Bisphenol A


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000002 Mitochondrial genome maintenance Decreases phenotype PMID:30194976
GO:0000045 Autophagosome assembly Increases phenotype PMID:29275510
GO:0000050 Urea cycle Increases phenotype PMID:29477810
GO:0000080 Mitotic g1 phase Affects phenotype PMID:36633214
GO:0000084 Mitotic s phase Increases phenotype PMID:28736785; PMID:29846718; PMID:30467747; PMID:31601247; PMID:31916403; PMID:33516137; PMID:34585602; PMID:35429799; PMID:36982678; PMID:37105472; PMID:38211720; PMID:38372072
GO:0000085 Mitotic g2 phase Affects phenotype PMID:33516137; PMID:36181250
GO:0000086 G2/m transition of mitotic cell cycle Decreases phenotype PMID:30467747; PMID:31601247; PMID:31916403; PMID:36633214; PMID:38372072
GO:0000089 Mitotic metaphase Affects phenotype PMID:36384894
GO:0000104 Succinate dehydrogenase activity Decreases phenotype PMID:37718616
GO:0000162 Tryptophan biosynthetic process Affects phenotype PMID:28549143; PMID:34082316
GO:0000236 Mitotic prometaphase Affects phenotype PMID:30980863
GO:0000262 Mitochondrial chromosome Decreases phenotype PMID:36966614
GO:0000266 Mitochondrial fission Increases phenotype PMID:36549428
GO:0000278 Mitotic cell cycle Increases phenotype PMID:26397976; PMID:30467747; PMID:36608567
GO:0000723 Telomere maintenance Affects phenotype PMID:31004310; PMID:36966614
GO:0000737 Dna catabolic process, endonucleolytic Increases phenotype PMID:36633214
GO:0001501 Skeletal system development Affects phenotype PMID:30321649
GO:0001503 Ossification Decreases phenotype PMID:23900028
GO:0001510 Rna methylation Increases phenotype PMID:24433282; PMID:31146095; PMID:36451259; PMID:36469784; PMID:37495067; PMID:38354435
GO:0001516 Prostaglandin biosynthetic process Affects phenotype PMID:23672405; PMID:30609183
GO:0001525 Angiogenesis Affects phenotype PMID:35051763
GO:0001541 Ovarian follicle development Decreases phenotype PMID:24034936; PMID:24051130; PMID:24625398; PMID:24458533; PMID:27208089; PMID:30629253; PMID:31424294; PMID:32407858; PMID:33509759; PMID:37108581; PMID:39322090
GO:0001544 Initiation of primordial ovarian follicle growth Decreases phenotype PMID:26049153
GO:0001546 Preantral ovarian follicle growth Decreases phenotype PMID:33718757
GO:0001547 Antral ovarian follicle growth Affects phenotype PMID:24025742; PMID:31424294
GO:0001548 Follicular fluid formation in ovarian follicle antrum Decreases phenotype PMID:29958887
GO:0001550 Ovarian cumulus expansion Decreases phenotype PMID:29458137
GO:0001551 Ovarian follicle endowment Decreases phenotype PMID:26049153
GO:0001552 Ovarian follicle atresia Increases phenotype PMID:28648634; PMID:29958887; PMID:30675821; PMID:32407858; PMID:37448361
GO:0001553 Luteinization Increases phenotype PMID:24625398; PMID:26161573; PMID:30675821
GO:0001556 Oocyte maturation Decreases phenotype PMID:38736411
GO:0001570 Vasculogenesis Decreases phenotype PMID:31756439
GO:0001649 Osteoblast differentiation Affects phenotype PMID:23900028; PMID:34097993; PMID:34850234; PMID:35780740
GO:0001662 Behavioral fear response Affects phenotype PMID:22760093
GO:0001787 Natural killer cell proliferation Increases phenotype PMID:38431166
GO:0001821 Histamine secretion Increases phenotype PMID:22446810; PMID:23782309
GO:0001824 Blastocyst development Affects phenotype PMID:33246333
GO:0001825 Blastocyst formation Decreases phenotype PMID:25772901
GO:0001836 Release of cytochrome c from mitochondria Increases phenotype PMID:24768697; PMID:24905940; PMID:26096086; PMID:27189055
GO:0001837 Epithelial to mesenchymal transition Increases phenotype PMID:33469997
GO:0001890 Placenta development Affects phenotype PMID:23593014; PMID:30303745; PMID:32071231
GO:0001891 Phagocytic cup Increases phenotype PMID:35250464
GO:0001892 Embryonic placenta development Affects phenotype PMID:38431166
GO:0001944 Vasculature development Increases phenotype PMID:39322090
GO:0001958 Endochondral ossification Decreases phenotype PMID:34850234
GO:0001966 Thigmotaxis Affects phenotype PMID:35560535
GO:0002027 Regulation of heart rate Affects phenotype PMID:32144343
GO:0002062 Chondrocyte differentiation Decreases phenotype PMID:34850234
GO:0002067 Glandular epithelial cell differentiation Affects phenotype PMID:26898831
GO:0002118 Aggressive behavior Affects phenotype PMID:25307304
GO:0002157 Positive regulation of thyroid hormone mediated signaling pathway Increases phenotype PMID:29146198
GO:0002209 Behavioral defense response Affects phenotype PMID:38152552
GO:0002265 Astrocyte activation involved in immune response Increases phenotype PMID:24824810
GO:0002377 Immunoglobulin production Increases phenotype PMID:27087817
GO:0002381 Immunoglobulin production involved in immunoglobulin-mediated immune response Increases phenotype PMID:24950052; PMID:29737898
GO:0002437 Inflammatory response to antigenic stimulus Increases phenotype PMID:24950052; PMID:27087817
GO:0002457 T cell antigen processing and presentation Increases phenotype PMID:32810514
GO:0002522 Leukocyte migration involved in immune response Affects phenotype PMID:26496021; PMID:29737898
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:27087817; PMID:28285737; PMID:28689058; PMID:33582552; PMID:36549428; PMID:36549428; PMID:37510359; PMID:38027817; PMID:39322090
GO:0002534 Cytokine production involved in inflammatory response Increases phenotype PMID:27087817
GO:0002609 Positive regulation of myeloid dendritic cell antigen processing and presentation Increases phenotype PMID:29737898
GO:0002639 Positive regulation of immunoglobulin production Increases phenotype PMID:29427786
GO:0002693 Positive regulation of cellular extravasation Increases phenotype PMID:28959593; PMID:29737898; PMID:30057697
GO:0002925 Positive regulation of humoral immune response mediated by circulating immunoglobulin Increases phenotype PMID:27869686
GO:0002931 Response to ischemia Decreases phenotype PMID:32319667
GO:0003006 Developmental process involved in reproduction Increases phenotype PMID:28750633; PMID:30629253; PMID:31132128; PMID:36508816
GO:0003014 Renal system process Decreases phenotype PMID:21147601
GO:0003084 Positive regulation of systemic arterial blood pressure Increases phenotype PMID:30496632; PMID:31489946
GO:0003093 Regulation of glomerular filtration Affects phenotype PMID:32645486
GO:0003300 Cardiac muscle hypertrophy Increases phenotype PMID:37611474
GO:0003720 Telomerase activity Increases phenotype PMID:26397976
GO:0003756 Protein disulfide isomerase activity Decreases phenotype PMID:25122773
GO:0003990 Acetylcholinesterase activity Affects phenotype PMID:34505250
GO:0003994 Aconitate hydratase activity Decreases phenotype PMID:33265944
GO:0004021 L-alanine:2-oxoglutarate aminotransferase activity Increases phenotype PMID:37211107; PMID:39260547; PMID:39722417
GO:0004035 Alkaline phosphatase activity Increases phenotype PMID:26450347; PMID:35890622; PMID:39722417; PMID:29477810; PMID:31733320; PMID:31979393; PMID:35780740; PMID:35945320; PMID:39722417
GO:0004053 Arginase activity Increases phenotype PMID:32172062
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Increases phenotype PMID:28689058; PMID:28689058; PMID:35890622; PMID:36597173; PMID:39722417; PMID:29477810; PMID:31470036; PMID:37701206; PMID:31979393; PMID:34067838; PMID:35945320; PMID:36597173; PMID:37211107; PMID:37701206; PMID:39260547; PMID:39722417
GO:0004096 Catalase activity Decreases phenotype PMID:39722417
GO:0004111 Creatine kinase activity Increases phenotype PMID:30496632
GO:0004129 Cytochrome-c oxidase activity Decreases phenotype PMID:26450347; PMID:31387175
GO:0004197 Cysteine-type endopeptidase activity Increases phenotype PMID:34655688
GO:0004359 Glutaminase activity Affects phenotype PMID:34434659; PMID:37372067
GO:0004362 Glutathione-disulfide reductase (nadph) activity Decreases phenotype PMID:39549767
GO:0004364 Glutathione transferase activity Affects phenotype PMID:12030774; PMID:25112833; PMID:28959593; PMID:30057697; PMID:34505250; PMID:35945320; PMID:37843661; PMID:39260547
GO:0004447 Iodide peroxidase activity Decreases phenotype PMID:30352396
GO:0004449 Isocitrate dehydrogenase (nad+) activity Decreases phenotype PMID:37718616
GO:0004457 Lactate dehydrogenase activity Increases phenotype PMID:26450347; PMID:28689058; PMID:28689058; PMID:29477810; PMID:37084542; PMID:39117098
