Acetaminophen


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000050 Urea cycle Affects phenotype PMID:24685772
GO:0000084 Mitotic s phase Affects phenotype PMID:33971260
GO:0000266 Mitochondrial fission Increases phenotype PMID:33432343; PMID:35713544
GO:0000278 Mitotic cell cycle Increases phenotype PMID:8861779
GO:0000422 Autophagy of mitochondrion Increases phenotype PMID:25752611; PMID:25752611; PMID:28827156
GO:0000737 Dna catabolic process, endonucleolytic Increases phenotype PMID:20465405
GO:0001516 Prostaglandin biosynthetic process Increases phenotype PMID:31048000; PMID:31444509
GO:0001525 Angiogenesis Decreases phenotype PMID:39032760
GO:0001541 Ovarian follicle development Decreases phenotype PMID:26732887; PMID:34383603
GO:0001547 Antral ovarian follicle growth Affects phenotype PMID:34383603
GO:0001552 Ovarian follicle atresia Affects phenotype PMID:34383603
GO:0001836 Release of cytochrome c from mitochondria Increases phenotype PMID:26767949
GO:0001890 Placenta development Decreases phenotype PMID:39032760
GO:0001944 Vasculature development Affects phenotype PMID:39032760
GO:0002027 Regulation of heart rate Increases phenotype PMID:21098520
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:23558424; PMID:32909844; PMID:33882750; PMID:26176337; PMID:26176337; PMID:26969520; PMID:27826632; PMID:28209544; PMID:28286204; PMID:29331651; PMID:29689376; PMID:32081044; PMID:34219507; PMID:35713544; PMID:37491939; PMID:26969520; PMID:27826632; PMID:28209544; PMID:28286204; PMID:32081044; PMID:32909844; PMID:33882750
GO:0002693 Positive regulation of cellular extravasation Increases phenotype PMID:29355602
GO:0003094 Glomerular filtration Increases phenotype PMID:12721325
GO:0004021 L-alanine:2-oxoglutarate aminotransferase activity Increases phenotype PMID:38521541; PMID:39617257; PMID:39617257; PMID:39827450
GO:0004035 Alkaline phosphatase activity Affects phenotype PMID:20804811; PMID:28682524; PMID:31625388; PMID:28682524; PMID:31625388; PMID:33350580; PMID:30273691; PMID:31625388; PMID:35662663; PMID:36150480
GO:0004062 Aryl sulfotransferase activity Decreases phenotype PMID:26772156
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Affects phenotype PMID:20804811; PMID:27720869; PMID:27720869; PMID:28286204; PMID:28435131; PMID:30273691; PMID:32081044; PMID:32677766; PMID:33021112; PMID:33949241; PMID:35713544; PMID:39617257; PMID:39827450; PMID:27720869; PMID:28435131; PMID:28286204; PMID:28435131; PMID:28682524; PMID:29441826; PMID:31625388; PMID:32909844; PMID:33350580; PMID:28682524; PMID:31625388; PMID:29441826; PMID:30273691; PMID:31625388; PMID:32081044; PMID:32677766; PMID:32909844; PMID:33021112; PMID:35662663; PMID:35713544; PMID:36150480; PMID:36227364; PMID:39617257
GO:0004129 Cytochrome-c oxidase activity Decreases phenotype PMID:26767949; PMID:28827156
GO:0004198 Calcium-dependent cysteine-type endopeptidase activity Increases phenotype PMID:35713544
GO:0004364 Glutathione transferase activity Decreases phenotype PMID:20804811; PMID:20804811; PMID:26767949; PMID:32677766; PMID:32677766; PMID:37458150; PMID:34078832; PMID:37458150
GO:0004457 Lactate dehydrogenase activity Affects phenotype PMID:20804811; PMID:24685772; PMID:26969520; PMID:26969520; PMID:28435131; PMID:28435131; PMID:29694836; PMID:30287234; PMID:33350580
GO:0004602 Glutathione peroxidase activity Affects phenotype PMID:20804811; PMID:20804811; PMID:28682524; PMID:31777137; PMID:33350580; PMID:20804811; PMID:31777137; PMID:20804811; PMID:33350580; PMID:26772156; PMID:26772156; PMID:26969520; PMID:32677766; PMID:37458150; PMID:26969520; PMID:28682524; PMID:28984147; PMID:31777137; PMID:32677766; PMID:37458150
