Dexamethasone


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000045 Autophagosome assembly Increases phenotype PMID:29902490; PMID:33359579
GO:0000080 Mitotic g1 phase Affects phenotype PMID:39986363
GO:0000084 Mitotic s phase Increases phenotype PMID:30248417; PMID:36065135; PMID:39986363
GO:0000086 G2/m transition of mitotic cell cycle Increases phenotype PMID:36065135; PMID:39986363
GO:0000122 Negative regulation of transcription by rna polymerase ii Increases phenotype PMID:25851902
GO:0000165 Mapk cascade Increases phenotype PMID:20002897; PMID:20363256
GO:0000278 Mitotic cell cycle Increases phenotype PMID:25559859
GO:0001503 Ossification Affects phenotype PMID:25062436; PMID:28298639; PMID:28758259; PMID:30878453; PMID:31472278; PMID:34020675; PMID:38081572
GO:0001544 Initiation of primordial ovarian follicle growth Decreases phenotype PMID:34537908
GO:0001552 Ovarian follicle atresia Increases phenotype PMID:34537908
GO:0001649 Osteoblast differentiation Affects phenotype PMID:23111315; PMID:28921615; PMID:28975700; PMID:30312686; PMID:30738844; PMID:34562440; PMID:39986363
GO:0001780 Neutrophil homeostasis Affects phenotype PMID:39067743
GO:0001890 Placenta development Affects phenotype PMID:25912570
GO:0002027 Regulation of heart rate Increases phenotype PMID:10780258; PMID:15769980; PMID:7947501
GO:0002076 Osteoblast development Increases phenotype PMID:27028516
GO:0002232 Leukocyte chemotaxis involved in inflammatory response Increases phenotype PMID:22446600; PMID:27452194
GO:0002296 T-helper 1 cell lineage commitment Decreases phenotype PMID:36350155
GO:0002297 T-helper 2 cell lineage commitment Increases phenotype PMID:36350155
GO:0002381 Immunoglobulin production involved in immunoglobulin-mediated immune response Increases phenotype PMID:31751647; PMID:36350155
GO:0002437 Inflammatory response to antigenic stimulus Increases phenotype PMID:25739523
GO:0002441 Histamine secretion involved in inflammatory response Increases phenotype PMID:36350155
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:25739523; PMID:25878373; PMID:26363199; PMID:31860763; PMID:33140555; PMID:27565714; PMID:28300665; PMID:28694203; PMID:28694203; PMID:29458014; PMID:30849337; PMID:32812458; PMID:34401976; PMID:34455893; PMID:34998855; PMID:35335934; PMID:35481609; PMID:37004399; PMID:38729284; PMID:39067743
GO:0002526 Acute inflammatory response Increases phenotype PMID:22099998
GO:0002539 Prostaglandin production involved in inflammatory response Decreases phenotype PMID:25314295
GO:0002674 Negative regulation of acute inflammatory response Increases phenotype PMID:22099998
GO:0002693 Positive regulation of cellular extravasation Increases phenotype PMID:25891457; PMID:31751647
GO:0002725 Negative regulation of t cell cytokine production Increases phenotype PMID:19997594
GO:0002922 Positive regulation of humoral immune response Increases phenotype PMID:23892921
GO:0002930 Trabecular meshwork development Increases phenotype PMID:28214551
GO:0003331 Positive regulation of extracellular matrix constituent secretion Increases phenotype PMID:26492236
GO:0003415 Chondrocyte hypertrophy Increases phenotype PMID:27608943
GO:0004035 Alkaline phosphatase activity Increases phenotype PMID:23108452; PMID:23111315; PMID:25062436; PMID:25448682; PMID:26089034; PMID:27387537; PMID:28921615; PMID:28975700; PMID:32473317; PMID:34020675; PMID:34562440; PMID:35866224; PMID:39986363; PMID:8745575
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Increases phenotype PMID:23108452; PMID:34998855; PMID:35866224
GO:0004111 Creatine kinase activity Increases phenotype PMID:26089034
GO:0004364 Glutathione transferase activity Increases phenotype PMID:19788401; PMID:28483492
GO:0004457 Lactate dehydrogenase activity Increases phenotype PMID:23108452; PMID:26089034; PMID:28300665; PMID:34998855
GO:0004602 Glutathione peroxidase activity Decreases phenotype PMID:21801858; PMID:30849337; PMID:32687258; PMID:35866224; PMID:38511873
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:26363199; PMID:31860763; PMID:37177863; PMID:38511873; PMID:38901789; PMID:30849337; PMID:30924981; PMID:32687258; PMID:32812458; PMID:35866224; PMID:37177863; PMID:37696682
GO:0004935 Adrenergic receptor activity Increases phenotype PMID:26419632
GO:0005980 Glycogen catabolic process Affects phenotype PMID:1566830; PMID:61140; PMID:6142694
GO:0006006 Glucose metabolic process Affects phenotype PMID:37337224
GO:0006029 Proteoglycan metabolic process Affects phenotype PMID:35148621
GO:0006071 Glycerol metabolic process Affects phenotype PMID:33476690
GO:0006094 Gluconeogenesis Increases phenotype PMID:22676303; PMID:3827816; PMID:3876337
GO:0006096 Glycolytic process Decreases phenotype PMID:26670611
GO:0006260 Dna replication Decreases phenotype PMID:39986363
GO:0006264 Mitochondrial dna replication Increases phenotype PMID:32417366
