DEDUCT | Database of Endocrine Disrupting chemicals and their Toxicity profiles

Ascorbic acid

Curated chemical-phenotype interactions from CTD

GO ID	GO name	Interaction type	Reference
GO:0000086	G2/m transition of mitotic cell cycle	Affects phenotype	PMID:28415704
GO:0000737	Dna catabolic process, endonucleolytic	Increases phenotype	PMID:28703385; PMID:37704839
GO:0001503	Ossification	Increases phenotype	PMID:25062436; PMID:31472278; PMID:32324263; PMID:34020675; PMID:38081572; PMID:38914176
GO:0001552	Ovarian follicle atresia	Increases phenotype	PMID:23470461
GO:0001649	Osteoblast differentiation	Increases phenotype	PMID:27387537; PMID:28921615; PMID:30312686; PMID:30731080; PMID:30738844; PMID:31887333; PMID:38914176
GO:0001776	Leukocyte homeostasis	Affects phenotype	PMID:37704839
GO:0001836	Release of cytochrome c from mitochondria	Increases phenotype	PMID:25845326
GO:0002076	Osteoblast development	Increases phenotype	PMID:27028516
GO:0002260	Lymphocyte homeostasis	Affects phenotype	PMID:37704839
GO:0002536	Respiratory burst involved in inflammatory response	Increases phenotype	PMID:23692848
GO:0002693	Positive regulation of cellular extravasation	Increases phenotype	PMID:27020608; PMID:39325335
GO:0003016	Respiratory system process	Affects phenotype	PMID:23379631
GO:0003331	Positive regulation of extracellular matrix constituent secretion	Increases phenotype	PMID:26492236
GO:0003341	Cilium movement	Increases phenotype	PMID:32374624
GO:0003918	Dna topoisomerase type ii (double strand cut, atp-hydrolyzing) activity	Increases phenotype	PMID:33760604
GO:0003954	Nadh dehydrogenase activity	Decreases phenotype	PMID:32407874
GO:0003990	Acetylcholinesterase activity	Decreases phenotype	PMID:27941167
GO:0003993	Acid phosphatase activity	Increases phenotype	PMID:19391111
GO:0004021	L-alanine:2-oxoglutarate aminotransferase activity	Increases phenotype	PMID:31739238
GO:0004035	Alkaline phosphatase activity	Increases phenotype	PMID:19391111; PMID:23108452; PMID:23619517; PMID:25062436; PMID:27387537; PMID:28105418; PMID:28921615; PMID:31739238; PMID:32473317; PMID:34020675; PMID:38914176
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	Increases phenotype	PMID:16758767; PMID:19391111; PMID:23108452; PMID:31739238
GO:0004096	Catalase activity	Decreases phenotype	PMID:37704839; PMID:38284084
GO:0004111	Creatine kinase activity	Increases phenotype	PMID:27941167
GO:0004345	Glucose-6-phosphate dehydrogenase activity	Decreases phenotype	PMID:38284084
GO:0004346	Glucose-6-phosphatase activity	Increases phenotype	PMID:16758767; PMID:38284084
GO:0004364	Glutathione transferase activity	Affects phenotype	PMID:16758767; PMID:18548748; PMID:23470461; PMID:25178734; PMID:31610155; PMID:33388378
GO:0004396	Hexokinase activity	Increases phenotype	PMID:38284084
GO:0004402	Histone acetyltransferase activity	Increases phenotype	PMID:25178734
GO:0004407	Histone deacetylase activity	Decreases phenotype	PMID:25178734
GO:0004457	Lactate dehydrogenase activity	Increases phenotype	PMID:23108452; PMID:24463055; PMID:27941167; PMID:31022331
GO:0004602	Glutathione peroxidase activity	Increases phenotype	PMID:18548748; PMID:19391111; PMID:23470461; PMID:28285367; PMID:29572072; PMID:31022331; PMID:32407874; PMID:32632975; PMID:38284084
GO:0004683	Calmodulin-dependent protein kinase activity	Increases phenotype	PMID:34286406
GO:0004705	Jun kinase activity	Increases phenotype	PMID:24907532
GO:0004707	Map kinase activity	Increases phenotype	PMID:24907532