GO:0004517 Nitric-oxide synthase activity Increases phenotype PMID:32629208; PMID:33967032
GO:0004602 Glutathione peroxidase activity Increases phenotype PMID:18246544; PMID:21840368; PMID:22269103; PMID:22623521; PMID:22623521; PMID:38513920; PMID:24472609; PMID:25112833; PMID:31387175; PMID:31387175; PMID:33485121; PMID:36633214; PMID:31453682; PMID:33485121; PMID:36633214; PMID:37718616; PMID:37843661; PMID:38348715; PMID:38513920; PMID:39722417
GO:0004679 Amp-activated protein kinase activity Decreases phenotype PMID:30228064; PMID:34664771
GO:0004784 Superoxide dismutase activity Affects phenotype PMID:22269103; PMID:22623521; PMID:22623521; PMID:23024759; PMID:30997025; PMID:38513920; PMID:24472609; PMID:25112833; PMID:25112833; PMID:30641872; PMID:30997025; PMID:34067838; PMID:35890622; PMID:36597173; PMID:39722417; PMID:25454643; PMID:26450347; PMID:28285737; PMID:28285737; PMID:30997025; PMID:38027817; PMID:30641872; PMID:30641872; PMID:30997025; PMID:39722417; PMID:30997025; PMID:30997025; PMID:38348715; PMID:31064381; PMID:31387175; PMID:31387175; PMID:33173981; PMID:31387175; PMID:33485121; PMID:36633214; PMID:31424294; PMID:31453682; PMID:33265944; PMID:33485121; PMID:33582552; PMID:33967032; PMID:34067838; PMID:34097988; PMID:34793900; PMID:36597173; PMID:36633214; PMID:36966614; PMID:37718616; PMID:37843661; PMID:38027817; PMID:38348715; PMID:38513920; PMID:39059691; PMID:39722417
GO:0005245 Voltage-gated calcium channel activity Increases phenotype PMID:28924161; PMID:35457000
GO:0005248 Voltage-gated sodium channel activity Affects phenotype PMID:31250031; PMID:31312012
GO:0005249 Voltage-gated potassium channel activity Decreases phenotype PMID:31250031; PMID:35457000
GO:0005391 P-type sodium:potassium-exchanging transporter activity Increases phenotype PMID:37718616
GO:0005911 Cell-cell junction Decreases phenotype PMID:28808208
GO:0005976 Polysaccharide metabolic process Affects phenotype PMID:33582552
GO:0005977 Glycogen metabolic process Affects phenotype PMID:23748860; PMID:32623698
GO:0005984 Disaccharide metabolic process Affects phenotype PMID:32071231
GO:0006000 Fructose metabolic process Affects phenotype PMID:32071231
GO:0006006 Glucose metabolic process Affects phenotype PMID:32574892; PMID:35489422; PMID:35504408; PMID:38200540
GO:0006007 Glucose catabolic process Decreases phenotype PMID:29793316
GO:0006071 Glycerol metabolic process Affects phenotype PMID:35504408
GO:0006089 Lactate metabolic process Affects phenotype PMID:35560535
GO:0006094 Gluconeogenesis Increases phenotype PMID:25796683; PMID:28689058; PMID:30997025; PMID:31121516; PMID:37657410
GO:0006096 Glycolytic process Decreases phenotype PMID:28849599; PMID:34771623; PMID:36011004
GO:0006105 Succinate metabolic process Affects phenotype PMID:31121516
GO:0006120 Mitochondrial electron transport, nadh to ubiquinone Increases phenotype PMID:31344369
GO:0006121 Mitochondrial electron transport, succinate to ubiquinone Increases phenotype PMID:31344369
GO:0006122 Mitochondrial electron transport, ubiquinol to cytochrome c Decreases phenotype PMID:26450347; PMID:30841469; PMID:35598803
GO:0006123 Mitochondrial electron transport, cytochrome c to oxygen Decreases phenotype PMID:30841469; PMID:35598803
GO:0006171 Camp biosynthetic process Affects phenotype PMID:24140712; PMID:28858478; PMID:31126612; PMID:31212720; PMID:32126385
GO:0006182 Cgmp biosynthetic process Affects phenotype PMID:32629208
GO:0006260 Dna replication Increases phenotype PMID:31011801
GO:0006264 Mitochondrial dna replication Affects phenotype PMID:25101517; PMID:31387175; PMID:33173981
GO:0006304 Dna modification Affects phenotype PMID:30194976; PMID:30626059; PMID:31489946
GO:0006306 Dna methylation Increases phenotype PMID:23590724; PMID:23593014; PMID:23653003; PMID:23748860; PMID:24034936; PMID:25748669; PMID:28597690; PMID:31463084; PMID:32763279; PMID:35504408; PMID:36473650
GO:0006338 Chromatin remodeling Increases phenotype PMID:33916708; PMID:36549428
GO:0006349 Regulation of gene expression by genomic imprinting Affects phenotype PMID:29165653
GO:0006355 Regulation of dna-templated transcription Affects phenotype PMID:25853433; PMID:35005817
GO:0006357 Regulation of transcription by rna polymerase ii Decreases phenotype PMID:30001178
GO:0006412 Translation Decreases phenotype PMID:22125951
GO:0006413 Translational initiation Decreases phenotype PMID:33431410
GO:0006486 Protein glycosylation Increases phenotype PMID:32339907
GO:0006497 Protein lipidation Increases phenotype PMID:34186417; PMID:37257343
GO:0006520 Amino acid metabolic process Affects phenotype PMID:36432690
GO:0006521 Regulation of cellular amino acid metabolic process Affects phenotype PMID:27514991; PMID:28973422
GO:0006523 Alanine biosynthetic process Affects phenotype PMID:31121516
GO:0006536 Glutamate metabolic process Affects phenotype PMID:34434659; PMID:37372067
GO:0006537 Glutamate biosynthetic process Affects phenotype PMID:31121516
GO:0006541 Glutamine metabolic process Affects phenotype PMID:34434659
GO:0006542 Glutamine biosynthetic process Affects phenotype PMID:31121516
GO:0006545 Glycine biosynthetic process Affects phenotype PMID:31121516
GO:0006556 S-adenosylmethionine biosynthetic process Increases phenotype PMID:24449424
GO:0006561 Proline biosynthetic process Increases phenotype PMID:27514991
GO:0006571 Tyrosine biosynthetic process Affects phenotype PMID:31121516
GO:0006577 Amino-acid betaine metabolic process Affects phenotype PMID:31778932
GO:0006590 Thyroid hormone generation Affects phenotype PMID:30761779; PMID:30761779; PMID:31979393; PMID:31979393
GO:0006600 Creatine metabolic process Affects phenotype PMID:35192832
GO:0006606 Protein import into nucleus Affects phenotype PMID:32360864; PMID:33437163; PMID:37257343; PMID:37414130
GO:0006629 Lipid metabolic process Increases phenotype PMID:24755147; PMID:24768697; PMID:31820560; PMID:35622622; PMID:36597173; PMID:36632902; PMID:39742910
GO:0006631 Fatty acid metabolic process Affects phenotype PMID:24768697; PMID:32071231; PMID:33221593; PMID:34165232; PMID:34165232; PMID:35504408; PMID:34165232; PMID:35504408; PMID:37570835; PMID:35504408; PMID:36632902; PMID:36835180; PMID:37570835; PMID:37718616; PMID:38048832
GO:0006633 Fatty acid biosynthetic process Increases phenotype PMID:27014939; PMID:30145421; PMID:34165232
GO:0006635 Fatty acid beta-oxidation Decreases phenotype PMID:34165232
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:24768697; PMID:31551937; PMID:34165232; PMID:35890622; PMID:36597173; PMID:31551937; PMID:31661889; PMID:34165232; PMID:37570835; PMID:31551937; PMID:34165232; PMID:35890622; PMID:36597173; PMID:31661889; PMID:31842455; PMID:32623698; PMID:32623698; PMID:33221593; PMID:37701206; PMID:37755785; PMID:32623698; PMID:37701206; PMID:37755785; PMID:33221593; PMID:33265944; PMID:34067838; PMID:34165232; PMID:34801515; PMID:36291063; PMID:36597173; PMID:36670177; PMID:37105096; PMID:37570835; PMID:37701206; PMID:37755785
GO:0006665 Sphingolipid metabolic process Affects phenotype PMID:33243495
GO:0006672 Ceramide metabolic process Affects phenotype PMID:38048832
GO:0006693 Prostaglandin metabolic process Affects phenotype PMID:38882385
GO:0006694 Steroid biosynthetic process Decreases phenotype PMID:24025742
GO:0006695 Cholesterol biosynthetic process Affects phenotype PMID:25168180; PMID:31470036; PMID:30997025; PMID:31126612; PMID:31270304; PMID:31470036; PMID:31979393
GO:0006699 Bile acid biosynthetic process Increases phenotype PMID:28549143
GO:0006701 Progesterone biosynthetic process Affects phenotype PMID:24769007; PMID:28859904; PMID:31063457; PMID:31424294
GO:0006702 Androgen biosynthetic process Increases phenotype PMID:23967237
GO:0006703 Estrogen biosynthetic process Increases phenotype PMID:24134786; PMID:28697429; PMID:28739533; PMID:24305612; PMID:24403293; PMID:24532816; PMID:24532816; PMID:24769007; PMID:28697429; PMID:28970132; PMID:29501275; PMID:31063457; PMID:31352099; PMID:31374317
GO:0006749 Glutathione metabolic process Increases phenotype PMID:27925325; PMID:30641872; PMID:33315269; PMID:35890622; PMID:27925325; PMID:30641872; PMID:35890622; PMID:28259788; PMID:30057697; PMID:30641872; PMID:30641872; PMID:31091348; PMID:31091348; PMID:31778932; PMID:36432690; PMID:31875995; PMID:32153214; PMID:32153214; PMID:37843661; PMID:32339907; PMID:32963736; PMID:33315269; PMID:34067838; PMID:35187753; PMID:35427877; PMID:35648353; PMID:35699857; PMID:36235125; PMID:36966614; PMID:37718616; PMID:37843661; PMID:38326183; PMID:38348715; PMID:39736419
