DEDUCT | Database of Endocrine Disrupting chemicals and their Toxicity profiles

Sodium fluoride

Curated chemical-phenotype interactions from CTD

GO ID	GO name	Interaction type	Reference
GO:0000045	Autophagosome assembly	Increases phenotype	PMID:31844926
GO:0000050	Urea cycle	Increases phenotype	PMID:30920066
GO:0000084	Mitotic s phase	Increases phenotype	PMID:30738887
GO:0000085	Mitotic g2 phase	Decreases phenotype	PMID:30738887
GO:0000104	Succinate dehydrogenase activity	Decreases phenotype	PMID:36947368
GO:0001516	Prostaglandin biosynthetic process	Increases phenotype	PMID:29777723; PMID:31175943
GO:0001649	Osteoblast differentiation	Increases phenotype	PMID:35218729
GO:0001774	Microglial cell activation	Increases phenotype	PMID:35172196
GO:0001836	Release of cytochrome c from mitochondria	Increases phenotype	PMID:36947368
GO:0002011	Morphogenesis of an epithelial sheet	Decreases phenotype	PMID:27548804
GO:0002027	Regulation of heart rate	Affects phenotype	PMID:37105417
GO:0002158	Osteoclast proliferation	Increases phenotype	PMID:25132241
GO:0002523	Leukocyte migration involved in inflammatory response	Increases phenotype	PMID:37105417
GO:0003096	Renal sodium ion transport	Decreases phenotype	PMID:27548804
GO:0003331	Positive regulation of extracellular matrix constituent secretion	Increases phenotype	PMID:29758312
GO:0004035	Alkaline phosphatase activity	Increases phenotype	PMID:25132241; PMID:30920066; PMID:35218729; PMID:39012504
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	Increases phenotype	PMID:30920066; PMID:33609566
GO:0004096	Catalase activity	Decreases phenotype	PMID:39613240
GO:0004364	Glutathione transferase activity	Decreases phenotype	PMID:28918527; PMID:30920066; PMID:31710167
GO:0004457	Lactate dehydrogenase activity	Affects phenotype	PMID:30920066; PMID:35714946
GO:0004602	Glutathione peroxidase activity	Decreases phenotype	PMID:27871895; PMID:28012895; PMID:30920066; PMID:34780879; PMID:35413380; PMID:35714946; PMID:39613240
GO:0004784	Superoxide dismutase activity	Affects phenotype	PMID:22870923; PMID:22870923; PMID:35413380; PMID:27840156; PMID:27871895; PMID:28012895; PMID:30920066; PMID:31710167; PMID:35413380; PMID:35714946; PMID:38823497; PMID:39613240
GO:0006119	Oxidative phosphorylation	Affects phenotype	PMID:36947368
GO:0006260	Dna replication	Decreases phenotype	PMID:35714946
GO:0006304	Dna modification	Increases phenotype	PMID:36947368
GO:0006412	Translation	Increases phenotype	PMID:7251582
GO:0006497	Protein lipidation	Increases phenotype	PMID:34536393
GO:0006601	Creatine biosynthetic process	Increases phenotype	PMID:30920066
GO:0006749	Glutathione metabolic process	Increases phenotype	PMID:28918527; PMID:29758312; PMID:32627286; PMID:35413380; PMID:38823497
GO:0006750	Glutathione biosynthetic process	Decreases phenotype	PMID:22870923; PMID:28012895; PMID:30920066; PMID:31710167
GO:0006809	Nitric oxide biosynthetic process	Increases phenotype	PMID:24072958; PMID:30920066
GO:0006811	Monoatomic ion transport	Decreases phenotype	PMID:27548804
GO:0006915	Apoptotic process	Increases phenotype	PMID:11331073; PMID:24231001; PMID:27871895; PMID:28012895; PMID:30130527; PMID:30633982; PMID:30738887; PMID:35172196; PMID:35714946; PMID:38823497
GO:0006935	Chemotaxis	Affects phenotype	PMID:23881332
GO:0006974	Cellular response to dna damage stimulus	Increases phenotype	PMID:30130527
GO:0007005	Mitochondrion organization	Increases phenotype	PMID:35172196; PMID:37105417; PMID:37739047
GO:0007009	Plasma membrane organization	Decreases phenotype	PMID:35714946
GO:0007033	Vacuole organization	Increases phenotype	PMID:37105417
GO:0007189	Adenylate cyclase-activating g protein-coupled receptor signaling pathway	Increases phenotype	PMID:16962941; PMID:18055527