GO:0004784	Superoxide dismutase activity	Affects phenotype	PMID:16758767; PMID:17879260; PMID:19391111; PMID:22870923; PMID:23470461; PMID:25178734; PMID:25721553; PMID:29572072; PMID:29992683; PMID:31022331; PMID:32632975; PMID:33475796; PMID:33592258; PMID:35187746; PMID:37704839; PMID:38284084
GO:0004791	Thioredoxin-disulfide reductase activity	Affects phenotype	PMID:25178734
GO:0005975	Carbohydrate metabolic process	Affects phenotype	PMID:35066937
GO:0006089	Lactate metabolic process	Affects phenotype	PMID:33475796; PMID:38160894
GO:0006090	Pyruvate metabolic process	Affects phenotype	PMID:38160894
GO:0006102	Isocitrate metabolic process	Decreases phenotype	PMID:24295472
GO:0006123	Mitochondrial electron transport, cytochrome c to oxygen	Increases phenotype	PMID:34089800
GO:0006304	Dna modification	Increases phenotype	PMID:26381084
GO:0006309	Apoptotic dna fragmentation	Increases phenotype	PMID:29992683; PMID:9694399; PMID:9828209
GO:0006401	Rna catabolic process	Increases phenotype	PMID:30140404
GO:0006641	Triglyceride metabolic process	Affects phenotype	PMID:33007364
GO:0006693	Prostaglandin metabolic process	Affects phenotype	PMID:28285367
GO:0006702	Androgen biosynthetic process	Decreases phenotype	PMID:28729172
GO:0006729	Tetrahydrobiopterin biosynthetic process	Increases phenotype	PMID:11243424
GO:0006735	Nadh regeneration	Decreases phenotype	PMID:24126434
GO:0006749	Glutathione metabolic process	Increases phenotype	PMID:23194016; PMID:24126434; PMID:24295472; PMID:24488945; PMID:28285367; PMID:31005848; PMID:31739238; PMID:32407874; PMID:35187746
GO:0006750	Glutathione biosynthetic process	Affects phenotype	PMID:16758767; PMID:17265541; PMID:17879260; PMID:18548748; PMID:19391111; PMID:21284339; PMID:22870923; PMID:25178734; PMID:25845326; PMID:27718046; PMID:29572072; PMID:29992683; PMID:30266311; PMID:31022331
GO:0006754	Atp biosynthetic process	Decreases phenotype	PMID:29158198; PMID:32407874
GO:0006776	Vitamin a metabolic process	Affects phenotype	PMID:28285367
GO:0006805	Xenobiotic metabolic process	Affects phenotype	PMID:24283477
GO:0006809	Nitric oxide biosynthetic process	Increases phenotype	PMID:23463385
GO:0006915	Apoptotic process	Increases phenotype	PMID:10079838; PMID:10502298; PMID:12356783; PMID:12478620; PMID:12496265; PMID:12606818; PMID:12750841; PMID:14632209; PMID:14871405; PMID:15158148; PMID:16397052; PMID:17041759; PMID:17325128; PMID:18344201; PMID:18442981; PMID:19301245; PMID:20179380; PMID:20737478; PMID:23470461; PMID:23535401; PMID:24732427; PMID:24907532; PMID:30526067; PMID:31585129; PMID:32632975; PMID:37704839; PMID:38160894; PMID:7811993; PMID:9224736; PMID:9247148; PMID:9252655; PMID:9359698; PMID:9694399
GO:0006954	Inflammatory response	Increases phenotype	PMID:22728154
GO:0006974	Cellular response to dna damage stimulus	Increases phenotype	PMID:17582584; PMID:23027624; PMID:25817893; PMID:29736388; PMID:30140404; PMID:32632975; PMID:33760604
GO:0006979	Response to oxidative stress	Increases phenotype	PMID:12423650; PMID:12477524; PMID:12767684; PMID:12949374; PMID:15379780; PMID:17487265; PMID:18549673; PMID:20025841; PMID:20028703; PMID:20525221; PMID:21104935; PMID:21114986; PMID:22530035; PMID:31032366; PMID:7797090; PMID:8900400
GO:0007049	Cell cycle	Decreases phenotype	PMID:16397052
GO:0007283	Spermatogenesis	Decreases phenotype	PMID:25637669; PMID:29663635; PMID:29940330; PMID:30240002; PMID:30526067; PMID:33372294
GO:0007286	Spermatid development	Decreases phenotype	PMID:30140404
GO:0007613	Memory	Affects phenotype	PMID:35187746
GO:0007625	Grooming behavior	Affects phenotype	PMID:35187746