GO:0006750 Glutathione biosynthetic process Affects phenotype PMID:21840368; PMID:22269103; PMID:22269103; PMID:24909818; PMID:22623521; PMID:24472609; PMID:24909818; PMID:25112833; PMID:25344109; PMID:25454643; PMID:26450347; PMID:28689058; PMID:28796629; PMID:30496632; PMID:30997025; PMID:30526071; PMID:30526071; PMID:30997025; PMID:30997025
GO:0006751 Glutathione catabolic process Increases phenotype PMID:38029875
GO:0006754 Atp biosynthetic process Affects phenotype PMID:24768697; PMID:24909818; PMID:25772901; PMID:26512966; PMID:28709040; PMID:28774890; PMID:29079494; PMID:30841469; PMID:31387175; PMID:31830493
GO:0006757 Atp generation from adp Decreases phenotype PMID:35598803
GO:0006805 Xenobiotic metabolic process Increases phenotype PMID:29162470
GO:0006809 Nitric oxide biosynthetic process Increases phenotype PMID:18246544; PMID:22446810; PMID:25103225; PMID:29964091; PMID:30609183; PMID:31416231; PMID:32629208
GO:0006865 Amino acid transport Affects phenotype PMID:32363662
GO:0006874 Cellular calcium ion homeostasis Affects phenotype PMID:31566189; PMID:31830493; PMID:33408296; PMID:33582411; PMID:34748853
GO:0006909 Phagocytosis Decreases phenotype PMID:26133781; PMID:30398665
GO:0006914 Autophagy Increases phenotype PMID:37257343
GO:0006915 Apoptotic process Increases phenotype PMID:11906184; PMID:14703490; PMID:16909604; PMID:18521933; PMID:19193734; PMID:19193734; PMID:26863571; PMID:20807545; PMID:22269103; PMID:22269103; PMID:24905940; PMID:23788033; PMID:23900028; PMID:24134786; PMID:25461564; PMID:27296223; PMID:37915476; PMID:24156707; PMID:24257414; PMID:24464975; PMID:24464975; PMID:27189055; PMID:24809654; PMID:24884420; PMID:25454643; PMID:25461909; PMID:26397976; PMID:26512966; PMID:26512966; PMID:35563431; PMID:27174447; PMID:27189055; PMID:28446726; PMID:31489793; PMID:36451259; PMID:28910977; PMID:28928807; PMID:29846718; PMID:30467747; PMID:30841469; PMID:31201698; PMID:31263496; PMID:31400064; PMID:31453682; PMID:31489793; PMID:36451259; PMID:31629898; PMID:31756439; PMID:31916403; PMID:32407858; PMID:32714078; PMID:32753632; PMID:33509759; PMID:33582411; PMID:33771661; PMID:34186417; PMID:34434659; PMID:34439521; PMID:34537452; PMID:34585602; PMID:35187753; PMID:35219798; PMID:35439536; PMID:35461094; PMID:35461094; PMID:35563431; PMID:35563431; PMID:36181250; PMID:36442689; PMID:36451259; PMID:36549428; PMID:36613676; PMID:36966614; PMID:37009741; PMID:37257343; PMID:37394128; PMID:38372072; PMID:38421590; PMID:39216304
GO:0006950 Response to stress Affects phenotype PMID:35427877
GO:0006954 Inflammatory response Increases phenotype PMID:31788436; PMID:32012983; PMID:32144343; PMID:34067838; PMID:34281243; PMID:34838672; PMID:35622622; PMID:36466761; PMID:37570835
GO:0006974 Cellular response to dna damage stimulus Affects phenotype PMID:19591892; PMID:24901218; PMID:26916392; PMID:25344109; PMID:28446726; PMID:29477810; PMID:30526071; PMID:30678825; PMID:30841469; PMID:31207516; PMID:31489793; PMID:34434659; PMID:34585602; PMID:35219798
GO:0006979 Response to oxidative stress Increases phenotype PMID:12767684; PMID:24604882; PMID:34619205
GO:0007005 Mitochondrion organization Decreases phenotype PMID:24105817; PMID:25448896; PMID:25461564; PMID:30641872; PMID:31830493; PMID:36830956; PMID:36966614; PMID:38882385
GO:0007028 Cytoplasm organization Decreases phenotype PMID:25448896
GO:0007033 Vacuole organization Increases phenotype PMID:25448896; PMID:34434659; PMID:36549428
GO:0007049 Cell cycle Decreases phenotype PMID:11906184; PMID:15879462
GO:0007058 Spindle assembly involved in female meiosis ii Decreases phenotype PMID:29958887
GO:0007094 Mitotic spindle assembly checkpoint signaling Increases phenotype PMID:30980863
GO:0007099 Centriole replication Increases phenotype PMID:30980863
GO:0007128 Meiotic prophase i Affects phenotype PMID:40036665
GO:0007129 Homologous chromosome pairing at meiosis Decreases phenotype PMID:25181051
GO:0007130 Synaptonemal complex assembly Affects phenotype PMID:40036665
GO:0007133 Meiotic anaphase i Increases phenotype PMID:29458137
GO:0007134 Meiotic telophase i Increases phenotype PMID:29458137
GO:0007137 Meiotic metaphase ii Increases phenotype PMID:29458137
GO:0007140 Male meiotic nuclear division Affects phenotype PMID:22951085; PMID:24085620
GO:0007141 Male meiosis i Decreases phenotype PMID:23788033; PMID:25181051
GO:0007144 Female meiosis i Affects phenotype PMID:40036665
GO:0007155 Cell adhesion Increases phenotype PMID:25096985
GO:0007166 Cell surface receptor signaling pathway Increases phenotype PMID:28255459
GO:0007202 Activation of phospholipase c activity Increases phenotype PMID:24140712
GO:0007204 Positive regulation of cytosolic calcium ion concentration Increases phenotype PMID:29214717; PMID:29960846; PMID:30022450; PMID:30036487
GO:0007214 Gamma-aminobutyric acid signaling pathway Affects phenotype PMID:23791455
GO:0007254 Jnk cascade Increases phenotype PMID:24349194; PMID:29793316
GO:0007267 Cell-cell signaling Decreases phenotype PMID:28736254
GO:0007281 Germ cell development Decreases phenotype PMID:29741722; PMID:31532523
GO:0007283 Spermatogenesis Decreases phenotype PMID:22951085; PMID:25575453; PMID:29940534; PMID:27539358; PMID:30755151; PMID:29741722; PMID:30228064; PMID:30275377; PMID:31201698; PMID:31532523; PMID:31489793; PMID:36315628; PMID:32956838; PMID:34684636; PMID:35810996; PMID:36451259; PMID:38021376; PMID:36864339; PMID:37364641; PMID:37915476; PMID:38513920; PMID:38882385; PMID:39549767
GO:0007286 Spermatid development Decreases phenotype PMID:30245210
GO:0007339 Binding of sperm to zona pellucida Decreases phenotype PMID:28178360
GO:0007340 Acrosome reaction Decreases phenotype PMID:27125968
GO:0007382 Specification of segmental identity, maxillary segment Decreases phenotype PMID:31756439
GO:0007409 Axonogenesis Decreases phenotype PMID:33582411
GO:0007416 Synapse assembly Affects phenotype PMID:24820113
GO:0007420 Brain development Decreases phenotype PMID:24820113; PMID:33441873; PMID:31756439; PMID:33441873
GO:0007507 Heart development Decreases phenotype PMID:31756439
GO:0007548 Sex differentiation Decreases phenotype PMID:27841950; PMID:30001178
GO:0007565 Female pregnancy Decreases phenotype PMID:30629253
GO:0007566 Embryo implantation Decreases phenotype PMID:24769007; PMID:26026914; PMID:29605410; PMID:34831106; PMID:38431166
GO:0007584 Response to nutrient Increases phenotype PMID:31489946
GO:0007610 Behavior Decreases phenotype PMID:20049216; PMID:22543054; PMID:25307304; PMID:34788942; PMID:35560535; PMID:37926988
GO:0007611 Learning or memory Decreases phenotype PMID:24333847; PMID:34082316; PMID:37495067
GO:0007612 Learning Decreases phenotype PMID:24820113; PMID:32153214; PMID:32926169; PMID:33441873; PMID:37843661; PMID:35489422
GO:0007613 Memory Decreases phenotype PMID:24820113; PMID:30312744; PMID:33441873; PMID:33666843; PMID:37843661; PMID:38583549; PMID:39617347; PMID:30761779; PMID:31597243; PMID:32153214; PMID:32153214; PMID:38043803; PMID:32926169; PMID:33666843; PMID:34838597; PMID:34838597; PMID:35489422; PMID:36656826; PMID:37926988; PMID:38160929; PMID:38043803
GO:0007614 Short-term memory Decreases phenotype PMID:31064381
GO:0007618 Mating Affects phenotype PMID:30629253
GO:0007623 Circadian rhythm Affects phenotype PMID:34049886; PMID:36181250
GO:0007625 Grooming behavior Decreases phenotype PMID:33666843; PMID:39617347
GO:0007631 Feeding behavior Affects phenotype PMID:31979393; PMID:36633214; PMID:37105096
GO:0008016 Regulation of heart contraction Affects phenotype PMID:37567409
GO:0008121 Ubiquinol-cytochrome-c reductase activity Decreases phenotype PMID:31387175
GO:0008137 Nadh dehydrogenase (ubiquinone) activity Decreases phenotype PMID:22623521; PMID:26450347; PMID:30841469
GO:0008152 Metabolic process Affects phenotype PMID:22050967
GO:0008177 Succinate dehydrogenase (ubiquinone) activity Decreases phenotype PMID:21840368; PMID:22623521; PMID:24105817; PMID:26450347; PMID:31387175
GO:0008184 Glycogen phosphorylase activity Decreases phenotype PMID:26063408