GO:0004784 Superoxide dismutase activity Affects phenotype PMID:20804811; PMID:20804811; PMID:22885820; PMID:28682524; PMID:29441826; PMID:33350580; PMID:20804811; PMID:26767949; PMID:20804811; PMID:33350580; PMID:22885820; PMID:26176337; PMID:26176337; PMID:26772156; PMID:26969520; PMID:28435131; PMID:30423402; PMID:31967706; PMID:32677766; PMID:37458150; PMID:26767949; PMID:26772156; PMID:26969520; PMID:28435131; PMID:28682524; PMID:29441826; PMID:30423402; PMID:30423402; PMID:37458150; PMID:31967706; PMID:32677766; PMID:35662663; PMID:37458150
GO:0005764 Lysosome Increases phenotype PMID:25752611
GO:0005776 Autophagosome Increases phenotype PMID:25752611; PMID:39032760
GO:0005980 Glycogen catabolic process Increases phenotype PMID:8690080
GO:0006006 Glucose metabolic process Affects phenotype PMID:30552463
GO:0006085 Acetyl-coa biosynthetic process Decreases phenotype PMID:30552463
GO:0006089 Lactate metabolic process Affects phenotype PMID:23333575
GO:0006098 Pentose-phosphate shunt Decreases phenotype PMID:30552463
GO:0006099 Tricarboxylic acid cycle Affects phenotype PMID:30552463
GO:0006121 Mitochondrial electron transport, succinate to ubiquinone Decreases phenotype PMID:26767949
GO:0006122 Mitochondrial electron transport, ubiquinol to cytochrome c Decreases phenotype PMID:33290831
GO:0006264 Mitochondrial dna replication Decreases phenotype PMID:28827156; PMID:33271250; PMID:33271250; PMID:37046119
GO:0006308 Dna catabolic process Increases phenotype PMID:14725611
GO:0006309 Apoptotic dna fragmentation Increases phenotype PMID:11562448; PMID:12005112; PMID:12005112; PMID:14725611; PMID:12085349; PMID:14725611; PMID:1957310; PMID:22885820
GO:0006468 Protein phosphorylation Increases phenotype PMID:30375433
GO:0006529 Asparagine biosynthetic process Affects phenotype PMID:30552463
GO:0006532 Aspartate biosynthetic process Increases phenotype PMID:29331651
GO:0006542 Glutamine biosynthetic process Affects phenotype PMID:30552463
GO:0006545 Glycine biosynthetic process Affects phenotype PMID:30552463
GO:0006564 L-serine biosynthetic process Affects phenotype PMID:30552463
GO:0006629 Lipid metabolic process Increases phenotype PMID:32479839; PMID:34401974
GO:0006631 Fatty acid metabolic process Affects phenotype PMID:23239188
GO:0006633 Fatty acid biosynthetic process Decreases phenotype PMID:30552463
GO:0006639 Acylglycerol metabolic process Affects phenotype PMID:39032760
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:33350580; PMID:39889813
GO:0006744 Ubiquinone biosynthetic process Affects phenotype PMID:33271250
GO:0006749 Glutathione metabolic process Increases phenotype PMID:23333575; PMID:23333575; PMID:27002509; PMID:27161652; PMID:27866976; PMID:28687253; PMID:29325178; PMID:29739258; PMID:32081044; PMID:32677766; PMID:33271250; PMID:33458793; PMID:33571619; PMID:33949241; PMID:34390818; PMID:34890640; PMID:37179516; PMID:37458150; PMID:37598316; PMID:38551724; PMID:38825056; PMID:39367970; PMID:39617257; PMID:25956474; PMID:25956474; PMID:26265018; PMID:29697884; PMID:33370591; PMID:34078832; PMID:35179299; PMID:26265018; PMID:26739624; PMID:26801986; PMID:26801986; PMID:28984147; PMID:26921665; PMID:27002509; PMID:27002509; PMID:28687253; PMID:32677766; PMID:38551724; PMID:39367970; PMID:27161652; PMID:27161652; PMID:27866976; PMID:28687253; PMID:32081044; PMID:32677766; PMID:33271250; PMID:33458793; PMID:33571619; PMID:33949241; PMID:34390818; PMID:34890640; PMID:37179516; PMID:37458150; PMID:38825056; PMID:39367970; PMID:39617257; PMID:27866976; PMID:28687253; PMID:28984147; PMID:29325178; PMID:29441826; PMID:29441826; PMID:33350580; PMID:33882750; PMID:29697884; PMID:29739258; PMID:32081044; PMID:32677766; PMID:33290831; PMID:33350580; PMID:33370591; PMID:33571619; PMID:33571619; PMID:34219507; PMID:33882750; PMID:33887374; PMID:33949241; PMID:34078832; PMID:34219507; PMID:34390818; PMID:34401974; PMID:35179299; PMID:35662663; PMID:36150480; PMID:37458150; PMID:37598316; PMID:38825056; PMID:39367970
