Dichlorodiphenyl dichloroethylene


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000045 Autophagosome assembly Increases phenotype PMID:32721735
GO:0001541 Ovarian follicle development Affects phenotype PMID:34383603
GO:0001547 Antral ovarian follicle growth Affects phenotype PMID:34383603
GO:0001552 Ovarian follicle atresia Affects phenotype PMID:34383603
GO:0002021 Response to dietary excess Decreases phenotype PMID:31022254
GO:0002377 Immunoglobulin production Affects phenotype PMID:15831097
GO:0002449 Lymphocyte mediated immunity Affects phenotype PMID:15831097
GO:0004177 Aminopeptidase activity Increases phenotype PMID:34225579
GO:0004364 Glutathione transferase activity Increases phenotype PMID:29554563
GO:0004457 Lactate dehydrogenase activity Increases phenotype PMID:29481894; PMID:32721735
GO:0004602 Glutathione peroxidase activity Decreases phenotype PMID:29481894
GO:0006119 Oxidative phosphorylation Increases phenotype PMID:34311058
GO:0006304 Dna modification Decreases phenotype PMID:28659405
GO:0006306 Dna methylation Affects phenotype PMID:20064773; PMID:23933504
GO:0006325 Chromatin organization Affects phenotype PMID:15687046
GO:0006749 Glutathione metabolic process Increases phenotype PMID:31022254
GO:0006783 Heme biosynthetic process Affects phenotype PMID:18941586
GO:0006915 Apoptotic process Increases phenotype PMID:15820723; PMID:24576310
GO:0006959 Humoral immune response Affects phenotype PMID:15831097
GO:0006979 Response to oxidative stress Increases phenotype PMID:15820723; PMID:25386960
GO:0007005 Mitochondrion organization Increases phenotype PMID:34311058
GO:0007033 Vacuole organization Increases phenotype PMID:29554563
GO:0007281 Germ cell development Affects phenotype PMID:34383603
GO:0007283 Spermatogenesis Affects phenotype PMID:15687046; PMID:34000504
GO:0007286 Spermatid development Decreases phenotype PMID:25410718; PMID:30153481
GO:0007565 Female pregnancy Decreases phenotype PMID:30153481
GO:0008152 Metabolic process Affects phenotype PMID:19165398
GO:0008206 Bile acid metabolic process Affects phenotype PMID:28392238
GO:0008219 Cell death Increases phenotype PMID:30075218
GO:0008234 Cysteine-type peptidase activity Decreases phenotype PMID:35563431
GO:0008283 Cell population proliferation Decreases phenotype PMID:17599374; PMID:23501609; PMID:23913582; PMID:24576310
GO:0008284 Positive regulation of cell population proliferation Affects phenotype PMID:25263748; PMID:28412309
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:28572628; PMID:29149346
GO:0008584 Male gonad development Affects phenotype PMID:34000504
GO:0008637 Apoptotic mitochondrial changes Increases phenotype PMID:25410718
GO:0010424 Dna methylation on cytosine within a cg sequence Affects phenotype PMID:38294233
GO:0010467 Gene expression Affects phenotype PMID:25386960
GO:0010822 Positive regulation of mitochondrion organization Decreases phenotype PMID:28397872
GO:0010884 Positive regulation of lipid storage Increases phenotype PMID:31022254
GO:0010890 Positive regulation of sequestering of triglyceride Increases phenotype PMID:26200599
GO:0010918 Positive regulation of mitochondrial membrane potential Affects phenotype PMID:28397872; PMID:34311058
GO:0010942 Positive regulation of cell death Increases phenotype PMID:26563996
GO:0015747 Urate transport Increases phenotype PMID:28572628
GO:0016042 Lipid catabolic process Increases phenotype PMID:29481894
GO:0016477 Cell migration Affects phenotype PMID:23913582; PMID:33571556
GO:0019217 Regulation of fatty acid metabolic process Affects phenotype PMID:28397872
GO:0019254 Carnitine metabolic process, coa-linked Increases phenotype PMID:31022254
GO:0019646 Aerobic electron transport chain Decreases phenotype PMID:28397872
GO:0019766 Iga receptor activity Decreases phenotype PMID:26649893
GO:0019770 Igg receptor activity Decreases phenotype PMID:26649893
GO:0022602 Ovulation cycle process Affects phenotype PMID:16299097
GO:0023056 Positive regulation of signaling Affects phenotype PMID:25386960
GO:0030264 Nuclear fragmentation involved in apoptotic nuclear change Increases phenotype PMID:26563996
GO:0030539 Male genitalia development Affects phenotype PMID:34000504
GO:0031959 Mineralocorticoid receptor signaling pathway Increases phenotype PMID:29149346
GO:0032000 Positive regulation of fatty acid beta-oxidation Increases phenotype PMID:31022254
GO:0032109 Positive regulation of response to nutrient levels Increases phenotype PMID:28572628
GO:0033148 Positive regulation of intracellular estrogen receptor signaling pathway Increases phenotype PMID:26022396
GO:0033993 Response to lipid Decreases phenotype PMID:28659405
GO:0034440 Lipid oxidation Increases phenotype PMID:30575243; PMID:30575243; PMID:31022254; PMID:31022254
GO:0035064 Methylated histone binding Affects phenotype PMID:34383603
GO:0035176 Social behavior Decreases phenotype PMID:32518293
GO:0036269 Swimming behavior Affects phenotype PMID:32518293
GO:0036343 Psychomotor behavior Affects phenotype PMID:17431495
GO:0040007 Growth Increases phenotype PMID:23963708
GO:0042403 Thyroid hormone metabolic process Affects phenotype PMID:19750101
GO:0042632 Cholesterol homeostasis Decreases phenotype PMID:31022254
GO:0042696 Menarche Affects phenotype PMID:16299097
