Chlorpyrifos


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000084 Mitotic s phase Affects phenotype PMID:30981936; PMID:33839396
GO:0000086 G2/m transition of mitotic cell cycle Affects phenotype PMID:33839396
GO:0000278 Mitotic cell cycle Affects phenotype PMID:30981936
GO:0000737 Dna catabolic process, endonucleolytic Increases phenotype PMID:33839396; PMID:34830855
GO:0001774 Microglial cell activation Increases phenotype PMID:33839396
GO:0001780 Neutrophil homeostasis Affects phenotype PMID:31226429; PMID:31807802; PMID:33524429
GO:0001836 Release of cytochrome c from mitochondria Increases phenotype PMID:29859868
GO:0001979 Regulation of systemic arterial blood pressure by chemoreceptor signaling Increases phenotype PMID:29471072
GO:0002009 Morphogenesis of an epithelium Affects phenotype PMID:25643018
GO:0002286 T cell activation involved in immune response Increases phenotype PMID:33524429
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:25233897; PMID:34060014; PMID:39419344
GO:0002638 Negative regulation of immunoglobulin production Increases phenotype PMID:29667781
GO:0002686 Negative regulation of leukocyte migration Increases phenotype PMID:29667781
GO:0003014 Renal system process Affects phenotype PMID:34200920
GO:0003016 Respiratory system process Decreases phenotype PMID:31981688
GO:0003019 Central nervous system control of baroreceptor feedback Increases phenotype PMID:29471072
GO:0003025 Regulation of systemic arterial blood pressure by baroreceptor feedback Increases phenotype PMID:29471072
GO:0003990 Acetylcholinesterase activity Decreases phenotype PMID:26519479; PMID:29939342
GO:0003993 Acid phosphatase activity Decreases phenotype PMID:34678318
GO:0004035 Alkaline phosphatase activity Affects phenotype PMID:32955216; PMID:33908150; PMID:34678318
GO:0004064 Arylesterase activity Increases phenotype PMID:24979751; PMID:34425170; PMID:36058312
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Increases phenotype PMID:32955216; PMID:33524429; PMID:33908150
GO:0004104 Cholinesterase activity Decreases phenotype PMID:29097212; PMID:29729306; PMID:29736246; PMID:29736246; PMID:30035273; PMID:30035273; PMID:35358535; PMID:30656380; PMID:35225412; PMID:34200920; PMID:35358535
GO:0004364 Glutathione transferase activity Decreases phenotype PMID:27268782; PMID:28373059; PMID:30267645; PMID:34425170; PMID:34678318; PMID:34678318; PMID:38522820
GO:0004457 Lactate dehydrogenase activity Affects phenotype PMID:23364943; PMID:34678318
GO:0004602 Glutathione peroxidase activity Affects phenotype PMID:25233897; PMID:28373059; PMID:28373059; PMID:30497708; PMID:29108776; PMID:30267645; PMID:30497708; PMID:32120800; PMID:32602772; PMID:33908150; PMID:33908150; PMID:38849050; PMID:34678318; PMID:38849050; PMID:39419344
GO:0004784 Superoxide dismutase activity Affects phenotype PMID:25233897; PMID:28373059; PMID:28373059; PMID:30497708; PMID:35448458; PMID:29108776; PMID:30267645; PMID:30497708; PMID:30758894; PMID:32120800; PMID:32602772; PMID:32955216; PMID:33908150; PMID:33908150; PMID:38849050; PMID:34678318; PMID:38849050; PMID:39419344
GO:0004935 Adrenergic receptor activity Increases phenotype PMID:26419632
GO:0005391 P-type sodium:potassium-exchanging transporter activity Decreases phenotype PMID:29736246
GO:0006006 Glucose metabolic process Affects phenotype PMID:32745781; PMID:39419344
GO:0006083 Acetate metabolic process Affects phenotype PMID:32745781
GO:0006089 Lactate metabolic process Affects phenotype PMID:34259569
GO:0006105 Succinate metabolic process Affects phenotype PMID:32745781
GO:0006117 Acetaldehyde metabolic process Affects phenotype PMID:34830855