GO:0008203	Cholesterol metabolic process	Affects phenotype	PMID:22421054; PMID:33007364
GO:0008217	Regulation of blood pressure	Decreases phenotype	PMID:9880127
GO:0008219	Cell death	Affects phenotype	PMID:11880902; PMID:12566691; PMID:12953835; PMID:14649725; PMID:15388883; PMID:15577407; PMID:15725397; PMID:16715183; PMID:17265541; PMID:17325128; PMID:20433922; PMID:24139157; PMID:24743698; PMID:25178734; PMID:25845326; PMID:27324791; PMID:29992683; PMID:31708536; PMID:33248029
GO:0008283	Cell population proliferation	Affects phenotype	PMID:16342676; PMID:25800560; PMID:26270818; PMID:37704839; PMID:38160894
GO:0008284	Positive regulation of cell population proliferation	Affects phenotype	PMID:23859036; PMID:24488945; PMID:24675465; PMID:25555879; PMID:27381660
GO:0008285	Negative regulation of cell population proliferation	Increases phenotype	PMID:20028703; PMID:22678527; PMID:25809564; PMID:30399392; PMID:33388378
GO:0008443	Phosphofructokinase activity	Decreases phenotype	PMID:38284084
GO:0008584	Male gonad development	Decreases phenotype	PMID:28729172
GO:0009060	Aerobic respiration	Decreases phenotype	PMID:24295472
GO:0009110	Vitamin biosynthetic process	Affects phenotype	PMID:31163222
GO:0010189	Vitamin e biosynthetic process	Decreases phenotype	PMID:19391111; PMID:21284339
GO:0010424	Dna methylation on cytosine within a cg sequence	Affects phenotype	PMID:27901495
GO:0010694	Positive regulation of alkaline phosphatase activity	Increases phenotype	PMID:31935364
GO:0010729	Positive regulation of hydrogen peroxide biosynthetic process	Increases phenotype	PMID:24675465; PMID:27941167
GO:0010906	Regulation of glucose metabolic process	Affects phenotype	PMID:38185084
GO:0010917	Negative regulation of mitochondrial membrane potential	Increases phenotype	PMID:25809564
GO:0010918	Positive regulation of mitochondrial membrane potential	Affects phenotype	PMID:24126434; PMID:24295472; PMID:24675465; PMID:34089800
GO:0010940	Positive regulation of necrotic cell death	Increases phenotype	PMID:23820267; PMID:24126434
GO:0010942	Positive regulation of cell death	Increases phenotype	PMID:20028703; PMID:23042718; PMID:23804405; PMID:24126434; PMID:25305479; PMID:25446496; PMID:25786529; PMID:25977998; PMID:27510327; PMID:39914626
GO:0010983	Positive regulation of high-density lipoprotein particle clearance	Increases phenotype	PMID:38284084
GO:0010989	Negative regulation of low-density lipoprotein particle clearance	Increases phenotype	PMID:38284084
GO:0015747	Urate transport	Increases phenotype	PMID:19391111
GO:0015840	Urea transport	Increases phenotype	PMID:19391111
GO:0015882	L-ascorbic acid transmembrane transport	Affects phenotype	PMID:25809564; PMID:31647942
GO:0016042	Lipid catabolic process	Increases phenotype	PMID:16758767; PMID:17265541; PMID:17879260; PMID:18548748; PMID:19391111; PMID:21284339; PMID:22728154; PMID:23470461; PMID:23619517; PMID:24026541; PMID:24523661; PMID:25178734; PMID:25721553; PMID:28259689; PMID:28285367; PMID:28709945; PMID:29572072; PMID:30140404; PMID:30526067; PMID:30676168; PMID:31585129; PMID:31610155; PMID:31739238; PMID:32407874; PMID:32632975; PMID:33007364; PMID:33248029; PMID:33475796; PMID:33592258; PMID:35187746; PMID:8968052
GO:0016049	Cell growth	Decreases phenotype	PMID:17879260; PMID:23212659; PMID:25178734; PMID:28690196; PMID:29467594; PMID:29663635
GO:0016174	Nad(p)h oxidase h2o2-forming activity	Increases phenotype	PMID:28285367
GO:0016209	Antioxidant activity	Decreases phenotype	PMID:29297235
GO:0016358	Dendrite development	Decreases phenotype	PMID:31708536