GO:0008202 Steroid metabolic process Affects phenotype PMID:24563381
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:23756648; PMID:31551937; PMID:31661889; PMID:31551937; PMID:31661889; PMID:33985639; PMID:31661889; PMID:31842455; PMID:33221593; PMID:37701206; PMID:33985639; PMID:34067838; PMID:34165232; PMID:34165232; PMID:35890622; PMID:36597173; PMID:36597173; PMID:37701206
GO:0008206 Bile acid metabolic process Affects phenotype PMID:33985639; PMID:36632902
GO:0008210 Estrogen metabolic process Increases phenotype PMID:24563381; PMID:32071231; PMID:32407858; PMID:32753632; PMID:35429613; PMID:33582552; PMID:33753083; PMID:33802611; PMID:34537452; PMID:34929288
GO:0008217 Regulation of blood pressure Affects phenotype PMID:22851732; PMID:32574892; PMID:33625709
GO:0008219 Cell death Affects phenotype PMID:25693136; PMID:26537420; PMID:26822619; PMID:27364615; PMID:30609183; PMID:32144343; PMID:32512148; PMID:35479511
GO:0008234 Cysteine-type peptidase activity Increases phenotype PMID:33312107; PMID:33916708; PMID:35461094; PMID:35563431; PMID:37372067
GO:0008239 Dipeptidyl-peptidase activity Increases phenotype PMID:32428650
GO:0008253 5'-nucleotidase activity Affects phenotype PMID:32172062; PMID:32428650; PMID:32810514
GO:0008283 Cell population proliferation Increases phenotype PMID:15116845; PMID:15116845; PMID:18186328; PMID:24004914; PMID:24062438; PMID:24156707; PMID:24213142; PMID:24284790; PMID:24586459; PMID:24831732; PMID:25004094; PMID:25130739; PMID:27026707; PMID:28616630; PMID:28763032; PMID:28808208; PMID:17599374; PMID:18246544; PMID:18521933; PMID:18640724; PMID:26916392; PMID:19654912; PMID:20553123; PMID:22269103; PMID:22269103; PMID:24905940; PMID:24909818; PMID:28645579; PMID:22649256; PMID:24884420; PMID:23719110; PMID:23915859; PMID:23915859; PMID:24793927; PMID:24090592; PMID:24156707; PMID:24213142; PMID:25004094; PMID:25130739; PMID:28808208; PMID:24231368; PMID:24257414; PMID:24257414; PMID:32753632; PMID:24495410; PMID:24495410; PMID:24909818; PMID:24532171; PMID:24632125; PMID:24831732; PMID:24884420; PMID:24909818; PMID:25004094; PMID:25056133; PMID:25084756; PMID:25111128; PMID:25381574; PMID:25461909; PMID:25963729; PMID:26098999; PMID:26537420; PMID:26224478; PMID:26397976; PMID:26397976; PMID:29128613; PMID:26443714; PMID:26496021; PMID:26863571; PMID:26877094; PMID:26942597; PMID:27022677; PMID:27025157; PMID:27026707; PMID:28446726; PMID:28466560; PMID:28500084; PMID:28657538; PMID:28709040; PMID:28709040; PMID:37080528; PMID:28729173; PMID:28765096; PMID:28811233; PMID:28811233; PMID:33419253; PMID:28855101; PMID:28882636; PMID:28964603; PMID:29128613; PMID:29275510; PMID:29653259; PMID:33258555; PMID:30352284; PMID:30557795; PMID:30677511; PMID:30822521; PMID:30892605; PMID:31629898; PMID:31788436; PMID:32012983; PMID:32028606; PMID:32360864; PMID:32805339; PMID:33516137; PMID:34186418; PMID:36011004; PMID:36608567; PMID:37080528; PMID:37182577; PMID:37414130; PMID:37675141; PMID:37834465; PMID:38091676; PMID:38302795; PMID:38354435; PMID:38563870; PMID:38701888
GO:0008284 Positive regulation of cell population proliferation Increases phenotype PMID:23810794; PMID:25933419; PMID:25933419; PMID:27514991; PMID:28711546; PMID:28844962; PMID:29783106; PMID:35307500; PMID:35597549; PMID:26363202; PMID:27177772; PMID:27366082; PMID:27551335; PMID:27623287; PMID:27740625; PMID:27903287; PMID:28238728; PMID:28238728; PMID:30022450; PMID:28426875; PMID:28426875; PMID:29330934; PMID:32105160; PMID:28591870; PMID:28844962; PMID:28959593; PMID:29146198; PMID:29307715; PMID:29330934; PMID:29783106; PMID:30022450; PMID:30099086; PMID:30187510; PMID:30196065; PMID:31143956; PMID:31681507; PMID:32023790; PMID:32105160; PMID:33683587; PMID:34270681; PMID:34486460; PMID:35263089; PMID:38555994; PMID:38828452; PMID:39809339; PMID:40132786
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:29192164; PMID:29214717; PMID:29228121; PMID:29383186; PMID:29552716; PMID:29605410; PMID:29721103; PMID:29737898; PMID:30015891; PMID:30036487; PMID:30099677; PMID:30099677; PMID:32763284; PMID:32949729; PMID:30194976; PMID:30196065; PMID:30238673; PMID:30547568; PMID:32023790; PMID:32105160; PMID:32353385; PMID:32763284; PMID:32949729; PMID:33706241; PMID:34664771; PMID:34831106; PMID:34953956; PMID:35041905; PMID:35739755; PMID:36315628; PMID:36534918; PMID:38134982; PMID:38725370
GO:0008286 Insulin receptor signaling pathway Decreases phenotype PMID:24349194
GO:0008291 Acetylcholine metabolic process Increases phenotype PMID:35648353
GO:0008292 Acetylcholine biosynthetic process Decreases phenotype PMID:30761779
GO:0008343 Adult feeding behavior Affects phenotype PMID:31661889
GO:0008344 Adult locomotory behavior Increases phenotype PMID:34049886
GO:0008361 Regulation of cell size Affects phenotype PMID:27022676; PMID:33441873
GO:0008395 Steroid hydroxylase activity Decreases phenotype PMID:10879814; PMID:9708877
GO:0008458 Carnitine o-octanoyltransferase activity Decreases phenotype PMID:33265944
GO:0008542 Visual learning Decreases phenotype PMID:31064381; PMID:32629208; PMID:34838597; PMID:34838597; PMID:36656826
GO:0008584 Male gonad development Affects phenotype PMID:31201698; PMID:37164221; PMID:38882385; PMID:36864339
GO:0008585 Female gonad development Affects phenotype PMID:24576723; PMID:32156529
GO:0008608 Attachment of spindle microtubules to kinetochore Affects phenotype PMID:28178360
GO:0008610 Lipid biosynthetic process Increases phenotype PMID:26942597; PMID:26996129; PMID:30959087; PMID:26996129; PMID:27815650; PMID:28483554; PMID:30408883; PMID:31470036; PMID:34165232; PMID:36835180
GO:0008652 Amino acid biosynthetic process Affects phenotype PMID:31121516; PMID:31778932
GO:0009060 Aerobic respiration Increases phenotype PMID:29161229; PMID:30194976; PMID:36469784
GO:0009070 Serine family amino acid biosynthetic process Affects phenotype PMID:31121516
GO:0009085 Lysine biosynthetic process Affects phenotype PMID:31121516
GO:0009088 Threonine biosynthetic process Affects phenotype PMID:31121516
GO:0009094 L-phenylalanine biosynthetic process Affects phenotype PMID:31121516
GO:0009097 Isoleucine biosynthetic process Affects phenotype PMID:31121516
GO:0009099 Valine biosynthetic process Affects phenotype PMID:31121516
GO:0009306 Protein secretion Decreases phenotype PMID:35648353
GO:0009395 Phospholipid catabolic process Increases phenotype PMID:38029875
GO:0009408 Response to heat Increases phenotype PMID:31312012
GO:0009437 Carnitine metabolic process Affects phenotype PMID:38048832
GO:0009441 Glycolate metabolic process Affects phenotype PMID:32071231
GO:0009448 Gamma-aminobutyric acid metabolic process Affects phenotype PMID:39617347
GO:0009566 Fertilization Decreases phenotype PMID:25772901; PMID:28178360; PMID:28178360; PMID:36347119
GO:0009749 Response to glucose Decreases phenotype PMID:29175711
GO:0009790 Embryo development Decreases phenotype PMID:31756439; PMID:36347119
GO:0009886 Post-embryonic animal morphogenesis Affects phenotype PMID:22951085
GO:0010001 Glial cell differentiation Increases phenotype PMID:25381574; PMID:25963729
GO:0010424 Dna methylation on cytosine within a cg sequence Increases phenotype PMID:27312807; PMID:27334623; PMID:27415467; PMID:29721103; PMID:29721103; PMID:31451752; PMID:31601247; PMID:31906378; PMID:33022573; PMID:33391824; PMID:34089743; PMID:34788942; PMID:35504408; PMID:36469784; PMID:38898774
GO:0010452 Histone h3-k36 methylation Affects phenotype PMID:36347119; PMID:37315367
GO:0010459 Negative regulation of heart rate Increases phenotype PMID:22851732
GO:0010467 Gene expression Affects phenotype PMID:31004310
GO:0010508 Positive regulation of autophagy Increases phenotype PMID:27539358; PMID:35357751; PMID:38006930; PMID:38103660; PMID:38725370
GO:0010536 Positive regulation of activation of janus kinase activity Increases phenotype PMID:35699857
GO:0010669 Epithelial structure maintenance Decreases phenotype PMID:29903210; PMID:36315628
GO:0010718 Positive regulation of epithelial to mesenchymal transition Increases phenotype PMID:26546977; PMID:27480627; PMID:28844962; PMID:29323181; PMID:29718440; PMID:35597549; PMID:39809339
GO:0010729 Positive regulation of hydrogen peroxide biosynthetic process Increases phenotype PMID:39260547
GO:0010742 Macrophage derived foam cell differentiation Increases phenotype PMID:24755147
