 Aerobic respiration Decreases phenotype PMID:29653124; PMID:34296331
GO:0009119 Ribonucleoside metabolic process Affects phenotype PMID:36100043
GO:0009410 Response to xenobiotic stimulus Increases phenotype PMID:30703373; PMID:30929998; PMID:34524571
GO:0009437 Carnitine metabolic process Affects phenotype PMID:36100043; PMID:36587877
GO:0009820 Alkaloid metabolic process Affects phenotype PMID:36100043
GO:0010424 Dna methylation on cytosine within a cg sequence Decreases phenotype PMID:28962528
GO:0010459 Negative regulation of heart rate Increases phenotype PMID:34015281; PMID:34296331; PMID:34296331; PMID:38244039
GO:0010460 Positive regulation of heart rate Increases phenotype PMID:30588110
GO:0010467 Gene expression Affects phenotype PMID:29959987
GO:0010508 Positive regulation of autophagy Increases phenotype PMID:35764897; PMID:38324556
GO:0010666 Positive regulation of cardiac muscle cell apoptotic process Affects phenotype PMID:24480152
GO:0010823 Negative regulation of mitochondrion organization Increases phenotype PMID:34296331
GO:0010917 Negative regulation of mitochondrial membrane potential Increases phenotype PMID:25452174; PMID:31066085; PMID:31226464; PMID:34296331; PMID:34648132; PMID:37257577; PMID:37499777; PMID:37739323
GO:0010918 Positive regulation of mitochondrial membrane potential Decreases phenotype PMID:24902966; PMID:24902966; PMID:25997894; PMID:28642010
GO:0010940 Positive regulation of necrotic cell death Increases phenotype PMID:24072175; PMID:24939721; PMID:26335259; PMID:26969377; PMID:28815802
GO:0010942 Positive regulation of cell death Increases phenotype PMID:18829547; PMID:18829547; PMID:19232821; PMID:24736981; PMID:25392124; PMID:25411067; PMID:19232821; PMID:20668838; PMID:20705681; PMID:21625222; PMID:21867607; PMID:21867607; PMID:23725749; PMID:22293659; PMID:22293659; PMID:25411067; PMID:23725749; PMID:23792648; PMID:23911960; PMID:23964924; PMID:24064738; PMID:24736981; PMID:24738333; PMID:25078587; PMID:25257666; PMID:28125064; PMID:25330770; PMID:25330770; PMID:25997894; PMID:26969377; PMID:27664577; PMID:25392124; PMID:25411067; PMID:25411067; PMID:25452174; PMID:25411067; PMID:26607004; PMID:25437709; PMID:25446851; PMID:25452174; PMID:25687049; PMID:26134001; PMID:26318906; PMID:26607004; PMID:26708503; PMID:26969377; PMID:27015953; PMID:27664577; PMID:27816693; PMID:29064158; PMID:29305325; PMID:31545955; PMID:32169436
GO:0010972 Negative regulation of g2/m transition of mitotic cell cycle Increases phenotype PMID:29066354
GO:0014899 Cardiac muscle atrophy Increases phenotype PMID:35134463
GO:0015746 Citrate transport Affects phenotype PMID:34057017
GO:0016042 Lipid catabolic process Increases phenotype PMID:17582587; PMID:17582587; PMID:28082111; PMID:31100273; PMID:31830546; PMID:17582587; PMID:31100273; PMID:24727461; PMID:26678157; PMID:26807765; PMID:26807765; PMID:30928397; PMID:31830546; PMID:28082111; PMID:29133031; PMID:29481770; PMID:29775573; PMID:29775573; PMID:30734460; PMID:30734460; PMID:30836069; PMID:30885636; PMID:30928397; PMID:31100273; PMID:31830546; PMID:32335150; PMID:32525084; PMID:32691977; PMID:32691977; PMID:33484087; PMID:33704910; PMID:34047412; PMID:35137609; PMID:33331091; PMID:33484087; PMID:33484087; PMID:33704910; PMID:34047412; PMID:35137609; PMID:33704910; PMID:34047412; PMID:34343525; PMID:34656704; PMID:35093381; PMID:35137609
GO:0016049 Cell growth Affects phenotype PMID:23212659; PMID:28987325; PMID:29061315; PMID:29112301; PMID:29341321; PMID:29655913; PMID:29729358; PMID:29775573; PMID:29803840; PMID:29913208; PMID:30107152; PMID:30316766; PMID:30482226; PMID:30831132; PMID:30885636; PMID:30928397; PMID:36503300; PMID:36807623
GO:0016209 Antioxidant activity Increases phenotype PMID:30636491
GO:0016477 Cell migration Affects phenotype PMID:14593496; PMID:25686905; PMID:26701723; PMID:35186504
GO:0016505 Peptidase activator activity involved in apoptotic process Increases phenotype PMID:29653124; PMID:31445075
GO:0016567 Protein ubiquitination Increases phenotype PMID:26450947; PMID:39442788; PMID:40035845
GO:0016615 Malate dehydrogenase activity Decreases phenotype PMID:34605098
GO:0016887 Atp hydrolysis activity Decreases phenotype PMID:26721193