GO:0006750 Glutathione biosynthetic process Increases phenotype PMID:15669031; PMID:15669031; PMID:24007882; PMID:24440347; PMID:25752611; PMID:25753323; PMID:26176337; PMID:26772156; PMID:26912412; PMID:26969520; PMID:27773698; PMID:27826632; PMID:27900802; PMID:28209544; PMID:28435131; PMID:29689376; PMID:30273691; PMID:30423402; PMID:31444509; PMID:31524377; PMID:31809757; PMID:20804811; PMID:20804811; PMID:24910983; PMID:28682524; PMID:20804811; PMID:26767949; PMID:24007882; PMID:24440347; PMID:24631341; PMID:24910983; PMID:24912781; PMID:25499718; PMID:25753323; PMID:26176337; PMID:26602168; PMID:26767949; PMID:26772156; PMID:26912412; PMID:26969520; PMID:27826632; PMID:27900802; PMID:28209544; PMID:28435131; PMID:28682524; PMID:28919358; PMID:30273691; PMID:30423402; PMID:30552463; PMID:31444509; PMID:31444509; PMID:31809757; PMID:31524377; PMID:31697998; PMID:31777137; PMID:31809757; PMID:31967706
GO:0006754 Atp biosynthetic process Decreases phenotype PMID:24912781; PMID:25704631; PMID:29873576
GO:0006805 Xenobiotic metabolic process Increases phenotype PMID:18347083; PMID:25956474; PMID:31145889; PMID:35243748
GO:0006809 Nitric oxide biosynthetic process Increases phenotype PMID:24910983; PMID:27900802; PMID:27900802; PMID:28435131; PMID:28435131
GO:0006879 Cellular iron ion homeostasis Decreases phenotype PMID:34401974
GO:0006880 Intracellular sequestering of iron ion Increases phenotype PMID:34401974
GO:0006915 Apoptotic process Increases phenotype PMID:11562448; PMID:12005112; PMID:12005112; PMID:14725611; PMID:12085349; PMID:12106828; PMID:12774022; PMID:14725611; PMID:15486922; PMID:20079345; PMID:20644519; PMID:20644519; PMID:33271250; PMID:37046119; PMID:21170329; PMID:22623522; PMID:24912781; PMID:27773698; PMID:31967706; PMID:33458793; PMID:33571619; PMID:34219507; PMID:37046119; PMID:38551724; PMID:30375433; PMID:31697998; PMID:31967706; PMID:33271250; PMID:33350580; PMID:33458793; PMID:37046119; PMID:38551724; PMID:39827450; PMID:9444671
GO:0006954 Inflammatory response Increases phenotype PMID:22319198; PMID:22363424; PMID:29441826; PMID:31967706; PMID:39617257
GO:0006956 Complement activation Affects phenotype PMID:22319198
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:27773698; PMID:28209544; PMID:29777724; PMID:29943110; PMID:31809757; PMID:28209544; PMID:29739258; PMID:29943110; PMID:31809757; PMID:33971260
GO:0006979 Response to oxidative stress Increases phenotype PMID:16156951; PMID:17245372; PMID:18047802; PMID:21219961; PMID:23333575; PMID:23628456
GO:0007005 Mitochondrion organization Increases phenotype PMID:28827156; PMID:34390818; PMID:35713544; PMID:39032760
GO:0007009 Plasma membrane organization Decreases phenotype PMID:28984147
GO:0007033 Vacuole organization Increases phenotype PMID:30273691; PMID:34219507
GO:0007049 Cell cycle Decreases phenotype PMID:9444671
GO:0007204 Positive regulation of cytosolic calcium ion concentration Increases phenotype PMID:28762043
GO:0007281 Germ cell development Decreases phenotype PMID:26732887; PMID:34383603
GO:0007612 Learning Affects phenotype PMID:24361869
GO:0008121 Ubiquinol-cytochrome-c reductase activity Affects phenotype PMID:28827156
GO:0008137 Nadh dehydrogenase (ubiquinone) activity Decreases phenotype PMID:28827156; PMID:33271250; PMID:33271250
GO:0008177 Succinate dehydrogenase (ubiquinone) activity Decreases phenotype PMID:26767949
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:32909844; PMID:32909844; PMID:33350580
GO:0008206 Bile acid metabolic process Affects phenotype PMID:33662127
GO:0008217 Regulation of blood pressure Affects phenotype PMID:14740077
GO:0008219 Cell death Increases phenotype PMID:12085349; PMID:1957310; PMID:27530964; PMID:29943110; PMID:31444509; PMID:33571619; PMID:17245372; PMID:23728527; PMID:28919358; PMID:29739258; PMID:25224400; PMID:25660481; PMID:25704631; PMID:27720869; PMID:30552463; PMID:25881548; PMID:26767949; PMID:27720869; PMID:28919358; PMID:29739258; PMID:29943110; PMID:30552463; PMID:31444509; PMID:34390818; PMID:8861779
