Crizotinib


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0006754 Atp biosynthetic process Decreases phenotype PMID:29655783
GO:0006915 Apoptotic process Increases phenotype PMID:31639374; PMID:31706006
GO:0006919 Activation of cysteine-type endopeptidase activity involved in apoptotic process Increases phenotype PMID:29655783
GO:0008219 Cell death Increases phenotype PMID:31533062; PMID:31639374
GO:0008283 Cell population proliferation Decreases phenotype PMID:21812414; PMID:25308930; PMID:37072838
GO:0018108 Peptidyl-tyrosine phosphorylation Decreases phenotype PMID:33087447
GO:0044237 Cellular metabolic process Decreases phenotype PMID:31706006; PMID:34861243
GO:0045214 Sarcomere organization Decreases phenotype PMID:31533062
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:31639374
GO:0060047 Heart contraction Decreases phenotype PMID:31533062
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:31639374
GO:1990603 Dark adaptation Decreases phenotype PMID:25326243

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.