Atrazine


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000045 Autophagosome assembly Increases phenotype PMID:30084861
GO:0000422 Autophagy of mitochondrion Increases phenotype PMID:30084861
GO:0000737 Dna catabolic process, endonucleolytic Increases phenotype PMID:34994930
GO:0001542 Ovulation from ovarian follicle Increases phenotype PMID:19368227
GO:0001712 Ectodermal cell fate commitment Decreases phenotype PMID:34146662
GO:0001774 Microglial cell activation Increases phenotype PMID:34624533
GO:0002367 Cytokine production involved in immune response Affects phenotype PMID:30629250
GO:0002381 Immunoglobulin production involved in immunoglobulin-mediated immune response Affects phenotype PMID:30629250
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:36282381
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Affects phenotype PMID:22897171; PMID:36282381
GO:0004115 3',5'-cyclic-amp phosphodiesterase activity Affects phenotype PMID:26377646; PMID:28859905
GO:0004364 Glutathione transferase activity Affects phenotype PMID:20136348; PMID:22897171; PMID:28882082; PMID:30360616
GO:0004457 Lactate dehydrogenase activity Increases phenotype PMID:22897171
GO:0004602 Glutathione peroxidase activity Affects phenotype PMID:20136348; PMID:22897171; PMID:24863870; PMID:30360616; PMID:36216167
GO:0004784 Superoxide dismutase activity Affects phenotype PMID:20136348; PMID:22897171; PMID:24632104; PMID:30360616; PMID:36216167; PMID:36282381
GO:0005776 Autophagosome Increases phenotype PMID:30360616
GO:0005975 Carbohydrate metabolic process Affects phenotype PMID:33485040
GO:0006006 Glucose metabolic process Affects phenotype PMID:34600026
GO:0006012 Galactose metabolic process Affects phenotype PMID:33485040
GO:0006171 Camp biosynthetic process Affects phenotype PMID:25433234; PMID:26377646; PMID:27554787; PMID:30065202
GO:0006534 Cysteine metabolic process Affects phenotype PMID:33485040
GO:0006560 Proline metabolic process Affects phenotype PMID:33485040
GO:0006591 Ornithine metabolic process Affects phenotype PMID:33485040
GO:0006629 Lipid metabolic process Affects phenotype PMID:33485040
GO:0006702 Androgen biosynthetic process Increases phenotype PMID:27554787
GO:0006703 Estrogen biosynthetic process Affects phenotype PMID:34600026
GO:0006749 Glutathione metabolic process Affects phenotype PMID:20136348; PMID:27102619; PMID:28882082; PMID:34994930; PMID:36216167
GO:0006750 Glutathione biosynthetic process Affects phenotype PMID:22897171; PMID:24632104; PMID:27957240; PMID:24863870
GO:0006805 Xenobiotic metabolic process Affects phenotype PMID:29162470; PMID:30545405
GO:0006914 Autophagy Increases phenotype PMID:26075868; PMID:30084861
GO:0006915 Apoptotic process Increases phenotype PMID:26075868; PMID:33485040; PMID:33766575; PMID:34663174
GO:0006954 Inflammatory response Increases phenotype PMID:36216167
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:24863870; PMID:27957240; PMID:29710542
GO:0006997 Nucleus organization Affects phenotype PMID:30580161
GO:0007005 Mitochondrion organization Decreases phenotype PMID:30065202; PMID:30084861; PMID:30360616; PMID:30580161; PMID:36216167
GO:0007033 Vacuole organization Affects phenotype PMID:30580161
GO:0007040 Lysosome organization Affects phenotype PMID:30580161
GO:0007140 Male meiotic nuclear division Affects phenotype PMID:27655631
GO:0007283 Spermatogenesis Decreases phenotype PMID:25403740; PMID:27655631; PMID:29710542; PMID:33715114; PMID:34600026
GO:0007286 Spermatid development Decreases phenotype PMID:25403740; PMID:27655631; PMID:34600026
GO:0007346 Regulation of mitotic cell cycle Increases phenotype PMID:25616260
GO:0007613 Memory Affects phenotype PMID:34030342
GO:0008137 Nadh dehydrogenase (ubiquinone) activity Decreases phenotype PMID:24863870
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:34600026