GO:0018158 Protein oxidation Increases phenotype PMID:28818578; PMID:29315967; PMID:29315967; PMID:30588110; PMID:33484087; PMID:30588110; PMID:33484087
GO:0018212 Peptidyl-tyrosine modification Increases phenotype PMID:31545955
GO:0019432 Triglyceride biosynthetic process Increases phenotype PMID:26721193
GO:0019471 4-hydroxyproline metabolic process Affects phenotype PMID:24939721
GO:0019538 Protein metabolic process Decreases phenotype PMID:31376360
GO:0019605 Butyrate metabolic process Affects phenotype PMID:36100043
GO:0019627 Urea metabolic process Affects phenotype PMID:33827303; PMID:33827303; PMID:34273911; PMID:37840533; PMID:36100043; PMID:37840533
GO:0019693 Ribose phosphate metabolic process Affects phenotype PMID:36100043
GO:0020027 Hemoglobin metabolic process Decreases phenotype PMID:28710503; PMID:35667395
GO:0030036 Actin cytoskeleton organization Decreases phenotype PMID:30611789
GO:0030199 Collagen fibril organization Increases phenotype PMID:28608983; PMID:34047412; PMID:34047412; PMID:35093381; PMID:34358621; PMID:34358621; PMID:34813134; PMID:38651543; PMID:34427160; PMID:34813134; PMID:35093381; PMID:35137609; PMID:36764612; PMID:36764612; PMID:37030624; PMID:38573338; PMID:39631538; PMID:37030624; PMID:37840533; PMID:38573338; PMID:38651543; PMID:39214269; PMID:39631538; PMID:40035845
GO:0030220 Platelet formation Increases phenotype PMID:35667395
GO:0030262 Apoptotic nuclear changes Increases phenotype PMID:30543781; PMID:31158416; PMID:34713381
GO:0030263 Apoptotic chromosome condensation Increases phenotype PMID:28082111; PMID:30142312; PMID:34392583; PMID:34427160; PMID:34427160; PMID:38651543; PMID:34635025; PMID:34635025; PMID:38997059; PMID:34813134; PMID:38651543; PMID:39426736
GO:0030308 Negative regulation of cell growth Increases phenotype PMID:34713381
GO:0030335 Positive regulation of cell migration Decreases phenotype PMID:26969377
GO:0030336 Negative regulation of cell migration Affects phenotype PMID:30611789; PMID:35213076
GO:0030595 Leukocyte chemotaxis Decreases phenotype PMID:3973653
GO:0031324 Negative regulation of cellular metabolic process Increases phenotype PMID:35710092
GO:0031398 Positive regulation of protein ubiquitination Increases phenotype PMID:25665036; PMID:25665036; PMID:25896364
GO:0031987 Locomotion involved in locomotory behavior Decreases phenotype PMID:39426736
GO:0032125 Micronucleus organization Increases phenotype PMID:30557669; PMID:32335150; PMID:32846153; PMID:34541749
GO:0032148 Activation of protein kinase b activity Decreases phenotype PMID:26318906; PMID:29087013; PMID:29087013; PMID:31563593
GO:0032308 Positive regulation of prostaglandin secretion Increases phenotype PMID:25687049
GO:0032760 Positive regulation of tumor necrosis factor production Affects phenotype PMID:24939721
GO:0032930 Positive regulation of superoxide anion generation Increases phenotype PMID:23964924; PMID:25437709; PMID:37739323
GO:0032964 Collagen biosynthetic process Increases phenotype PMID:31307187
GO:0032967 Positive regulation of collagen biosynthetic process Increases phenotype PMID:28318631; PMID:30588110; PMID:32068018
GO:0033316 Meiotic spindle assembly checkpoint signaling Increases phenotype PMID:31368505
GO:0033864 Positive regulation of nad(p)h oxidase activity Increases phenotype PMID:25437709
GO:0034101 Erythrocyte homeostasis Decreases phenotype PMID:29775573; PMID:38943348
GO:0034275 Kynurenic acid metabolic process Affects phenotype PMID:36100043
GO:0034440 Lipid oxidation Affects phenotype PMID:24902966; PMID:25411067; PMID:25411067; PMID:31376360; PMID:33827303; PMID:25437709; PMID:26036690; PMID:26036690; PMID:29315967; PMID:30588110; PMID:26335259; PMID:26335259; PMID:33827303; PMID:38567888; PMID:28642010; PMID:28815802; PMID:28818578; PMID:29064158; PMID:29315967; PMID:29315967; PMID:30588110; PMID:30543781; PMID:30588110; PMID:31376360; PMID:31545955; PMID:34713381; PMID:31563593; PMID:33827303; PMID:34105389; PMID:34105389; PMID:34648132; PMID:34648132; PMID:34713381; PMID:34713381; PMID:38573338; PMID:35843304; PMID:35843304; PMID:39426736; PMID:36811345; PMID:36811345; PMID:37867446; PMID:37867446; PMID:38567888; PMID:38573338; PMID:39426736
GO:0034599 Cellular response to oxidative stress Affects phenotype PMID:24275640