GO:0006121 Mitochondrial electron transport, succinate to ubiquinone Decreases phenotype PMID:36269219
GO:0006122 Mitochondrial electron transport, ubiquinol to cytochrome c Decreases phenotype PMID:36269219
GO:0006304 Dna modification Increases phenotype PMID:27941166; PMID:29359425; PMID:33078895
GO:0006537 Glutamate biosynthetic process Increases phenotype PMID:29665406
GO:0006568 Tryptophan metabolic process Affects phenotype PMID:34259569
GO:0006580 Ethanolamine metabolic process Affects phenotype PMID:36858108
GO:0006631 Fatty acid metabolic process Affects phenotype PMID:28433638; PMID:32745781
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:27760213; PMID:39419344
GO:0006693 Prostaglandin metabolic process Affects phenotype PMID:34424684
GO:0006749 Glutathione metabolic process Increases phenotype PMID:26257840; PMID:27268782; PMID:27268782; PMID:33908150; PMID:29667781; PMID:29859868; PMID:31823260; PMID:32651842; PMID:33586219; PMID:33586219; PMID:34678318; PMID:33908150; PMID:34425170; PMID:34425170; PMID:39419344; PMID:34678318; PMID:36058312; PMID:36811218; PMID:39419344
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:23850137; PMID:24979751; PMID:28373059; PMID:30267645
GO:0006805 Xenobiotic metabolic process Affects phenotype PMID:24283477
GO:0006809 Nitric oxide biosynthetic process Increases phenotype PMID:28373059
GO:0006874 Cellular calcium ion homeostasis Affects phenotype PMID:26187449
GO:0006915 Apoptotic process Affects phenotype PMID:14976342; PMID:24793810; PMID:26435000; PMID:26519479; PMID:28549829; PMID:30378422; PMID:30497708; PMID:30758894; PMID:30835941; PMID:32096903; PMID:35457321; PMID:36252918
GO:0006919 Activation of cysteine-type endopeptidase activity involved in apoptotic process Increases phenotype PMID:26198043; PMID:27737797
GO:0006954 Inflammatory response Increases phenotype PMID:23416140; PMID:31807802; PMID:33586219; PMID:33908150
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:29859868; PMID:30981936; PMID:33908150
GO:0006979 Response to oxidative stress Affects phenotype PMID:31400774
GO:0007005 Mitochondrion organization Decreases phenotype PMID:32955216
GO:0007197 Adenylate cyclase-inhibiting g protein-coupled acetylcholine receptor signaling pathway Increases phenotype PMID:36058312
GO:0007283 Spermatogenesis Decreases phenotype PMID:23172834; PMID:34678318
GO:0007601 Visual perception Affects phenotype PMID:27773359
GO:0007610 Behavior Affects phenotype PMID:27773359; PMID:32057829
GO:0007612 Learning Increases phenotype PMID:30656380; PMID:32387648
GO:0007613 Memory Decreases phenotype PMID:27773359; PMID:30497708; PMID:36811218
GO:0007631 Feeding behavior Increases phenotype PMID:31226429; PMID:31472362
GO:0008088 Axo-dendritic transport Decreases phenotype PMID:25614231
GO:0008152 Metabolic process Affects phenotype PMID:32179266
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:32745781; PMID:39419344
GO:0008210 Estrogen metabolic process Affects phenotype PMID:32440878; PMID:32440878; PMID:36769379; PMID:36769379
GO:0008219 Cell death Increases phenotype PMID:19589100; PMID:23994500; PMID:24979751; PMID:26210949; PMID:27163631; PMID:29665406
GO:0008283 Cell population proliferation Increases phenotype PMID:24793810; PMID:25137620; PMID:26018426; PMID:26514924; PMID:30236991; PMID:32736067; PMID:34424684; PMID:34424684; PMID:39832751; PMID:34830855; PMID:35457321
GO:0008284 Positive regulation of cell population proliferation Affects phenotype PMID:26079056; PMID:26257840; PMID:31136966; PMID:32171938
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:24215065; PMID:26198043; PMID:29555536; PMID:32651842; PMID:32800223; PMID:32949729; PMID:33078895