GO:0006308 Dna catabolic process Increases phenotype PMID:2429833; PMID:35866224
GO:0006309 Apoptotic dna fragmentation Increases phenotype PMID:10331302; PMID:11090465; PMID:11399061; PMID:11399061; PMID:9371682; PMID:11421811; PMID:12400870; PMID:15133238; PMID:15964614; PMID:9466323; PMID:1641906; PMID:17953376; PMID:19070971; PMID:19339209; PMID:21244764; PMID:7673702; PMID:7728769; PMID:7777588; PMID:7831194; PMID:7831194; PMID:8376790; PMID:8132215; PMID:8376790; PMID:9326359; PMID:9371682; PMID:9466323
GO:0006355 Regulation of dna-templated transcription Affects phenotype PMID:35483669
GO:0006412 Translation Decreases phenotype PMID:23493372; PMID:33567340
GO:0006497 Protein lipidation Increases phenotype PMID:33359579
GO:0006536 Glutamate metabolic process Affects phenotype PMID:32445661; PMID:32494933; PMID:34189720
GO:0006600 Creatine metabolic process Affects phenotype PMID:34998855
GO:0006606 Protein import into nucleus Affects phenotype PMID:31778773; PMID:34273429; PMID:34273429; PMID:34500009; PMID:34500009
GO:0006629 Lipid metabolic process Increases phenotype PMID:18586010; PMID:31596606
GO:0006635 Fatty acid beta-oxidation Increases phenotype PMID:26670611
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:30446312; PMID:34302803; PMID:35589016; PMID:36708982; PMID:36764644
GO:0006693 Prostaglandin metabolic process Affects phenotype PMID:31860763
GO:0006695 Cholesterol biosynthetic process Affects phenotype PMID:32234517
GO:0006699 Bile acid biosynthetic process Affects phenotype PMID:29222744
GO:0006749 Glutathione metabolic process Affects phenotype PMID:21801858; PMID:26089034; PMID:28363435; PMID:35866224; PMID:37177863; PMID:37696682
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:25448682; PMID:26360969; PMID:28088388
GO:0006805 Xenobiotic metabolic process Increases phenotype PMID:11091129; PMID:12695342; PMID:19903449
GO:0006809 Nitric oxide biosynthetic process Increases phenotype PMID:22185406; PMID:23373965; PMID:26271896
GO:0006874 Cellular calcium ion homeostasis Affects phenotype PMID:34189720; PMID:37337224
GO:0006914 Autophagy Increases phenotype PMID:19855186; PMID:33359579; PMID:36708982; PMID:38286393
GO:0006915 Apoptotic process Increases phenotype PMID:10200551; PMID:10331302; PMID:10453071; PMID:10453071; PMID:14996839; PMID:16445836; PMID:8554984; PMID:10572627; PMID:10919278; PMID:11012613; PMID:11012613; PMID:11776405; PMID:11040338; PMID:11044214; PMID:11090465; PMID:11114198; PMID:11311531; PMID:11311531; PMID:29111458; PMID:11319611; PMID:11331073; PMID:11397893; PMID:11399061; PMID:9070360; PMID:9147362; PMID:11399663; PMID:11421811; PMID:11677114; PMID:11692113; PMID:11751287; PMID:11751517; PMID:11756569; PMID:12094262; PMID:12234484; PMID:12238564; PMID:12400870; PMID:12513834; PMID:14996839; PMID:9016789; PMID:12589357; PMID:12730077; PMID:12746047; PMID:14632786; PMID:14633444; PMID:14982598; PMID:14996839; PMID:15133238; PMID:15330010; PMID:15343345; PMID:15353912; PMID:15388240; PMID:15491851; PMID:15574755; PMID:15574755; PMID:16505121; PMID:15576458; PMID:15705788; PMID:15799306; PMID:15829407; PMID:15964614; PMID:15987750; PMID:15990687; PMID:16151648; PMID:16164824; PMID:16330256; PMID:1641906; PMID:16445836; PMID:16462032; PMID:16462032; PMID:18476001; PMID:16505121; PMID:16616082; PMID:16944584; PMID:17070682; PMID:17180084; PMID:17690025; PMID:17953376; PMID:18437985; PMID:18515658; PMID:18611438; PMID:18830898; PMID:21597759; PMID:19005922; PMID:19080409; PMID:19339209; PMID:19891978; PMID:20067466; PMID:20578217; PMID:20578217; PMID:30878453; PMID:21244764; PMID:21277400; PMID:21277400; PMID:28940008; PMID:21442075; PMID:21569845; PMID:25612170; PMID:27608943; PMID:28940008; PMID:29928335; PMID:30526067; PMID:30628712; PMID:30878453; PMID:34189720; PMID:39986363; PMID:7517174; PMID:7524498; PMID:7540953; PMID:7549842; PMID:7579413; PMID:7673702; PMID:7728769; PMID:7777588; PMID:7831194; PMID:7831194; PMID:8376790; PMID:7945400; PMID:8048048; PMID:7969078; PMID:8048048; PMID:8132215; PMID:8338788; PMID:8376790; PMID:8630077; PMID:8660802; PMID:8825066; PMID:9016789; PMID:9029185; PMID:9042522; PMID:9147362; PMID:9326359; PMID:9371682; PMID:9374718; PMID:9408059; PMID:9528991; PMID:9531328; PMID:9790906
GO:0006919 Activation of cysteine-type endopeptidase activity involved in apoptotic process Increases phenotype PMID:11137978; PMID:25841707
GO:0006954 Inflammatory response Increases phenotype PMID:26089034; PMID:29458014; PMID:30924981; PMID:31669322
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:21986892; PMID:26739637
GO:0006979 Response to oxidative stress Increases phenotype PMID:12414515; PMID:16678324; PMID:19969022; PMID:19997867
GO:0007005 Mitochondrion organization Affects phenotype PMID:34323617; PMID:35866224
