Cypermethrin


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000080 Mitotic g1 phase Affects phenotype PMID:29945211
GO:0000084 Mitotic s phase Decreases phenotype PMID:29945211; PMID:32214279
GO:0000085 Mitotic g2 phase Decreases phenotype PMID:32214279
GO:0000086 G2/m transition of mitotic cell cycle Increases phenotype PMID:29945211; PMID:32214279
GO:0001525 Angiogenesis Decreases phenotype PMID:24759048
GO:0001541 Ovarian follicle development Affects phenotype PMID:35031408
GO:0001659 Temperature homeostasis Affects phenotype PMID:30009846
GO:0001818 Negative regulation of cytokine production Increases phenotype PMID:29040392
GO:0001819 Positive regulation of cytokine production Increases phenotype PMID:29040392
GO:0001893 Maternal placenta development Decreases phenotype PMID:38582279
GO:0001894 Tissue homeostasis Decreases phenotype PMID:22147539
GO:0001964 Startle response Decreases phenotype PMID:29020013
GO:0004017 Adenylate kinase activity Affects phenotype PMID:32028016
GO:0004035 Alkaline phosphatase activity Increases phenotype PMID:33396045; PMID:35678313
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Increases phenotype PMID:33396045; PMID:35678313
GO:0004096 Catalase activity Affects phenotype PMID:33396045
GO:0004197 Cysteine-type endopeptidase activity Decreases phenotype PMID:38040083
GO:0004303 Estradiol 17-beta-dehydrogenase activity Decreases phenotype PMID:34896426
GO:0004364 Glutathione transferase activity Increases phenotype PMID:25816392; PMID:25926273; PMID:33396045
GO:0004457 Lactate dehydrogenase activity Increases phenotype PMID:23900960; PMID:35678313
GO:0004602 Glutathione peroxidase activity Increases phenotype PMID:25926273; PMID:33396045; PMID:35678313; PMID:35678313
GO:0004784 Superoxide dismutase activity Increases phenotype PMID:23900960; PMID:25816392; PMID:25926273; PMID:35678313
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:33396045; PMID:33396045; PMID:35678313; PMID:35678313
GO:0006701 Progesterone biosynthetic process Decreases phenotype PMID:29253587
GO:0006703 Estrogen biosynthetic process Increases phenotype PMID:29253587
GO:0006749 Glutathione metabolic process Increases phenotype PMID:28584332; PMID:35876585
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:23900960; PMID:25926273
GO:0006809 Nitric oxide biosynthetic process Increases phenotype PMID:23900960; PMID:25926273; PMID:27704156
GO:0006874 Cellular calcium ion homeostasis Decreases phenotype PMID:26187449; PMID:29149324
GO:0006915 Apoptotic process Increases phenotype PMID:24810582; PMID:31907151; PMID:32214279; PMID:34714723; PMID:35031408
GO:0007005 Mitochondrion organization Affects phenotype PMID:34794910
GO:0007009 Plasma membrane organization Decreases phenotype PMID:32028016
GO:0007204 Positive regulation of cytosolic calcium ion concentration Increases phenotype PMID:28731686
GO:0007254 Jnk cascade Affects phenotype PMID:29471534
GO:0007283 Spermatogenesis Decreases phenotype PMID:22147539; PMID:34794910; PMID:34896426
GO:0007340 Acrosome reaction Decreases phenotype PMID:33396045; PMID:34896426
GO:0007566 Embryo implantation Decreases phenotype PMID:29253587; PMID:36116546; PMID:37011868; PMID:37011868
GO:0008137 Nadh dehydrogenase (ubiquinone) activity Decreases phenotype PMID:25370934
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:35678313
GO:0008210 Estrogen metabolic process Affects phenotype PMID:35031408; PMID:35031408; PMID:36116546; PMID:36116546
GO:0008219 Cell death Increases phenotype PMID:27704156
GO:0008283 Cell population proliferation Increases phenotype PMID:25370934; PMID:25684042; PMID:27704156; PMID:35031408; PMID:36116546; PMID:37011868
GO:0008284 Positive regulation of cell population proliferation Increases phenotype PMID:26877835; PMID:28431163; PMID:28531659
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:29040392; PMID:30974244; PMID:31549662; PMID:36063984
GO:0008306 Associative learning Decreases phenotype PMID:32920670
GO:0008343 Adult feeding behavior Affects phenotype PMID:32006337
GO:0008360 Regulation of cell shape Decreases phenotype PMID:36063984
GO:0010424 Dna methylation on cytosine within a cg sequence Increases phenotype PMID:35605701
GO:0010917 Negative regulation of mitochondrial membrane potential Increases phenotype PMID:35102696; PMID:38040083; PMID:38582279
