Rifampin


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000045 Autophagosome assembly Increases phenotype PMID:31648047
GO:0000050 Urea cycle Affects phenotype PMID:24685772
GO:0002253 Activation of immune response Increases phenotype PMID:27933861
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:35544702
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:27919644; PMID:36878459
GO:0006007 Glucose catabolic process Decreases phenotype PMID:26616219
GO:0006722 Triterpenoid metabolic process Increases phenotype PMID:32633501
GO:0006749 Glutathione metabolic process Affects phenotype PMID:35190838; PMID:36878459
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:24101390; PMID:27919644
GO:0006754 Atp biosynthetic process Increases phenotype PMID:27470132
GO:0006805 Xenobiotic metabolic process Increases phenotype PMID:12695342; PMID:18799805; PMID:23685082; PMID:29162470; PMID:35597399
GO:0006914 Autophagy Increases phenotype PMID:18608530
GO:0006915 Apoptotic process Affects phenotype PMID:11958592; PMID:12645856; PMID:17280646; PMID:17369605; PMID:21357946; PMID:27470132; PMID:9448109
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:27919644; PMID:28428138
GO:0006979 Response to oxidative stress Decreases phenotype PMID:21357946
GO:0007049 Cell cycle Decreases phenotype PMID:9448109
GO:0007283 Spermatogenesis Decreases phenotype PMID:27919644
GO:0007596 Blood coagulation Decreases phenotype PMID:24594507
GO:0008206 Bile acid metabolic process Affects phenotype PMID:35544702; PMID:35835356
GO:0008209 Androgen metabolic process Increases phenotype PMID:18347083
GO:0008219 Cell death Increases phenotype PMID:16515773
GO:0008283 Cell population proliferation Decreases phenotype PMID:24638036; PMID:25069801; PMID:27470132
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:35678845
GO:0008610 Lipid biosynthetic process Increases phenotype PMID:25628225; PMID:32535746
GO:0009060 Aerobic respiration Affects phenotype PMID:38734219
GO:0010694 Positive regulation of alkaline phosphatase activity Increases phenotype PMID:25886055
GO:0010917 Negative regulation of mitochondrial membrane potential Increases phenotype PMID:27461009
GO:0010918 Positive regulation of mitochondrial membrane potential Decreases phenotype PMID:26086368
GO:0010940 Positive regulation of necrotic cell death Increases phenotype PMID:25886055
GO:0010942 Positive regulation of cell death Increases phenotype PMID:16479312; PMID:22524704; PMID:24502637; PMID:25451576; PMID:26086368; PMID:33629115
GO:0015711 Organic anion transport Decreases phenotype PMID:25297453
GO:0015723 Bilirubin transport Increases phenotype PMID:25886055
GO:0016042 Lipid catabolic process Increases phenotype PMID:27919644
GO:0019249 Lactate biosynthetic process Increases phenotype PMID:27461009
GO:0019395 Fatty acid oxidation Decreases phenotype PMID:32535746
GO:0019674 Nad metabolic process Affects phenotype PMID:27461009
GO:0030595 Leukocyte chemotaxis Increases phenotype PMID:6318656
GO:0032125 Micronucleus organization Increases phenotype PMID:36372259; PMID:38823534
GO:0032782 Bile acid secretion Decreases phenotype PMID:27160211
GO:0033235 Positive regulation of protein sumoylation Increases phenotype PMID:28132806
GO:0034440 Lipid oxidation Increases phenotype PMID:36878459
GO:0035752 Lysosomal lumen ph elevation Increases phenotype PMID:31648047
GO:0042104 Positive regulation of activated t cell proliferation Increases phenotype PMID:27933861
GO:0042178 Xenobiotic catabolic process Increases phenotype PMID:27917125
GO:0042554 Superoxide anion generation Increases phenotype PMID:24101390
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:28132806
GO:0043372 Positive regulation of cd4-positive, alpha-beta t cell differentiation Increases phenotype PMID:27933861
GO:0043378 Positive regulation of cd8-positive, alpha-beta t cell differentiation Increases phenotype PMID:27933861
GO:0043966 Histone h3 acetylation Affects phenotype PMID:31877331
GO:0043967 Histone h4 acetylation Affects phenotype PMID:31877331
GO:0043983 Histone h4-k12 acetylation Affects phenotype PMID:31877331
GO:0043985 Histone h4-r3 methylation Affects phenotype PMID:31877331
GO:0044237 Cellular metabolic process Decreases phenotype PMID:31678598; PMID:32535746; PMID:35354423; PMID:35835356; PMID:36878459; PMID:38491867
GO:0044754 Autolysosome Increases phenotype PMID:31648047
GO:0045930 Negative regulation of mitotic cell cycle Affects phenotype PMID:27919644
GO:0046034 Atp metabolic process Affects phenotype PMID:23685082; PMID:32535746
GO:0046326 Positive regulation of glucose import Decreases phenotype PMID:26616219
GO:0046460 Neutral lipid biosynthetic process Increases phenotype PMID:32535746
GO:0046466 Membrane lipid catabolic process Affects phenotype PMID:16515773; PMID:20305954
GO:0046618 Xenobiotic export from cell Decreases phenotype PMID:26301745
GO:0046622 Positive regulation of organ growth Increases phenotype PMID:33412187
GO:0047810 D-alanine:2-oxoglutarate aminotransferase activity Increases phenotype PMID:25886055
GO:0050872 White fat cell differentiation Increases phenotype PMID:33412187
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:36878459
GO:0051882 Mitochondrial depolarization Increases phenotype PMID:31678598
GO:0055072 Iron ion homeostasis Affects phenotype PMID:36878459
GO:0060613 Fat pad development Decreases phenotype PMID:33412187
GO:0061024 Membrane organization Affects phenotype PMID:23685082
GO:0070265 Necrotic cell death Increases phenotype PMID:31629065; PMID:35544702; PMID:36878459
GO:0070859 Positive regulation of bile acid biosynthetic process Increases phenotype PMID:25886055
GO:0070994 Detection of oxidative stress Increases phenotype PMID:24486436; PMID:32633153
GO:0072593 Reactive oxygen species metabolic process Affects phenotype PMID:36878459
GO:0090207 Regulation of triglyceride metabolic process Affects phenotype PMID:27806127
GO:0097153 Cysteine-type endopeptidase activity involved in apoptotic process Increases phenotype PMID:31629065
GO:0097254 Renal tubular secretion Decreases phenotype PMID:25297453
GO:0098657 Import into cell Affects phenotype PMID:33307820; PMID:38101600
GO:0140042 Lipid droplet formation Increases phenotype PMID:32633153; PMID:35835356; PMID:36878459
GO:1900182 Positive regulation of protein localization to nucleus Increases phenotype PMID:32682830
GO:1900226 Negative regulation of nlrp3 inflammasome complex assembly Increases phenotype PMID:26086368
GO:1901526 Positive regulation of mitophagy Increases phenotype PMID:27461009
GO:1902512 Positive regulation of apoptotic dna fragmentation Increases phenotype PMID:17936189
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:31678598
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:25886055; PMID:26086368
GO:1904179 Positive regulation of adipose tissue development Increases phenotype PMID:33412187
GO:1904648 Cellular response to rotenone Increases phenotype PMID:28132806
GO:1990266 Neutrophil migration Increases phenotype PMID:24101390
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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.