GO:0007033 Vacuole organization Increases phenotype PMID:29222744
GO:0007040 Lysosome organization Increases phenotype PMID:39393751
GO:0007049 Cell cycle Decreases phenotype PMID:10335920; PMID:10383846; PMID:11751517; PMID:12734332; PMID:15266821; PMID:1641906; PMID:16510457; PMID:16707792; PMID:1806033; PMID:18395440
GO:0007283 Spermatogenesis Decreases phenotype PMID:30526067; PMID:36790081
GO:0007406 Negative regulation of neuroblast proliferation Increases phenotype PMID:29524569
GO:0007613 Memory Decreases phenotype PMID:34189720
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:32234517
GO:0008209 Androgen metabolic process Increases phenotype PMID:19903449
GO:0008217 Regulation of blood pressure Increases phenotype PMID:10584476; PMID:10780258; PMID:15769980; PMID:16158007; PMID:16740865; PMID:9858113; PMID:10780258; PMID:15050533; PMID:15050533; PMID:18753797; PMID:15106802; PMID:1656149; PMID:16603690; PMID:18753797; PMID:19644504; PMID:24218149; PMID:24587916; PMID:2706798; PMID:282066; PMID:3015796; PMID:6276583; PMID:2719105; PMID:3142437; PMID:9865512
GO:0008219 Cell death Affects phenotype PMID:12953835; PMID:12967722; PMID:16403471; PMID:16644695; PMID:17591945; PMID:1806033; PMID:19855186; PMID:19969022; PMID:22471522; PMID:23872705; PMID:2429833; PMID:24519941; PMID:27387537; PMID:29222744; PMID:6284950
GO:0008283 Cell population proliferation Increases phenotype PMID:10335920; PMID:10383846; PMID:10690878; PMID:11040338; PMID:11162775; PMID:11751517; PMID:11792629; PMID:11831116; PMID:12539583; PMID:18097517; PMID:14632786; PMID:15266821; PMID:16045733; PMID:16239108; PMID:16707792; PMID:17077316; PMID:1806033; PMID:18395440; PMID:19158320; PMID:1917160; PMID:20363256; PMID:20922465; PMID:21351055; PMID:23872705; PMID:24239970; PMID:24239970; PMID:6832067; PMID:24576443; PMID:24646949; PMID:24930440; PMID:2547564; PMID:2547564; PMID:8206753; PMID:26468166; PMID:27387537; PMID:29111458; PMID:29458014; PMID:29624291; PMID:30359671; PMID:30878453; PMID:33359579; PMID:34323617; PMID:36065135; PMID:3606722; PMID:39909212; PMID:39986363; PMID:6689138; PMID:6832067; PMID:7264675; PMID:7348582; PMID:7549842; PMID:7621058; PMID:8157359; PMID:9024675; PMID:9184091; PMID:9442036; PMID:9580644
GO:0008284 Positive regulation of cell population proliferation Affects phenotype PMID:26468166; PMID:26821882; PMID:27816694; PMID:28031460; PMID:29288687
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:23137833; PMID:32619553; PMID:32791177; PMID:34742744
GO:0008361 Regulation of cell size Increases phenotype PMID:19158320; PMID:6319489
GO:0008610 Lipid biosynthetic process Increases phenotype PMID:23493372; PMID:24576443; PMID:27003841; PMID:27475717; PMID:27475717; PMID:30248417; PMID:28625492; PMID:30248417; PMID:30408883; PMID:3041967; PMID:31154084; PMID:35589016
GO:0009448 Gamma-aminobutyric acid metabolic process Affects phenotype PMID:32445661; PMID:35595036
GO:0009604 Detection of symbiotic bacterium Affects phenotype PMID:38729284
GO:0010455 Positive regulation of cell fate commitment Increases phenotype PMID:30133442
GO:0010460 Positive regulation of heart rate Increases phenotype PMID:30940551
GO:0010694 Positive regulation of alkaline phosphatase activity Increases phenotype PMID:22940495; PMID:31935364
GO:0010719 Negative regulation of epithelial to mesenchymal transition Increases phenotype PMID:32619553
GO:0010729 Positive regulation of hydrogen peroxide biosynthetic process Increases phenotype PMID:22940495; PMID:24587916
GO:0010765 Positive regulation of sodium ion transport Increases phenotype PMID:1328298
GO:0010867 Positive regulation of triglyceride biosynthetic process Increases phenotype PMID:26164185; PMID:31053639
GO:0010884 Positive regulation of lipid storage Increases phenotype PMID:15273253; PMID:17290005; PMID:17290005; PMID:30133442; PMID:27273607; PMID:28031460; PMID:28285642; PMID:27605626; PMID:28031460; PMID:28285642; PMID:29782964; PMID:30133442; PMID:30382123; PMID:30611848; PMID:34560244
GO:0010890 Positive regulation of sequestering of triglyceride Increases phenotype PMID:25761413; PMID:26200599; PMID:26820058; PMID:30721698; PMID:29288687; PMID:30721698
GO:0010906 Regulation of glucose metabolic process Affects phenotype PMID:26164185
GO:0010917 Negative regulation of mitochondrial membrane potential Increases phenotype PMID:38286393
GO:0010940 Positive regulation of necrotic cell death Increases phenotype PMID:22940495
GO:0010942 Positive regulation of cell death Affects phenotype PMID:19760634; PMID:23063726; PMID:25447644; PMID:25786529; PMID:25851902; PMID:8014883
GO:0014732 Skeletal muscle atrophy Increases phenotype PMID:33567340
GO:0014889 Muscle atrophy Increases phenotype PMID:31706954
GO:0014902 Myotube differentiation Affects phenotype PMID:36822333
GO:0014904 Myotube cell development Decreases phenotype PMID:34464682