GO:0010940 Positive regulation of necrotic cell death Increases phenotype PMID:22147539
GO:0010972 Negative regulation of g2/m transition of mitotic cell cycle Increases phenotype PMID:32920670
GO:0010996 Response to auditory stimulus Decreases phenotype PMID:29020013
GO:0014043 Negative regulation of neuron maturation Increases phenotype PMID:32920670
GO:0014054 Positive regulation of gamma-aminobutyric acid secretion Increases phenotype PMID:28975519
GO:0016042 Lipid catabolic process Increases phenotype PMID:23900960; PMID:25370934; PMID:25926273; PMID:27704156; PMID:32006337; PMID:33396045; PMID:33396045; PMID:35678313; PMID:35678313
GO:0016887 Atp hydrolysis activity Decreases phenotype PMID:32006337
GO:0019226 Transmission of nerve impulse Decreases phenotype PMID:38599286
GO:0019432 Triglyceride biosynthetic process Increases phenotype PMID:30738135
GO:0030225 Macrophage differentiation Affects phenotype PMID:29471534
GO:0030283 Testosterone dehydrogenase [nad(p)] activity Decreases phenotype PMID:33396045
GO:0030335 Positive regulation of cell migration Increases phenotype PMID:29471534
GO:0030336 Negative regulation of cell migration Increases phenotype PMID:38582279
GO:0030534 Adult behavior Affects phenotype PMID:29020013; PMID:30009846; PMID:32006337
GO:0031393 Negative regulation of prostaglandin biosynthetic process Increases phenotype PMID:26359731
GO:0031959 Mineralocorticoid receptor signaling pathway Increases phenotype PMID:29149346
GO:0032274 Gonadotropin secretion Affects phenotype PMID:35931855
GO:0033148 Positive regulation of intracellular estrogen receptor signaling pathway Increases phenotype PMID:25449125; PMID:26877835
GO:0033327 Leydig cell differentiation Decreases phenotype PMID:35102696
GO:0033686 Positive regulation of luteinizing hormone secretion Increases phenotype PMID:29149324
GO:0034440 Lipid oxidation Increases phenotype PMID:31659573; PMID:35102696; PMID:35876585
GO:0035176 Social behavior Affects phenotype PMID:29020013
GO:0035937 Estrogen secretion Increases phenotype PMID:35931855
GO:0040015 Negative regulation of multicellular organism growth Increases phenotype PMID:29020013
GO:0040018 Positive regulation of multicellular organism growth Decreases phenotype PMID:28655647
GO:0042116 Macrophage activation Affects phenotype PMID:29471534
GO:0042417 Dopamine metabolic process Affects phenotype PMID:32006337
GO:0042428 Serotonin metabolic process Affects phenotype PMID:32006337
GO:0042448 Progesterone metabolic process Affects phenotype PMID:36116546
GO:0042632 Cholesterol homeostasis Decreases phenotype PMID:31659573
GO:0042711 Maternal behavior Decreases phenotype PMID:29020013
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:32920670; PMID:37871686; PMID:38582279
GO:0043068 Positive regulation of programmed cell death Increases phenotype PMID:32920670
GO:0043369 Cd4-positive or cd8-positive, alpha-beta t cell lineage commitment Decreases phenotype PMID:28584332
GO:0043619 Regulation of transcription from rna polymerase ii promoter in response to oxidative stress Affects phenotype PMID:29040392
GO:0044237 Cellular metabolic process Decreases phenotype PMID:29945211; PMID:31907151; PMID:32028016; PMID:32214279; PMID:32573024; PMID:34714723; PMID:34794910
GO:0045023 G0 to g1 transition Affects phenotype PMID:32214279
GO:0045665 Negative regulation of neuron differentiation Increases phenotype PMID:32920670
GO:0045746 Negative regulation of notch signaling pathway Increases phenotype PMID:38582279
GO:0045834 Positive regulation of lipid metabolic process Increases phenotype PMID:35512476
GO:0045930 Negative regulation of mitotic cell cycle Increases phenotype PMID:21987380; PMID:29945211; PMID:32214279; PMID:36063984
GO:0045992 Negative regulation of embryonic development Increases phenotype PMID:38582279
GO:0046209 Nitric oxide metabolic process Affects phenotype PMID:32006337; PMID:35678313
GO:0046621 Negative regulation of organ growth Increases phenotype PMID:22147539
GO:0046622 Positive regulation of organ growth Increases phenotype PMID:28731686
GO:0046661 Male sex differentiation Increases phenotype PMID:28731686
GO:0046697 Decidualization Increases phenotype PMID:36116546
GO:0046881 Positive regulation of follicle-stimulating hormone secretion Increases phenotype PMID:29149324