GO:0017121	Plasma membrane phospholipid scrambling	Increases phenotype	PMID:26139164
GO:0018158	Protein oxidation	Increases phenotype	PMID:12818473; PMID:12919963; PMID:18548748; PMID:23238474; PMID:25178734; PMID:26381084; PMID:28285367; PMID:32407874; PMID:37704839
GO:0019228	Neuronal action potential	Increases phenotype	PMID:33713149
GO:0019627	Urea metabolic process	Affects phenotype	PMID:21284339
GO:0019852	L-ascorbic acid metabolic process	Increases phenotype	PMID:20020850; PMID:20100038; PMID:20583318; PMID:22627169; PMID:23716880; PMID:23716880; PMID:26286522; PMID:33724628; PMID:23857379; PMID:25062976; PMID:25367288; PMID:26089033; PMID:26120027; PMID:26210702; PMID:26286522; PMID:28077287; PMID:28285367; PMID:28364781; PMID:29758312; PMID:30088836; PMID:31476248; PMID:31476248; PMID:33759307; PMID:31584213; PMID:31710167; PMID:32001261; PMID:32302048; PMID:32662567; PMID:32752303; PMID:33003968; PMID:33063951; PMID:33347680; PMID:33347680; PMID:35243731; PMID:33724628; PMID:33736254; PMID:33759307; PMID:34506763; PMID:34517062; PMID:34560258; PMID:34791780; PMID:34816538; PMID:35103375; PMID:35189178; PMID:35243731; PMID:36868495; PMID:37920212
GO:0019853	L-ascorbic acid biosynthetic process	Decreases phenotype	PMID:19391111; PMID:21284339; PMID:23470461
GO:0020027	Hemoglobin metabolic process	Affects phenotype	PMID:37704839
GO:0030036	Actin cytoskeleton organization	Affects phenotype	PMID:25758670
GO:0030182	Neuron differentiation	Increases phenotype	PMID:33713149
GO:0030194	Positive regulation of blood coagulation	Increases phenotype	PMID:26139164
GO:0030263	Apoptotic chromosome condensation	Increases phenotype	PMID:31708536; PMID:35187746; PMID:37704839
GO:0030282	Bone mineralization	Affects phenotype	PMID:12496288; PMID:25062436; PMID:27028516; PMID:27387537; PMID:30731080; PMID:30738844
GO:0030316	Osteoclast differentiation	Increases phenotype	PMID:26319416
GO:0030321	Transepithelial chloride transport	Increases phenotype	PMID:17215323
GO:0030595	Leukocyte chemotaxis	Increases phenotype	PMID:11861947
GO:0031175	Neuron projection development	Decreases phenotype	PMID:30075218
GO:0031324	Negative regulation of cellular metabolic process	Decreases phenotype	PMID:36063024
GO:0031987	Locomotion involved in locomotory behavior	Affects phenotype	PMID:35187746
GO:0032024	Positive regulation of insulin secretion	Increases phenotype	PMID:38284084
GO:0032125	Micronucleus organization	Increases phenotype	PMID:16758767; PMID:29736388; PMID:32632975
GO:0032332	Positive regulation of chondrocyte differentiation	Increases phenotype	PMID:26526931
GO:0032436	Positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Decreases phenotype	PMID:26598004
GO:0032496	Response to lipopolysaccharide	Increases phenotype	PMID:30606963
GO:0032755	Positive regulation of interleukin-6 production	Affects phenotype	PMID:24239723
GO:0032757	Positive regulation of interleukin-8 production	Increases phenotype	PMID:25551565
GO:0032760	Positive regulation of tumor necrosis factor production	Affects phenotype	PMID:24239723
GO:0032769	Negative regulation of monooxygenase activity	Increases phenotype	PMID:28726718
GO:0032914	Positive regulation of transforming growth factor beta1 production	Affects phenotype	PMID:24239723
GO:0032930	Positive regulation of superoxide anion generation	Increases phenotype	PMID:24126434; PMID:24675465
GO:0032964	Collagen biosynthetic process	Affects phenotype	PMID:27028516
GO:0032967	Positive regulation of collagen biosynthetic process	Increases phenotype	PMID:27381660; PMID:31935364
