Manganese chloride


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000045 Autophagosome assembly Increases phenotype PMID:28856835; PMID:28856835; PMID:30578841; PMID:30578841; PMID:30672645
GO:0000084 Mitotic s phase Affects phenotype PMID:34822792; PMID:38503349
GO:0000086 G2/m transition of mitotic cell cycle Affects phenotype PMID:34822792; PMID:38503349
GO:0000422 Autophagy of mitochondrion Increases phenotype PMID:30040983
GO:0000423 Mitophagy Decreases phenotype PMID:31690173
GO:0001774 Microglial cell activation Affects phenotype PMID:34018660
GO:0001836 Release of cytochrome c from mitochondria Increases phenotype PMID:21704098
GO:0002038 Positive regulation of l-glutamate import across plasma membrane Decreases phenotype PMID:24782323
GO:0003993 Acid phosphatase activity Decreases phenotype PMID:28040552
GO:0004035 Alkaline phosphatase activity Decreases phenotype PMID:28040552
GO:0004364 Glutathione transferase activity Affects phenotype PMID:19778223; PMID:28040552; PMID:30844427; PMID:32445656; PMID:33314588
GO:0004402 Histone acetyltransferase activity Decreases phenotype PMID:29155171
GO:0004457 Lactate dehydrogenase activity Affects phenotype PMID:28040552; PMID:30738988
GO:0004602 Glutathione peroxidase activity Affects phenotype PMID:19778223; PMID:20503066; PMID:24969583; PMID:29990519; PMID:30844427; PMID:32445656; PMID:33314588
GO:0004784 Superoxide dismutase activity Increases phenotype PMID:20503066; PMID:24969583; PMID:28040552; PMID:30844427; PMID:30844427; PMID:38129942; PMID:32445656; PMID:33314588; PMID:38129942
GO:0005391 P-type sodium:potassium-exchanging transporter activity Decreases phenotype PMID:37598760
GO:0005764 Lysosome Decreases phenotype PMID:31690173
GO:0006497 Protein lipidation Decreases phenotype PMID:31690173
GO:0006521 Regulation of cellular amino acid metabolic process Affects phenotype PMID:30715528
GO:0006602 Creatinine catabolic process Increases phenotype PMID:27599793
GO:0006606 Protein import into nucleus Affects phenotype PMID:31690173
GO:0006631 Fatty acid metabolic process Affects phenotype PMID:30715528
GO:0006749 Glutathione metabolic process Increases phenotype PMID:19778223; PMID:29054681; PMID:29183790; PMID:33314588
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:20503066; PMID:24969583; PMID:24969583; PMID:25288107; PMID:28040552; PMID:29222055; PMID:30844427
GO:0006809 Nitric oxide biosynthetic process Affects phenotype PMID:26064043; PMID:28040552; PMID:28856835; PMID:30844427
GO:0006914 Autophagy Decreases phenotype PMID:31690173
GO:0006915 Apoptotic process Increases phenotype PMID:21704098; PMID:23764342; PMID:23764342; PMID:28856835; PMID:30578841; PMID:23954760; PMID:24969583; PMID:24969583; PMID:25288107; PMID:25732873; PMID:26419736; PMID:28856835; PMID:30040983; PMID:30578841; PMID:30951808; PMID:30991096; PMID:31676349; PMID:32659473; PMID:35690225; PMID:38503349
GO:0006919 Activation of cysteine-type endopeptidase activity involved in apoptotic process Increases phenotype PMID:16168523
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:20820627; PMID:32574669; PMID:35063473
GO:0006979 Response to oxidative stress Increases phenotype PMID:23385959
GO:0007005 Mitochondrion organization Decreases phenotype PMID:30040983
GO:0007042 Lysosomal lumen acidification Decreases phenotype PMID:31690173
GO:0007190 Activation of adenylate cyclase activity Increases phenotype PMID:1653373; PMID:6094742; PMID:8763401
GO:0007204 Positive regulation of cytosolic calcium ion concentration Increases phenotype PMID:29289693
GO:0007283 Spermatogenesis Decreases phenotype PMID:29990519; PMID:32445656; PMID:34822792
GO:0007610 Behavior Affects phenotype PMID:30118795
GO:0007612 Learning Affects phenotype PMID:37598760; PMID:38129942
GO:0007613 Memory Decreases phenotype PMID:24972623; PMID:24972623; PMID:30844427; PMID:30844427; PMID:38129942
GO:0007626 Locomotory behavior Affects phenotype PMID:32692843