GO:0008291 Acetylcholine metabolic process Affects phenotype PMID:33930485
GO:0008344 Adult locomotory behavior Affects phenotype PMID:30267645
GO:0008584 Male gonad development Affects phenotype PMID:30378422
GO:0008635 Activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c Affects phenotype PMID:23416140
GO:0008652 Amino acid biosynthetic process Affects phenotype PMID:28433638
GO:0009448 Gamma-aminobutyric acid metabolic process Affects phenotype PMID:34259569
GO:0010459 Negative regulation of heart rate Increases phenotype PMID:29471072
GO:0010507 Negative regulation of autophagy Increases phenotype PMID:35439518
GO:0010508 Positive regulation of autophagy Increases phenotype PMID:34289071
GO:0010637 Negative regulation of mitochondrial fusion Increases phenotype PMID:28112198
GO:0010718 Positive regulation of epithelial to mesenchymal transition Increases phenotype PMID:32956863
GO:0010917 Negative regulation of mitochondrial membrane potential Increases phenotype PMID:28112198
GO:0010918 Positive regulation of mitochondrial membrane potential Decreases phenotype PMID:26070385
GO:0010942 Positive regulation of cell death Increases phenotype PMID:23416140; PMID:26299976; PMID:29893964; PMID:40434365
GO:0010976 Positive regulation of neuron projection development Increases phenotype PMID:28385489
GO:0010977 Negative regulation of neuron projection development Increases phenotype PMID:28369648
GO:0014002 Astrocyte development Increases phenotype PMID:33011216
GO:0014054 Positive regulation of gamma-aminobutyric acid secretion Increases phenotype PMID:28975519
GO:0014721 Twitch skeletal muscle contraction Increases phenotype PMID:31879696
GO:0016042 Lipid catabolic process Increases phenotype PMID:27163631; PMID:28373059; PMID:30267645; PMID:30497708; PMID:30497708; PMID:32006337; PMID:30758894; PMID:31226429; PMID:32006337; PMID:32096903; PMID:32096903; PMID:33908150; PMID:32120800; PMID:32955216; PMID:33586219; PMID:33586219; PMID:34678318; PMID:33908150; PMID:33930485; PMID:34425170; PMID:34678318
GO:0016049 Cell growth Affects phenotype PMID:28887667; PMID:29665406; PMID:30236991
GO:0016209 Antioxidant activity Decreases phenotype PMID:26519479
GO:0016887 Atp hydrolysis activity Decreases phenotype PMID:32006337; PMID:34425170
GO:0018158 Protein oxidation Increases phenotype PMID:30990955; PMID:31400774
GO:0019226 Transmission of nerve impulse Decreases phenotype PMID:38599286
GO:0019369 Arachidonic acid metabolic process Affects phenotype PMID:33900070
GO:0019627 Urea metabolic process Affects phenotype PMID:27268782; PMID:32745781; PMID:33908150; PMID:33908150; PMID:38849050; PMID:38849050; PMID:39419344
GO:0019915 Lipid storage Increases phenotype PMID:28291828
GO:0022402 Cell cycle process Increases phenotype PMID:26514924
GO:0030262 Apoptotic nuclear changes Increases phenotype PMID:31136966
GO:0030263 Apoptotic chromosome condensation Affects phenotype PMID:31981688; PMID:33586219
GO:0030317 Flagellated sperm motility Decreases phenotype PMID:34678318
GO:0030335 Positive regulation of cell migration Increases phenotype PMID:32800223; PMID:32956863
GO:0030899 Calcium-dependent atpase activity Decreases phenotype PMID:29736246; PMID:35439518
GO:0031324 Negative regulation of cellular metabolic process Increases phenotype PMID:30765052; PMID:36058312
GO:0031987 Locomotion involved in locomotory behavior Increases phenotype PMID:29803855; PMID:29859868; PMID:30267645; PMID:31618664; PMID:32736067
GO:0032024 Positive regulation of insulin secretion Increases phenotype PMID:32685429
GO:0032148 Activation of protein kinase b activity Decreases phenotype PMID:36058312