GO:0008283 Cell population proliferation Affects phenotype PMID:10079213; PMID:12005112; PMID:12005112; PMID:14725611; PMID:18090125; PMID:20644519; PMID:20644519; PMID:29174983; PMID:24685772; PMID:28919358; PMID:25069801; PMID:25704631; PMID:27720869; PMID:30552463; PMID:26732887; PMID:27720869; PMID:27888128; PMID:28919358; PMID:29665328; PMID:32045647; PMID:3421998; PMID:39032760; PMID:9444671
GO:0008284 Positive regulation of cell population proliferation Increases phenotype PMID:34546377; PMID:38614205
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:23411599; PMID:26801986; PMID:26801986; PMID:33811995; PMID:32949729; PMID:34401974; PMID:38657942
GO:0008344 Adult locomotory behavior Affects phenotype PMID:24361869
GO:0008361 Regulation of cell size Affects phenotype PMID:39032760
GO:0008593 Regulation of notch signaling pathway Affects phenotype PMID:38657942
GO:0008652 Amino acid biosynthetic process Affects phenotype PMID:32479839
GO:0009060 Aerobic respiration Decreases phenotype PMID:34401974
GO:0009403 Toxin biosynthetic process Increases phenotype PMID:35243748
GO:0010508 Positive regulation of autophagy Increases phenotype PMID:38180883
GO:0010637 Negative regulation of mitochondrial fusion Increases phenotype PMID:27792760
GO:0010729 Positive regulation of hydrogen peroxide biosynthetic process Increases phenotype PMID:39947258
GO:0010759 Positive regulation of macrophage chemotaxis Increases phenotype PMID:34078832
GO:0010760 Negative regulation of macrophage chemotaxis Increases phenotype PMID:35292334
GO:0010907 Positive regulation of glucose metabolic process Decreases phenotype PMID:27161652
GO:0010917 Negative regulation of mitochondrial membrane potential Increases phenotype PMID:27792760; PMID:33432343; PMID:34401974
GO:0010918 Positive regulation of mitochondrial membrane potential Decreases phenotype PMID:28762043
GO:0010940 Positive regulation of necrotic cell death Increases phenotype PMID:22319198; PMID:22363424; PMID:23333575; PMID:29355602; PMID:29355602; PMID:31132129; PMID:34668565; PMID:30903181; PMID:32315716; PMID:38042273; PMID:39947258; PMID:39952301; PMID:30903181; PMID:38042273; PMID:31132129; PMID:34668565; PMID:38042273; PMID:39947258; PMID:39952301; PMID:39985503
GO:0010942 Positive regulation of cell death Increases phenotype PMID:25512232; PMID:25860621; PMID:26706816; PMID:26706816; PMID:27792760; PMID:27836570; PMID:27866976; PMID:28762043; PMID:29136249; PMID:31132129
GO:0014068 Positive regulation of phosphatidylinositol 3-kinase signaling Affects phenotype PMID:23472850
GO:0015723 Bilirubin transport Increases phenotype PMID:27161652; PMID:27161652; PMID:27866976; PMID:27161652; PMID:29697884; PMID:27866976; PMID:29697884
GO:0016042 Lipid catabolic process Increases phenotype PMID:15669031; PMID:15669031; PMID:26176337; PMID:26602168; PMID:26772156; PMID:26969520; PMID:27720869; PMID:27989599; PMID:30423402; PMID:31444509; PMID:31524377; PMID:31697998; PMID:20804811; PMID:20804811; PMID:26767949; PMID:20804811; PMID:28682524; PMID:26176337; PMID:26602168; PMID:26772156; PMID:26969520; PMID:27720869; PMID:27720869; PMID:30423402; PMID:27989599; PMID:28435131; PMID:28682524; PMID:28984147; PMID:29441826; PMID:29441826; PMID:31777137; PMID:33350580; PMID:30423402; PMID:31444509; PMID:31444509; PMID:31524377; PMID:31697998; PMID:31524377; PMID:31697998; PMID:31777137; PMID:31967706; PMID:31967706; PMID:32040233; PMID:32677766; PMID:33571619; PMID:32040233; PMID:32677766; PMID:33350580; PMID:33571619; PMID:34390818
GO:0016049 Cell growth Decreases phenotype PMID:29902661; PMID:30552463; PMID:30287234; PMID:30375433
GO:0016615 Malate dehydrogenase activity Increases phenotype PMID:33350580
GO:0016887 Atp hydrolysis activity Affects phenotype PMID:28827156
GO:0018158 Protein oxidation Increases phenotype PMID:26767949; PMID:27161652; PMID:27161652; PMID:29697884; PMID:29943110; PMID:28984147; PMID:29697884; PMID:29943110; PMID:37491939
GO:0018198 Peptidyl-cysteine modification Increases phenotype PMID:27002509; PMID:29325178; PMID:29325178