GO:0015707 Nitrite transport Increases phenotype PMID:37777167
GO:0015908 Fatty acid transport Affects phenotype PMID:34323617; PMID:35589016
GO:0015980 Energy derivation by oxidation of organic compounds Affects phenotype PMID:26670611
GO:0016042 Lipid catabolic process Increases phenotype PMID:10067847; PMID:12906939; PMID:16835395; PMID:18328801; PMID:26363199; PMID:27085773; PMID:28292967; PMID:30526067; PMID:30849337; PMID:30924981; PMID:31860763; PMID:32687258; PMID:34302803; PMID:34627953; PMID:36031164
GO:0016043 Cellular component organization Affects phenotype PMID:35483669
GO:0016049 Cell growth Decreases phenotype PMID:25612170; PMID:28940008
GO:0016160 Amylase activity Increases phenotype PMID:37177863
GO:0016477 Cell migration Affects phenotype PMID:24722316; PMID:25497111; PMID:31471547; PMID:31669322; PMID:33157413
GO:0019216 Regulation of lipid metabolic process Affects phenotype PMID:26164185
GO:0019226 Transmission of nerve impulse Decreases phenotype PMID:21282223
GO:0019395 Fatty acid oxidation Decreases phenotype PMID:38676573
GO:0019432 Triglyceride biosynthetic process Increases phenotype PMID:23493372; PMID:24418828; PMID:24576443; PMID:25900201; PMID:27163856; PMID:28292967; PMID:29094436; PMID:30055130; PMID:30665118
GO:0019627 Urea metabolic process Affects phenotype PMID:37177863
GO:0019722 Calcium-mediated signaling Decreases phenotype PMID:8648096
GO:0019915 Lipid storage Increases phenotype PMID:28291828; PMID:30382123
GO:0021781 Glial cell fate commitment Decreases phenotype PMID:29524569
GO:0022008 Neurogenesis Decreases phenotype PMID:33619658
GO:0030154 Cell differentiation Increases phenotype PMID:10614771; PMID:11416043; PMID:14632786; PMID:14984747; PMID:14984747; PMID:15748605; PMID:16330256; PMID:16997883; PMID:17690025; PMID:1917160; PMID:20717928; PMID:21350315; PMID:6882797; PMID:7517174; PMID:7654470; PMID:7909661
GO:0030194 Positive regulation of blood coagulation Increases phenotype PMID:23696885
GO:0030199 Collagen fibril organization Increases phenotype PMID:34998855
GO:0030282 Bone mineralization Increases phenotype PMID:25062436; PMID:27028516; PMID:27387537; PMID:28975700; PMID:30738844; PMID:31709877; PMID:34562440; PMID:35148621; PMID:38971901; PMID:39986363
GO:0030316 Osteoclast differentiation Affects phenotype PMID:30878453; PMID:39393751
GO:0030317 Flagellated sperm motility Decreases phenotype PMID:36790081
GO:0030324 Lung development Affects phenotype PMID:26283537
GO:0030335 Positive regulation of cell migration Increases phenotype PMID:26468166
GO:0030336 Negative regulation of cell migration Increases phenotype PMID:32619553
GO:0030501 Positive regulation of bone mineralization Increases phenotype PMID:26468166; PMID:34575692
GO:0030512 Negative regulation of transforming growth factor beta receptor signaling pathway Increases phenotype PMID:29329878
GO:0030887 Positive regulation of myeloid dendritic cell activation Increases phenotype PMID:28463086
GO:0031323 Regulation of cellular metabolic process Affects phenotype PMID:26820058
GO:0031941 Filamentous actin Increases phenotype PMID:39393751
GO:0031987 Locomotion involved in locomotory behavior Increases phenotype PMID:34189720
GO:0032088 Negative regulation of nf-kappab transcription factor activity Increases phenotype PMID:23872422
GO:0032125 Micronucleus organization Increases phenotype PMID:35866224
GO:0032148 Activation of protein kinase b activity Affects phenotype PMID:28285642; PMID:28363435; PMID:30696844; PMID:32404561; PMID:35616142
GO:0032310 Prostaglandin secretion Increases phenotype PMID:37777167
GO:0032332 Positive regulation of chondrocyte differentiation Increases phenotype PMID:26526931
GO:0032689 Negative regulation of type ii interferon production Increases phenotype PMID:19997594
GO:0032700 Negative regulation of interleukin-17 production Increases phenotype PMID:19997594
GO:0032725 Positive regulation of granulocyte macrophage colony-stimulating factor production Affects phenotype PMID:23981542
GO:0032922 Circadian regulation of gene expression Increases phenotype PMID:29229235
GO:0032963 Collagen metabolic process Increases phenotype PMID:35335934
GO:0032964 Collagen biosynthetic process Decreases phenotype PMID:23493372; PMID:27028516
GO:0032967 Positive regulation of collagen biosynthetic process Increases phenotype PMID:31935364
GO:0033148 Positive regulation of intracellular estrogen receptor signaling pathway Increases phenotype PMID:26944108
GO:0033327 Leydig cell differentiation Decreases phenotype PMID:29902490; PMID:30526067
GO:0034145 Positive regulation of toll-like receptor 4 signaling pathway Increases phenotype PMID:27568862
GO:0034199 Activation of protein kinase a activity Affects phenotype PMID:29288687