GO:0035332 Positive regulation of hippo signaling Increases phenotype PMID:23671600
GO:0035498 Carnosine metabolic process Affects phenotype PMID:36100043
GO:0035794 Positive regulation of mitochondrial membrane permeability Increases phenotype PMID:30543781
GO:0036164 Cell-abiotic substrate adhesion Decreases phenotype PMID:34856211
GO:0036211 Protein modification process Increases phenotype PMID:30734460
GO:0036336 Dendritic cell migration Increases phenotype PMID:30482226
GO:0040011 Locomotion Decreases phenotype PMID:26678157
GO:0040015 Negative regulation of multicellular organism growth Increases phenotype PMID:32068018; PMID:32289291
GO:0042133 Neurotransmitter metabolic process Increases phenotype PMID:28815802
GO:0042178 Xenobiotic catabolic process Decreases phenotype PMID:30611789
GO:0042307 Positive regulation of protein import into nucleus Affects phenotype PMID:24154490; PMID:30009776
GO:0042431 Indole metabolic process Affects phenotype PMID:36100043
GO:0042448 Progesterone metabolic process Affects phenotype PMID:32810592
GO:0042541 Hemoglobin biosynthetic process Decreases phenotype PMID:29775573
GO:0042554 Superoxide anion generation Increases phenotype PMID:28456571; PMID:28608983; PMID:29061315
GO:0042632 Cholesterol homeostasis Decreases phenotype PMID:29474904; PMID:29474904; PMID:34015281; PMID:30682439
GO:0042743 Hydrogen peroxide metabolic process Affects phenotype PMID:34047412
GO:0042756 Drinking behavior Affects phenotype PMID:36805482
GO:0042775 Mitochondrial atp synthesis coupled electron transport Increases phenotype PMID:25997894
GO:0042908 Xenobiotic transport Affects phenotype PMID:33009882
GO:0043065 Positive regulation of apoptotic process Affects phenotype PMID:22010212; PMID:22484629; PMID:22484629; PMID:24072175; PMID:24902966; PMID:25896364; PMID:32068018; PMID:22684020; PMID:24072175; PMID:24738333; PMID:24902966; PMID:24902966; PMID:25997894; PMID:29087013; PMID:37597758; PMID:25195822; PMID:25195822; PMID:29066354; PMID:25446852; PMID:25452174; PMID:25896364; PMID:25912555; PMID:25980584; PMID:26036690; PMID:26036690; PMID:28445944; PMID:29087013; PMID:29315967; PMID:26320837; PMID:26335259; PMID:26335259; PMID:34713381; PMID:37499777; PMID:26969377; PMID:27634759; PMID:27736728; PMID:28191284; PMID:28329872; PMID:28445944; PMID:28710503; PMID:28710503; PMID:38327044; PMID:39914624; PMID:29066354; PMID:29087013; PMID:29105997; PMID:29315967; PMID:29749404; PMID:30611789; PMID:31066085; PMID:31376360; PMID:32068018; PMID:32289291; PMID:32877659; PMID:33984456; PMID:34519926; PMID:34713381; PMID:35186504; PMID:35213076; PMID:35438302; PMID:35438302; PMID:37257577; PMID:35524977; PMID:35764897; PMID:35963316; PMID:36309171; PMID:37257577; PMID:37406984; PMID:37499777; PMID:37597758; PMID:37739323; PMID:38327044; PMID:38943348; PMID:39914624; PMID:9525472
GO:0043277 Apoptotic cell clearance Increases phenotype PMID:17187072
GO:0043408 Regulation of mapk cascade Decreases phenotype PMID:31563593
GO:0043436 Oxoacid metabolic process Affects phenotype PMID:36587877
GO:0043517 Positive regulation of dna damage response, signal transduction by p53 class mediator Increases phenotype PMID:38447685
GO:0043653 Mitochondrial fragmentation involved in apoptotic process Increases phenotype PMID:18006463
GO:0043966 Histone h3 acetylation Decreases phenotype PMID:25124555; PMID:31545955
GO:0043967 Histone h4 acetylation Affects phenotype PMID:25124555
GO:0043970 Histone h3-k9 acetylation Increases phenotype PMID:26519223; PMID:31768571
GO:0044154 Histone h3-k14 acetylation Increases phenotype PMID:26519223
GO:0044237 Cellular metabolic process Increases phenotype