GO:0008219 Cell death Increases phenotype PMID:26865462; PMID:27107493; PMID:29100878; PMID:29222055; PMID:32659473
GO:0008252 Nucleotidase activity Decreases phenotype PMID:19778223
GO:0008283 Cell population proliferation Affects phenotype PMID:21704098; PMID:22542671; PMID:32659473
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:29155171; PMID:29723552; PMID:30399392; PMID:33012730
GO:0008344 Adult locomotory behavior Decreases phenotype PMID:29778792
GO:0008361 Regulation of cell size Affects phenotype PMID:32659473
GO:0008542 Visual learning Decreases phenotype PMID:24972623; PMID:24972623; PMID:30844427; PMID:30844427
GO:0008635 Activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c Increases phenotype PMID:25416158
GO:0009060 Aerobic respiration Decreases phenotype PMID:28539244; PMID:28595911
GO:0010507 Negative regulation of autophagy Increases phenotype PMID:23604964
GO:0010508 Positive regulation of autophagy Affects phenotype PMID:23604964
GO:0010729 Positive regulation of hydrogen peroxide biosynthetic process Increases phenotype PMID:27701121
GO:0010800 Positive regulation of peptidyl-threonine phosphorylation Increases phenotype PMID:8662792
GO:0010823 Negative regulation of mitochondrion organization Increases phenotype PMID:34738708
GO:0010917 Negative regulation of mitochondrial membrane potential Increases phenotype PMID:34738708
GO:0010918 Positive regulation of mitochondrial membrane potential Decreases phenotype PMID:25981801; PMID:28378122; PMID:28801915; PMID:29288688
GO:0010940 Positive regulation of necrotic cell death Increases phenotype PMID:10328827
GO:0010942 Positive regulation of cell death Increases phenotype PMID:24782323; PMID:25981801; PMID:28801915; PMID:29288688; PMID:29289693; PMID:30715528
GO:0014046 Dopamine secretion Increases phenotype PMID:22479410
GO:0016042 Lipid catabolic process Increases phenotype PMID:20503066; PMID:24969583; PMID:24969583; PMID:25288107; PMID:28040552; PMID:30738988; PMID:30844427; PMID:32445656; PMID:33314588
GO:0016049 Cell growth Decreases phenotype PMID:30040983
GO:0016712 Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Decreases phenotype PMID:19778223
GO:0018158 Protein oxidation Increases phenotype PMID:20503066; PMID:30738988
GO:0019249 Lactate biosynthetic process Decreases phenotype PMID:28801915
GO:0019853 L-ascorbic acid biosynthetic process Decreases phenotype PMID:20503066
GO:0022008 Neurogenesis Affects phenotype PMID:25575534
GO:0030168 Platelet activation Increases phenotype PMID:30537864
GO:0031143 Pseudopodium Increases phenotype PMID:30537864
GO:0031987 Locomotion involved in locomotory behavior Decreases phenotype PMID:34018660; PMID:37598760
GO:0032461 Positive regulation of protein oligomerization Increases phenotype PMID:28595911
GO:0032930 Positive regulation of superoxide anion generation Increases phenotype PMID:28778520
GO:0033861 Negative regulation of nad(p)h oxidase activity Increases phenotype PMID:30152904
GO:0034440 Lipid oxidation Increases phenotype PMID:106178; PMID:19778223; PMID:23385959; PMID:28595911; PMID:29183790
GO:0035067 Negative regulation of histone acetylation Decreases phenotype PMID:29155171
GO:0035307 Positive regulation of protein dephosphorylation Decreases phenotype PMID:2475105
GO:0036091 Positive regulation of transcription from rna polymerase ii promoter in response to oxidative stress Increases phenotype PMID:29054681
GO:0036483 Neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Increases phenotype PMID:23934647
GO:0040018 Positive regulation of multicellular organism growth Decreases phenotype PMID:28511934
GO:0042048 Olfactory behavior Decreases phenotype PMID:28595911
GO:0042053 Regulation of dopamine metabolic process Affects phenotype PMID:28539244
GO:0042133 Neurotransmitter metabolic process Affects phenotype PMID:30715528
GO:0042416 Dopamine biosynthetic process Decreases phenotype PMID:24969583