GO:0008210 Estrogen metabolic process Affects phenotype PMID:28859905
GO:0008217 Regulation of blood pressure Affects phenotype PMID:24218149
GO:0008283 Cell population proliferation Increases phenotype PMID:17599374; PMID:22372587; PMID:23070809; PMID:26984284; PMID:34624533; PMID:38185387
GO:0008284 Positive regulation of cell population proliferation Increases phenotype PMID:25616260; PMID:25616260; PMID:34435054; PMID:34435054
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:29149346; PMID:34146662
GO:0008542 Visual learning Decreases phenotype PMID:30065202; PMID:34030342
GO:0008584 Male gonad development Decreases phenotype PMID:33463082; PMID:34600026
GO:0009117 Nucleotide metabolic process Affects phenotype PMID:33485040
GO:0009712 Catechol-containing compound metabolic process Affects phenotype PMID:33485040
GO:0009820 Alkaloid metabolic process Affects phenotype PMID:33485040
GO:0010424 Dna methylation on cytosine within a cg sequence Affects phenotype PMID:34516295
GO:0010729 Positive regulation of hydrogen peroxide biosynthetic process Increases phenotype PMID:26518232; PMID:38301994
GO:0010917 Negative regulation of mitochondrial membrane potential Increases phenotype PMID:36181348; PMID:38056589
GO:0010942 Positive regulation of cell death Increases phenotype PMID:27114639; PMID:29893964
GO:0010960 Magnesium ion homeostasis Decreases phenotype PMID:27112537; PMID:33960999
GO:0015444 P-type magnesium transporter activity Affects phenotype PMID:27112537
GO:0016042 Lipid catabolic process Increases phenotype PMID:22897171; PMID:24863870; PMID:29710542; PMID:30360616
GO:0016134 Saponin metabolic process Affects phenotype PMID:33485040
GO:0018158 Protein oxidation Increases phenotype PMID:27957240
GO:0019585 Glucuronate metabolic process Affects phenotype PMID:33485040
GO:0019627 Urea metabolic process Affects phenotype PMID:34600026
GO:0019695 Choline metabolic process Affects phenotype PMID:33485040
GO:0019825 Oxygen binding Increases phenotype PMID:26775023
GO:0019853 L-ascorbic acid biosynthetic process Decreases phenotype PMID:22897171
GO:0021860 Pyramidal neuron development Affects phenotype PMID:34994930
GO:0030199 Collagen fibril organization Increases phenotype PMID:36282381
GO:0030263 Apoptotic chromosome condensation Increases phenotype PMID:30084861; PMID:34624533; PMID:34994930
GO:0030335 Positive regulation of cell migration Increases phenotype PMID:25616260; PMID:34435054
GO:0030521 Androgen receptor signaling pathway Increases phenotype PMID:19368227
GO:0030534 Adult behavior Affects phenotype PMID:24913803
GO:0031507 Heterochromatin formation Increases phenotype PMID:26518232
GO:0031646 Positive regulation of nervous system process Increases phenotype PMID:28011073
GO:0031959 Mineralocorticoid receptor signaling pathway Increases phenotype PMID:29149346
GO:0031987 Locomotion involved in locomotory behavior Affects phenotype PMID:30084861; PMID:34624533
GO:0032049 Cardiolipin biosynthetic process Decreases phenotype PMID:36181348
GO:0032148 Activation of protein kinase b activity Increases phenotype PMID:25253736
GO:0032689 Negative regulation of type ii interferon production Increases phenotype PMID:25433234
GO:0032831 Positive regulation of cd4-positive, cd25-positive, alpha-beta regulatory t cell differentiation Increases phenotype PMID:25433234
GO:0033108 Mitochondrial respiratory chain complex assembly Decreases phenotype PMID:36181348
GO:0033148 Positive regulation of intracellular estrogen receptor signaling pathway Increases phenotype PMID:19368227
GO:0033484 Cellular nitric oxide homeostasis Affects phenotype PMID:27431321
GO:0034440 Lipid oxidation Increases phenotype PMID:27102619
GO:0035640 Exploration behavior Affects phenotype PMID:24913803
GO:0035702 Monocyte homeostasis Affects phenotype PMID:34090108
GO:0035936 Testosterone secretion Increases phenotype PMID:33766575