GO:0007190	Activation of adenylate cyclase activity	Increases phenotype	PMID:1653373; PMID:18441196; PMID:2153673; PMID:2986305; PMID:6094742
GO:0007283	Spermatogenesis	Decreases phenotype	PMID:38823497
GO:0007342	Fusion of sperm to egg plasma membrane involved in single fertilization	Decreases phenotype	PMID:21089161
GO:0007613	Memory	Decreases phenotype	PMID:29187078; PMID:32627286; PMID:35172196; PMID:39613240; PMID:36228752; PMID:39613240
GO:0007625	Grooming behavior	Affects phenotype	PMID:27840156
GO:0008137	Nadh dehydrogenase (ubiquinone) activity	Decreases phenotype	PMID:34780879
GO:0008152	Metabolic process	Affects phenotype	PMID:34089294
GO:0008210	Estrogen metabolic process	Affects phenotype	PMID:24071475; PMID:38342390
GO:0008219	Cell death	Increases phenotype	PMID:28012895
GO:0008283	Cell population proliferation	Increases phenotype	PMID:21626649; PMID:24072958; PMID:24231001; PMID:24296261; PMID:24300170; PMID:28012895; PMID:29505816; PMID:31710167; PMID:34536393; PMID:35714946; PMID:39613240
GO:0008284	Positive regulation of cell population proliferation	Increases phenotype	PMID:30259626
GO:0008542	Visual learning	Affects phenotype	PMID:35172196
GO:0009410	Response to xenobiotic stimulus	Decreases phenotype	PMID:29323457
GO:0010506	Regulation of autophagy	Affects phenotype	PMID:37694959
GO:0010759	Positive regulation of macrophage chemotaxis	Increases phenotype	PMID:29758312
GO:0010917	Negative regulation of mitochondrial membrane potential	Increases phenotype	PMID:37694959
GO:0010942	Positive regulation of cell death	Increases phenotype	PMID:27664006
GO:0016042	Lipid catabolic process	Increases phenotype	PMID:22870923; PMID:24384758; PMID:27840156; PMID:27871895; PMID:28012895; PMID:30920066; PMID:31710167; PMID:31710167; PMID:35413380; PMID:32627286; PMID:35413380; PMID:35714946
GO:0016049	Cell growth	Affects phenotype	PMID:29127033
GO:0018158	Protein oxidation	Increases phenotype	PMID:28012895; PMID:29758312; PMID:31710167
GO:0019852	L-ascorbic acid metabolic process	Increases phenotype	PMID:29758312; PMID:31710167
GO:0021766	Hippocampus development	Decreases phenotype	PMID:36286330
GO:0030154	Cell differentiation	Increases phenotype	PMID:34942272
GO:0030199	Collagen fibril organization	Increases phenotype	PMID:37105417
GO:0030282	Bone mineralization	Affects phenotype	PMID:29447955
GO:0030317	Flagellated sperm motility	Decreases phenotype	PMID:21089161
GO:0030900	Forebrain development	Decreases phenotype	PMID:36286330
GO:0031987	Locomotion involved in locomotory behavior	Affects phenotype	PMID:27840156
GO:0032125	Micronucleus organization	Increases phenotype	PMID:28089781
GO:0032967	Positive regulation of collagen biosynthetic process	Increases phenotype	PMID:29447955
GO:0033690	Positive regulation of osteoblast proliferation	Increases phenotype	PMID:33982124
GO:0033864	Positive regulation of nad(p)h oxidase activity	Increases phenotype	PMID:21089161
GO:0034109	Homotypic cell-cell adhesion	Decreases phenotype	PMID:38043629
GO:0034440	Lipid oxidation	Increases phenotype	PMID:21089161; PMID:27750169; PMID:28918527; PMID:29743442; PMID:29758312; PMID:34089294; PMID:34089294; PMID:36947368; PMID:36947368; PMID:38823497; PMID:39613240
GO:0034504	Protein localization to nucleus	Increases phenotype	PMID:30633982
GO:0035004	Phosphatidylinositol 3-kinase activity	Decreases phenotype	PMID:35413380
GO:0035640	Exploration behavior	Affects phenotype	PMID:31710167
GO:0035641	Locomotory exploration behavior	Decreases phenotype	PMID:33609566; PMID:39613240
GO:0035847	Uterine epithelium development	Decreases phenotype	PMID:29323457
GO:0035932	Aldosterone secretion	Affects phenotype	PMID:37105417
GO:0035938	Estradiol secretion	Decreases phenotype	PMID:38342390
GO:0036343	Psychomotor behavior	Decreases phenotype	PMID:32627286
GO:0040015	Negative regulation of multicellular organism growth	Increases phenotype	PMID:36286330