GO:0032811 Negative regulation of epinephrine secretion Increases phenotype PMID:31400786
GO:0034263 Positive regulation of autophagy in response to er overload Increases phenotype PMID:34289071
GO:0034275 Kynurenic acid metabolic process Affects phenotype PMID:34259569
GO:0034377 Plasma lipoprotein particle assembly Increases phenotype PMID:31400774; PMID:32179266
GO:0034440 Lipid oxidation Increases phenotype PMID:23172834; PMID:23172834; PMID:31823260; PMID:25233897; PMID:26257840; PMID:27268782; PMID:27941166; PMID:29667781; PMID:31823260; PMID:39419344
GO:0035176 Social behavior Increases phenotype PMID:30823929; PMID:36113784; PMID:36796608; PMID:31472362; PMID:32179266; PMID:32736067; PMID:32976529
GO:0035640 Exploration behavior Affects phenotype PMID:29859868; PMID:31472362
GO:0035702 Monocyte homeostasis Affects phenotype PMID:31226429; PMID:33524429
GO:0035882 Defecation rhythm Affects phenotype PMID:30267645
GO:0035937 Estrogen secretion Affects phenotype PMID:35457321
GO:0036126 Sperm flagellum Affects phenotype PMID:34678318
GO:0036145 Dendritic cell homeostasis Affects phenotype PMID:33900070
GO:0036343 Psychomotor behavior Decreases phenotype PMID:26297601
GO:0036483 Neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Increases phenotype PMID:34289071
GO:0040011 Locomotion Decreases phenotype PMID:32387648
GO:0040018 Positive regulation of multicellular organism growth Decreases phenotype PMID:25643018
GO:0042053 Regulation of dopamine metabolic process Decreases phenotype PMID:26297601
GO:0042100 B cell proliferation Increases phenotype PMID:32120800
GO:0042403 Thyroid hormone metabolic process Affects phenotype PMID:34571837
GO:0042417 Dopamine metabolic process Affects phenotype PMID:29859868; PMID:32006337
GO:0042421 Norepinephrine biosynthetic process Increases phenotype PMID:21453761; PMID:26419632
GO:0042428 Serotonin metabolic process Affects phenotype PMID:32006337
GO:0042448 Progesterone metabolic process Affects phenotype PMID:32440878
GO:0042541 Hemoglobin biosynthetic process Decreases phenotype PMID:27905518
GO:0042554 Superoxide anion generation Increases phenotype PMID:29859868; PMID:30981936; PMID:33839396
GO:0042593 Glucose homeostasis Decreases phenotype PMID:29097212; PMID:31400774; PMID:32685429
GO:0042632 Cholesterol homeostasis Decreases phenotype PMID:31400774; PMID:32685429
GO:0042743 Hydrogen peroxide metabolic process Affects phenotype PMID:27268782; PMID:33930485
GO:0043029 T cell homeostasis Affects phenotype PMID:31807802; PMID:33524429
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:23416140; PMID:26070385; PMID:26070385; PMID:36058312; PMID:29893964; PMID:31823260; PMID:32800223
GO:0043249 Erythrocyte maturation Decreases phenotype PMID:27905518
GO:0043525 Positive regulation of neuron apoptotic process Increases phenotype PMID:34289071; PMID:35439518
GO:0044237 Cellular metabolic process Increases phenotype PMID:29859868; PMID:30378422; PMID:30758894; PMID:30835941; PMID:31152760; PMID:32017950; PMID:32120800; PMID:32798940; PMID:33839396; PMID:33930485; PMID:34259569; PMID:34352351; PMID:34678318; PMID:35457321; PMID:36252918
GO:0044403 Biological process involved in symbiotic interaction Affects phenotype PMID:31622728
GO:0045217 Cell-cell junction maintenance Decreases phenotype PMID:36167171
GO:0045333 Cellular respiration Decreases phenotype PMID:29859868; PMID:34528356
GO:0045428 Regulation of nitric oxide biosynthetic process Affects phenotype PMID:32526215
GO:0045429 Positive regulation of nitric oxide biosynthetic process Increases phenotype PMID:31823260
GO:0045444 Fat cell differentiation Increases phenotype PMID:28291828; PMID:32017950