PMID:18164200; PMID:19655762; PMID:19655762; PMID:31479713; PMID:31645432; PMID:32335150; PMID:33880675; PMID:35182693; PMID:36122806; PMID:36576707; PMID:25673179; PMID:34605098; PMID:35152301; PMID:36764612; PMID:37062353; PMID:37217155; PMID:38964637; PMID:26701723; PMID:26701723; PMID:27129165; PMID:30581319; PMID:31207345; PMID:32886829; PMID:37591408; PMID:27129165; PMID:27922187; PMID:27922187; PMID:30769864; PMID:28392768; PMID:28392768; PMID:35803438; PMID:30482226; PMID:30482226; PMID:30769864; PMID:32024692; PMID:34719826; PMID:34783124; PMID:30557669; PMID:30769864; PMID:30769864; PMID:32024692; PMID:31307187; PMID:31307187; PMID:31570982; PMID:32525084; PMID:35093381; PMID:31570982; PMID:31645432; PMID:31682804; PMID:31682804; PMID:33507000; PMID:31843629; PMID:31976328; PMID:32024692; PMID:32173973; PMID:32185414; PMID:32335150; PMID:32525084; PMID:32562081; PMID:32652078; PMID:32751388; PMID:32846153; PMID:32886829; PMID:33009882; PMID:33507000; PMID:33771646; PMID:33880675; PMID:34105389; PMID:34105389; PMID:36639017; PMID:39631538; PMID:34182011; PMID:34358621; PMID:34605098; PMID:34719826; PMID:34783124; PMID:34856211; PMID:35085581; PMID:35093381; PMID:35134463; PMID:35218280; PMID:35478211; PMID:35524977; PMID:35803438; PMID:36503300; PMID:36564854; PMID:36576707; PMID:36634904; PMID:36639017; PMID:36764612; PMID:36804490; PMID:36805482; PMID:36805482; PMID:38573338; PMID:39631538; PMID:36811345; PMID:37030624; PMID:37062353; PMID:37217155; PMID:37345903; PMID:37393350; PMID:38367674; PMID:38573338; PMID:38830565; PMID:38964637; PMID:39427782; PMID:39442788; PMID:39631538; PMID:39725191; PMID:39922518
GO:0044242 Cellular lipid catabolic process Increases phenotype PMID:24799355
GO:0044319 Wound healing, spreading of cells Decreases phenotype PMID:22992727; PMID:26519223; PMID:31207345; PMID:33775688; PMID:32886829; PMID:33507000; PMID:33775688; PMID:37345903
GO:0044403 Biological process involved in symbiotic interaction Increases phenotype PMID:32068018
GO:0044754 Autolysosome Increases phenotype PMID:38964637
GO:0044843 Cell cycle g1/s phase transition Decreases phenotype PMID:28323900
GO:0045019 Negative regulation of nitric oxide biosynthetic process Increases phenotype PMID:31158416
GO:0045023 G0 to g1 transition Increases phenotype PMID:31207347; PMID:32562081; PMID:33331091; PMID:34126102
GO:0045333 Cellular respiration Decreases phenotype PMID:28608983; PMID:30557669; PMID:36805482; PMID:39043266
GO:0045429 Positive regulation of nitric oxide biosynthetic process Increases phenotype PMID:23964924; PMID:25411067; PMID:29474904; PMID:30588110; PMID:35843304; PMID:37257577; PMID:37257577; PMID:38327044; PMID:38327044
GO:0045454 Cell redox homeostasis Decreases phenotype PMID:37257577
GO:0045542 Positive regulation of cholesterol biosynthetic process Increases phenotype PMID:19558898
GO:0045621 Positive regulation of lymphocyte differentiation Increases phenotype PMID:32068018
GO:0045648 Positive regulation of erythrocyte differentiation Decreases phenotype PMID:28710503
GO:0045660 Positive regulation of neutrophil differentiation Increases phenotype PMID:32068018
GO:0045777 Positive regulation of blood pressure Increases phenotype PMID:31158416
GO:0045820 Negative regulation of glycolytic process Increases phenotype PMID:29653124
GO:0045837 Negative regulation of membrane potential Increases phenotype PMID:30636491
GO:0045840 Positive regulation of mitotic nuclear division Decreases phenotype PMID:26320837
GO:0045907 Positive regulation of vasoconstriction Increases phenotype PMID:31158416
GO:0045930 Negative regulation of mitotic cell cycle Increases phenotype PMID:21557330; PMID:22785532; PMID:25124555; PMID:25124555; PMID:26317544; PMID:26025680; PMID:26317544; PMID:27163855; PMID:31207345; PMID:30142312; PMID:30557669; PMID:31207345; PMID:31207347; PMID:31207347; PMID:31843629; PMID:31597699; PMID:31843629; PMID:33984456
GO:0045931 Positive regulation of mitotic cell cycle Affects phenotype PMID:26969377; PMID:28710503; PMID:34519926
GO:0046034 Atp metabolic process Decreases phenotype PMID:34358621; PMID:35093381; PMID:36805482; PMID:39089415; PMID:39442788; PMID:39725191
GO:0046058 Camp metabolic process Affects phenotype PMID:36270296
GO:0046068 Cgmp metabolic process Affects phenotype PMID:36270296
GO:0046110 Xanthine metabolic process Affects phenotype PMID:36100043
GO:0046209 Nitric oxide metabolic process Increases phenotype PMID:28608983; PMID:32812453; PMID:33827303
GO:0046323 Glucose import Affects phenotype PMID:34057017; PMID:36805482
GO:0046330 Positive regulation of jnk cascade Increases phenotype PMID:25856345; PMID:30588110
GO:0046415 Urate metabolic process Decreases phenotype PMID:25411067; PMID:30682439; PMID:31376360; PMID:31376360; PMID:34015281; PMID:39029857