GO:0010759 Positive regulation of macrophage chemotaxis Increases phenotype PMID:25862758; PMID:28903498; PMID:29161229; PMID:29737898
GO:0010761 Fibroblast migration Increases phenotype PMID:35051763
GO:0010801 Negative regulation of peptidyl-threonine phosphorylation Affects phenotype PMID:30228064; PMID:34664771
GO:0010811 Positive regulation of cell-substrate adhesion Increases phenotype PMID:32559890
GO:0010820 Positive regulation of t cell chemotaxis Increases phenotype PMID:29161229; PMID:35533451
GO:0010825 Positive regulation of centrosome duplication Increases phenotype PMID:27998958
GO:0010826 Negative regulation of centrosome duplication Decreases phenotype PMID:27998958
GO:0010867 Positive regulation of triglyceride biosynthetic process Increases phenotype PMID:39260547
GO:0010884 Positive regulation of lipid storage Increases phenotype PMID:26944108; PMID:27273607; PMID:29410257; PMID:30133442; PMID:32353385; PMID:39537008
GO:0010886 Positive regulation of cholesterol storage Increases phenotype PMID:27502578
GO:0010890 Positive regulation of sequestering of triglyceride Increases phenotype PMID:26820058; PMID:27502578; PMID:32763284
GO:0010906 Regulation of glucose metabolic process Affects phenotype PMID:35739755; PMID:37364641
GO:0010907 Positive regulation of glucose metabolic process Increases phenotype PMID:36328215
GO:0010917 Negative regulation of mitochondrial membrane potential Increases phenotype PMID:32040846; PMID:33039870; PMID:34664771; PMID:35427877; PMID:38006930
GO:0010918 Positive regulation of mitochondrial membrane potential Affects phenotype PMID:25572651; PMID:32515636
GO:0010940 Positive regulation of necrotic cell death Increases phenotype PMID:29552716; PMID:30057697; PMID:35887390
GO:0010942 Positive regulation of cell death Increases phenotype PMID:25534675; PMID:26196221; PMID:27491884; PMID:27825933; PMID:28959593; PMID:29161229; PMID:29958887; PMID:30196065; PMID:30228064; PMID:32023790; PMID:33706241; PMID:34831106; PMID:38440074
GO:0010952 Positive regulation of peptidase activity Increases phenotype PMID:32428650
GO:0010972 Negative regulation of g2/m transition of mitotic cell cycle Increases phenotype PMID:35041905
GO:0010975 Regulation of neuron projection development Affects phenotype PMID:38750585
GO:0010976 Positive regulation of neuron projection development Affects phenotype PMID:27903287; PMID:37843801
GO:0010983 Positive regulation of high-density lipoprotein particle clearance Increases phenotype PMID:35945320; PMID:37211107; PMID:39260547
GO:0010989 Negative regulation of low-density lipoprotein particle clearance Increases phenotype PMID:35945320; PMID:37211107; PMID:39260547
GO:0014002 Astrocyte development Decreases phenotype PMID:35560535
GO:0014008 Positive regulation of microglia differentiation Increases phenotype PMID:29248573
GO:0014063 Negative regulation of serotonin secretion Increases phenotype PMID:34082316
GO:0014808 Release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Increases phenotype PMID:24140712
GO:0014902 Myotube differentiation Decreases phenotype PMID:29680376; PMID:38701888
GO:0015705 Iodide transport Decreases phenotype PMID:30352396
GO:0015727 Lactate transport Affects phenotype PMID:37080528
GO:0015908 Fatty acid transport Affects phenotype PMID:32623698
GO:0015980 Energy derivation by oxidation of organic compounds Decreases phenotype PMID:31536778
GO:0016042 Lipid catabolic process Increases phenotype PMID:21840368; PMID:22623521; PMID:22623521; PMID:30526071; PMID:30997025; PMID:25111128; PMID:25112833; PMID:25454643; PMID:26450347; PMID:26788107; PMID:26822619; PMID:27296223; PMID:28285737; PMID:28285737; PMID:30997025; PMID:28689058; PMID:30496632; PMID:30997025; PMID:30526071; PMID:30526071; PMID:30997025; PMID:30641872; PMID:30641872; PMID:31091348; PMID:32172062; PMID:30997025; PMID:31064381; PMID:31091348; PMID:31387175; PMID:31424294; PMID:31453682; PMID:32172062; PMID:32701268; PMID:34067838; PMID:32810514; PMID:33265944; PMID:34067838; PMID:34097988
GO:0016049 Cell growth Increases phenotype PMID:26096086; PMID:26096086; PMID:28446726; PMID:28928807; PMID:29128613; PMID:30352284
GO:0016209 Antioxidant activity Decreases phenotype PMID:26376105; PMID:37682394
GO:0016264 Gap junction assembly Decreases phenotype PMID:29458137
GO:0016358 Dendrite development Affects phenotype PMID:24231043; PMID:32512148; PMID:35560535
GO:0016477 Cell migration Affects phenotype PMID:23915859; PMID:24997338; PMID:24997338; PMID:26407941; PMID:26027920; PMID:26363213; PMID:28709031; PMID:26407941; PMID:26604029; PMID:26855429; PMID:26869994; PMID:27025157; PMID:28466560; PMID:28709031; PMID:28709031; PMID:33437163; PMID:28808208; PMID:31230753; PMID:31629898; PMID:33437163; PMID:34910997; PMID:36011004
GO:0016571 Histone methylation Affects phenotype PMID:24533973; PMID:24604882
GO:0016573 Histone acetylation Increases phenotype PMID:24533973; PMID:25088689; PMID:25088689
GO:0016615 Malate dehydrogenase activity Decreases phenotype PMID:37718616
GO:0016887 Atp hydrolysis activity Affects phenotype PMID:26450347; PMID:29079494; PMID:30841469; PMID:31387175; PMID:32172062; PMID:32810514
GO:0017014 Protein nitrosylation Increases phenotype PMID:29960846
GO:0018158 Protein oxidation Affects phenotype PMID:25103225; PMID:26450347; PMID:29079494; PMID:31574244; PMID:34793900
GO:0018910 Benzene metabolic process Affects phenotype PMID:38734222
GO:0019058 Viral life cycle Decreases phenotype PMID:26684252
GO:0019216 Regulation of lipid metabolic process Affects phenotype PMID:27514991
GO:0019228 Neuronal action potential Increases phenotype PMID:31312012
GO:0019233 Sensory perception of pain Affects phenotype PMID:24189132
GO:0019249 Lactate biosynthetic process Increases phenotype PMID:25796683; PMID:28709040; PMID:30761779; PMID:31121516
GO:0019369 Arachidonic acid metabolic process Affects phenotype PMID:38882385
GO:0019370 Leukotriene biosynthetic process Increases phenotype PMID:23782309
GO:0019413 Acetate biosynthetic process Affects phenotype PMID:31121516
GO:0019432 Triglyceride biosynthetic process Affects phenotype PMID:23756648; PMID:24418828; PMID:24959901; PMID:24959901; PMID:28483554; PMID:28796629; PMID:31470036; PMID:25111128; PMID:25111128; PMID:28483554; PMID:28500084; PMID:25878060; PMID:27322340; PMID:28433925; PMID:28483554; PMID:28483554; PMID:31470036; PMID:28657538; PMID:30997025; PMID:28689058; PMID:28689058; PMID:31979393; PMID:30665118; PMID:30722647; PMID:30997025
GO:0019627 Urea metabolic process Affects phenotype PMID:39722417
GO:0019695 Choline metabolic process Increases phenotype PMID:24449424; PMID:31778932
GO:0021703 Locus ceruleus development Affects phenotype PMID:24985408
GO:0021766 Hippocampus development Affects phenotype PMID:32629208; PMID:33441873
GO:0021860 Pyramidal neuron development Affects phenotype PMID:30312744
GO:0021915 Neural tube development Decreases phenotype PMID:31756439
GO:0022008 Neurogenesis Increases phenotype PMID:17761398; PMID:25381574; PMID:25963729; PMID:35560535
GO:0022602 Ovulation cycle process Affects phenotype PMID:30629253; PMID:38200540
GO:0022904 Respiratory electron transport chain Affects phenotype PMID:24768697
GO:0030010 Establishment of cell polarity Decreases phenotype PMID:36608567
GO:0030030 Cell projection organization Increases phenotype PMID:25096985
GO:0030032 Lamellipodium assembly Increases phenotype PMID:37414130
GO:0030036 Actin cytoskeleton organization Affects phenotype PMID:32963737
GO:0030042 Actin filament depolymerization Increases phenotype PMID:24532171
GO:0030073 Insulin secretion Increases phenotype PMID:32339907
GO:0030097 Hemopoiesis Increases phenotype PMID:34067838
GO:0030154 Cell differentiation Affects phenotype PMID:27022677
GO:0030182 Neuron differentiation Affects phenotype PMID:25084756; PMID:25963729; PMID:28597690; PMID:31400064; PMID:37664457
GO:0030186 Melatonin metabolic process Affects phenotype PMID:36633214
GO:0030199 Collagen fibril organization Affects phenotype PMID:32370801; PMID:33265944; PMID:33582552; PMID:33912069; PMID:34281243; PMID:35051763; PMID:36466761; PMID:37570835; PMID:37718616; PMID:38027817
GO:0030262 Apoptotic nuclear changes Increases phenotype PMID:28959593
GO:0030263 Apoptotic chromosome condensation Increases phenotype PMID:30228064; PMID:33582411; PMID:34434659; PMID:36830956; PMID:37570835