GO:0034440 Lipid oxidation Increases phenotype PMID:22940495; PMID:26089034; PMID:28363435; PMID:32812458; PMID:34455893; PMID:35866224; PMID:37177863; PMID:37177863; PMID:38511873; PMID:38901789; PMID:37696682; PMID:38729284
GO:0035377 Transepithelial water transport Decreases phenotype PMID:31076804
GO:0035640 Exploration behavior Decreases phenotype PMID:33619658
GO:0035774 Positive regulation of insulin secretion involved in cellular response to glucose stimulus Affects phenotype PMID:25851902
GO:0035784 Nickel cation homeostasis Decreases phenotype PMID:27452194
GO:0035810 Positive regulation of urine volume Increases phenotype PMID:10334502; PMID:10334502; PMID:2719105; PMID:2719105
GO:0035812 Renal sodium excretion Affects phenotype PMID:10334502; PMID:2995143; PMID:3015796; PMID:7554322
GO:0035930 Corticosteroid hormone secretion Affects phenotype PMID:32445661
GO:0036211 Protein modification process Increases phenotype PMID:2818624; PMID:8014883; PMID:8386241
GO:0036269 Swimming behavior Affects phenotype PMID:30628712
GO:0040029 Epigenetic regulation of gene expression Decreases phenotype PMID:35246761
GO:0042102 Positive regulation of t cell proliferation Increases phenotype PMID:28463086
GO:0042116 Macrophage activation Decreases phenotype PMID:2579101
GO:0042127 Regulation of cell population proliferation Affects phenotype PMID:2615355
GO:0042178 Xenobiotic catabolic process Increases phenotype PMID:9817083
GO:0042221 Response to chemical Increases phenotype PMID:35595036
GO:0042307 Positive regulation of protein import into nucleus Increases phenotype PMID:32619553
GO:0042310 Vasoconstriction Affects phenotype PMID:10484530; PMID:10598616; PMID:15802370; PMID:16603690; PMID:17562850; PMID:3631295; PMID:4058751
GO:0042311 Vasodilation Increases phenotype PMID:10484530; PMID:15769980
GO:0042391 Regulation of membrane potential Affects phenotype PMID:8179849
GO:0042403 Thyroid hormone metabolic process Affects phenotype PMID:39909212
GO:0042421 Norepinephrine biosynthetic process Decreases phenotype PMID:21453761; PMID:29935188
GO:0042445 Hormone metabolic process Affects phenotype PMID:37177863
GO:0042554 Superoxide anion generation Increases phenotype PMID:28940008; PMID:37177863
GO:0042593 Glucose homeostasis Affects phenotype PMID:27653037; PMID:32791177
GO:0042692 Muscle cell differentiation Decreases phenotype PMID:22936724
GO:0042908 Xenobiotic transport Affects phenotype PMID:34998855
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:11426834; PMID:19760634; PMID:19997594; PMID:22010212; PMID:22940495; PMID:23063726; PMID:25447644; PMID:34742744; PMID:38336255
GO:0043114 Regulation of vascular permeability Affects phenotype PMID:29458014
GO:0043124 Negative regulation of i-kappab kinase/nf-kappab signaling Increases phenotype PMID:32619553
GO:0043299 Leukocyte degranulation Decreases phenotype PMID:7730645
GO:0043966 Histone h3 acetylation Increases phenotype PMID:33567340
GO:0043967 Histone h4 acetylation Increases phenotype PMID:33567340
GO:0043970 Histone h3-k9 acetylation Affects phenotype PMID:30359671; PMID:33619658; PMID:35246761
GO:0043974 Histone h3-k27 acetylation Decreases phenotype PMID:30359671; PMID:35246761
GO:0044028 Dna hypomethylation Increases phenotype PMID:29094436
GO:0044154 Histone h3-k14 acetylation Decreases phenotype PMID:35246761
GO:0044237 Cellular metabolic process Increases phenotype PMID:17452641; PMID:29928335; PMID:31076804; PMID:32812458; PMID:33091441; PMID:35866224; PMID:37956312; PMID:39244184; PMID:39986363
GO:0044242 Cellular lipid catabolic process Increases phenotype PMID:29288687
GO:0044255 Cellular lipid metabolic process Affects phenotype PMID:34323617
GO:0044307 Dendritic branch Affects phenotype PMID:33619658
GO:0045023 G0 to g1 transition Decreases phenotype PMID:32023857; PMID:36065135
GO:0045123 Cellular extravasation Increases phenotype PMID:36031164
GO:0045333 Cellular respiration Affects phenotype PMID:31596606; PMID:32417366; PMID:34323617
GO:0045429 Positive regulation of nitric oxide biosynthetic process Increases phenotype PMID:27568862; PMID:28906110; PMID:32738331; PMID:34218561
GO:0045444 Fat cell differentiation Affects phenotype PMID:12496288; PMID:12496288; PMID:18586010; PMID:25338179; PMID:27384973; PMID:30959087; PMID:31078726; PMID:31154084; PMID:32017950; PMID:32220626; PMID:34302803; PMID:34323617; PMID:36152787; PMID:12496288; PMID:32017950; PMID:18591783; PMID:19064586; PMID:22732655; PMID:23503329; PMID:25559859; PMID:27475717; PMID:27507602; PMID:30248417; PMID:30409764; PMID:31199990; PMID:31470850; PMID:33945810; PMID:34968464; PMID:39842701; PMID:24418828; PMID:24576443; PMID:24646949; PMID:24646949; PMID:33026256; PMID:33203037; PMID:33689779; PMID:35504408; PMID:24911977; PMID:34800597; PMID:25062436; PMID:2523799; PMID:26996129; PMID:27085773; PMID:30446312; PMID:25338179; PMID:26117538; PMID:26504594; PMID:26972250; PMID:27085773; PMID:27507602; PMID:28291828; PMID:28298639; PMID:28437481; PMID:28528971; PMID:28528971; PMID:30408883; PMID:28625492; PMID:28628672; PMID:28758259; PMID:28849599; PMID:32473317; PMID:32522588; PMID:28921615; PMID:29094436; PMID:29704545; PMID:30055130; PMID:30248417; PMID:30408883; PMID:30446312; PMID:30665118; PMID:30665118; PMID:30920877; PMID:36708982; PMID:30738844; PMID:30920877; PMID:31154084; PMID:31596606; PMID:32017950; PMID:32407875; PMID:32473317; PMID:33395283; PMID:33476690; PMID:33836827; PMID:33865937; PMID:35736896; PMID:33945810; PMID:34323617; PMID:34800597; PMID:34864131; PMID:36065135; PMID:36706894; PMID:36708982; PMID:36764644; PMID:37142754; PMID:38048832; PMID:38971901