GO:0045454 Cell redox homeostasis Decreases phenotype PMID:31823260; PMID:35439518
GO:0045687 Positive regulation of glial cell differentiation Decreases phenotype PMID:27816694
GO:0045727 Positive regulation of translation Increases phenotype PMID:35137321
GO:0045766 Positive regulation of angiogenesis Increases phenotype PMID:32526215
GO:0045776 Negative regulation of blood pressure Increases phenotype PMID:29471072
GO:0045777 Positive regulation of blood pressure Increases phenotype PMID:29471072
GO:0045919 Positive regulation of cytolysis Increases phenotype PMID:27941166; PMID:31400774
GO:0045930 Negative regulation of mitotic cell cycle Affects phenotype PMID:21987380; PMID:26198043; PMID:29893964
GO:0046034 Atp metabolic process Affects phenotype PMID:29859868; PMID:32949729; PMID:35448458; PMID:35457321
GO:0046209 Nitric oxide metabolic process Affects phenotype PMID:27268782; PMID:27268782; PMID:38849050; PMID:32006337; PMID:34425170; PMID:34425170; PMID:39419344; PMID:34678318; PMID:38042398; PMID:38849050
GO:0046330 Positive regulation of jnk cascade Affects phenotype PMID:23416140
GO:0046415 Urate metabolic process Decreases phenotype PMID:32715474
GO:0046449 Creatinine metabolic process Decreases phenotype PMID:27268782; PMID:32715474; PMID:33908150; PMID:33908150; PMID:38849050; PMID:39419344; PMID:38849050; PMID:39419344
GO:0046459 Short-chain fatty acid metabolic process Affects phenotype PMID:27760213; PMID:31622728
GO:0046466 Membrane lipid catabolic process Increases phenotype PMID:26519479; PMID:35439518; PMID:36152060
GO:0046498 S-adenosylhomocysteine metabolic process Affects phenotype PMID:34259569
GO:0046500 S-adenosylmethionine metabolic process Affects phenotype PMID:34259569
GO:0046541 Saliva secretion Increases phenotype PMID:31981688
GO:0046621 Negative regulation of organ growth Increases phenotype PMID:31823260
GO:0046655 Folic acid metabolic process Affects phenotype PMID:34259569
GO:0046683 Response to organophosphorus Affects phenotype PMID:31981688
GO:0048149 Behavioral response to ethanol Affects phenotype PMID:24849677
GO:0048266 Behavioral response to pain Increases phenotype PMID:26409647
GO:0048621 Post-embryonic digestive tract morphogenesis Affects phenotype PMID:25643018
GO:0048666 Neuron development Increases phenotype PMID:33011216
GO:0048675 Axon extension Decreases phenotype PMID:18076960
GO:0048874 Host-mediated regulation of intestinal microbiota composition Increases phenotype PMID:31400786
GO:0050665 Hydrogen peroxide biosynthetic process Increases phenotype PMID:27163631; PMID:28373059; PMID:30267645
GO:0050769 Positive regulation of neurogenesis Increases phenotype PMID:28112198
GO:0050808 Synapse organization Decreases phenotype PMID:33011216
GO:0050872 White fat cell differentiation Increases phenotype PMID:32745781
GO:0050890 Cognition Decreases phenotype PMID:27773359; PMID:33540251
GO:0050995 Negative regulation of lipid catabolic process Increases phenotype PMID:38522820
GO:0051092 Positive regulation of nf-kappab transcription factor activity Increases phenotype PMID:30978295
GO:0051301 Cell division Decreases phenotype PMID:34425170
GO:0051318 G1 phase Affects phenotype PMID:30378422
GO:0051319 G2 phase Decreases phenotype PMID:30378422
GO:0051320 S phase Affects phenotype PMID:30378422
GO:0051345 Positive regulation of hydrolase activity Increases phenotype PMID:36058312
GO:0051346 Negative regulation of hydrolase activity Affects phenotype PMID:29097212
GO:0051560 Mitochondrial calcium ion homeostasis Increases phenotype PMID:26435000
GO:0051602 Response to electrical stimulus Affects phenotype PMID:26409647
GO:0051726 Regulation of cell cycle Affects phenotype PMID:30378422