GO:0030282 Bone mineralization Increases phenotype PMID:35780740
GO:0030283 Testosterone dehydrogenase [nad(p)] activity Decreases phenotype PMID:39313105; PMID:39549767
GO:0030284 Nuclear estrogen receptor activity Increases phenotype PMID:28255459
GO:0030307 Positive regulation of cell growth Affects phenotype PMID:27145005; PMID:27641926
GO:0030316 Osteoclast differentiation Decreases phenotype PMID:23900028
GO:0030317 Flagellated sperm motility Decreases phenotype PMID:24786630; PMID:25772901; PMID:27125968
GO:0030324 Lung development Affects phenotype PMID:26283537
GO:0030325 Adrenal gland development Affects phenotype PMID:24323913
GO:0030335 Positive regulation of cell migration Increases phenotype PMID:25534675; PMID:25690688; PMID:25690688; PMID:29718440; PMID:33683587; PMID:26546977; PMID:27366082; PMID:27480627; PMID:28844962; PMID:28844962; PMID:35597549; PMID:31143956; PMID:33683587; PMID:35597549; PMID:36232920; PMID:37308018; PMID:38555994; PMID:38828452; PMID:39809339; PMID:40132786
GO:0030336 Negative regulation of cell migration Increases phenotype PMID:34270681
GO:0030432 Peristalsis Decreases phenotype PMID:25884437
GO:0030502 Negative regulation of bone mineralization Increases phenotype PMID:35628159
GO:0030511 Positive regulation of transforming growth factor beta receptor signaling pathway Increases phenotype PMID:35069845
GO:0030513 Positive regulation of bmp signaling pathway Increases phenotype PMID:27740625
GO:0030520 Intracellular estrogen receptor signaling pathway Increases phenotype PMID:21831745; PMID:23211298; PMID:24284790; PMID:29192164; PMID:36513145
GO:0030534 Adult behavior Affects phenotype PMID:24857958
GO:0030728 Ovulation Decreases phenotype PMID:32407858
GO:0030838 Positive regulation of actin filament polymerization Increases phenotype PMID:39527977
GO:0030861 Negative regulation of polarized epithelial cell differentiation Increases phenotype PMID:35278557
GO:0030879 Mammary gland development Decreases phenotype PMID:24566421; PMID:28938483
GO:0030889 Negative regulation of b cell proliferation Increases phenotype PMID:29428349
GO:0030954 Astral microtubule nucleation Increases phenotype PMID:27998958
GO:0030964 Nadh dehydrogenase complex Decreases phenotype PMID:31387175
GO:0031116 Positive regulation of microtubule polymerization Increases phenotype PMID:27998958
GO:0031175 Neuron projection development Affects phenotype PMID:30953815; PMID:34838597
GO:0031324 Negative regulation of cellular metabolic process Increases phenotype PMID:32559890; PMID:34174261; PMID:35413382
GO:0031394 Positive regulation of prostaglandin biosynthetic process Increases phenotype PMID:33706241
GO:0031532 Actin cytoskeleton reorganization Increases phenotype PMID:31629898
GO:0031547 Brain-derived neurotrophic factor receptor signaling pathway Affects phenotype PMID:23185968
GO:0031585 Regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity Increases phenotype PMID:24140712
GO:0031589 Cell-substrate adhesion Affects phenotype PMID:32466334; PMID:32670863; PMID:34801682
GO:0031669 Cellular response to nutrient levels Increases phenotype PMID:27623287
GO:0031941 Filamentous actin Decreases phenotype PMID:32963737; PMID:36206637
GO:0031987 Locomotion involved in locomotory behavior Increases phenotype PMID:30761779; PMID:32297422; PMID:32810514; PMID:32926169; PMID:33666843; PMID:33666843; PMID:39617347; PMID:37843661; PMID:38152552
GO:0032024 Positive regulation of insulin secretion Increases phenotype PMID:35622622; PMID:38844119
GO:0032125 Micronucleus organization Increases phenotype PMID:30678825; PMID:35395335; PMID:39515574
GO:0032148 Activation of protein kinase b activity Increases phenotype PMID:27176707; PMID:27539358; PMID:30228064; PMID:29161229; PMID:29330934; PMID:29793316; PMID:30036487; PMID:30133442; PMID:30194976; PMID:30228064; PMID:31536778; PMID:32559890
GO:0032205 Negative regulation of telomere maintenance Increases phenotype PMID:29643374
GO:0032275 Luteinizing hormone secretion Increases phenotype PMID:24786630
GO:0032278 Positive regulation of gonadotropin secretion Increases phenotype PMID:31278978; PMID:35220427
GO:0032334 Inhibin secretion Decreases phenotype PMID:28637469
GO:0032355 Response to estradiol Decreases phenotype PMID:26898831; PMID:32319667
GO:0032466 Negative regulation of cytokinesis Increases phenotype PMID:35041905
GO:0032613 Interleukin-10 production Increases phenotype PMID:24189131
GO:0032620 Interleukin-17 production Increases phenotype PMID:24189131
GO:0032623 Interleukin-2 production Increases phenotype PMID:24189131
GO:0032755 Positive regulation of interleukin-6 production Increases phenotype PMID:33315269
GO:0032760 Positive regulation of tumor necrosis factor production Increases phenotype PMID:33315269; PMID:35699857
GO:0032774 Rna biosynthetic process Decreases phenotype PMID:22125951
GO:0032776 Dna methylation on cytosine Affects phenotype PMID:30196065; PMID:32636712; PMID:36347119
GO:0032780 Negative regulation of atp-dependent activity Increases phenotype PMID:32428650
GO:0032781 Positive regulation of atp-dependent activity Increases phenotype PMID:32428650
GO:0032869 Cellular response to insulin stimulus Decreases phenotype PMID:29935216; PMID:34186270
GO:0032874 Positive regulation of stress-activated mapk cascade Increases phenotype PMID:23900028
GO:0032922 Circadian regulation of gene expression Affects phenotype PMID:33297044
GO:0032930 Positive regulation of superoxide anion generation Increases phenotype PMID:29214717; PMID:33348264; PMID:38029875; PMID:39260547
GO:0032945 Negative regulation of mononuclear cell proliferation Increases phenotype PMID:29428349
GO:0032956 Regulation of actin cytoskeleton organization Decreases phenotype PMID:38828519
GO:0032964 Collagen biosynthetic process Increases phenotype PMID:27025157
GO:0032967 Positive regulation of collagen biosynthetic process Increases phenotype PMID:27177772
GO:0033077 T cell differentiation in thymus Affects phenotype PMID:35752395
GO:0033123 Positive regulation of purine nucleotide catabolic process Increases phenotype PMID:24449424
GO:0033147 Negative regulation of intracellular estrogen receptor signaling pathway Increases phenotype PMID:29958887
GO:0033148 Positive regulation of intracellular estrogen receptor signaling pathway Affects phenotype PMID:25371027; PMID:26139245; PMID:26898831; PMID:27366082; PMID:27473340; PMID:28711546; PMID:29330934; PMID:29330934; PMID:31388671; PMID:34831106
GO:0033183 Negative regulation of histone ubiquitination Increases phenotype PMID:35567931
GO:0033192 Calmodulin-dependent protein phosphatase activity Increases phenotype PMID:31830493
GO:0033313 Meiotic cell cycle checkpoint signaling Affects phenotype PMID:23788033; PMID:29458137
GO:0033327 Leydig cell differentiation Affects phenotype PMID:29524480; PMID:31201698; PMID:35810996
GO:0033574 Response to testosterone Decreases phenotype PMID:29778459
GO:0033685 Negative regulation of luteinizing hormone secretion Increases phenotype PMID:39239657
GO:0033686 Positive regulation of luteinizing hormone secretion Increases phenotype PMID:37448361
GO:0034063 Stress granule assembly Increases phenotype PMID:33431410; PMID:38734221
GO:0034103 Regulation of tissue remodeling Affects phenotype PMID:25862758
GO:0034109 Homotypic cell-cell adhesion Increases phenotype PMID:34049886; PMID:37610061
GO:0034116 Positive regulation of heterotypic cell-cell adhesion Increases phenotype PMID:33683587
GO:0034144 Negative regulation of toll-like receptor 4 signaling pathway Increases phenotype PMID:33706241
GO:0034197 Triglyceride transport Affects phenotype PMID:34801515
GO:0034199 Activation of protein kinase a activity Increases phenotype PMID:24140712
GO:0034377 Plasma lipoprotein particle assembly Affects phenotype PMID:30057697
GO:0034389 Lipid droplet organization Increases phenotype PMID:26820058
GO:0034440 Lipid oxidation Increases phenotype PMID:27539358; PMID:27539358; PMID:29940534; PMID:27539358; PMID:32339907; PMID:27925325; PMID:30057697; PMID:27925325; PMID:30057697; PMID:36597173; PMID:28202054; PMID:28259788; PMID:29793316; PMID:29940534; PMID:30036487; PMID:30057697; PMID:32040846; PMID:32428650; PMID:32963736; PMID:37843661; PMID:33173981; PMID:33315269; PMID:34664771; PMID:34797181; PMID:35648353; PMID:36432690; PMID:36597173; PMID:36632902; PMID:37718616; PMID:37843661; PMID:38326183; PMID:38348715; PMID:38882385