GO:0045600 Positive regulation of fat cell differentiation Increases phenotype PMID:10777552; PMID:17290005; PMID:25617244; PMID:15273253; PMID:17290005; PMID:23917077; PMID:26820058; PMID:30031040; PMID:30721698; PMID:25617244; PMID:25851902; PMID:26408789; PMID:27273607; PMID:28031460; PMID:28285642; PMID:30577593; PMID:30903904; PMID:26200599; PMID:26408789; PMID:26492236; PMID:26824325; PMID:26944108; PMID:26944108; PMID:32171850; PMID:27145005; PMID:27605626; PMID:27714895; PMID:28031460; PMID:28163246; PMID:28242765; PMID:28595985; PMID:29410257; PMID:30611848; PMID:31319077; PMID:28285642; PMID:28527915; PMID:28595985; PMID:29782964; PMID:30031040; PMID:30382123; PMID:30577593; PMID:30721698; PMID:30903904; PMID:32044341; PMID:32171850; PMID:32553695; PMID:34560244
GO:0045669 Positive regulation of osteoblast differentiation Affects phenotype PMID:22940495; PMID:26424790; PMID:26492236; PMID:27714895; PMID:27932991; PMID:28189605; PMID:28363435; PMID:30382123; PMID:30639440; PMID:31935364
GO:0045672 Positive regulation of osteoclast differentiation Increases phenotype PMID:28363435
GO:0045687 Positive regulation of glial cell differentiation Affects phenotype PMID:27816694; PMID:29524569
GO:0045722 Positive regulation of gluconeogenesis Increases phenotype PMID:26616219
GO:0045777 Positive regulation of blood pressure Increases phenotype PMID:30940551
GO:0045834 Positive regulation of lipid metabolic process Increases phenotype PMID:32171850
GO:0045907 Positive regulation of vasoconstriction Increases phenotype PMID:27568862
GO:0045930 Negative regulation of mitotic cell cycle Increases phenotype PMID:30409764
GO:0045931 Positive regulation of mitotic cell cycle Increases phenotype PMID:30903904
GO:0045944 Positive regulation of transcription by rna polymerase ii Increases phenotype PMID:25851902
GO:0046034 Atp metabolic process Affects phenotype PMID:37337224
GO:0046209 Nitric oxide metabolic process Affects phenotype PMID:32812458; PMID:37177863; PMID:38901789; PMID:39067743
GO:0046325 Negative regulation of glucose import Increases phenotype PMID:32976960
GO:0046449 Creatinine metabolic process Affects phenotype PMID:37177863
GO:0046466 Membrane lipid catabolic process Increases phenotype PMID:6284950; PMID:9285037
GO:0046620 Regulation of organ growth Decreases phenotype PMID:19644504
GO:0046621 Negative regulation of organ growth Increases phenotype PMID:32791177; PMID:34537908; PMID:35246761
GO:0046651 Lymphocyte proliferation Increases phenotype PMID:39067743
GO:0046676 Negative regulation of insulin secretion Increases phenotype PMID:32791177
GO:0046685 Response to arsenic-containing substance Increases phenotype PMID:33129825
GO:0048266 Behavioral response to pain Increases phenotype PMID:30261224
GO:0048663 Neuron fate commitment Decreases phenotype PMID:29524569
GO:0050649 Testosterone 6-beta-hydroxylase activity Increases phenotype PMID:25900201
GO:0050729 Positive regulation of inflammatory response Increases phenotype PMID:32738331
GO:0050872 White fat cell differentiation Increases phenotype PMID:26972250; PMID:27605626; PMID:30133442; PMID:33412187
GO:0050873 Brown fat cell differentiation Increases phenotype PMID:25761413; PMID:26972250; PMID:32417366
GO:0050901 Leukocyte tethering or rolling Increases phenotype PMID:10807495; PMID:28559105
GO:0050966 Detection of mechanical stimulus involved in sensory perception of pain Increases phenotype PMID:33259823
GO:0051092 Positive regulation of nf-kappab transcription factor activity Affects phenotype PMID:23063726; PMID:25080890; PMID:25851902
GO:0051463 Negative regulation of cortisol secretion Increases phenotype PMID:35246761
GO:0051649 Establishment of localization in cell Affects phenotype PMID:38729284
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:16944584; PMID:17070682; PMID:21244764; PMID:21569845; PMID:35866224; PMID:37337224
GO:0051882 Mitochondrial depolarization Increases phenotype PMID:35866224
GO:0055062 Phosphate ion homeostasis Affects phenotype PMID:35738543; PMID:38971901
GO:0055064 Chloride ion homeostasis Affects phenotype PMID:35595036
GO:0055074 Calcium ion homeostasis Affects phenotype PMID:35595036; PMID:38971901