GO:0018212 Peptidyl-tyrosine modification Increases phenotype PMID:27002509
GO:0019249 Lactate biosynthetic process Increases phenotype PMID:30552463
GO:0019395 Fatty acid oxidation Decreases phenotype PMID:34401974
GO:0019627 Urea metabolic process Affects phenotype PMID:31777137
GO:0019674 Nad metabolic process Affects phenotype PMID:33949241
GO:0022604 Regulation of cell morphogenesis Affects phenotype PMID:27792760
GO:0030263 Apoptotic chromosome condensation Increases phenotype PMID:32909844
GO:0030264 Nuclear fragmentation involved in apoptotic nuclear change Increases phenotype PMID:29458164
GO:0031393 Negative regulation of prostaglandin biosynthetic process Affects phenotype PMID:24448467
GO:0031622 Positive regulation of fever generation Affects phenotype PMID:24448467
GO:0031987 Locomotion involved in locomotory behavior Affects phenotype PMID:35391823; PMID:37491939; PMID:37491939
GO:0032464 Positive regulation of protein homooligomerization Increases phenotype PMID:34401974
GO:0032496 Response to lipopolysaccharide Decreases phenotype PMID:24448467
GO:0032613 Interleukin-10 production Increases phenotype PMID:22319198
GO:0032635 Interleukin-6 production Increases phenotype PMID:22319198
GO:0032640 Tumor necrosis factor production Increases phenotype PMID:22319198
GO:0032691 Negative regulation of interleukin-1 beta production Affects phenotype PMID:24448467
GO:0032720 Negative regulation of tumor necrosis factor production Affects phenotype PMID:24448467
GO:0032930 Positive regulation of superoxide anion generation Increases phenotype PMID:28762043; PMID:33290831
GO:0032964 Collagen biosynthetic process Increases phenotype PMID:28286204
GO:0032967 Positive regulation of collagen biosynthetic process Increases phenotype PMID:29355602
GO:0034418 Urate biosynthetic process Increases phenotype PMID:30794797
GO:0034440 Lipid oxidation Increases phenotype PMID:25818464; PMID:27161652; PMID:27161652; PMID:27866976; PMID:29355602; PMID:29697884; PMID:32081044; PMID:34078832; PMID:35179299; PMID:37046119; PMID:37458150; PMID:39367970; PMID:27866976; PMID:29355602; PMID:29697884; PMID:30099449; PMID:32081044; PMID:33882750; PMID:34078832; PMID:35179299; PMID:37046119; PMID:37458150; PMID:39367970
GO:0035064 Methylated histone binding Affects phenotype PMID:34383603
GO:0035148 Tube formation Decreases phenotype PMID:39032760
GO:0035810 Positive regulation of urine volume Increases phenotype PMID:12721325
GO:0035812 Renal sodium excretion Affects phenotype PMID:12721325
GO:0035938 Estradiol secretion Decreases phenotype PMID:33098425
GO:0036211 Protein modification process Increases phenotype PMID:26772156; PMID:26772156; PMID:28286204; PMID:28687253; PMID:29246445; PMID:33458793; PMID:28286204; PMID:28687253; PMID:33458793; PMID:29246445; PMID:30447259; PMID:33290831; PMID:33458793; PMID:34401974
GO:0036333 Hepatocyte homeostasis Affects phenotype PMID:29441826
GO:0042126 Nitrate metabolic process Increases phenotype PMID:26265018
GO:0042307 Positive regulation of protein import into nucleus Increases phenotype PMID:29355602; PMID:29355602; PMID:29540258; PMID:29540258
GO:0042417 Dopamine metabolic process Affects phenotype PMID:39032760
GO:0042448 Progesterone metabolic process Affects phenotype PMID:39032760
GO:0042554 Superoxide anion generation Increases phenotype PMID:26767949; PMID:31809757; PMID:36184561
GO:0042711 Maternal behavior Affects phenotype PMID:34383603
GO:0042743 Hydrogen peroxide metabolic process Affects phenotype PMID:33571619
GO:0042752 Regulation of circadian rhythm Decreases phenotype PMID:25238856
GO:0042775 Mitochondrial atp synthesis coupled electron transport Decreases phenotype PMID:25746382
GO:0042853 L-alanine catabolic process Affects phenotype PMID:23333575
GO:0043030 Regulation of macrophage activation Affects phenotype PMID:35292334
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:25818464; PMID:28762043; PMID:35166444; PMID:35179299; PMID:38042273