GO:0034454 Microtubule anchoring at centrosome Increases phenotype PMID:27998958
GO:0034501 Protein localization to kinetochore Affects phenotype PMID:30980863
GO:0034698 Response to gonadotropin Affects phenotype PMID:28648634
GO:0034772 Histone h4-k20 dimethylation Decreases phenotype PMID:40036665
GO:0035066 Positive regulation of histone acetylation Increases phenotype PMID:27182052
GO:0035115 Embryonic forelimb morphogenesis Affects phenotype PMID:31756439
GO:0035116 Embryonic hindlimb morphogenesis Decreases phenotype PMID:31756439
GO:0035148 Tube formation Increases phenotype PMID:24632125; PMID:30352284
GO:0035176 Social behavior Increases phenotype PMID:20691692; PMID:28641223; PMID:31188430; PMID:28747197; PMID:30580332; PMID:33666843; PMID:30761779; PMID:32297422; PMID:32518293; PMID:33666843; PMID:34049886
GO:0035640 Exploration behavior Decreases phenotype PMID:32450286; PMID:38152552; PMID:39617347
GO:0035641 Locomotory exploration behavior Increases phenotype PMID:24820113; PMID:33666843
GO:0035702 Monocyte homeostasis Affects phenotype PMID:37510359
GO:0035774 Positive regulation of insulin secretion involved in cellular response to glucose stimulus Increases phenotype PMID:27836638
GO:0035794 Positive regulation of mitochondrial membrane permeability Increases phenotype PMID:30196065
GO:0035809 Regulation of urine volume Affects phenotype PMID:29477810
GO:0035847 Uterine epithelium development Increases phenotype PMID:24769007; PMID:27473340
GO:0035934 Corticosterone secretion Increases phenotype PMID:24323913; PMID:38152552
GO:0035936 Testosterone secretion Increases phenotype PMID:24024361; PMID:24786630; PMID:24945889; PMID:30755151; PMID:31201698; PMID:31532523; PMID:35427877
GO:0035937 Estrogen secretion Affects phenotype PMID:33258555
GO:0035938 Estradiol secretion Increases phenotype PMID:24786630; PMID:29275510; PMID:30817981; PMID:31075703; PMID:31132128; PMID:31201698; PMID:31532523; PMID:31697385
GO:0036098 Male germ-line stem cell population maintenance Increases phenotype PMID:30245210
GO:0036123 Histone h3-k9 dimethylation Increases phenotype PMID:36347119
GO:0036124 Histone h3-k9 trimethylation Decreases phenotype PMID:24034936; PMID:28765096; PMID:36347119; PMID:36572933
GO:0036126 Sperm flagellum Affects phenotype PMID:38882385
GO:0036128 Catsper complex Decreases phenotype PMID:27125968
GO:0036164 Cell-abiotic substrate adhesion Decreases phenotype PMID:33024228
GO:0036211 Protein modification process Increases phenotype PMID:30953815
GO:0036269 Swimming behavior Affects phenotype PMID:32518293
GO:0036440 Citrate synthase activity Decreases phenotype PMID:31344369
GO:0036446 Myofibroblast differentiation Increases phenotype PMID:35051763
GO:0038179 Neurotrophin signaling pathway Affects phenotype PMID:23185968
GO:0040015 Negative regulation of multicellular organism growth Increases phenotype PMID:35278557
GO:0040016 Embryonic cleavage Decreases phenotype PMID:36347119
GO:0040018 Positive regulation of multicellular organism growth Affects phenotype PMID:27143994; PMID:27641926; PMID:29596923; PMID:32145629
GO:0040029 Epigenetic regulation of gene expression Affects phenotype PMID:31532523; PMID:33391824; PMID:38338858
GO:0040038 Polar body extrusion after meiotic divisions Affects phenotype PMID:28178360
GO:0042023 Dna endoreduplication Increases phenotype PMID:26027920
GO:0042048 Olfactory behavior Increases phenotype PMID:30185693
GO:0042098 T cell proliferation Increases phenotype PMID:38431166
GO:0042110 T cell activation Affects phenotype PMID:35752395
GO:0042116 Macrophage activation Increases phenotype PMID:28500084; PMID:31108126; PMID:32144343; PMID:37510359
GO:0042117 Monocyte activation Increases phenotype PMID:37510359
GO:0042127 Regulation of cell population proliferation Affects phenotype PMID:30196065; PMID:37084542
GO:0042133 Neurotransmitter metabolic process Affects phenotype PMID:32027964
GO:0042138 Meiotic dna double-strand break formation Increases phenotype PMID:23788033; PMID:24085620
GO:0042157 Lipoprotein metabolic process Increases phenotype PMID:32339907; PMID:32540565
GO:0042158 Lipoprotein biosynthetic process Increases phenotype PMID:37837293
GO:0042168 Heme metabolic process Affects phenotype PMID:29627605; PMID:30057697
GO:0042305 Specification of segmental identity, mandibular segment Decreases phenotype PMID:31756439
GO:0042307 Positive regulation of protein import into nucleus Increases phenotype PMID:27684650; PMID:29214717; PMID:29307715; PMID:30022450
GO:0042310 Vasoconstriction Increases phenotype PMID:36385337
GO:0042393 Histone binding Increases phenotype PMID:33022573
GO:0042403 Thyroid hormone metabolic process Affects phenotype PMID:34314248; PMID:37915476
GO:0042414 Epinephrine metabolic process Affects phenotype PMID:33912069
GO:0042417 Dopamine metabolic process Affects phenotype PMID:32071231; PMID:33666843; PMID:33666843; PMID:39617347; PMID:34505250
GO:0042428 Serotonin metabolic process Increases phenotype PMID:23567477; PMID:32071231; PMID:33666843; PMID:33666843; PMID:39617347; PMID:34505250
GO:0042445 Hormone metabolic process Affects phenotype PMID:20797929
GO:0042448 Progesterone metabolic process Affects phenotype PMID:32407858; PMID:33582552; PMID:34929288; PMID:35429613
GO:0042452 Deoxyguanosine biosynthetic process Affects phenotype PMID:35622622
GO:0042531 Positive regulation of tyrosine phosphorylation of stat protein Increases phenotype PMID:35699857
GO:0042540 Hemoglobin catabolic process Increases phenotype PMID:30057697
GO:0042552 Myelination Decreases phenotype PMID:25084756; PMID:27364615
GO:0042554 Superoxide anion generation Increases phenotype PMID:25103225; PMID:26450347; PMID:33024228; PMID:34793900; PMID:37718616
GO:0042593 Glucose homeostasis Decreases phenotype PMID:24705360; PMID:27502578; PMID:28959593; PMID:29935216; PMID:30057697; PMID:38042274
GO:0042630 Behavioral response to water deprivation Affects phenotype PMID:35644309
GO:0042632 Cholesterol homeostasis Decreases phenotype PMID:27502578; PMID:32540565; PMID:27641926; PMID:28959593; PMID:30057697; PMID:32540565; PMID:33243495; PMID:33315269; PMID:33315269; PMID:34505250; PMID:33315269; PMID:34505250; PMID:36137816; PMID:34505250; PMID:35341816; PMID:35622622; PMID:35739755; PMID:36137816
GO:0042701 Progesterone secretion Increases phenotype PMID:23672405; PMID:31075703; PMID:33258555; PMID:37182577
GO:0042713 Sperm ejaculation Decreases phenotype PMID:19906654
GO:0042733 Embryonic digit morphogenesis Affects phenotype PMID:38898774
GO:0042756 Drinking behavior Affects phenotype PMID:31661889; PMID:31979393; PMID:35644309
GO:0042775 Mitochondrial atp synthesis coupled electron transport Decreases phenotype PMID:25572651
GO:0042800 Histone h3k4 methyltransferase activity Affects phenotype PMID:31610501
GO:0042866 Pyruvate biosynthetic process Affects phenotype PMID:28709040; PMID:30761779
GO:0042908 Xenobiotic transport Increases phenotype PMID:29961922
GO:0042994 Cytoplasmic sequestering of transcription factor Increases phenotype PMID:27745655
GO:0043011 Myeloid dendritic cell differentiation Decreases phenotype PMID:29428349
GO:0043025 Neuronal cell body Increases phenotype PMID:30953815; PMID:33441873
GO:0043032 Positive regulation of macrophage activation Increases phenotype PMID:31143956; PMID:33239236; PMID:38828452
GO:0043046 Dna methylation involved in gamete generation Affects phenotype PMID:28582417
GO:0043061 Meiotic metaphase ii plate congression Decreases phenotype PMID:29958887
GO:0043065 Positive regulation of apoptotic process Affects phenotype PMID:24189131; PMID:25181051; PMID:26049153; PMID:26320837; PMID:27539358; PMID:27623287; PMID:27925325; PMID:33847390; PMID:35887390; PMID:29214717; PMID:29552716; PMID:38006930; PMID:30036487; PMID:32488702; PMID:32515636; PMID:33039870; PMID:34664771; PMID:35567931; PMID:37682394; PMID:35648353; PMID:35739755; PMID:35940389; PMID:36315628; PMID:36858637; PMID:37105472; PMID:37364641; PMID:37682394; PMID:38006930; PMID:38134982; PMID:38440074; PMID:38538260; PMID:38725370; PMID:38844119; PMID:39117098; PMID:39260547
GO:0043066 Negative regulation of apoptotic process Increases phenotype PMID:38828452