GO:0040018	Positive regulation of multicellular organism growth	Decreases phenotype	PMID:27664006
GO:0042311	Vasodilation	Increases phenotype	PMID:7586449
GO:0042332	Gravitaxis	Affects phenotype	PMID:27840156; PMID:33609566
GO:0042448	Progesterone metabolic process	Affects phenotype	PMID:24071475
GO:0042554	Superoxide anion generation	Increases phenotype	PMID:24072958
GO:0043065	Positive regulation of apoptotic process	Increases phenotype	PMID:27862939; PMID:28962382; PMID:29758312; PMID:31927229; PMID:36736877; PMID:37694959
GO:0043114	Regulation of vascular permeability	Affects phenotype	PMID:37683593
GO:0043117	Positive regulation of vascular permeability	Increases phenotype	PMID:29758312
GO:0043525	Positive regulation of neuron apoptotic process	Increases phenotype	PMID:30273629
GO:0044237	Cellular metabolic process	Increases phenotype	PMID:34151709; PMID:34536393; PMID:34942272; PMID:35172196; PMID:35218729; PMID:35714946; PMID:36456742
GO:0044242	Cellular lipid catabolic process	Increases phenotype	PMID:27871895
GO:0044319	Wound healing, spreading of cells	Decreases phenotype	PMID:28012895
GO:0045023	G0 to g1 transition	Decreases phenotype	PMID:30738887
GO:0045202	Synapse	Decreases phenotype	PMID:34780879
GO:0045429	Positive regulation of nitric oxide biosynthetic process	Decreases phenotype	PMID:27750169
GO:0045453	Bone resorption	Increases phenotype	PMID:25132241; PMID:29127033
GO:0045454	Cell redox homeostasis	Decreases phenotype	PMID:28918527; PMID:29743442
GO:0045672	Positive regulation of osteoclast differentiation	Increases phenotype	PMID:32156525
GO:0045762	Positive regulation of adenylate cyclase activity	Increases phenotype	PMID:20074626
GO:0045780	Positive regulation of bone resorption	Increases phenotype	PMID:29447955
GO:0045834	Positive regulation of lipid metabolic process	Increases phenotype	PMID:36736877; PMID:37121536
GO:0045930	Negative regulation of mitotic cell cycle	Affects phenotype	PMID:30738887
GO:0046034	Atp metabolic process	Affects phenotype	PMID:34780879
GO:0046148	Pigment biosynthetic process	Affects phenotype	PMID:35172196
GO:0046209	Nitric oxide metabolic process	Affects phenotype	PMID:31710167
GO:0046449	Creatinine metabolic process	Increases phenotype	PMID:26779593; PMID:30920066
GO:0046456	Icosanoid biosynthetic process	Affects phenotype	PMID:31175943
GO:0046621	Negative regulation of organ growth	Increases phenotype	PMID:36286330
GO:0048060	Negative gravitaxis	Decreases phenotype	PMID:28099871
GO:0050665	Hydrogen peroxide biosynthetic process	Increases phenotype	PMID:27840156; PMID:31710167
GO:0050729	Positive regulation of inflammatory response	Increases phenotype	PMID:27750169
GO:0050890	Cognition	Decreases phenotype	PMID:34780879
GO:0050996	Positive regulation of lipid catabolic process	Increases phenotype	PMID:37245782
GO:0051208	Sequestering of calcium ion	Affects phenotype	PMID:21786382
GO:0051220	Cytoplasmic sequestering of protein	Decreases phenotype	PMID:30633982
GO:0051726	Regulation of cell cycle	Increases phenotype	PMID:27862939
GO:0051881	Regulation of mitochondrial membrane potential	Affects phenotype	PMID:28012895; PMID:34780879
GO:0051901	Positive regulation of mitochondrial depolarization	Increases phenotype	PMID:28962382
GO:0055072	Iron ion homeostasis	Decreases phenotype	PMID:29743442
GO:0055074	Calcium ion homeostasis	Affects phenotype	PMID:28012895
GO:0055075	Potassium ion homeostasis	Affects phenotype	PMID:37105417
GO:0060013	Righting reflex	Affects phenotype	PMID:33609566
GO:0060754	Positive regulation of mast cell chemotaxis	Increases phenotype	PMID:29758312
GO:0060996	Dendritic spine development	Decreases phenotype	PMID:30130557
GO:0061370	Testosterone biosynthetic process	Decreases phenotype	PMID:30633982; PMID:38823497