GO:0043603 Amide metabolic process Affects phenotype PMID:34517062
GO:0043931 Ossification involved in bone maturation Affects phenotype PMID:37741353
GO:0043970 Histone h3-k9 acetylation Affects phenotype PMID:34383603
GO:0044237 Cellular metabolic process Decreases phenotype PMID:20465405; PMID:20465405; PMID:33887374; PMID:20465405; PMID:35662663; PMID:28984147; PMID:28984147; PMID:35354423; PMID:31678598; PMID:31697998; PMID:33387578; PMID:33887374; PMID:33971260; PMID:34762139; PMID:35354423; PMID:35662663; PMID:36150480; PMID:36396002; PMID:39032760; PMID:39827450
GO:0044319 Wound healing, spreading of cells Increases phenotype PMID:39032760
GO:0044537 Regulation of circulating fibrinogen levels Affects phenotype PMID:22507835
GO:0044849 Estrous cycle Affects phenotype PMID:34383603
GO:0045023 G0 to g1 transition Affects phenotype PMID:33971260
GO:0045454 Cell redox homeostasis Decreases phenotype PMID:29873576; PMID:36928416; PMID:39952301; PMID:39952301
GO:0045730 Respiratory burst Increases phenotype PMID:39428054
GO:0045787 Positive regulation of cell cycle Affects phenotype PMID:22319198
GO:0046034 Atp metabolic process Affects phenotype PMID:32949729; PMID:33022361; PMID:34762139
GO:0046209 Nitric oxide metabolic process Increases phenotype PMID:31967706; PMID:32909844; PMID:32909844; PMID:33350580; PMID:33350580; PMID:33882750
GO:0046330 Positive regulation of jnk cascade Increases phenotype PMID:25956474; PMID:25956474; PMID:27562556; PMID:33290831
GO:0046415 Urate metabolic process Decreases phenotype PMID:30099449; PMID:30794797; PMID:39889813
GO:0046449 Creatinine metabolic process Decreases phenotype PMID:15669031; PMID:30099449; PMID:30099449; PMID:35243748; PMID:31777137; PMID:31777137; PMID:35020164; PMID:35020164; PMID:35243748
GO:0046466 Membrane lipid catabolic process Affects phenotype PMID:11890740; PMID:16156951; PMID:18047802; PMID:18047802; PMID:20933533; PMID:21219961; PMID:26801986; PMID:3421998; PMID:9703209
GO:0046620 Regulation of organ growth Increases phenotype PMID:3973835
GO:0046722 Lactic acid secretion Increases phenotype PMID:30552463
GO:0046959 Habituation Decreases phenotype PMID:30165669
GO:0048135 Female germ-line cyst formation Affects phenotype PMID:34383603
GO:0048266 Behavioral response to pain Decreases phenotype PMID:26429929; PMID:31524377
GO:0050728 Negative regulation of inflammatory response Decreases phenotype PMID:35292334
GO:0050729 Positive regulation of inflammatory response Increases phenotype PMID:30099449; PMID:35292334; PMID:39947258
GO:0050890 Cognition Affects phenotype PMID:35391823
GO:0050996 Positive regulation of lipid catabolic process Increases phenotype PMID:39947258; PMID:39952301
GO:0051348 Negative regulation of transferase activity Affects phenotype PMID:34078832
GO:0051388 Positive regulation of neurotrophin trk receptor signaling pathway Affects phenotype PMID:23472850
GO:0051726 Regulation of cell cycle Decreases phenotype PMID:28123000
GO:0051881 Regulation of mitochondrial membrane potential Increases phenotype PMID:15486922; PMID:20079345; PMID:22885820; PMID:25752611; PMID:26767949; PMID:27773698; PMID:33432343; PMID:33971260
GO:0051882 Mitochondrial depolarization Increases phenotype PMID:25224400; PMID:31678598; PMID:31809757; PMID:37046119
GO:0051897 Positive regulation of protein kinase b signaling Affects phenotype PMID:23472850
GO:0051898 Negative regulation of protein kinase b signaling Increases phenotype PMID:29697884
GO:0051901 Positive regulation of mitochondrial depolarization Increases phenotype PMID:32315716
GO:0055072 Iron ion homeostasis Affects phenotype PMID:38825056
GO:0055074 Calcium ion homeostasis Affects phenotype PMID:33350580
GO:0060207 Diestrus Affects phenotype PMID:34383603
GO:0060208 Proestrus Affects phenotype PMID:34383603
GO:0060209 Estrus Affects phenotype PMID:34383603
GO:0060283 Negative regulation of oocyte development Increases phenotype PMID:38657942