GO:0046449 Creatinine metabolic process Increases phenotype PMID:19558898; PMID:19558898; PMID:31830546; PMID:32812453; PMID:33827303; PMID:36988379; PMID:37840533; PMID:39029857; PMID:39043266; PMID:25411067; PMID:29481770; PMID:31376360; PMID:31830546; PMID:32812453; PMID:33827303; PMID:36988379; PMID:37840533; PMID:39029857; PMID:39043266; PMID:32812453; PMID:33827303; PMID:36988379; PMID:37840533; PMID:39029857; PMID:39043266; PMID:39922518
GO:0046466 Membrane lipid catabolic process Increases phenotype PMID:19342159; PMID:21104935; PMID:24072175; PMID:2543512; PMID:2606537; PMID:26818447; PMID:26825964; PMID:30636491; PMID:31010378; PMID:3169265; PMID:3194911; PMID:35987278; PMID:36309171; PMID:6411900; PMID:7744298; PMID:8470886
GO:0046618 Xenobiotic export from cell Decreases phenotype PMID:25841332; PMID:27423937
GO:0046622 Positive regulation of organ growth Increases phenotype PMID:32068018
GO:0046685 Response to arsenic-containing substance Decreases phenotype PMID:27736728
GO:0046902 Regulation of mitochondrial membrane permeability Affects phenotype PMID:34105389
GO:0047823 D-glutamyltransferase activity Decreases phenotype PMID:29481770
GO:0048146 Positive regulation of fibroblast proliferation Increases phenotype PMID:31376360
GO:0048771 Tissue remodeling Increases phenotype PMID:40035845
GO:0048871 Multicellular organismal homeostasis Decreases phenotype PMID:31376360
GO:0048874 Host-mediated regulation of intestinal microbiota composition Increases phenotype PMID:32068018
GO:0050665 Hydrogen peroxide biosynthetic process Increases phenotype PMID:22484629
GO:0050729 Positive regulation of inflammatory response Increases phenotype PMID:27181935; PMID:28445944; PMID:38327044; PMID:38943348
GO:0050890 Cognition Decreases phenotype PMID:39426736
GO:0050898 Nitrile metabolic process Affects phenotype PMID:39922518
GO:0050996 Positive regulation of lipid catabolic process Increases phenotype PMID:23695218; PMID:24939721; PMID:37257577; PMID:37257577; PMID:37499777; PMID:38327044; PMID:39914624; PMID:37499777; PMID:38327044; PMID:39914624
GO:0051092 Positive regulation of nf-kappab transcription factor activity Affects phenotype PMID:26969377; PMID:9582369
GO:0051156 Glucose 6-phosphate metabolic process Affects phenotype PMID:36100043
GO:0051298 Centrosome duplication Affects phenotype PMID:22785532
GO:0051316 Attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation Affects phenotype PMID:31368505
GO:0051353 Positive regulation of oxidoreductase activity Affects phenotype PMID:29064158; PMID:31563593
GO:0051457 Maintenance of protein location in nucleus Affects phenotype PMID:37030624
GO:0051480 Regulation of cytosolic calcium ion concentration Affects phenotype PMID:24287111
GO:0051560 Mitochondrial calcium ion homeostasis Affects phenotype PMID:34605098
GO:0051726 Regulation of cell cycle Increases phenotype PMID:25452174
GO:0051881 Regulation of mitochondrial membrane potential Decreases phenotype PMID:12628736; PMID:15538571; PMID:15811867; PMID:21775390; PMID:21775390; PMID:24211423; PMID:30928397; PMID:24211423; PMID:24287111; PMID:25339540; PMID:28456571; PMID:28495616; PMID:29061315; PMID:29141199; PMID:29397400; PMID:29549912; PMID:29729358; PMID:29775573; PMID:29913208; PMID:35093381; PMID:30377735; PMID:30831132; PMID:30840857; PMID:30928397; PMID:32652078; PMID:33331091; PMID:34783124; PMID:35093381; PMID:37062353; PMID:39089415; PMID:39442788; PMID:39725191
GO:0051882 Mitochondrial depolarization Increases phenotype PMID:32075913; PMID:32525084; PMID:32562081; PMID:39089415; PMID:39725191
GO:0051897 Positive regulation of protein kinase b signaling Increases phenotype PMID:25856345
GO:0051901 Positive regulation of mitochondrial depolarization Increases phenotype PMID:30543781
GO:0051983 Regulation of chromosome segregation Decreases phenotype PMID:34519926
GO:0055003 Cardiac myofibril assembly Decreases phenotype PMID:30142312
GO:0055010 Ventricular cardiac muscle tissue morphogenesis Affects phenotype PMID:35137609
GO:0055072 Iron ion homeostasis Affects phenotype PMID:35667395; PMID:35667395; PMID:36195186; PMID:36195186; PMID:37030624
GO:0055074 Calcium ion homeostasis Affects phenotype PMID:26678157; PMID:28495616
GO:0055118 Negative regulation of cardiac muscle contraction Increases phenotype PMID:29966675