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:26435000; PMID:29859868; PMID:30981936; PMID:32798940
GO:0051882 Mitochondrial depolarization Increases phenotype PMID:29859868
GO:0052689 Carboxylic ester hydrolase activity Increases phenotype PMID:29097212; PMID:29935250; PMID:33900070; PMID:35151815
GO:0055074 Calcium ion homeostasis Affects phenotype PMID:30056177; PMID:34425170
GO:0060004 Reflex Affects phenotype PMID:32976529
GO:0060011 Sertoli cell proliferation Decreases phenotype PMID:38522820
GO:0060018 Astrocyte fate commitment Increases phenotype PMID:31136966
GO:0060073 Micturition Increases phenotype PMID:29471072
GO:0060179 Male mating behavior Affects phenotype PMID:34060014
GO:0060603 Mammary gland duct morphogenesis Increases phenotype PMID:26518068
GO:0060749 Mammary gland alveolus development Increases phenotype PMID:26518068
GO:0061370 Testosterone biosynthetic process Affects phenotype PMID:34060014; PMID:34060014; PMID:34678318; PMID:34678318
GO:0061744 Motor behavior Affects phenotype PMID:30267645
GO:0061827 Sperm head Affects phenotype PMID:34678318
GO:0070050 Neuron cellular homeostasis Affects phenotype PMID:30497708
GO:0070075 Tear secretion Increases phenotype PMID:29471072
GO:0070265 Necrotic cell death Affects phenotype PMID:27737797; PMID:28549829; PMID:39419344; PMID:39832751
GO:0070269 Pyroptosis Increases phenotype PMID:26435000
GO:0070328 Triglyceride homeostasis Decreases phenotype PMID:29097212; PMID:31400774
GO:0070374 Positive regulation of erk1 and erk2 cascade Affects phenotype PMID:23416140
GO:0070994 Detection of oxidative stress Increases phenotype PMID:24793810; PMID:26435000; PMID:28433638; PMID:33839396; PMID:34060014; PMID:35448458; PMID:36341877; PMID:36811218; PMID:38849050
GO:0071425 Hematopoietic stem cell proliferation Decreases phenotype PMID:21987380
GO:0071493 Cellular response to uv-b Affects phenotype PMID:30765052
GO:0071897 Dna biosynthetic process Increases phenotype PMID:30981936
GO:0072019 Proximal convoluted tubule development Decreases phenotype PMID:32715474
GO:0072215 Regulation of metanephros development Decreases phenotype PMID:32715474
GO:0072309 Mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis Decreases phenotype PMID:32715474
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:23850137; PMID:29859868; PMID:30378422; PMID:32120800; PMID:32798940; PMID:35448458; PMID:35457321; PMID:36252918; PMID:36811218
GO:0090200 Positive regulation of release of cytochrome c from mitochondria Increases phenotype PMID:23416140
GO:0090326 Positive regulation of locomotion involved in locomotory behavior Increases phenotype PMID:28975519
GO:0090398 Cellular senescence Increases phenotype PMID:34830855
GO:0090400 Stress-induced premature senescence Increases phenotype PMID:21987380
GO:0097153 Cysteine-type endopeptidase activity involved in apoptotic process Increases phenotype PMID:36252918
GO:0097225 Sperm midpiece Affects phenotype PMID:34678318
GO:0097511 Dendritic cell dendrite Decreases phenotype PMID:23994500
GO:0097722 Sperm motility Decreases phenotype PMID:32798940; PMID:33586219; PMID:34060014
GO:0098508 Endothelial to hematopoietic transition Increases phenotype PMID:31404653
GO:0098598 Learned vocalization behavior or vocal learning Decreases phenotype PMID:33540251
GO:0098874 Spike train Increases phenotype PMID:26409647
GO:0106435 Carboxylesterase activity Decreases phenotype PMID:35225412
GO:0120193 Tight junction organization Affects phenotype PMID:37263558
GO:0140042 Lipid droplet formation Increases phenotype PMID:32017950
GO:0140058 Neuron projection arborization Decreases phenotype PMID:33011216