GO:0042417 Dopamine metabolic process Affects phenotype PMID:34590183
GO:0042428 Serotonin metabolic process Affects phenotype PMID:37598760
GO:0042465 Kinesis Decreases phenotype PMID:24969583
GO:0042554 Superoxide anion generation Increases phenotype PMID:22906169; PMID:31690173
GO:0042743 Hydrogen peroxide metabolic process Affects phenotype PMID:33314588
GO:0042776 Proton motive force-driven mitochondrial atp synthesis Decreases phenotype PMID:28539244; PMID:28595911
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:10328827; PMID:24464479; PMID:24464479; PMID:29155171; PMID:28778520; PMID:29155171
GO:0043525 Positive regulation of neuron apoptotic process Increases phenotype PMID:16168523; PMID:25416158
GO:0043653 Mitochondrial fragmentation involved in apoptotic process Increases phenotype PMID:34738708
GO:0043666 Regulation of phosphoprotein phosphatase activity Affects phenotype PMID:23385959
GO:0043966 Histone h3 acetylation Decreases phenotype PMID:29155171; PMID:29778792
GO:0043967 Histone h4 acetylation Decreases phenotype PMID:29155171; PMID:29778792
GO:0043971 Histone h3-k18 acetylation Increases phenotype PMID:38129942
GO:0044114 Development of symbiont in host Affects phenotype PMID:28610994
GO:0044237 Cellular metabolic process Decreases phenotype PMID:29957541; PMID:31676349; PMID:32574669; PMID:34822792; PMID:35063473; PMID:35690225; PMID:38503349
GO:0044238 Primary metabolic process Decreases phenotype PMID:28539244
GO:0045023 G0 to g1 transition Affects phenotype PMID:38503349
GO:0045333 Cellular respiration Decreases phenotype PMID:31690173
GO:0045821 Positive regulation of glycolytic process Affects phenotype PMID:28539244
GO:0045892 Negative regulation of dna-templated transcription Increases phenotype PMID:33012730
GO:0045930 Negative regulation of mitotic cell cycle Increases phenotype PMID:22542671
GO:0046034 Atp metabolic process Increases phenotype PMID:28801915; PMID:30152904; PMID:31690173
GO:0046209 Nitric oxide metabolic process Affects phenotype PMID:33314588
GO:0046466 Membrane lipid catabolic process Increases phenotype PMID:39414706
GO:0048873 Homeostasis of number of cells within a tissue Affects phenotype PMID:30991096
GO:0050665 Hydrogen peroxide biosynthetic process Increases phenotype PMID:20503066; PMID:28040552; PMID:30738988; PMID:30844427
GO:0050729 Positive regulation of inflammatory response Increases phenotype PMID:32692843; PMID:39414706
GO:0050731 Positive regulation of peptidyl-tyrosine phosphorylation Increases phenotype PMID:8662792; PMID:9751194
GO:0050767 Regulation of neurogenesis Decreases phenotype PMID:25698507
GO:0051092 Positive regulation of nf-kappab transcription factor activity Increases phenotype PMID:32692843
GO:0051402 Neuron apoptotic process Increases phenotype PMID:32692843; PMID:34018660
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:21704098; PMID:30040983; PMID:31676349; PMID:31690173; PMID:35063473; PMID:38503349
GO:0051896 Regulation of protein kinase b signaling Affects phenotype PMID:23385959
GO:0051901 Positive regulation of mitochondrial depolarization Increases phenotype PMID:30152904
GO:0051938 L-glutamate import Decreases phenotype PMID:29778792
GO:0055070 Copper ion homeostasis Affects phenotype PMID:25575534
GO:0055071 Manganese ion homeostasis Affects phenotype PMID:25575534
GO:0061370 Testosterone biosynthetic process Decreases phenotype PMID:28040552
GO:0061517 Macrophage proliferation Increases phenotype PMID:25219578
GO:0061518 Microglial cell proliferation Increases phenotype PMID:25219578
GO:0061526 Acetylcholine secretion Decreases phenotype PMID:30738988
GO:0061726 Mitochondrion disassembly Increases phenotype PMID:21704098
GO:0061900 Glial cell activation Increases phenotype PMID:32692843
GO:0070212 Protein poly-adp-ribosylation Increases phenotype PMID:35063473
GO:0070265 Necrotic cell death Increases phenotype PMID:32659473; PMID:38129942
GO:0070509 Calcium ion import Increases phenotype PMID:30951808