GO:0033327	Leydig cell differentiation	Decreases phenotype	PMID:30526067
GO:0034101	Erythrocyte homeostasis	Affects phenotype	PMID:37704839
GO:0034418	Urate biosynthetic process	Affects phenotype	PMID:21284339
GO:0034440	Lipid oxidation	Affects phenotype	PMID:12818473; PMID:21751221; PMID:23238474; PMID:24295472; PMID:25305479; PMID:25637669; PMID:31005848; PMID:32805337; PMID:33372294; PMID:33388378; PMID:34089294
GO:0035092	Sperm dna condensation	Increases phenotype	PMID:30140404
GO:0035640	Exploration behavior	Affects phenotype	PMID:35187746
GO:0035794	Positive regulation of mitochondrial membrane permeability	Increases phenotype	PMID:22226756; PMID:24295472; PMID:24675465
GO:0035934	Corticosterone secretion	Increases phenotype	PMID:37704839
GO:0035936	Testosterone secretion	Decreases phenotype	PMID:23470461; PMID:30140404
GO:0035937	Estrogen secretion	Decreases phenotype	PMID:23470461
GO:0036146	Cellular response to mycotoxin	Increases phenotype	PMID:23719927
GO:0036211	Protein modification process	Increases phenotype	PMID:8723729
GO:0036394	Amylase secretion	Increases phenotype	PMID:38284084
GO:0042178	Xenobiotic catabolic process	Decreases phenotype	PMID:19138980
GO:0042391	Regulation of membrane potential	Decreases phenotype	PMID:29297235
GO:0042554	Superoxide anion generation	Increases phenotype	PMID:18548748; PMID:28285367; PMID:33592258
GO:0042593	Glucose homeostasis	Affects phenotype	PMID:38284084
GO:0042632	Cholesterol homeostasis	Affects phenotype	PMID:23194016; PMID:27941167
GO:0042701	Progesterone secretion	Decreases phenotype	PMID:23470461
GO:0042743	Hydrogen peroxide metabolic process	Affects phenotype	PMID:32632975
GO:0043065	Positive regulation of apoptotic process	Increases phenotype	PMID:23172806; PMID:23194016; PMID:23675469; PMID:24126434; PMID:24675465; PMID:7828537
GO:0043123	Positive regulation of i-kappab kinase/nf-kappab signaling	Affects phenotype	PMID:24239723
GO:0043480	Pigment accumulation in tissues	Affects phenotype	PMID:35150043
GO:0043966	Histone h3 acetylation	Increases phenotype	PMID:25178734
GO:0043967	Histone h4 acetylation	Increases phenotype	PMID:25178734
GO:0044237	Cellular metabolic process	Decreases phenotype	PMID:20465405; PMID:28285367; PMID:31610155; PMID:32632975; PMID:33248029; PMID:35478211; PMID:38160894
GO:0044319	Wound healing, spreading of cells	Decreases phenotype	PMID:29992683; PMID:38160894
GO:0045333	Cellular respiration	Decreases phenotype	PMID:24732427
GO:0045429	Positive regulation of nitric oxide biosynthetic process	Increases phenotype	PMID:20028703; PMID:24295472
GO:0045444	Fat cell differentiation	Increases phenotype	PMID:25062436; PMID:28758259; PMID:32473317
GO:0045454	Cell redox homeostasis	Decreases phenotype	PMID:26004525; PMID:26732703; PMID:30821249; PMID:31005848; PMID:32151596; PMID:33388378
GO:0045669	Positive regulation of osteoblast differentiation	Increases phenotype	PMID:26424790; PMID:26492236; PMID:28189605; PMID:30382123; PMID:30639440; PMID:31150804; PMID:31935364; PMID:32156525
GO:0045722	Positive regulation of gluconeogenesis	Increases phenotype	PMID:38284084
GO:0045907	Positive regulation of vasoconstriction	Increases phenotype	PMID:26599707
GO:0045912	Negative regulation of carbohydrate metabolic process	Increases phenotype	PMID:38284084
GO:0045930	Negative regulation of mitotic cell cycle	Increases phenotype	PMID:25178734; PMID:29736388; PMID:29992683
GO:0046034	Atp metabolic process	Increases phenotype	PMID:24732427; PMID:28703385; PMID:38160894