GO:0036269 Swimming behavior Affects phenotype PMID:24913803
GO:0040015 Negative regulation of multicellular organism growth Increases phenotype PMID:28931070
GO:0040018 Positive regulation of multicellular organism growth Decreases phenotype PMID:27102619
GO:0042214 Terpene metabolic process Affects phenotype PMID:33485040
GO:0042416 Dopamine biosynthetic process Increases phenotype PMID:24913803; PMID:30065202
GO:0042431 Indole metabolic process Affects phenotype PMID:33485040
GO:0042448 Progesterone metabolic process Affects phenotype PMID:28859905
GO:0042743 Hydrogen peroxide metabolic process Affects phenotype PMID:30360616; PMID:36216167
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:25259610; PMID:26518232; PMID:29893964; PMID:34090108
GO:0043083 Synaptic cleft Affects phenotype PMID:30580161
GO:0043462 Regulation of atp-dependent activity Affects phenotype PMID:27112537
GO:0044030 Regulation of dna methylation Affects phenotype PMID:28931070
GO:0044237 Cellular metabolic process Decreases phenotype PMID:30084861; PMID:33766575; PMID:34663174
GO:0044319 Wound healing, spreading of cells Increases phenotype PMID:24211529
GO:0045429 Positive regulation of nitric oxide biosynthetic process Increases phenotype PMID:26256823; PMID:37236337
GO:0045786 Negative regulation of cell cycle Increases phenotype PMID:38301994
GO:0045787 Positive regulation of cell cycle Increases phenotype PMID:34435054
GO:0045930 Negative regulation of mitotic cell cycle Increases phenotype PMID:29893964; PMID:34146662
GO:0045964 Positive regulation of dopamine metabolic process Increases phenotype PMID:28341570
GO:0046058 Camp metabolic process Affects phenotype PMID:28859905
GO:0046449 Creatinine metabolic process Affects phenotype PMID:34600026
GO:0046622 Positive regulation of organ growth Increases phenotype PMID:27102619
GO:0048137 Spermatocyte division Decreases phenotype PMID:26518232
GO:0048712 Negative regulation of astrocyte differentiation Increases phenotype PMID:34146662
GO:0048808 Male genitalia morphogenesis Decreases phenotype PMID:33463082
GO:0050879 Multicellular organismal movement Decreases phenotype PMID:28011073
GO:0050996 Positive regulation of lipid catabolic process Increases phenotype PMID:38056589
GO:0051091 Positive regulation of dna-binding transcription factor activity Increases phenotype PMID:28973306
GO:0052838 Thiazole metabolic process Affects phenotype PMID:33485040
GO:0055064 Chloride ion homeostasis Affects phenotype PMID:33960999
GO:0055072 Iron ion homeostasis Affects phenotype PMID:34030342
GO:0055074 Calcium ion homeostasis Decreases phenotype PMID:26476475; PMID:27112537; PMID:27957240; PMID:33960999
GO:0055075 Potassium ion homeostasis Decreases phenotype PMID:27112537; PMID:33960999
GO:0055078 Sodium ion homeostasis Decreases phenotype PMID:27112537; PMID:33960999
GO:0060068 Vagina development Affects phenotype PMID:14962502
GO:0060279 Positive regulation of ovulation Increases phenotype PMID:26923738
GO:0060322 Head development Decreases phenotype PMID:21367690
GO:0060326 Cell chemotaxis Affects phenotype PMID:38185387
GO:0061180 Mammary gland epithelium development Affects phenotype PMID:14962502
GO:0061370 Testosterone biosynthetic process Decreases phenotype PMID:29710542; PMID:29710542; PMID:34600026; PMID:33463082; PMID:33766575
GO:0070050 Neuron cellular homeostasis Affects phenotype PMID:30580161
GO:0070374 Positive regulation of erk1 and erk2 cascade Increases phenotype PMID:25616260; PMID:29329451
GO:0070994 Detection of oxidative stress Increases phenotype PMID:20136348; PMID:34624533; PMID:34994930; PMID:36216167; PMID:36282381
GO:0071763 Nuclear membrane organization Affects phenotype PMID:30580161
GO:0072520 Seminiferous tubule development Affects phenotype PMID:34600026
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:23070809; PMID:30084861; PMID:34624533