GO:0070527 Platelet aggregation Increases phenotype PMID:30537864
GO:0070534 Protein k63-linked ubiquitination Increases phenotype PMID:31690173
GO:0070577 Lysine-acetylated histone binding Decreases phenotype PMID:38129942
GO:0070585 Protein localization to mitochondrion Increases phenotype PMID:34738708
GO:0070994 Detection of oxidative stress Affects phenotype PMID:35063473; PMID:38129942
GO:0071287 Cellular response to manganese ion Increases phenotype PMID:24067723
GO:0072378 Blood coagulation, fibrin clot formation Increases phenotype PMID:30537864
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:24969583; PMID:24969583; PMID:25288107; PMID:34310962; PMID:38503349
GO:0090141 Positive regulation of mitochondrial fission Increases phenotype PMID:28539244
GO:0090200 Positive regulation of release of cytochrome c from mitochondria Increases phenotype PMID:28378122; PMID:34738708
GO:0090263 Positive regulation of canonical wnt signaling pathway Decreases phenotype PMID:24464479
GO:0090326 Positive regulation of locomotion involved in locomotory behavior Decreases phenotype PMID:28539244; PMID:28595911; PMID:28595911
GO:0090327 Negative regulation of locomotion involved in locomotory behavior Increases phenotype PMID:29183790; PMID:29183790; PMID:34738708; PMID:34738708
GO:0097202 Activation of cysteine-type endopeptidase activity Increases phenotype PMID:30738988
GO:0097214 Positive regulation of lysosomal membrane permeability Increases phenotype PMID:28378122
GO:0097722 Sperm motility Decreases phenotype PMID:28040552; PMID:29990519; PMID:32445656
GO:0110090 Positive regulation of hippocampal neuron apoptotic process Increases phenotype PMID:34738708
GO:0140058 Neuron projection arborization Decreases phenotype PMID:35063473
GO:0140657 Atp-dependent activity Decreases phenotype PMID:19778223
GO:0150104 Transport across blood-brain barrier Increases phenotype PMID:19778223
GO:1900744 Regulation of p38mapk cascade Affects phenotype PMID:23385959
GO:1901216 Positive regulation of neuron death Increases phenotype PMID:28511934; PMID:28595911; PMID:29183790
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:39414706
GO:1901727 Positive regulation of histone deacetylase activity Increases phenotype PMID:29155171
GO:1902237 Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Affects phenotype PMID:23948121
GO:1902512 Positive regulation of apoptotic dna fragmentation Increases phenotype PMID:9751194
GO:1902552 Negative regulation of catalase activity Increases phenotype PMID:39414706
GO:1903039 Positive regulation of leukocyte cell-cell adhesion Increases phenotype PMID:23329836
GO:1903047 Mitotic cell cycle process Affects phenotype PMID:34822792; PMID:38503349
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:21704098; PMID:29222055; PMID:30040983; PMID:30991096
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:23329836; PMID:27599793; PMID:29054681; PMID:30152904; PMID:34738708
GO:1903753 Negative regulation of p38mapk cascade Increases phenotype PMID:29288688
GO:1903787 Negative regulation of glutathione biosynthetic process Increases phenotype PMID:39414706
GO:1903980 Positive regulation of microglial cell activation Increases phenotype PMID:28511934
GO:1990138 Neuron projection extension Increases phenotype PMID:28801915
GO:1990404 Nad+-protein adp-ribosyltransferase activity Increases phenotype PMID:20820627
GO:2000302 Positive regulation of synaptic vesicle exocytosis Increases phenotype PMID:29289693
GO:2000845 Positive regulation of testosterone secretion Decreases phenotype PMID:25981801
GO:2001056 Positive regulation of cysteine-type endopeptidase activity Affects phenotype PMID:23385959
GO:2001170 Negative regulation of atp biosynthetic process Increases phenotype PMID:34738708
GO:2001272 Positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis Increases phenotype PMID:28378122
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