GO:0060047 Heart contraction Decreases phenotype PMID:28099878; PMID:30928397; PMID:30928397; PMID:35137609; PMID:35134463; PMID:36764612
GO:0060048 Cardiac muscle contraction Decreases phenotype PMID:15811867; PMID:20543097
GO:0060326 Cell chemotaxis Decreases phenotype PMID:33507000; PMID:37345903
GO:0060545 Positive regulation of necroptotic process Increases phenotype PMID:35843304
GO:0061002 Negative regulation of dendritic spine morphogenesis Increases phenotype PMID:29228376
GO:0061024 Membrane organization Decreases phenotype PMID:28099878
GO:0061117 Negative regulation of heart growth Increases phenotype PMID:28818578
GO:0061178 Regulation of insulin secretion involved in cellular response to glucose stimulus Affects phenotype PMID:27255381
GO:0061370 Testosterone biosynthetic process Affects phenotype PMID:32394736
GO:0061739 Protein lipidation involved in autophagosome assembly Increases phenotype PMID:31226464; PMID:31563593; PMID:34296331; PMID:39631538; PMID:39725191
GO:0061890 Positive regulation of astrocyte activation Increases phenotype PMID:35843304
GO:0061909 Autophagosome-lysosome fusion Affects phenotype PMID:34296331
GO:0062034 L-pipecolic acid biosynthetic process Affects phenotype PMID:36587877
GO:0062197 Cellular response to chemical stress Increases phenotype PMID:28534845
GO:0070212 Protein poly-adp-ribosylation Increases phenotype PMID:31174020
GO:0070265 Necrotic cell death Increases phenotype PMID:28495616; PMID:31100273; PMID:32846153; PMID:33882726; PMID:33882726; PMID:34369273; PMID:36270296; PMID:34392583; PMID:34635025; PMID:35182693; PMID:36270296; PMID:37867446; PMID:39089415; PMID:39214269; PMID:40035845
GO:0070266 Necroptotic process Affects phenotype PMID:34358621; PMID:36764612
GO:0070301 Cellular response to hydrogen peroxide Increases phenotype PMID:26519223
GO:0070328 Triglyceride homeostasis Decreases phenotype PMID:29474904; PMID:30682439
GO:0070343 White fat cell proliferation Decreases phenotype PMID:39706312
GO:0070374 Positive regulation of erk1 and erk2 cascade Affects phenotype PMID:25856345; PMID:27806920; PMID:30588110
GO:0070665 Positive regulation of leukocyte proliferation Affects phenotype PMID:28710503; PMID:32068018
GO:0070936 Protein k48-linked ubiquitination Increases phenotype PMID:39089415
GO:0070994 Detection of oxidative stress Increases phenotype PMID:24727461; PMID:24727461; PMID:34427160; PMID:34635025; PMID:34813134; PMID:36270296; PMID:38997059; PMID:39029857; PMID:39214269; PMID:26721193; PMID:33882726; PMID:38651543; PMID:32394736; PMID:34933056; PMID:33882726; PMID:33882726; PMID:38651543; PMID:34105389; PMID:34105389; PMID:36639017; PMID:34427160; PMID:34427160; PMID:34635025; PMID:34813134; PMID:36270296; PMID:38997059; PMID:39029857; PMID:39214269; PMID:34605098; PMID:34635025; PMID:34635025; PMID:34813134; PMID:36270296; PMID:38997059; PMID:39029857; PMID:39214269; PMID:34635025; PMID:38997059; PMID:39029857; PMID:34813134; PMID:34933056; PMID:35137609; PMID:35667395; PMID:36639017; PMID:37030624; PMID:36270296; PMID:36639017; PMID:36764612; PMID:36764612; PMID:39089415; PMID:36988379; PMID:36988379; PMID:37840533; PMID:39029857; PMID:39043266; PMID:36988379; PMID:39029857; PMID:39043266; PMID:37030624; PMID:37840533; PMID:38651543; PMID:38997059; PMID:39029857; PMID:39043266; PMID:39089415; PMID:39214269
GO:0071447 Cellular response to hydroperoxide Decreases phenotype PMID:26607004
GO:0071466 Cellular response to xenobiotic stimulus Increases phenotype PMID:27417252
GO:0071897 Dna biosynthetic process Decreases phenotype PMID:32185414
GO:0071901 Negative regulation of protein serine/threonine kinase activity Affects phenotype PMID:34296331
GO:0071902 Positive regulation of protein serine/threonine kinase activity Affects phenotype PMID:31563593
GO:0072558 Nlrp1 inflammasome complex Increases phenotype PMID:35764897
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:18164200; PMID:20666448; PMID:22927544; PMID:23293585; PMID:24211423; PMID:24287111; PMID:25824409; PMID:32335150; PMID:32525084; PMID:32525084; PMID:35093381; PMID:32652078; PMID:33331091; PMID:33775688; PMID:34105389; PMID:34358621; PMID:34605098; PMID:34605098; PMID:38395252; PMID:34783124; PMID:35093381; PMID:35478211; PMID:36639017; PMID:36811345; PMID:37030624; PMID:38395252; PMID:38573338; PMID:39442788; PMID:39725191