GO:0160024 Leydig cell proliferation Decreases phenotype PMID:38522820
GO:1900182 Positive regulation of protein localization to nucleus Increases phenotype PMID:32956863
GO:1900745 Positive regulation of p38mapk cascade Affects phenotype PMID:23416140
GO:1901386 Negative regulation of voltage-gated calcium channel activity Increases phenotype PMID:24913802; PMID:26187449
GO:1901526 Positive regulation of mitophagy Increases phenotype PMID:26070385
GO:1901568 Fatty acid derivative metabolic process Affects phenotype PMID:29097212
GO:1901569 Fatty acid derivative catabolic process Decreases phenotype PMID:26215119
GO:1901610 Positive regulation of vesicle transport along microtubule Decreases phenotype PMID:28600141
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:27268782; PMID:27268782; PMID:29667781; PMID:29667781; PMID:31823260
GO:1901671 Positive regulation of superoxide dismutase activity Increases phenotype PMID:23172834; PMID:26257840; PMID:31400774
GO:1902177 Positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Affects phenotype PMID:23416140
GO:1902259 Regulation of delayed rectifier potassium channel activity Affects phenotype PMID:26409647
GO:1902632 Positive regulation of membrane hyperpolarization Increases phenotype PMID:26409647
GO:1903047 Mitotic cell cycle process Affects phenotype PMID:33839396
GO:1903077 Negative regulation of protein localization to plasma membrane Increases phenotype PMID:32956863
GO:1903184 L-dopa metabolic process Affects phenotype PMID:29859868
GO:1903283 Negative regulation of glutathione peroxidase activity Increases phenotype PMID:29667781; PMID:31823260
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:24979751; PMID:26435000; PMID:28887667; PMID:30758894; PMID:30835941; PMID:30981936; PMID:31152760
GO:1903427 Negative regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:35395341
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:26070385; PMID:29359425; PMID:36058312; PMID:26257840; PMID:29359425; PMID:29893964; PMID:29893964; PMID:33078895; PMID:32800223; PMID:35439518
GO:1904457 Positive regulation of neuronal action potential Increases phenotype PMID:26409647
GO:1905051 Regulation of base-excision repair Affects phenotype PMID:29359425
GO:1905555 Positive regulation of blood vessel branching Increases phenotype PMID:32526215
GO:1905605 Positive regulation of blood-brain barrier permeability Increases phenotype PMID:36167171; PMID:37263558
GO:1905956 Positive regulation of endothelial tube morphogenesis Increases phenotype PMID:32526215
GO:1990138 Neuron projection extension Decreases phenotype PMID:29859868
GO:1990266 Neutrophil migration Increases phenotype PMID:33524429
GO:1990739 Granulosa cell proliferation Decreases phenotype PMID:36769379
GO:1990962 Xenobiotic transport across blood-brain barrier Increases phenotype PMID:36167171
GO:2000251 Positive regulation of actin cytoskeleton reorganization Increases phenotype PMID:32956863
GO:2000294 Positive regulation of defecation Increases phenotype PMID:29471072
GO:2000377 Regulation of reactive oxygen species metabolic process Affects phenotype PMID:23416140
GO:2000844 Negative regulation of testosterone secretion Increases phenotype PMID:31400786; PMID:31823260
GO:2000845 Positive regulation of testosterone secretion Decreases phenotype PMID:23172834
GO:2000865 Negative regulation of estradiol secretion Increases phenotype PMID:26518068
GO:2000871 Negative regulation of progesterone secretion Increases phenotype PMID:26518068
GO:2001170 Negative regulation of atp biosynthetic process Increases phenotype PMID:28112198
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.