GO:0046209	Nitric oxide metabolic process	Increases phenotype	PMID:30606963
GO:0046330	Positive regulation of jnk cascade	Increases phenotype	PMID:24488945
GO:0046449	Creatinine metabolic process	Affects phenotype	PMID:19391111; PMID:21284339
GO:0046466	Membrane lipid catabolic process	Increases phenotype	PMID:10580364; PMID:10690761; PMID:10741692; PMID:10741692; PMID:20524970; PMID:11551671; PMID:12197998; PMID:12531249; PMID:18758914; PMID:12755500; PMID:12763288; PMID:12767684; PMID:1544873; PMID:16187034; PMID:18549673; PMID:18758914; PMID:20025841; PMID:20028703; PMID:20524970; PMID:21452598; PMID:23194016; PMID:2353831; PMID:2366755; PMID:23692848; PMID:26921358; PMID:2706019; PMID:2769018; PMID:27941167; PMID:30240002; PMID:3587766; PMID:6619568; PMID:6650302; PMID:7248325; PMID:7495250; PMID:7616398; PMID:7732629; PMID:8900400; PMID:9139234; PMID:9303565; PMID:9764785; PMID:9765353; PMID:9806698
GO:0046620	Regulation of organ growth	Increases phenotype	PMID:1544873
GO:0046902	Regulation of mitochondrial membrane permeability	Affects phenotype	PMID:18022205
GO:0048715	Negative regulation of oligodendrocyte differentiation	Increases phenotype	PMID:35701726
GO:0050665	Hydrogen peroxide biosynthetic process	Increases phenotype	PMID:23470461
GO:0050729	Positive regulation of inflammatory response	Increases phenotype	PMID:23692848
GO:0051092	Positive regulation of nf-kappab transcription factor activity	Increases phenotype	PMID:17879260; PMID:23692848
GO:0051348	Negative regulation of transferase activity	Affects phenotype	PMID:33388378
GO:0051458	Corticotropin secretion	Increases phenotype	PMID:37704839
GO:0051562	Negative regulation of mitochondrial calcium ion concentration	Increases phenotype	PMID:24295472
GO:0051726	Regulation of cell cycle	Increases phenotype	PMID:23172806
GO:0051881	Regulation of mitochondrial membrane potential	Affects phenotype	PMID:24907532; PMID:32407874; PMID:33592258
GO:0051882	Mitochondrial depolarization	Increases phenotype	PMID:30266311; PMID:33248029
GO:0051901	Positive regulation of mitochondrial depolarization	Increases phenotype	PMID:22226756; PMID:22678527
GO:0051924	Regulation of calcium ion transport	Affects phenotype	PMID:25758670
GO:0055074	Calcium ion homeostasis	Affects phenotype	PMID:27718046
GO:0055088	Lipid homeostasis	Decreases phenotype	PMID:24295472
GO:0060326	Cell chemotaxis	Decreases phenotype	PMID:29992683; PMID:38160894
GO:0060591	Chondroblast differentiation	Increases phenotype	PMID:26492236
GO:0060996	Dendritic spine development	Increases phenotype	PMID:33872575
GO:0061024	Membrane organization	Decreases phenotype	PMID:26808022
GO:0061370	Testosterone biosynthetic process	Decreases phenotype	PMID:29663635; PMID:30526067; PMID:33372294
GO:0061890	Positive regulation of astrocyte activation	Increases phenotype	PMID:34286406
GO:0070169	Positive regulation of biomineral tissue development	Increases phenotype	PMID:26492236; PMID:28189605; PMID:30382123; PMID:31935364
GO:0070254	Mucus secretion	Increases phenotype	PMID:32374624
GO:0070265	Necrotic cell death	Increases phenotype	PMID:33372294
GO:0070328	Triglyceride homeostasis	Decreases phenotype	PMID:23194016; PMID:27941167; PMID:31005848; PMID:38284084
GO:0070365	Hepatocyte differentiation	Increases phenotype	PMID:23108452
GO:0070368	Positive regulation of hepatocyte differentiation	Increases phenotype	PMID:34480604
GO:0070585	Protein localization to mitochondrion	Decreases phenotype	PMID:25809564
GO:0070661	Leukocyte proliferation	Increases phenotype	PMID:37704839