GO:0042701 Progesterone secretion Affects phenotype PMID:34311058
GO:0042711 Maternal behavior Affects phenotype PMID:34383603
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:25410718
GO:0043433 Negative regulation of dna-binding transcription factor activity Increases phenotype PMID:26022396
GO:0043970 Histone h3-k9 acetylation Affects phenotype PMID:34383603
GO:0044028 Dna hypomethylation Increases phenotype PMID:26563996
GO:0044030 Regulation of dna methylation Affects phenotype PMID:31272017
GO:0044065 Regulation of respiratory system process Decreases phenotype PMID:31362153
GO:0044127 Regulation of development of symbiont in host Affects phenotype PMID:28392238
GO:0044237 Cellular metabolic process Increases phenotype PMID:34311058; PMID:35457000; PMID:36613676; PMID:36674557
GO:0044849 Estrous cycle Affects phenotype PMID:34383603
GO:0045019 Negative regulation of nitric oxide biosynthetic process Increases phenotype PMID:37236336
GO:0045600 Positive regulation of fat cell differentiation Increases phenotype PMID:26200599
GO:0046034 Atp metabolic process Affects phenotype PMID:34311058
GO:0046323 Glucose import Decreases phenotype PMID:34311058
GO:0046470 Phosphatidylcholine metabolic process Affects phenotype PMID:38048832
GO:0046622 Positive regulation of organ growth Increases phenotype PMID:32518293
GO:0046722 Lactic acid secretion Increases phenotype PMID:28572628
GO:0048135 Female germ-line cyst formation Affects phenotype PMID:34383603
GO:0048386 Positive regulation of retinoic acid receptor signaling pathway Increases phenotype PMID:26563996
GO:0048589 Developmental growth Increases phenotype PMID:25014249; PMID:25095280; PMID:25742056
GO:0050679 Positive regulation of epithelial cell proliferation Decreases phenotype PMID:28659405
GO:0050847 Progesterone receptor signaling pathway Decreases phenotype PMID:26022396
GO:0050890 Cognition Decreases phenotype PMID:16818570; PMID:26414943
GO:0051308 Male meiosis chromosome separation Affects phenotype PMID:26535963
GO:0055064 Chloride ion homeostasis Decreases phenotype PMID:28572628
GO:0055078 Sodium ion homeostasis Decreases phenotype PMID:28572628
GO:0060207 Diestrus Affects phenotype PMID:34383603
GO:0060208 Proestrus Affects phenotype PMID:34383603
GO:0060209 Estrus Affects phenotype PMID:34383603
GO:0060322 Head development Affects phenotype PMID:25014249
GO:0060326 Cell chemotaxis Increases phenotype PMID:33571556
GO:0061028 Establishment of endothelial barrier Decreases phenotype PMID:33571556
GO:0061078 Positive regulation of prostaglandin secretion involved in immune response Increases phenotype PMID:26748080
GO:0061179 Negative regulation of insulin secretion involved in cellular response to glucose stimulus Increases phenotype PMID:28867213
GO:0061370 Testosterone biosynthetic process Affects phenotype PMID:34000504
GO:0061458 Reproductive system development Affects phenotype PMID:34000504
GO:0061517 Macrophage proliferation Affects phenotype PMID:26748080
GO:0061519 Macrophage homeostasis Affects phenotype PMID:26748080
GO:0061628 H3k27me3 modified histone binding Affects phenotype PMID:34383603
GO:0070091 Glucagon secretion Affects phenotype PMID:36613676; PMID:36674557
GO:0070328 Triglyceride homeostasis Decreases phenotype PMID:31022254
GO:0070577 Lysine-acetylated histone binding Affects phenotype PMID:34383603
GO:0071514 Genomic imprinting Affects phenotype PMID:30153481
GO:0080182 Histone h3-k4 trimethylation Affects phenotype PMID:34383603; PMID:38294233
GO:0090326 Positive regulation of locomotion involved in locomotory behavior Increases phenotype PMID:32518293
GO:0097722 Sperm motility Decreases phenotype PMID:30153481
GO:0098532 Histone h3-k27 trimethylation Affects phenotype PMID:34383603
GO:0120041 Positive regulation of macrophage proliferation Increases phenotype PMID:31022254
GO:0140042 Lipid droplet formation Increases phenotype PMID:28397872; PMID:30575243; PMID:38092172; PMID:39778647
GO:1901671 Positive regulation of superoxide dismutase activity Affects phenotype PMID:25410718; PMID:31022254
GO:1902093 Positive regulation of flagellated sperm motility Decreases phenotype PMID:25410718
GO:1903284 Positive regulation of glutathione peroxidase activity Affects phenotype PMID:25263748; PMID:25410718; PMID:30575243; PMID:30575243; PMID:31022254
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:28273962
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:25263748; PMID:37236336
GO:1903788 Positive regulation of glutathione biosynthetic process Decreases phenotype PMID:25263748
GO:1904179 Positive regulation of adipose tissue development Increases phenotype PMID:31022254
GO:1905867 Epididymis development Affects phenotype PMID:34000504
GO:2000077 Negative regulation of type b pancreatic cell development Increases phenotype PMID:28867213
GO:2000439 Positive regulation of monocyte extravasation Increases phenotype PMID:26748080
GO:2000609 Regulation of thyroid hormone generation Affects phenotype PMID:25965908
GO:2000612 Regulation of thyroid-stimulating hormone secretion Affects phenotype PMID:19750101
GO:2001171 Positive regulation of atp biosynthetic process Decreases phenotype PMID:28397872
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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.