GO:0060326 Cell chemotaxis Increases phenotype PMID:39032760
GO:0061367 Behavioral response to acetic acid induced pain Decreases phenotype PMID:29499192
GO:0061370 Testosterone biosynthetic process Affects phenotype PMID:39032760
GO:0061628 H3k27me3 modified histone binding Affects phenotype PMID:34383603
GO:0070265 Necrotic cell death Increases phenotype PMID:22623522; PMID:23558424; PMID:33882750; PMID:28123000; PMID:28123000; PMID:28435131; PMID:28827156; PMID:29325178; PMID:29739258; PMID:31809757; PMID:31967706; PMID:32040233; PMID:32045647; PMID:32081044; PMID:33271250; PMID:33458793; PMID:33949241; PMID:34219507; PMID:34390818; PMID:35713544; PMID:37046119; PMID:37458150; PMID:37491939; PMID:37598316; PMID:38551724; PMID:39827450; PMID:28435131; PMID:28435131; PMID:37458150; PMID:37598316; PMID:38551724; PMID:28827156; PMID:29174983; PMID:33021112; PMID:34724096; PMID:34890640; PMID:39617257; PMID:29325178; PMID:29739258; PMID:38551724; PMID:30273691; PMID:31809757; PMID:31967706; PMID:32040233; PMID:32081044; PMID:33021112; PMID:33271250; PMID:33458793; PMID:33882750; PMID:33887374; PMID:33949241; PMID:34390818; PMID:34724096; PMID:34890640; PMID:35713544; PMID:37046119; PMID:37107324; PMID:37458150; PMID:37598316; PMID:38551724; PMID:39617257
GO:0070267 Oncosis Increases phenotype PMID:25499718
GO:0070577 Lysine-acetylated histone binding Affects phenotype PMID:34383603
GO:0070584 Mitochondrion morphogenesis Affects phenotype PMID:33432343
GO:0070585 Protein localization to mitochondrion Affects phenotype PMID:33290831; PMID:35292334
GO:0070994 Detection of oxidative stress Increases phenotype PMID:20465405; PMID:22885820; PMID:22885820; PMID:32909844; PMID:32909844; PMID:34390818; PMID:34390818; PMID:36126895; PMID:39617257; PMID:36126895; PMID:37491939; PMID:39617257
GO:0071971 Extracellular exosome assembly Affects phenotype PMID:26962055
GO:0072378 Blood coagulation, fibrin clot formation Affects phenotype PMID:22507835
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:22885820; PMID:24631341; PMID:25224400; PMID:25704631; PMID:33271250; PMID:33271250; PMID:34890640; PMID:33971260; PMID:35662663; PMID:36150480; PMID:37046119; PMID:38825056; PMID:39428054; PMID:39827450
GO:0072672 Neutrophil extravasation Increases phenotype PMID:11019995; PMID:20933533; PMID:20933533; PMID:36928416; PMID:36928416
GO:0080182 Histone h3-k4 trimethylation Affects phenotype PMID:34383603
GO:0090023 Positive regulation of neutrophil chemotaxis Increases phenotype PMID:33370591; PMID:35292334
GO:0090026 Positive regulation of monocyte chemotaxis Increases phenotype PMID:35292334
GO:0090592 Dna synthesis involved in dna replication Decreases phenotype PMID:3343983
GO:0097272 Ammonium homeostasis Affects phenotype PMID:37491939
GO:0097284 Hepatocyte apoptotic process Increases phenotype PMID:37107324
GO:0097370 Protein o-glcnacylation via threonine Increases phenotype PMID:29325178
GO:0097421 Liver regeneration Affects phenotype PMID:28123000; PMID:29540258; PMID:34546377
GO:0097707 Ferroptosis Increases phenotype PMID:34401974
GO:0097734 Extracellular exosome biogenesis Affects phenotype PMID:30375433
GO:0098532 Histone h3-k27 trimethylation Increases phenotype PMID:29665328; PMID:34383603
GO:0098868 Bone growth Decreases phenotype PMID:37741353
GO:0099156 Cell-cell signaling via exosome Affects phenotype PMID:30375433
GO:0140112 Extracellular vesicle biogenesis Increases phenotype PMID:30447259
GO:0140644 Neutrophil extracellular trap Increases phenotype PMID:39428054
GO:0140645 Neutrophic extracellular trap formation Increases phenotype PMID:39428054
GO:1900158 Negative regulation of bone mineralization involved in bone maturation Increases phenotype PMID:37741353
GO:1900181 Negative regulation of protein localization to nucleus Increases phenotype PMID:35243748
GO:1900409 Positive regulation of cellular response to oxidative stress Affects phenotype PMID:23333575
