DEDUCT | Database of Endocrine Disrupting chemicals and their Toxicity profiles

Chlorophenothane

Curated chemical-phenotype interactions from CTD

GO ID	GO name	Interaction type	Reference
GO:0000723	Telomere maintenance	Affects phenotype	PMID:23774483
GO:0001503	Ossification	Increases phenotype	PMID:25014179
GO:0002024	Diet induced thermogenesis	Affects phenotype	PMID:25076055
GO:0004784	Superoxide dismutase activity	Decreases phenotype	PMID:24820114; PMID:24968063
GO:0005243	Gap junction channel activity	Decreases phenotype	PMID:26023933
GO:0006007	Glucose catabolic process	Decreases phenotype	PMID:29477483
GO:0006021	Inositol biosynthetic process	Increases phenotype	PMID:29477483
GO:0006094	Gluconeogenesis	Decreases phenotype	PMID:29477483
GO:0006096	Glycolytic process	Affects phenotype	PMID:31724279
GO:0006114	Glycerol biosynthetic process	Decreases phenotype	PMID:29477483
GO:0006304	Dna modification	Decreases phenotype	PMID:28659405
GO:0006306	Dna methylation	Decreases phenotype	PMID:20064773; PMID:28263910; PMID:30207508; PMID:31079544
GO:0006526	Arginine biosynthetic process	Decreases phenotype	PMID:29477483
GO:0006529	Asparagine biosynthetic process	Decreases phenotype	PMID:29477483
GO:0006532	Aspartate biosynthetic process	Increases phenotype	PMID:29477483
GO:0006545	Glycine biosynthetic process	Affects phenotype	PMID:29477483
GO:0006561	Proline biosynthetic process	Decreases phenotype	PMID:29477483
GO:0006592	Ornithine biosynthetic process	Decreases phenotype	PMID:29477483
GO:0006750	Glutathione biosynthetic process	Decreases phenotype	PMID:24820114; PMID:24968063
GO:0006915	Apoptotic process	Increases phenotype	PMID:15820723
GO:0006979	Response to oxidative stress	Increases phenotype	PMID:15820723
GO:0007160	Cell-matrix adhesion	Increases phenotype	PMID:24820114
GO:0007613	Memory	Decreases phenotype	PMID:16968864
GO:0008219	Cell death	Increases phenotype	PMID:29477483
GO:0008283	Cell population proliferation	Affects phenotype	PMID:20623010; PMID:24968063; PMID:25014179
GO:0008285	Negative regulation of cell population proliferation	Increases phenotype	PMID:29149346; PMID:32949729
GO:0009085	Lysine biosynthetic process	Decreases phenotype	PMID:29477483
GO:0009086	Methionine biosynthetic process	Decreases phenotype	PMID:29477483
GO:0009097	Isoleucine biosynthetic process	Decreases phenotype	PMID:29477483
GO:0009098	Leucine biosynthetic process	Decreases phenotype	PMID:29477483
GO:0009099	Valine biosynthetic process	Decreases phenotype	PMID:29477483
GO:0010424	Dna methylation on cytosine within a cg sequence	Affects phenotype	PMID:38294233
GO:0019344	Cysteine biosynthetic process	Affects phenotype	PMID:29477483
GO:0019393	Glucarate biosynthetic process	Increases phenotype	PMID:29477483
GO:0022602	Ovulation cycle process	Affects phenotype	PMID:16299097
GO:0031324	Negative regulation of cellular metabolic process	Increases phenotype	PMID:35413382
GO:0031959	Mineralocorticoid receptor signaling pathway	Increases phenotype	PMID:29149346
GO:0032715	Negative regulation of interleukin-6 production	Increases phenotype	PMID:31542660
GO:0032755	Positive regulation of interleukin-6 production	Increases phenotype	PMID:31542660
GO:0032776	Dna methylation on cytosine	Affects phenotype	PMID:31682807
GO:0032868	Response to insulin	Affects phenotype	PMID:25076055
GO:0033148	Positive regulation of intracellular estrogen receptor signaling pathway	Increases phenotype	PMID:26022396; PMID:26139245
GO:0033610	Oxalate biosynthetic process	Decreases phenotype	PMID:29477483
GO:0033993	Response to lipid	Decreases phenotype	PMID:28659405
GO:0034587	Pirna processing	Increases phenotype	PMID:30207508
GO:0035938	Estradiol secretion	Increases phenotype	PMID:30817981
GO:0040015	Negative regulation of multicellular organism growth	Increases phenotype	PMID:31682807
GO:0040029	Epigenetic regulation of gene expression	Affects phenotype	PMID:30207508
GO:0042427	Serotonin biosynthetic process	Decreases phenotype	PMID:28263910
GO:0042554	Superoxide anion generation	Affects phenotype	PMID:31923579
GO:0042593	Glucose homeostasis	Decreases phenotype	PMID:25076055
GO:0042696	Menarche	Affects phenotype	PMID:16299097
GO:0043433	Negative regulation of dna-binding transcription factor activity	Increases phenotype	PMID:26022396
GO:0043651	Linoleic acid metabolic process	Affects phenotype	PMID:29477483
GO:0045444	Fat cell differentiation	Increases phenotype	PMID:25014179
GO:0046034	Atp metabolic process	Affects phenotype	PMID:32949729
GO:0046323	Glucose import	Affects phenotype	PMID:31923579
GO:0046370	Fructose biosynthetic process	Affects phenotype	PMID:29477483
GO:0050679	Positive regulation of epithelial cell proliferation	Decreases phenotype	PMID:28659405
GO:0050847	Progesterone receptor signaling pathway	Decreases phenotype	PMID:26022396
GO:0050890	Cognition	Decreases phenotype	PMID:16818570; PMID:16968864; PMID:26414943; PMID:29648420
GO:0051091	Positive regulation of dna-binding transcription factor activity	Increases phenotype	PMID:26022396
GO:0051882	Mitochondrial depolarization	Increases phenotype	PMID:31404653
GO:0060612	Adipose tissue development	Increases phenotype	PMID:25076055; PMID:31746186
GO:0061744	Motor behavior	Affects phenotype	PMID:29648420
GO:0071514	Genomic imprinting	Affects phenotype	PMID:30005188
GO:0072593	Reactive oxygen species metabolic process	Increases phenotype	PMID:24820114; PMID:24968063; PMID:31724279; PMID:31923579
GO:0080182	Histone h3-k4 trimethylation	Affects phenotype	PMID:38294233
GO:0098609	Cell-cell adhesion	Decreases phenotype	PMID:24820114
GO:0098781	Ncrna transcription	Increases phenotype	PMID:30207508
GO:1900222	Negative regulation of amyloid-beta clearance	Increases phenotype	PMID:34045954
GO:1900223	Positive regulation of amyloid-beta clearance	Affects phenotype	PMID:34045954
GO:1900535	Palmitic acid biosynthetic process	Increases phenotype	PMID:29477483
GO:1901142	Insulin metabolic process	Affects phenotype	PMID:31746186
GO:1901538	Changes to dna methylation involved in embryo development	Affects phenotype	PMID:30005188
GO:1990349	Gap junction-mediated intercellular transport	Decreases phenotype	PMID:35413382
GO:2000610	Negative regulation of thyroid hormone generation	Increases phenotype	PMID:31284115
GO:2001057	Reactive nitrogen species metabolic process	Affects phenotype	PMID:31923579

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.