Ibuprofen


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000278 Mitotic cell cycle Decreases phenotype PMID:15099639
GO:0001516 Prostaglandin biosynthetic process Increases phenotype PMID:31048000
GO:0001776 Leukocyte homeostasis Decreases phenotype PMID:32289289
GO:0002027 Regulation of heart rate Increases phenotype PMID:11545620
GO:0002693 Positive regulation of cellular extravasation Increases phenotype PMID:32289289
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:36346500
GO:0006309 Apoptotic dna fragmentation Increases phenotype PMID:11583291
GO:0006693 Prostaglandin metabolic process Affects phenotype PMID:37453669
GO:0006699 Bile acid biosynthetic process Affects phenotype PMID:29222744
GO:0006749 Glutathione metabolic process Increases phenotype PMID:21360558; PMID:26921665
GO:0006874 Cellular calcium ion homeostasis Affects phenotype PMID:34748853
GO:0006915 Apoptotic process Affects phenotype PMID:11583291; PMID:12357301; PMID:15263833; PMID:15670648; PMID:18348186; PMID:19438858
GO:0007033 Vacuole organization Increases phenotype PMID:29222744
GO:0007049 Cell cycle Decreases phenotype PMID:11583291; PMID:12357301; PMID:15670648
GO:0007204 Positive regulation of cytosolic calcium ion concentration Increases phenotype PMID:24333387
GO:0007286 Spermatid development Decreases phenotype PMID:37844793
GO:0007613 Memory Affects phenotype PMID:36346500
GO:0008206 Bile acid metabolic process Affects phenotype PMID:38815664
GO:0008210 Estrogen metabolic process Affects phenotype PMID:37453669
GO:0008217 Regulation of blood pressure Affects phenotype PMID:18622250; PMID:9773140; PMID:8227469
GO:0008219 Cell death Increases phenotype PMID:15099639; PMID:16388830; PMID:29222744
GO:0008283 Cell population proliferation Decreases phenotype PMID:11583291; PMID:15746067; PMID:18348186; PMID:19908241; PMID:29665328
GO:0009636 Response to toxic substance Decreases phenotype PMID:21319177
GO:0010918 Positive regulation of mitochondrial membrane potential Decreases phenotype PMID:26921665
GO:0010942 Positive regulation of cell death Increases phenotype PMID:23799623
GO:0015721 Bile acid and bile salt transport Decreases phenotype PMID:38815664
GO:0032967 Positive regulation of collagen biosynthetic process Increases phenotype PMID:21360558
GO:0034101 Erythrocyte homeostasis Decreases phenotype PMID:32289289
GO:0034440 Lipid oxidation Increases phenotype PMID:21360558
GO:0035812 Renal sodium excretion Increases phenotype PMID:3136271
GO:0040018 Positive regulation of multicellular organism growth Increases phenotype PMID:37844793
GO:0042307 Positive regulation of protein import into nucleus Increases phenotype PMID:21360558
GO:0042311 Vasodilation Increases phenotype PMID:2113882
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:24333387; PMID:37844793
GO:0044237 Cellular metabolic process Decreases phenotype PMID:34748853
GO:0046466 Membrane lipid catabolic process Decreases phenotype PMID:2116696
GO:0046622 Positive regulation of organ growth Increases phenotype PMID:37844793
GO:0048143 Astrocyte activation Increases phenotype PMID:24333387
GO:0048266 Behavioral response to pain Increases phenotype PMID:32289289
GO:0060209 Estrus Affects phenotype PMID:37453669
GO:0060326 Cell chemotaxis Decreases phenotype PMID:6853143
GO:0072520 Seminiferous tubule development Affects phenotype PMID:37844793
GO:0072593 Reactive oxygen species metabolic process Affects phenotype PMID:34748853
GO:0072719 Cellular response to cisplatin Decreases phenotype PMID:33785417
GO:0090557 Establishment of endothelial intestinal barrier Increases phenotype PMID:34506768
GO:0098532 Histone h3-k27 trimethylation Increases phenotype PMID:29665328
GO:0098743 Cell aggregation Increases phenotype PMID:33785417
GO:1900227 Positive regulation of nlrp3 inflammasome complex assembly Increases phenotype PMID:36088791
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:24333387
GO:1904231 Positive regulation of succinate dehydrogenase activity Decreases phenotype PMID:24333387
GO:1905523 Positive regulation of macrophage migration Increases phenotype PMID:36088791
GO:2000242 Negative regulation of reproductive process Increases phenotype PMID:37844793
GO:2001170 Negative regulation of atp biosynthetic process Increases phenotype PMID:33147516
GO:2001171 Positive regulation of atp biosynthetic process Decreases phenotype PMID:26921665
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.