GO:0048060 Negative gravitaxis Affects phenotype PMID:29020013
GO:0048135 Female germ-line cyst formation Decreases phenotype PMID:35031408
GO:0048240 Sperm capacitation Decreases phenotype PMID:33396045; PMID:34896426
GO:0048599 Oocyte development Affects phenotype PMID:35031408
GO:0048711 Positive regulation of astrocyte differentiation Increases phenotype PMID:32920670
GO:0048771 Tissue remodeling Decreases phenotype PMID:37011868
GO:0050765 Negative regulation of phagocytosis Increases phenotype PMID:29040392
GO:0050996 Positive regulation of lipid catabolic process Increases phenotype PMID:37871686; PMID:37984602; PMID:38582279
GO:0055074 Calcium ion homeostasis Affects phenotype PMID:30056177; PMID:35931855
GO:0060013 Righting reflex Decreases phenotype PMID:29020013
GO:0060252 Positive regulation of glial cell proliferation Increases phenotype PMID:32920670
GO:0061045 Negative regulation of wound healing Increases phenotype PMID:38582279
GO:0061370 Testosterone biosynthetic process Increases phenotype PMID:28655647; PMID:28731686; PMID:34794910; PMID:34896426; PMID:35031408; PMID:36053783
GO:0070328 Triglyceride homeostasis Increases phenotype PMID:31659573
GO:0070374 Positive regulation of erk1 and erk2 cascade Increases phenotype PMID:29149324
GO:0071425 Hematopoietic stem cell proliferation Decreases phenotype PMID:21987380
GO:0072520 Seminiferous tubule development Affects phenotype PMID:34794910
GO:0072593 Reactive oxygen species metabolic process Affects phenotype PMID:29945211; PMID:31907151; PMID:32028016; PMID:32214279
GO:0090327 Negative regulation of locomotion involved in locomotory behavior Increases phenotype PMID:28975519
GO:0090400 Stress-induced premature senescence Increases phenotype PMID:21987380
GO:0097150 Neuronal stem cell population maintenance Decreases phenotype PMID:32920670
GO:0097202 Activation of cysteine-type endopeptidase activity Increases phenotype PMID:32028016
GO:0102727 3beta-hydroxysteroid dehydrogenase activity Decreases phenotype PMID:33396045; PMID:34896426; PMID:36053783
GO:1901343 Negative regulation of vasculature development Increases phenotype PMID:37984602
GO:1901386 Negative regulation of voltage-gated calcium channel activity Increases phenotype PMID:24913802; PMID:26187449
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:28584332; PMID:31659573; PMID:35876585
GO:1902512 Positive regulation of apoptotic dna fragmentation Increases phenotype PMID:36063984
GO:1903283 Negative regulation of glutathione peroxidase activity Increases phenotype PMID:28584332; PMID:35876585
GO:1903284 Positive regulation of glutathione peroxidase activity Increases phenotype PMID:31659573
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:29040392; PMID:35102696; PMID:35512476; PMID:37871686; PMID:38582279
GO:1903514 Release of sequestered calcium ion into cytosol by endoplasmic reticulum Increases phenotype PMID:29149324
GO:1903611 Negative regulation of calcium-dependent atpase activity Increases phenotype PMID:29149324
GO:1903787 Negative regulation of glutathione biosynthetic process Increases phenotype PMID:37871686
GO:1904879 Positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel Increases phenotype PMID:29149324
GO:1990911 Response to psychosocial stress Decreases phenotype PMID:29020013
GO:2000178 Negative regulation of neural precursor cell proliferation Increases phenotype PMID:32920670
GO:2000355 Negative regulation of ovarian follicle development Increases phenotype PMID:37984602
GO:2000409 Positive regulation of t cell extravasation Increases phenotype PMID:35512476
GO:2000421 Positive regulation of eosinophil extravasation Increases phenotype PMID:35512476
GO:2000774 Positive regulation of cellular senescence Increases phenotype PMID:36063984
GO:2000844 Negative regulation of testosterone secretion Increases phenotype PMID:22147539; PMID:35102696
GO:2000845 Positive regulation of testosterone secretion Increases phenotype PMID:28731686
GO:2001022 Positive regulation of response to dna damage stimulus Increases phenotype PMID:36063984; PMID:37871686
GO:2001244 Positive regulation of intrinsic apoptotic signaling pathway Increases phenotype PMID:29040392
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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.