GO:0072676 Lymphocyte migration Increases phenotype PMID:36216167
GO:0080182 Histone h3-k4 trimethylation Decreases phenotype PMID:26518232; PMID:27655631
GO:0090173 Regulation of synaptonemal complex assembly Decreases phenotype PMID:26518232
GO:0090205 Positive regulation of cholesterol metabolic process Increases phenotype PMID:38056589
GO:0090327 Negative regulation of locomotion involved in locomotory behavior Increases phenotype PMID:28011073
GO:0097722 Sperm motility Decreases phenotype PMID:22897171; PMID:25403740; PMID:33715114; PMID:34600026
GO:0098655 Monoatomic cation transmembrane transport Decreases phenotype PMID:26476475
GO:0120008 Positive regulation of glutamatergic neuron differentiation Increases phenotype PMID:34146662
GO:0140042 Lipid droplet formation Increases phenotype PMID:37046073
GO:0140354 Lipid import into cell Increases phenotype PMID:38056589
GO:0140639 Positive regulation of pyroptosis Increases phenotype PMID:38301994
GO:1901216 Positive regulation of neuron death Increases phenotype PMID:26256823; PMID:31187311
GO:1901671 Positive regulation of superoxide dismutase activity Decreases phenotype PMID:27102619
GO:1901894 Regulation of atpase-coupled calcium transmembrane transporter activity Affects phenotype PMID:27112537
GO:1901896 Positive regulation of atpase-coupled calcium transmembrane transporter activity Affects phenotype PMID:26476475; PMID:27112537
GO:1902512 Positive regulation of apoptotic dna fragmentation Increases phenotype PMID:27102619
GO:1903181 Positive regulation of dopamine biosynthetic process Decreases phenotype PMID:26331294
GO:1903284 Positive regulation of glutathione peroxidase activity Decreases phenotype PMID:27102619
GO:1903406 Regulation of p-type sodium:potassium-exchanging transporter activity Affects phenotype PMID:27112537
GO:1903408 Positive regulation of p-type sodium:potassium-exchanging transporter activity Increases phenotype PMID:26476475
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:27957240; PMID:34435054
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:26256823; PMID:29893964; PMID:38056589; PMID:38301994
GO:1903578 Regulation of atp metabolic process Increases phenotype PMID:27114639
GO:1903788 Positive regulation of glutathione biosynthetic process Increases phenotype PMID:38056589
GO:1903980 Positive regulation of microglial cell activation Increases phenotype PMID:26256823
GO:1904124 Microglial cell migration Increases phenotype PMID:34624533
GO:1904339 Negative regulation of dopaminergic neuron differentiation Increases phenotype PMID:34146662
GO:1904480 Positive regulation of intestinal absorption Increases phenotype PMID:30545405
GO:1990918 Double-strand break repair involved in meiotic recombination Decreases phenotype PMID:26518232
GO:1990959 Eosinophil homeostasis Affects phenotype PMID:34090108
GO:2000224 Regulation of testosterone biosynthetic process Affects phenotype PMID:22461451
GO:2000225 Negative regulation of testosterone biosynthetic process Increases phenotype PMID:25403740
GO:2000386 Positive regulation of ovarian follicle development Increases phenotype PMID:26923738
GO:2000562 Negative regulation of cd4-positive, alpha-beta t cell proliferation Increases phenotype PMID:25433234
GO:2000611 Positive regulation of thyroid hormone generation Increases phenotype PMID:31362416
GO:2000844 Negative regulation of testosterone secretion Increases phenotype PMID:33715114
GO:2000845 Positive regulation of testosterone secretion Affects phenotype PMID:26377646; PMID:26518232
GO:2000854 Positive regulation of corticosterone secretion Decreases phenotype PMID:27102619
GO:2000866 Positive regulation of estradiol secretion Increases phenotype PMID:26923738
GO:2000872 Positive regulation of progesterone secretion Increases phenotype PMID:25253736
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.