GO:0072678 T cell migration Increases phenotype PMID:30482226; PMID:36807623
GO:0072718 Response to cisplatin Decreases phenotype PMID:31563593
GO:0086003 Cardiac muscle cell contraction Decreases phenotype PMID:25538221; PMID:28495616; PMID:29385562
GO:0086004 Regulation of cardiac muscle cell contraction Affects phenotype PMID:25237062
GO:0090116 C-5 methylation of cytosine Decreases phenotype PMID:30557669
GO:0090141 Positive regulation of mitochondrial fission Increases phenotype PMID:29966675
GO:0090200 Positive regulation of release of cytochrome c from mitochondria Affects phenotype PMID:25169008; PMID:28642010; PMID:31226464; PMID:31563593
GO:0090238 Positive regulation of arachidonic acid secretion Increases phenotype PMID:38984448
GO:0090296 Regulation of mitochondrial dna replication Affects phenotype PMID:26781513
GO:0090305 Nucleic acid phosphodiester bond hydrolysis Increases phenotype PMID:11062742; PMID:2825970; PMID:2836060
GO:0090398 Cellular senescence Increases phenotype PMID:22927544; PMID:30142312
GO:0097212 Lysosomal membrane organization Affects phenotype PMID:34105389
GO:0097214 Positive regulation of lysosomal membrane permeability Increases phenotype PMID:31226464
GO:0097237 Cellular response to toxic substance Increases phenotype PMID:23466342
GO:0097280 Histamine secretion mediated by immunoglobulin Increases phenotype PMID:2452008
GO:0097327 Response to antineoplastic agent Affects phenotype PMID:20705681; PMID:21371438; PMID:21625222; PMID:22293659; PMID:24736981; PMID:25078587; PMID:25351371; PMID:27664577; PMID:27736728; PMID:29315967; PMID:29618387; PMID:30391378; PMID:30703373; PMID:30974157; PMID:32212926
GO:0097412 Hyaline inclusion Increases phenotype PMID:35137609
GO:0097707 Ferroptosis Increases phenotype PMID:34648132; PMID:35667395; PMID:38984448; PMID:36195186; PMID:38984448
GO:0097722 Sperm motility Decreases phenotype PMID:31174020
GO:0098743 Cell aggregation Decreases phenotype PMID:30703373
GO:0106292 Superoxide-generating nadph oxidase activity Increases phenotype PMID:34047412
GO:0120041 Positive regulation of macrophage proliferation Increases phenotype PMID:19558898
GO:0120183 Positive regulation of focal adhesion disassembly Increases phenotype PMID:30611789
GO:0120331 Endothelial tube formation Affects phenotype PMID:35524977
GO:0140042 Lipid droplet formation Increases phenotype PMID:34246718; PMID:39922518
GO:0150033 Negative regulation of protein localization to lysosome Increases phenotype PMID:31226464
GO:1900181 Negative regulation of protein localization to nucleus Increases phenotype PMID:34296331
GO:1900407 Regulation of cellular response to oxidative stress Affects phenotype PMID:26607004
GO:1900745 Positive regulation of p38mapk cascade Increases phenotype PMID:25856345; PMID:30588110; PMID:31376360; PMID:35843304
GO:1900753 Doxorubicin transport Increases phenotype PMID:18829547; PMID:20020937; PMID:30482226
GO:1901097 Negative regulation of autophagosome maturation Increases phenotype PMID:34296331
GO:1901135 Carbohydrate derivative metabolic process Affects phenotype PMID:36100043
GO:1901216 Positive regulation of neuron death Increases phenotype PMID:35843304
GO:1901526 Positive regulation of mitophagy Increases phenotype PMID:37406984
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:24939721; PMID:26825964; PMID:26825964; PMID:31376360; PMID:29315967; PMID:29315967; PMID:30588110; PMID:30588110; PMID:31066085; PMID:31376360; PMID:34713381; PMID:34713381; PMID:38327044; PMID:38327044; PMID:38395252
GO:1901671 Positive regulation of superoxide dismutase activity Affects phenotype PMID:24902966; PMID:25169008; PMID:25437709; PMID:26335259
GO:1901673 Regulation of mitotic spindle assembly Decreases phenotype PMID:34519926
GO:1901800 Positive regulation of proteasomal protein catabolic process Affects phenotype PMID:25665036; PMID:25665036; PMID:25896364; PMID:29066354; PMID:31563593
GO:1902093 Positive regulation of flagellated sperm motility Decreases phenotype PMID:28818578
GO:1902255 Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator Increases phenotype PMID:29653124
