Butyl benzyl phthalate


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0001525 Angiogenesis Increases phenotype PMID:22905168; PMID:25081364
GO:0001541 Ovarian follicle development Decreases phenotype PMID:29969652; PMID:34597818; PMID:35762964
GO:0001547 Antral ovarian follicle growth Decreases phenotype PMID:28013214
GO:0001568 Blood vessel development Increases phenotype PMID:37021957
GO:0001825 Blastocyst formation Decreases phenotype PMID:36756972
GO:0002191 Cap-dependent translational initiation Affects phenotype PMID:27992464
GO:0003006 Developmental process involved in reproduction Affects phenotype PMID:37788136
GO:0003093 Regulation of glomerular filtration Affects phenotype PMID:32645486
GO:0004691 Camp-dependent protein kinase activity Increases phenotype PMID:33711355
GO:0006007 Glucose catabolic process Increases phenotype PMID:31629899
GO:0006171 Camp biosynthetic process Increases phenotype PMID:37552060
GO:0006306 Dna methylation Affects phenotype PMID:28392331
GO:0006606 Protein import into nucleus Affects phenotype PMID:27129165
GO:0006694 Steroid biosynthetic process Decreases phenotype PMID:35762964
GO:0006754 Atp biosynthetic process Increases phenotype PMID:31629899
GO:0006805 Xenobiotic metabolic process Increases phenotype PMID:29162470
GO:0006874 Cellular calcium ion homeostasis Affects phenotype PMID:25081364
GO:0006879 Cellular iron ion homeostasis Affects phenotype PMID:39921026
GO:0006954 Inflammatory response Increases phenotype PMID:28392331
GO:0007281 Germ cell development Decreases phenotype PMID:30802670; PMID:37788136
GO:0007283 Spermatogenesis Decreases phenotype PMID:29029336; PMID:30802670; PMID:37364641; PMID:39921026
GO:0007286 Spermatid development Decreases phenotype PMID:30802670
GO:0008210 Estrogen metabolic process Affects phenotype PMID:28611354; PMID:34597818
GO:0008219 Cell death Increases phenotype PMID:26520405; PMID:33711355
GO:0008283 Cell population proliferation Increases phenotype PMID:21241498; PMID:24213142; PMID:24213142; PMID:29864457; PMID:27129165; PMID:28855101; PMID:29864457; PMID:31016752; PMID:31319113; PMID:34428494
GO:0008284 Positive regulation of cell population proliferation Increases phenotype PMID:35307500
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:35739755
GO:0008584 Male gonad development Affects phenotype PMID:28611354; PMID:30802670
GO:0009566 Fertilization Decreases phenotype PMID:33711355
GO:0009790 Embryo development Decreases phenotype PMID:33711355
GO:0010468 Regulation of gene expression Affects phenotype PMID:38995844
GO:0010890 Positive regulation of sequestering of triglyceride Increases phenotype PMID:26820058
GO:0010906 Regulation of glucose metabolic process Affects phenotype PMID:35739755; PMID:37364641
GO:0010907 Positive regulation of glucose metabolic process Increases phenotype PMID:32905190
GO:0010917 Negative regulation of mitochondrial membrane potential Increases phenotype PMID:36756972
GO:0015278 Calcium-release channel activity Affects phenotype PMID:25081364
GO:0016049 Cell growth Increases phenotype PMID:29864457; PMID:30243731
GO:0016477 Cell migration Increases phenotype PMID:25081364; PMID:27129165
GO:0018108 Peptidyl-tyrosine phosphorylation Increases phenotype PMID:33711355
GO:0019249 Lactate biosynthetic process Increases phenotype PMID:31629899
GO:0019695 Choline metabolic process Affects phenotype PMID:32949613
GO:0022602 Ovulation cycle process Affects phenotype PMID:29969652
GO:0030263 Apoptotic chromosome condensation Increases phenotype PMID:28611354; PMID:29029336; PMID:36746855
GO:0030728 Ovulation Increases phenotype PMID:33316053
GO:0030836 Positive regulation of actin filament depolymerization Increases phenotype PMID:36756972
GO:0030850 Prostate gland development Decreases phenotype PMID:30802670
