FD&C Red 3


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000737 Dna catabolic process, endonucleolytic Increases phenotype PMID:12160896; PMID:39400474; PMID:39843243
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:39400474; PMID:39843243
GO:0003990 Acetylcholinesterase activity Increases phenotype PMID:39400474; PMID:39843243
GO:0004096 Catalase activity Decreases phenotype PMID:39400474; PMID:39843243
GO:0004364 Glutathione transferase activity Decreases phenotype PMID:39400474; PMID:39600142; PMID:39843243
GO:0004457 Lactate dehydrogenase activity Increases phenotype PMID:39400474; PMID:39600142; PMID:39843243
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:39400474; PMID:39843243
GO:0006979 Response to oxidative stress Affects phenotype PMID:33748463
GO:0007283 Spermatogenesis Affects phenotype PMID:33565293
GO:0007612 Learning Decreases phenotype PMID:551301; PMID:7464455
GO:0007613 Memory Decreases phenotype PMID:33748463
GO:0007626 Locomotory behavior Affects phenotype PMID:551301; PMID:7464455
GO:0008219 Cell death Increases phenotype PMID:7953637
GO:0008283 Cell population proliferation Increases phenotype PMID:39843243
GO:0010730 Negative regulation of hydrogen peroxide biosynthetic process Increases phenotype PMID:39600142
GO:0015734 Taurine transport Decreases phenotype PMID:39341
GO:0015816 Glycine transport Decreases phenotype PMID:39341
GO:0015871 Choline transport Decreases phenotype PMID:39341
GO:0019627 Urea metabolic process Affects phenotype PMID:32981412
GO:0031987 Locomotion involved in locomotory behavior Affects phenotype PMID:22323474
GO:0032099 Negative regulation of appetite Increases phenotype PMID:6146662
GO:0032125 Micronucleus organization Increases phenotype PMID:22847138
GO:0034440 Lipid oxidation Increases phenotype PMID:39400474
GO:0035640 Exploration behavior Decreases phenotype PMID:19264092
GO:0040013 Negative regulation of locomotion Increases phenotype PMID:6146662
GO:0042428 Serotonin metabolic process Affects phenotype PMID:19264092
GO:0042743 Hydrogen peroxide metabolic process Increases phenotype PMID:39400474
GO:0044782 Cilium organization Affects phenotype PMID:24941295
GO:0046449 Creatinine metabolic process Affects phenotype PMID:32981412
GO:0046959 Habituation Decreases phenotype PMID:551301
GO:0050996 Positive regulation of lipid catabolic process Increases phenotype PMID:39600142
GO:0051612 Negative regulation of serotonin uptake Increases phenotype PMID:39341
GO:0051622 Negative regulation of norepinephrine uptake Increases phenotype PMID:39341
GO:0051782 Negative regulation of cell division Increases phenotype PMID:20667460
GO:0051938 L-glutamate import Decreases phenotype PMID:39341
GO:0051939 Gamma-aminobutyric acid import Decreases phenotype PMID:39341
GO:0061370 Testosterone biosynthetic process Affects phenotype PMID:33565293
GO:0061533 Norepinephrine secretion, neurotransmission Increases phenotype PMID:6146388
GO:0061534 Gamma-aminobutyric acid secretion, neurotransmission Increases phenotype PMID:6146388
GO:0061744 Motor behavior Decreases phenotype PMID:19264092
GO:0070265 Necrotic cell death Increases phenotype PMID:39400474; PMID:39843243
GO:0070588 Calcium ion transmembrane transport Decreases phenotype PMID:6098274
GO:0070994 Detection of oxidative stress Increases phenotype PMID:39843243
GO:0090494 Dopamine uptake Decreases phenotype PMID:451609
GO:1901668 Regulation of superoxide dismutase activity Affects phenotype PMID:39600142
GO:1902552 Negative regulation of catalase activity Increases phenotype PMID:39600142
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.