4-Nonylphenol


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0002176 Male germ cell proliferation Affects phenotype PMID:27109770
GO:0004602 Glutathione peroxidase activity Decreases phenotype PMID:27087316; PMID:27109770
GO:0004679 Amp-activated protein kinase activity Decreases phenotype PMID:30228064
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:27087316; PMID:27109770
GO:0006754 Atp biosynthetic process Decreases phenotype PMID:28849599
GO:0006915 Apoptotic process Increases phenotype PMID:14703490; PMID:26804764; PMID:27087316; PMID:27109770
GO:0007040 Lysosome organization Increases phenotype PMID:26804764
GO:0007283 Spermatogenesis Decreases phenotype PMID:27087316; PMID:29029336; PMID:30228064
GO:0008210 Estrogen metabolic process Affects phenotype PMID:28611354
GO:0008283 Cell population proliferation Affects phenotype PMID:23626723; PMID:24062438; PMID:26804764; PMID:28855101
GO:0008284 Positive regulation of cell population proliferation Increases phenotype PMID:26804032; PMID:29783106
GO:0008584 Male gonad development Affects phenotype PMID:28611354
GO:0010801 Negative regulation of peptidyl-threonine phosphorylation Affects phenotype PMID:30228064
GO:0010942 Positive regulation of cell death Increases phenotype PMID:30228064
GO:0016042 Lipid catabolic process Increases phenotype PMID:27087316; PMID:27109770
GO:0016477 Cell migration Decreases phenotype PMID:26027920
GO:0030263 Apoptotic chromosome condensation Increases phenotype PMID:28611354; PMID:29029336; PMID:30228064
GO:0030317 Flagellated sperm motility Affects phenotype PMID:27109770
GO:0030335 Positive regulation of cell migration Increases phenotype PMID:26804032
GO:0032007 Negative regulation of tor signaling Increases phenotype PMID:28041982
GO:0032148 Activation of protein kinase b activity Increases phenotype PMID:27086933; PMID:30228064
GO:0032640 Tumor necrosis factor production Decreases phenotype PMID:28490175
GO:0034063 Stress granule assembly Increases phenotype PMID:33431410
GO:0034440 Lipid oxidation Increases phenotype PMID:30228064
GO:0042023 Dna endoreduplication Increases phenotype PMID:26027920
GO:0045333 Cellular respiration Decreases phenotype PMID:28849599
GO:0045600 Positive regulation of fat cell differentiation Increases phenotype PMID:26944108
GO:0045930 Negative regulation of mitotic cell cycle Increases phenotype PMID:26804764
GO:0046621 Negative regulation of organ growth Increases phenotype PMID:35005817
GO:0046622 Positive regulation of organ growth Increases phenotype PMID:30228064
GO:0048870 Cell motility Increases phenotype PMID:24460192
GO:0060326 Cell chemotaxis Increases phenotype PMID:32466334
GO:0061370 Testosterone biosynthetic process Decreases phenotype PMID:27087316
GO:0071902 Positive regulation of protein serine/threonine kinase activity Increases phenotype PMID:28041982
GO:0072520 Seminiferous tubule development Decreases phenotype PMID:29029336
GO:0097202 Activation of cysteine-type endopeptidase activity Increases phenotype PMID:29029336
GO:0140354 Lipid import into cell Decreases phenotype PMID:35005817
GO:0160024 Leydig cell proliferation Affects phenotype PMID:28611354
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:30228064
GO:1901671 Positive regulation of superoxide dismutase activity Increases phenotype PMID:30228064
GO:1902512 Positive regulation of apoptotic dna fragmentation Increases phenotype PMID:30228064
GO:1903047 Mitotic cell cycle process Affects phenotype PMID:32466334
GO:1903284 Positive regulation of glutathione peroxidase activity Increases phenotype PMID:30228064
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:26804764
GO:1903923 Positive regulation of protein processing in phagocytic vesicle Increases phenotype PMID:30228064
GO:1905037 Autophagosome organization Increases phenotype PMID:26804764
GO:2000786 Positive regulation of autophagosome assembly Increases phenotype PMID:28041982; PMID:30228064
GO:2000844 Negative regulation of testosterone secretion Increases phenotype PMID:35005817
GO:2000845 Positive regulation of testosterone secretion Increases phenotype PMID:30228064
GO:2000865 Negative regulation of estradiol secretion Increases phenotype PMID:29029336
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.