GO:0031323 Regulation of cellular metabolic process Affects phenotype PMID:26820058
GO:0032308 Positive regulation of prostaglandin secretion Increases phenotype PMID:33316053
GO:0033148 Positive regulation of intracellular estrogen receptor signaling pathway Increases phenotype PMID:25449125; PMID:27473340
GO:0034199 Activation of protein kinase a activity Increases phenotype PMID:37552060
GO:0034255 Regulation of urea metabolic process Affects phenotype PMID:32949613
GO:0034389 Lipid droplet organization Increases phenotype PMID:26820058
GO:0034440 Lipid oxidation Increases phenotype PMID:39921026
GO:0035148 Tube formation Increases phenotype PMID:22905168
GO:0035176 Social behavior Decreases phenotype PMID:32518293
GO:0035360 Positive regulation of peroxisome proliferator activated receptor signaling pathway Increases phenotype PMID:26519955
GO:0035936 Testosterone secretion Decreases phenotype PMID:28013214; PMID:30802670; PMID:31199487
GO:0035938 Estradiol secretion Decreases phenotype PMID:28013214
GO:0035941 Androstenedione secretion Decreases phenotype PMID:28013214
GO:0035943 Estrone secretion Decreases phenotype PMID:28013214
GO:0036269 Swimming behavior Affects phenotype PMID:32518293
GO:0042221 Response to chemical Increases phenotype PMID:34428494
GO:0042448 Progesterone metabolic process Affects phenotype PMID:34597818
GO:0042632 Cholesterol homeostasis Decreases phenotype PMID:35739755
GO:0042692 Muscle cell differentiation Increases phenotype PMID:28298639
GO:0042701 Progesterone secretion Affects phenotype PMID:33316053
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:33511402; PMID:35739755; PMID:36756972; PMID:37364641
GO:0043066 Negative regulation of apoptotic process Increases phenotype PMID:31016752
GO:0043970 Histone h3-k9 acetylation Increases phenotype PMID:27129165
GO:0044237 Cellular metabolic process Affects phenotype PMID:22905168; PMID:27129165; PMID:27992464; PMID:31629899; PMID:33822518; PMID:34697989; PMID:39921026
GO:0044319 Wound healing, spreading of cells Increases phenotype PMID:22905168; PMID:31212022
GO:0044849 Estrous cycle Affects phenotype PMID:36929940
GO:0045333 Cellular respiration Increases phenotype PMID:31629899
GO:0045444 Fat cell differentiation Increases phenotype PMID:24155963; PMID:27923775; PMID:34520170
GO:0045600 Positive regulation of fat cell differentiation Increases phenotype PMID:26820058; PMID:28595985
GO:0045931 Positive regulation of mitotic cell cycle Increases phenotype PMID:35307500
GO:0046034 Atp metabolic process Affects phenotype PMID:33711355
GO:0046622 Positive regulation of organ growth Increases phenotype PMID:32518293
GO:0046881 Positive regulation of follicle-stimulating hormone secretion Increases phenotype PMID:37364641
GO:0048240 Sperm capacitation Increases phenotype PMID:33711355
GO:0048246 Macrophage chemotaxis Increases phenotype PMID:40323316
GO:0048599 Oocyte development Decreases phenotype PMID:28013214
GO:0050679 Positive regulation of epithelial cell proliferation Increases phenotype PMID:40323316
GO:0050729 Positive regulation of inflammatory response Increases phenotype PMID:31199487
GO:0050890 Cognition Decreases phenotype PMID:36746855
GO:0051726 Regulation of cell cycle Affects phenotype PMID:29864457
GO:0055072 Iron ion homeostasis Affects phenotype PMID:39921026
GO:0060305 Regulation of cell diameter Affects phenotype PMID:37021957
GO:0060326 Cell chemotaxis Increases phenotype PMID:22905168; PMID:25081364
GO:0060376 Positive regulation of mast cell differentiation Increases phenotype PMID:37021957
GO:0060443 Mammary gland morphogenesis Affects phenotype PMID:21241498
GO:0060467 Negative regulation of fertilization Increases phenotype PMID:36756972
GO:0060512 Prostate gland morphogenesis Decreases phenotype PMID:31199487