GO:0060013 Righting reflex Affects phenotype PMID:30628712
GO:0060055 Angiogenesis involved in wound healing Decreases phenotype PMID:17295090
GO:0060253 Negative regulation of glial cell proliferation Increases phenotype PMID:29524569
GO:0060326 Cell chemotaxis Affects phenotype PMID:1659155; PMID:314231; PMID:3606722; PMID:7766432
GO:0060348 Bone development Affects phenotype PMID:35148621
GO:0060480 Lung goblet cell differentiation Increases phenotype PMID:34998855; PMID:35335934
GO:0060591 Chondroblast differentiation Increases phenotype PMID:26492236
GO:0060612 Adipose tissue development Increases phenotype PMID:10496339; PMID:11101056; PMID:20206132; PMID:31709877; PMID:33091441; PMID:9543393
GO:0060644 Mammary gland epithelial cell differentiation Increases phenotype PMID:28174119; PMID:31783125
GO:0061351 Neural precursor cell proliferation Decreases phenotype PMID:33619658
GO:0061370 Testosterone biosynthetic process Decreases phenotype PMID:29902490; PMID:30526067; PMID:33983380
GO:0061517 Macrophage proliferation Increases phenotype PMID:37177863
GO:0061756 Leukocyte adhesion to vascular endothelial cell Increases phenotype PMID:32679256
GO:0061951 Establishment of protein localization to plasma membrane Increases phenotype PMID:30591588
GO:0061975 Articular cartilage development Decreases phenotype PMID:29329878
GO:0070085 Glycosylation Increases phenotype PMID:8392465
GO:0070169 Positive regulation of biomineral tissue development Increases phenotype PMID:22940495; PMID:26492236; PMID:28189605; PMID:30382123; PMID:31935364
GO:0070212 Protein poly-adp-ribosylation Increases phenotype PMID:22940495
GO:0070257 Positive regulation of mucus secretion Increases phenotype PMID:31751647
GO:0070328 Triglyceride homeostasis Decreases phenotype PMID:31053639
GO:0070341 Fat cell proliferation Increases phenotype PMID:38971901
GO:0070346 Positive regulation of fat cell proliferation Increases phenotype PMID:27605626; PMID:30382123; PMID:30903904
GO:0070352 Positive regulation of white fat cell proliferation Increases phenotype PMID:27605626
GO:0070365 Hepatocyte differentiation Increases phenotype PMID:20501703; PMID:28552552; PMID:23108452; PMID:26739637; PMID:36603777
GO:0070368 Positive regulation of hepatocyte differentiation Increases phenotype PMID:25084468; PMID:27427493
GO:0070989 Oxidative demethylation Increases phenotype PMID:22499231
GO:0070994 Detection of oxidative stress Increases phenotype PMID:34455893
GO:0071441 Negative regulation of histone h3-k14 acetylation Increases phenotype PMID:32791177
GO:0071486 Cellular response to high light intensity Increases phenotype PMID:24519941
GO:0071577 Zinc ion transmembrane transport Increases phenotype PMID:24311739
GO:0071736 Igg immunoglobulin complex, circulating Increases phenotype PMID:31669322
GO:0071743 Ige immunoglobulin complex, circulating Increases phenotype PMID:31669322
GO:0071897 Dna biosynthetic process Decreases phenotype PMID:33359579
GO:0072540 T-helper 17 cell lineage commitment Increases phenotype PMID:28463086
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:21801858; PMID:22471522; PMID:24239970; PMID:34998855; PMID:35866224; PMID:38286393
GO:0072672 Neutrophil extravasation Affects phenotype PMID:11557319; PMID:11820457; PMID:24188200; PMID:7542281
GO:0072676 Lymphocyte migration Increases phenotype PMID:35335934
GO:0072677 Eosinophil migration Increases phenotype PMID:31669322; PMID:35335934; PMID:37004399
GO:0072682 Eosinophil extravasation Increases phenotype PMID:24188200
GO:0072683 T cell extravasation Increases phenotype PMID:24188200
GO:0090023 Positive regulation of neutrophil chemotaxis Increases phenotype PMID:18670081
GO:0090297 Positive regulation of mitochondrial dna replication Increases phenotype PMID:29288687
GO:0090336 Positive regulation of brown fat cell differentiation Increases phenotype PMID:25761413; PMID:29288687
GO:0097154 Gabaergic neuron differentiation Increases phenotype PMID:32445661
GO:0097280 Histamine secretion mediated by immunoglobulin Affects phenotype PMID:2434566; PMID:6180017
GO:0097722 Sperm motility Decreases phenotype PMID:30526067
GO:0098609 Cell-cell adhesion Increases phenotype PMID:28559105
GO:0098868 Bone growth Decreases phenotype PMID:28363435; PMID:35148621
GO:0110090 Positive regulation of hippocampal neuron apoptotic process Increases phenotype PMID:31518422
GO:0140042 Lipid droplet formation Increases phenotype PMID:19064586; PMID:26164185; PMID:28242765; PMID:28242765; PMID:28595985; PMID:30611848; PMID:28298639; PMID:28437481; PMID:28595985; PMID:28628672; PMID:28758259; PMID:28921615; PMID:29094436; PMID:30055130; PMID:30409764; PMID:30409764; PMID:31470850; PMID:33945810; PMID:30446312; PMID:30738844; PMID:30920877; PMID:30920877; PMID:36708982; PMID:31016361; PMID:31016361; PMID:34864131; PMID:31470850; PMID:32017950; PMID:32017950; PMID:32220626; PMID:36152787; PMID:32023857; PMID:32220626; PMID:32407875; PMID:32553695; PMID:33091441; PMID:33203037; PMID:33476690; PMID:33836827; PMID:33865937; PMID:33945810; PMID:34302803; PMID:34864131; PMID:35589016; PMID:36708982; PMID:36764644; PMID:37142754; PMID:38971901