GO:1902512 Positive regulation of apoptotic dna fragmentation Increases phenotype PMID:16609701; PMID:21567185; PMID:25452174; PMID:25665036; PMID:26822305; PMID:27255381; PMID:28329872; PMID:31226464; PMID:34296331; PMID:34648132
GO:1902520 Response to doxorubicin Decreases phenotype PMID:31563593; PMID:34524571; PMID:35213076
GO:1902552 Negative regulation of catalase activity Increases phenotype PMID:26825964; PMID:31066085; PMID:38327044
GO:1902806 Regulation of cell cycle g1/s phase transition Affects phenotype PMID:28323900
GO:1902884 Positive regulation of response to oxidative stress Increases phenotype PMID:23695218; PMID:26825964
GO:1903047 Mitotic cell cycle process Affects phenotype PMID:31597699; PMID:32466334; PMID:33331091; PMID:34719826; PMID:34856211; PMID:38423379
GO:1903283 Negative regulation of glutathione peroxidase activity Increases phenotype PMID:26825964; PMID:29315967; PMID:38327044
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:27155237; PMID:27565713; PMID:28082111; PMID:28456571; PMID:29729358; PMID:29775573; PMID:29775573; PMID:30734460; PMID:29913208; PMID:30636491; PMID:30734460; PMID:30831132; PMID:30840857; PMID:30885636; PMID:30928397
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:23964924; PMID:24072175; PMID:24902966; PMID:24902966; PMID:29087013; PMID:37597758; PMID:24902966; PMID:37453608; PMID:26607004; PMID:26969377; PMID:29087013; PMID:30543781; PMID:31066085; PMID:31158416; PMID:33984456; PMID:34296331; PMID:34296331; PMID:35438302; PMID:34713381; PMID:34713381; PMID:37499777; PMID:35438302; PMID:36309171; PMID:37406984; PMID:37453608; PMID:37499777; PMID:37499777; PMID:39914624; PMID:37597758; PMID:38984448; PMID:39914624
GO:1903514 Release of sequestered calcium ion into cytosol by endoplasmic reticulum Increases phenotype PMID:30476324
GO:1903543 Positive regulation of exosomal secretion Increases phenotype PMID:37820772
GO:1903779 Regulation of cardiac conduction Decreases phenotype PMID:30588110
GO:1903780 Negative regulation of cardiac conduction Increases phenotype PMID:32877659
GO:1903999 Negative regulation of eating behavior Increases phenotype PMID:32068018
GO:1904145 Negative regulation of meiotic cell cycle process involved in oocyte maturation Increases phenotype PMID:28329872; PMID:31368505
GO:1904183 Negative regulation of pyruvate dehydrogenase activity Increases phenotype PMID:29653124
GO:1904440 Positive regulation of iron ion import across plasma membrane Increases phenotype PMID:34648132
GO:1905037 Autophagosome organization Increases phenotype PMID:32434049; PMID:39442788
GO:1905071 Tight junction disassembly Increases phenotype PMID:36100150
GO:1990248 Regulation of transcription from rna polymerase ii promoter in response to dna damage Increases phenotype PMID:27181935
GO:1990584 Cardiac troponin complex Increases phenotype PMID:34605098
GO:1990961 Xenobiotic detoxification by transmembrane export across the plasma membrane Decreases phenotype PMID:25392124
GO:2000355 Negative regulation of ovarian follicle development Increases phenotype PMID:28329872
GO:2000573 Positive regulation of dna biosynthetic process Decreases phenotype PMID:25452174
GO:2000617 Positive regulation of histone h3-k9 acetylation Increases phenotype PMID:34713381
GO:2000774 Positive regulation of cellular senescence Increases phenotype PMID:38395252
GO:2000786 Positive regulation of autophagosome assembly Affects phenotype PMID:26969377; PMID:31226464
GO:2000865 Negative regulation of estradiol secretion Increases phenotype PMID:28329872; PMID:32505695
GO:2000866 Positive regulation of estradiol secretion Increases phenotype PMID:32505695
GO:2001022 Positive regulation of response to dna damage stimulus Increases phenotype PMID:27181935
GO:2001038 Regulation of cellular response to drug Decreases phenotype PMID:32217108; PMID:34801851
GO:2001040 Positive regulation of cellular response to drug Increases phenotype PMID:15294447
GO:2001057 Reactive nitrogen species metabolic process Increases phenotype PMID:26607004; PMID:32652078
GO:2001170 Negative regulation of atp biosynthetic process Increases phenotype PMID:29653124; PMID:29966675; PMID:34296331; PMID:37453608; PMID:37499777
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.