GO:0060618 Nipple development Affects phenotype PMID:37788136
GO:0061107 Seminal vesicle development Decreases phenotype PMID:30802670
GO:0061180 Mammary gland epithelium development Affects phenotype PMID:21241498
GO:0061370 Testosterone biosynthetic process Affects phenotype PMID:31319113; PMID:33983380; PMID:34597818
GO:0061458 Reproductive system development Decreases phenotype PMID:37788136
GO:0070328 Triglyceride homeostasis Decreases phenotype PMID:35739755
GO:0070352 Positive regulation of white fat cell proliferation Increases phenotype PMID:32905190
GO:0071929 Alpha-tubulin acetylation Decreases phenotype PMID:36756972
GO:0072497 Mesenchymal stem cell differentiation Decreases phenotype PMID:28298639
GO:0072520 Seminiferous tubule development Decreases phenotype PMID:29029336; PMID:30802670; PMID:37364641
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:39921026
GO:0072677 Eosinophil migration Increases phenotype PMID:28392331
GO:0080182 Histone h3-k4 trimethylation Increases phenotype PMID:27129165
GO:0090116 C-5 methylation of cytosine Decreases phenotype PMID:35487445
GO:0090326 Positive regulation of locomotion involved in locomotory behavior Increases phenotype PMID:32518293
GO:0097202 Activation of cysteine-type endopeptidase activity Increases phenotype PMID:29029336
GO:0097368 Establishment of sertoli cell barrier Decreases phenotype PMID:39921026
GO:0097722 Sperm motility Decreases phenotype PMID:30802670; PMID:33711355; PMID:39921026
GO:0110088 Hippocampal neuron apoptotic process Increases phenotype PMID:36746855
GO:0140042 Lipid droplet formation Increases phenotype PMID:28595985; PMID:31016361; PMID:34864131; PMID:32407875; PMID:34520170
GO:0140354 Lipid import into cell Increases phenotype PMID:35739755
GO:0160024 Leydig cell proliferation Affects phenotype PMID:28611354
GO:1900015 Regulation of cytokine production involved in inflammatory response Affects phenotype PMID:38954831
GO:1900017 Positive regulation of cytokine production involved in inflammatory response Increases phenotype PMID:40323316
GO:1900194 Negative regulation of oocyte maturation Increases phenotype PMID:36756972
GO:1902884 Positive regulation of response to oxidative stress Increases phenotype PMID:35739755
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:26520405
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:36756972; PMID:38227285
GO:1903786 Regulation of glutathione biosynthetic process Affects phenotype PMID:32949613
GO:1904177 Regulation of adipose tissue development Affects phenotype PMID:37021957
GO:1904598 Positive regulation of connective tissue replacement involved in inflammatory response wound healing Increases phenotype PMID:35739755
GO:1905071 Tight junction disassembly Affects phenotype PMID:39921026
GO:1905831 Negative regulation of spindle assembly Affects phenotype PMID:36756972
GO:1905867 Epididymis development Affects phenotype PMID:30802670
GO:2000184 Positive regulation of progesterone biosynthetic process Increases phenotype PMID:37552060
GO:2000225 Negative regulation of testosterone biosynthetic process Increases phenotype PMID:35739735; PMID:37788136
GO:2000387 Regulation of antral ovarian follicle growth Decreases phenotype PMID:36756972
GO:2000437 Regulation of monocyte extravasation Affects phenotype PMID:37743007
GO:2000844 Negative regulation of testosterone secretion Increases phenotype PMID:37839492; PMID:38227285; PMID:39947446
GO:2000845 Positive regulation of testosterone secretion Increases phenotype PMID:37364641
GO:2000865 Negative regulation of estradiol secretion Increases phenotype PMID:29029336; PMID:35163327; PMID:37839492
GO:2000866 Positive regulation of estradiol secretion Increases phenotype PMID:31016752; PMID:37364641
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.