GO:0070994	Detection of oxidative stress	Increases phenotype	PMID:31576639; PMID:34601066; PMID:35187746; PMID:37704839; PMID:38439645
GO:0070995	Nadph oxidation	Decreases phenotype	PMID:24295472
GO:0070997	Neuron death	Increases phenotype	PMID:35187746
GO:0071493	Cellular response to uv-b	Decreases phenotype	PMID:19138980; PMID:36063024
GO:0071542	Dopaminergic neuron differentiation	Decreases phenotype	PMID:25891525
GO:0071902	Positive regulation of protein serine/threonine kinase activity	Increases phenotype	PMID:34286406
GO:0072593	Reactive oxygen species metabolic process	Increases phenotype	PMID:15055539; PMID:18442981; PMID:22530035; PMID:24463055; PMID:24732427; PMID:25800560; PMID:28285367; PMID:28415704; PMID:32407874; PMID:33007364; PMID:33248029; PMID:33372294; PMID:33475796; PMID:33592258; PMID:35349355; PMID:35478211; PMID:37704839; PMID:38042493
GO:0090026	Positive regulation of monocyte chemotaxis	Increases phenotype	PMID:25551565
GO:0090116	C-5 methylation of cytosine	Decreases phenotype	PMID:33388378
GO:0090200	Positive regulation of release of cytochrome c from mitochondria	Increases phenotype	PMID:22678527
GO:0090398	Cellular senescence	Increases phenotype	PMID:36500241
GO:0097045	Phosphatidylserine exposure on blood platelet	Increases phenotype	PMID:31428780
GO:0097214	Positive regulation of lysosomal membrane permeability	Increases phenotype	PMID:22678527
GO:0097722	Sperm motility	Decreases phenotype	PMID:29158198; PMID:30140404; PMID:30526067
GO:0098658	Inorganic anion import across plasma membrane	Decreases phenotype	PMID:25977998
GO:0098703	Calcium ion import across plasma membrane	Increases phenotype	PMID:23820267
GO:0098869	Cellular oxidant detoxification	Increases phenotype	PMID:30512238; PMID:31433962; PMID:31545954; PMID:34655286
GO:0140042	Lipid droplet formation	Increases phenotype	PMID:28758259
GO:1900015	Regulation of cytokine production involved in inflammatory response	Affects phenotype	PMID:24239723
GO:1900745	Positive regulation of p38mapk cascade	Increases phenotype	PMID:24142891; PMID:24488945; PMID:29940330; PMID:31935364
GO:1901224	Positive regulation of nik/nf-kappab signaling	Increases phenotype	PMID:27381660
GO:1901670	Negative regulation of superoxide dismutase activity	Increases phenotype	PMID:20028703; PMID:23194016; PMID:27941167; PMID:33388378; PMID:34089294
GO:1901671	Positive regulation of superoxide dismutase activity	Affects phenotype	PMID:24295472; PMID:25305479; PMID:31005848
GO:1901687	Glutathione derivative biosynthetic process	Decreases phenotype	PMID:24295472
GO:1901896	Positive regulation of atpase-coupled calcium transmembrane transporter activity	Decreases phenotype	PMID:24295472
GO:1902093	Positive regulation of flagellated sperm motility	Decreases phenotype	PMID:25637669
GO:1902107	Positive regulation of leukocyte differentiation	Decreases phenotype	PMID:27020608
GO:1902174	Positive regulation of keratinocyte apoptotic process	Affects phenotype	PMID:19138980
GO:1902512	Positive regulation of apoptotic dna fragmentation	Increases phenotype	PMID:22678527; PMID:24295472; PMID:24488945; PMID:25809564
GO:1902514	Regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	Affects phenotype	PMID:23820267
GO:1902552	Negative regulation of catalase activity	Increases phenotype	PMID:20028703; PMID:23194016; PMID:30738991
GO:1902553	Positive regulation of catalase activity	Increases phenotype	PMID:30240002
GO:1902884	Positive regulation of response to oxidative stress	Increases phenotype	PMID:27941167
GO:1902958	Positive regulation of mitochondrial electron transport, nadh to ubiquinone	Decreases phenotype	PMID:24295472