GO:0061518	Microglial cell proliferation	Increases phenotype	PMID:31710167
GO:0061744	Motor behavior	Affects phenotype	PMID:27840156
GO:0070174	Negative regulation of enamel mineralization	Increases phenotype	PMID:27257137
GO:0070374	Positive regulation of erk1 and erk2 cascade	Increases phenotype	PMID:30273629
GO:0070633	Transepithelial transport	Decreases phenotype	PMID:27548804; PMID:37683593
GO:0070994	Detection of oxidative stress	Increases phenotype	PMID:37739047
GO:0070995	Nadph oxidation	Increases phenotype	PMID:27750169
GO:0070997	Neuron death	Affects phenotype	PMID:34780879
GO:0071243	Cellular response to arsenic-containing substance	Decreases phenotype	PMID:27750169
GO:0072593	Reactive oxygen species metabolic process	Increases phenotype	PMID:21786382; PMID:26119525; PMID:32627286; PMID:34780879; PMID:35714946; PMID:39012504
GO:0072674	Multinuclear osteoclast differentiation	Increases phenotype	PMID:29127033; PMID:29447955
GO:0090263	Positive regulation of canonical wnt signaling pathway	Increases phenotype	PMID:33982124
GO:0140131	Positive regulation of lymphocyte chemotaxis	Increases phenotype	PMID:29758312
GO:0140657	Atp-dependent activity	Decreases phenotype	PMID:36947368
GO:0150104	Transport across blood-brain barrier	Affects phenotype	PMID:37683593
GO:0160020	Positive regulation of ferroptosis	Increases phenotype	PMID:37245782
GO:1900087	Positive regulation of g1/s transition of mitotic cell cycle	Increases phenotype	PMID:30259626
GO:1900272	Negative regulation of long-term synaptic potentiation	Increases phenotype	PMID:30273629
GO:1900745	Positive regulation of p38mapk cascade	Increases phenotype	PMID:30273629
GO:1901670	Negative regulation of superoxide dismutase activity	Increases phenotype	PMID:21089161; PMID:29743442; PMID:29758312; PMID:34089294
GO:1901987	Regulation of cell cycle phase transition	Affects phenotype	PMID:37694959
GO:1902512	Positive regulation of apoptotic dna fragmentation	Increases phenotype	PMID:28962382
GO:1903012	Positive regulation of bone development	Increases phenotype	PMID:29447955
GO:1903283	Negative regulation of glutathione peroxidase activity	Increases phenotype	PMID:29743442; PMID:29758312; PMID:34089294
GO:1903284	Positive regulation of glutathione peroxidase activity	Decreases phenotype	PMID:28918527
GO:1903409	Reactive oxygen species biosynthetic process	Increases phenotype	PMID:24072958; PMID:27871895; PMID:28012895; PMID:30130527; PMID:30738887
GO:1903424	Fluoride transmembrane transport	Increases phenotype	PMID:29758312
GO:1903428	Positive regulation of reactive oxygen species biosynthetic process	Increases phenotype	PMID:21089161; PMID:27750169; PMID:29758312; PMID:36063856; PMID:36736877; PMID:37245782; PMID:37694959
GO:1903926	Cellular response to bisphenol a	Increases phenotype	PMID:27257137
GO:1903980	Positive regulation of microglial cell activation	Increases phenotype	PMID:30273629
GO:1905037	Autophagosome organization	Increases phenotype	PMID:29505816; PMID:30225638
GO:1905690	Nucleus disassembly	Increases phenotype	PMID:28089781
GO:1905845	Positive regulation of cellular response to gamma radiation	Increases phenotype	PMID:28962382
GO:2000134	Negative regulation of g1/s transition of mitotic cell cycle	Increases phenotype	PMID:28962382
GO:2000354	Regulation of ovarian follicle development	Affects phenotype	PMID:29323457
GO:2000391	Positive regulation of neutrophil extravasation	Increases phenotype	PMID:29758312
GO:2000421	Positive regulation of eosinophil extravasation	Increases phenotype	PMID:29758312
GO:2000610	Negative regulation of thyroid hormone generation	Increases phenotype	PMID:29323457
GO:2000768	Positive regulation of nephron tubule epithelial cell differentiation	Decreases phenotype	PMID:27548804

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.