GO:1901033 Positive regulation of response to reactive oxygen species Affects phenotype PMID:23628456
GO:1901224 Positive regulation of nik/nf-kappab signaling Increases phenotype PMID:27866976
GO:1901526 Positive regulation of mitophagy Increases phenotype PMID:27792760
GO:1901554 Response to paracetamol Increases phenotype PMID:23728527; PMID:29325178; PMID:29739258; PMID:31524377; PMID:36073954
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:26801986; PMID:26801986; PMID:31385618; PMID:29697884; PMID:29697884; PMID:34078832; PMID:35179299; PMID:39952301; PMID:31385618; PMID:34078832; PMID:35179299; PMID:39952301
GO:1901671 Positive regulation of superoxide dismutase activity Decreases phenotype PMID:26265018; PMID:26265018; PMID:27161652; PMID:27161652
GO:1901687 Glutathione derivative biosynthetic process Decreases phenotype PMID:27866976
GO:1901988 Negative regulation of cell cycle phase transition Increases phenotype PMID:38614205
GO:1902110 Positive regulation of mitochondrial membrane permeability involved in apoptotic process Affects phenotype PMID:35292334
GO:1902512 Positive regulation of apoptotic dna fragmentation Increases phenotype PMID:27002509; PMID:27002509; PMID:33370591; PMID:35292334; PMID:33370591; PMID:34401974; PMID:35292334
GO:1902958 Positive regulation of mitochondrial electron transport, nadh to ubiquinone Increases phenotype PMID:27562556
GO:1903047 Mitotic cell cycle process Affects phenotype PMID:33971260
GO:1903215 Negative regulation of protein targeting to mitochondrion Increases phenotype PMID:27002509
GO:1903283 Negative regulation of glutathione peroxidase activity Increases phenotype PMID:31385618; PMID:34078832
GO:1903284 Positive regulation of glutathione peroxidase activity Decreases phenotype PMID:26265018; PMID:26265018; PMID:27161652; PMID:27866976; PMID:27161652; PMID:27866976
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:26767949; PMID:27900802; PMID:27900802; PMID:28209544; PMID:30423402; PMID:28209544; PMID:30375433; PMID:30423402; PMID:31678598
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:25818464; PMID:26265018; PMID:28762043; PMID:29136249; PMID:29136249; PMID:29355602; PMID:35166444; PMID:29355602; PMID:34401974; PMID:37517432
GO:1903578 Regulation of atp metabolic process Affects phenotype PMID:25746382
GO:1903626 Positive regulation of dna catabolic process Increases phenotype PMID:27161652
GO:1903787 Negative regulation of glutathione biosynthetic process Increases phenotype PMID:39947258
GO:1903788 Positive regulation of glutathione biosynthetic process Decreases phenotype PMID:25818464
GO:1903955 Positive regulation of protein targeting to mitochondrion Increases phenotype PMID:27002509
GO:1904161 Dna synthesis involved in uv-damage excision repair Decreases phenotype PMID:3343983
GO:1905517 Macrophage migration Increases phenotype PMID:37046119
GO:1990266 Neutrophil migration Increases phenotype PMID:31697998; PMID:31697998; PMID:37046119; PMID:33887374; PMID:37046119
GO:1990414 Replication-born double-strand break repair via sister chromatid exchange Increases phenotype PMID:3343983
GO:2000375 Negative regulation of oxygen metabolic process Increases phenotype PMID:35748891
GO:2000491 Positive regulation of hepatic stellate cell activation Increases phenotype PMID:29355602
GO:2000782 Regulation of establishment of cell polarity regulating cell shape Affects phenotype PMID:27792760
GO:2000865 Negative regulation of estradiol secretion Increases phenotype PMID:38657942
GO:2001057 Reactive nitrogen species metabolic process Increases phenotype PMID:28209544
GO:2001170 Negative regulation of atp biosynthetic process Increases phenotype PMID:27792760
GO:2001171 Positive regulation of atp biosynthetic process Decreases phenotype PMID:26739624; PMID:26739624; PMID:26921665
GO:2001205 Negative regulation of osteoclast development Increases phenotype PMID:37741353
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.