GO:1903012	Positive regulation of bone development	Increases phenotype	PMID:25932594
GO:1903047	Mitotic cell cycle process	Affects phenotype	PMID:28415704
GO:1903220	Positive regulation of malate dehydrogenase (decarboxylating) (nadp+) activity	Decreases phenotype	PMID:24295472
GO:1903283	Negative regulation of glutathione peroxidase activity	Increases phenotype	PMID:23194016; PMID:27941167; PMID:30240002; PMID:33388378; PMID:34089294
GO:1903284	Positive regulation of glutathione peroxidase activity	Affects phenotype	PMID:24295472; PMID:25305479; PMID:26545973
GO:1903408	Positive regulation of p-type sodium:potassium-exchanging transporter activity	Decreases phenotype	PMID:24295472
GO:1903409	Reactive oxygen species biosynthetic process	Affects phenotype	PMID:18548748; PMID:19301245; PMID:22728154; PMID:25178734; PMID:25845326; PMID:26270818; PMID:27345029; PMID:29158198; PMID:29297235; PMID:29663635; PMID:29992683; PMID:30266311; PMID:31276663; PMID:31585129; PMID:31610155; PMID:31610156; PMID:31647942
GO:1903427	Negative regulation of reactive oxygen species biosynthetic process	Affects phenotype	PMID:23284918
GO:1903428	Positive regulation of reactive oxygen species biosynthetic process	Affects phenotype	PMID:1764212; PMID:23172806; PMID:23692848; PMID:24026617; PMID:24142891; PMID:24295472; PMID:25305479; PMID:27381660; PMID:27510327; PMID:28703385; PMID:29940330; PMID:30399392; PMID:30597948; PMID:32028152; PMID:33388378; PMID:36063024
GO:1903578	Regulation of atp metabolic process	Increases phenotype	PMID:24126434
GO:1903626	Positive regulation of dna catabolic process	Increases phenotype	PMID:1764212
GO:1903935	Response to sodium arsenite	Decreases phenotype	PMID:20028703
GO:1904028	Positive regulation of collagen fibril organization	Increases phenotype	PMID:39325335
GO:1904094	Positive regulation of autophagic cell death	Increases phenotype	PMID:24675465
GO:1904146	Positive regulation of meiotic cell cycle process involved in oocyte maturation	Increases phenotype	PMID:26545973
GO:1904231	Positive regulation of succinate dehydrogenase activity	Decreases phenotype	PMID:24295472
GO:1904445	Negative regulation of establishment of sertoli cell barrier	Decreases phenotype	PMID:29940330
GO:1904960	Positive regulation of cytochrome-c oxidase activity	Decreases phenotype	PMID:24295472
GO:1905665	Positive regulation of calcium ion import across plasma membrane	Increases phenotype	PMID:34286406
GO:1990414	Replication-born double-strand break repair via sister chromatid exchange	Increases phenotype	PMID:22342611
GO:2000083	Negative regulation of l-ascorbic acid biosynthetic process	Increases phenotype	PMID:32805337
GO:2000225	Negative regulation of testosterone biosynthetic process	Increases phenotype	PMID:30240002
GO:2000375	Negative regulation of oxygen metabolic process	Increases phenotype	PMID:25809564
GO:2000376	Positive regulation of oxygen metabolic process	Increases phenotype	PMID:23675469
GO:2000379	Positive regulation of reactive oxygen species metabolic process	Increases phenotype	PMID:22678527; PMID:25305479
GO:2000738	Positive regulation of stem cell differentiation	Decreases phenotype	PMID:25786529
GO:2000786	Positive regulation of autophagosome assembly	Increases phenotype	PMID:24675465
GO:2001057	Reactive nitrogen species metabolic process	Affects phenotype	PMID:32407874
GO:2001170	Negative regulation of atp biosynthetic process	Increases phenotype	PMID:33147516

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.