GO:0140059 Dendrite arborization Affects phenotype PMID:33619658
GO:0140115 Export across plasma membrane Decreases phenotype PMID:28549670
GO:0140354 Lipid import into cell Increases phenotype PMID:37511356
GO:0140639 Positive regulation of pyroptosis Increases phenotype PMID:38286393
GO:1900035 Negative regulation of cellular response to heat Affects phenotype PMID:14673132
GO:1900171 Positive regulation of glucocorticoid mediated signaling pathway Increases phenotype PMID:25851902
GO:1900181 Negative regulation of protein localization to nucleus Increases phenotype PMID:32619553
GO:1900182 Positive regulation of protein localization to nucleus Increases phenotype PMID:34537908; PMID:36350155
GO:1900535 Palmitic acid biosynthetic process Increases phenotype PMID:31053639
GO:1900745 Positive regulation of p38mapk cascade Increases phenotype PMID:27568862; PMID:30721698; PMID:31935364; PMID:35616142
GO:1901082 Positive regulation of relaxation of smooth muscle Affects phenotype PMID:24380835
GO:1901113 Erythromycin metabolic process Increases phenotype PMID:16673044; PMID:16673044; PMID:16844145; PMID:16844145
GO:1901331 Positive regulation of odontoblast differentiation Increases phenotype PMID:35738543
GO:1901666 Positive regulation of nad+ adp-ribosyltransferase activity Increases phenotype PMID:22940495
GO:1901671 Positive regulation of superoxide dismutase activity Decreases phenotype PMID:28363435
GO:1901675 Negative regulation of histone h3-k27 acetylation Increases phenotype PMID:32791177
GO:1901992 Positive regulation of mitotic cell cycle phase transition Increases phenotype PMID:28285642
GO:1902117 Positive regulation of organelle assembly Increases phenotype PMID:29288687
GO:1902512 Positive regulation of apoptotic dna fragmentation Increases phenotype PMID:11137978
GO:1902608 Positive regulation of large conductance calcium-activated potassium channel activity Increases phenotype PMID:27605626
GO:1903012 Positive regulation of bone development Increases phenotype PMID:25932594
GO:1903047 Mitotic cell cycle process Affects phenotype PMID:33359579; PMID:36065135; PMID:39986363
GO:1903141 Negative regulation of establishment of endothelial barrier Increases phenotype PMID:32404561
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:28181396; PMID:28940008
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:27568862
GO:1903583 Positive regulation of basophil degranulation Increases phenotype PMID:31751647
GO:1904340 Positive regulation of dopaminergic neuron differentiation Increases phenotype PMID:29524569
GO:1904860 Dna synthesis involved in mitotic dna replication Increases phenotype PMID:24646949
GO:1905144 Response to acetylcholine Decreases phenotype PMID:27568862
GO:1905517 Macrophage migration Increases phenotype PMID:31860763; PMID:35335934
GO:1905962 Glutamatergic neuron differentiation Decreases phenotype PMID:32445661
GO:1990266 Neutrophil migration Increases phenotype PMID:30924981; PMID:31860763; PMID:35335934; PMID:37004399
GO:2000077 Negative regulation of type b pancreatic cell development Increases phenotype PMID:32791177
GO:2000324 Positive regulation of glucocorticoid receptor signaling pathway Increases phenotype PMID:2298732
GO:2000355 Negative regulation of ovarian follicle development Increases phenotype PMID:34537908
GO:2000376 Positive regulation of oxygen metabolic process Decreases phenotype PMID:25851902
GO:2000388 Positive regulation of antral ovarian follicle growth Increases phenotype PMID:34537908
GO:2000391 Positive regulation of neutrophil extravasation Increases phenotype PMID:29960001; PMID:35616142
GO:2000421 Positive regulation of eosinophil extravasation Increases phenotype PMID:25739523
GO:2000439 Positive regulation of monocyte extravasation Increases phenotype PMID:29960001
GO:2000490 Negative regulation of hepatic stellate cell activation Increases phenotype PMID:26806094
GO:2000491 Positive regulation of hepatic stellate cell activation Increases phenotype PMID:26435214; PMID:26435214; PMID:26806094; PMID:26739621; PMID:26739621; PMID:29535048
GO:2000553 Positive regulation of t-helper 2 cell cytokine production Increases phenotype PMID:27884791
GO:2000616 Negative regulation of histone h3-k9 acetylation Increases phenotype PMID:32791177
GO:2000738 Positive regulation of stem cell differentiation Affects phenotype PMID:25786529; PMID:34575692
GO:2001171 Positive regulation of atp biosynthetic process Increases phenotype PMID:25851902
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.