GO:0043084 Penile erection Decreases phenotype PMID:19906654; PMID:20467048
GO:0043123 Positive regulation of i-kappab kinase/nf-kappab signaling Increases phenotype PMID:29793316
GO:0043149 Stress fiber assembly Increases phenotype PMID:25096985; PMID:37414130
GO:0043197 Dendritic spine Decreases phenotype PMID:34838597; PMID:38043803
GO:0043262 Adp phosphatase activity Affects phenotype PMID:32172062; PMID:32428650; PMID:32810514
GO:0043306 Positive regulation of mast cell degranulation Increases phenotype PMID:31551929
GO:0043408 Regulation of mapk cascade Increases phenotype PMID:24231043
GO:0043491 Protein kinase b signaling Increases phenotype PMID:24464975
GO:0043507 Positive regulation of jun kinase activity Increases phenotype PMID:23900028
GO:0043513 Inhibin b complex Increases phenotype PMID:33256105
GO:0043929 Primary ovarian follicle growth involved in double layer follicle stage Decreases phenotype PMID:30675821
GO:0043966 Histone h3 acetylation Increases phenotype PMID:25748669; PMID:27697584; PMID:28496034; PMID:29718165
GO:0043967 Histone h4 acetylation Increases phenotype PMID:25748669; PMID:36572933
GO:0043970 Histone h3-k9 acetylation Affects phenotype PMID:28765096; PMID:34097993; PMID:34838597; PMID:34910997; PMID:36347119
GO:0043974 Histone h3-k27 acetylation Affects phenotype PMID:36306618
GO:0044022 Histone h3s28 kinase activity Affects phenotype PMID:36347119
GO:0044029 Hypomethylation of cpg island Increases phenotype PMID:27478869; PMID:30352284
GO:0044030 Regulation of dna methylation Decreases phenotype PMID:25853433; PMID:30001178; PMID:38338858
GO:0044154 Histone h3-k14 acetylation Increases phenotype PMID:36347119
GO:0044237 Cellular metabolic process Increases phenotype PMID:30467747; PMID:30467747; PMID:30552153; PMID:31601247; PMID:33181973; PMID:33376534; PMID:37315367; PMID:30552153; PMID:30615907; PMID:30841469; PMID:31016847; PMID:31400064; PMID:31601247; PMID:31610501; PMID:31714645; PMID:31715268; PMID:31733320; PMID:31812737; PMID:31830493; PMID:31916403; PMID:32144343; PMID:32244372; PMID:32363662; PMID:32512148; PMID:32610363; PMID:32636712; PMID:32753632; PMID:32963737; PMID:32976987; PMID:33024228; PMID:33181973; PMID:33376534; PMID:33441873; PMID:33509759; PMID:33582411; PMID:33662508; PMID:33771661; PMID:33841860; PMID:33916708; PMID:34186417; PMID:34439521; PMID:34474090; PMID:34602561; PMID:34655688; PMID:34743013; PMID:34748853; PMID:38211720; PMID:34910997; PMID:34929288; PMID:35219798; PMID:35457000; PMID:35461094; PMID:35563431; PMID:35996481; PMID:36181250; PMID:36277366; PMID:36306618; PMID:36336871; PMID:36466761; PMID:36549428; PMID:36613676; PMID:36674557; PMID:36982678; PMID:37009741; PMID:37080528; PMID:37143426; PMID:37257343; PMID:37315367; PMID:37372067; PMID:37394128; PMID:37610061; PMID:37915476; PMID:38211720; PMID:38326183; PMID:38372072; PMID:38421590; PMID:38701888; PMID:38892447; PMID:39216304; PMID:39736419
GO:0044255 Cellular lipid metabolic process Increases phenotype PMID:24472609; PMID:34323617
GO:0044307 Dendritic branch Increases phenotype PMID:34838597
GO:0044319 Wound healing, spreading of cells Increases phenotype PMID:25312822; PMID:25784559; PMID:27038254; PMID:27038254; PMID:28858478; PMID:32325111; PMID:28858478; PMID:30611077; PMID:31601247; PMID:32012983; PMID:32325111; PMID:32360864; PMID:32981897; PMID:33419253; PMID:33469997; PMID:34743013; PMID:35051763; PMID:37080528; PMID:37414130; PMID:38372072
GO:0044381 Glucose import in response to insulin stimulus Increases phenotype PMID:31536778
GO:0044527 Formation of peptidyl-cystine persulfide by sulphur transfer from h2s Decreases phenotype PMID:34314248
GO:0044565 Dendritic cell proliferation Increases phenotype PMID:29428349
GO:0044648 Histone h3-k4 dimethylation Increases phenotype PMID:25748669; PMID:35429613; PMID:36347119
GO:0044849 Estrous cycle Affects phenotype PMID:31132128; PMID:36136478
GO:0045019 Negative regulation of nitric oxide biosynthetic process Increases phenotype PMID:32428650
GO:0045023 G0 to g1 transition Increases phenotype PMID:30467747; PMID:31916403; PMID:35429799; PMID:36982678; PMID:38372072
GO:0045333 Cellular respiration Decreases phenotype PMID:33265944; PMID:34771623; PMID:36011004; PMID:37657410
GO:0045348 Positive regulation of mhc class ii biosynthetic process Increases phenotype PMID:29737898
GO:0045429 Positive regulation of nitric oxide biosynthetic process Increases phenotype PMID:29718165; PMID:29960846; PMID:30238673; PMID:32559890; PMID:33706241; PMID:34505250; PMID:37715411; PMID:38042274; PMID:38369087; PMID:39260547
GO:0045444 Fat cell differentiation Increases phenotype PMID:24155963; PMID:24418828; PMID:24503497; PMID:25068083; PMID:26942597; PMID:26996129; PMID:25143472; PMID:26996129; PMID:30408883; PMID:30665118; PMID:33254826; PMID:34186270; PMID:36469784; PMID:37105096
GO:0045454 Cell redox homeostasis Decreases phenotype PMID:38103660; PMID:39260547
GO:0045542 Positive regulation of cholesterol biosynthetic process Increases phenotype PMID:38029875; PMID:39260547
GO:0045600 Positive regulation of fat cell differentiation Increases phenotype PMID:26820058; PMID:26944108; PMID:27145005; PMID:27273607
GO:0045723 Positive regulation of fatty acid biosynthetic process Increases phenotype PMID:38029875
GO:0045738 Negative regulation of dna repair Increases phenotype PMID:33239236
GO:0045741 Positive regulation of epidermal growth factor-activated receptor activity Increases phenotype PMID:30022450
GO:0045766 Positive regulation of angiogenesis Increases phenotype PMID:37224931
GO:0045777 Positive regulation of blood pressure Affects phenotype PMID:33315269
GO:0045793 Positive regulation of cell size Increases phenotype PMID:28244015; PMID:28774890; PMID:36469784
GO:0045795 Positive regulation of cell volume Increases phenotype PMID:31830493; PMID:37755785
GO:0045821 Positive regulation of glycolytic process Increases phenotype PMID:31536778; PMID:36328215
GO:0045880 Positive regulation of smoothened signaling pathway Increases phenotype PMID:29307715
GO:0045919 Positive regulation of cytolysis Increases phenotype PMID:35220427; PMID:36235125
GO:0045930 Negative regulation of mitotic cell cycle Increases phenotype PMID:26604029; PMID:29383186; PMID:30036487; PMID:30467747; PMID:31916403; PMID:34664771
GO:0045931 Positive regulation of mitotic cell cycle Increases phenotype PMID:32023790; PMID:32387340; PMID:35307500
GO:0046034 Atp metabolic process Affects phenotype PMID:32949729; PMID:33312107; PMID:34474090; PMID:37080528
GO:0046082 5-methylcytosine biosynthetic process Increases phenotype PMID:30303745
GO:0046110 Xanthine metabolic process Affects phenotype PMID:31778932
GO:0046209 Nitric oxide metabolic process Increases phenotype PMID:30112920; PMID:30641872; PMID:31489946; PMID:32172062; PMID:32810514; PMID:33024228; PMID:33408296; PMID:34434659; PMID:34797181; PMID:36336871
GO:0046325 Negative regulation of glucose import Increases phenotype PMID:30133442; PMID:32976960
GO:0046326 Positive regulation of glucose import Increases phenotype PMID:36328215
GO:0046329 Negative regulation of jnk cascade Increases phenotype PMID:30036487
GO:0046415 Urate metabolic process Affects phenotype PMID:31091348
GO:0046449 Creatinine metabolic process Increases phenotype PMID:30997025; PMID:31091348; PMID:31091348; PMID:33985639; PMID:39722417; PMID:39722417
GO:0046460 Neutral lipid biosynthetic process Increases phenotype PMID:27014939
GO:0046462 Monoacylglycerol metabolic process Affects phenotype PMID:33243495
GO:0046466 Membrane lipid catabolic process Increases phenotype PMID:12767684; PMID:36858637
GO:0046470 Phosphatidylcholine metabolic process Affects phenotype PMID:38048832; PMID:38882385
GO:0046620 Regulation of organ growth Affects phenotype PMID:32145629
GO:0046621 Negative regulation of organ growth Increases phenotype PMID:32145629; PMID:35005817; PMID:35278557; PMID:36315628
GO:0046622 Positive regulation of organ growth Affects phenotype PMID:27473340; PMID:27830003; PMID:29323181; PMID:29596923; PMID:30228064; PMID:30675821; PMID:32488702; PMID:32145629; PMID:32488702; PMID:32518293; PMID:32540565; PMID:36214340
GO:0046627 Negative regulation of insulin receptor signaling pathway Increases phenotype PMID:29793316
GO:0046697 Decidualization Decreases phenotype PMID:28729173; PMID:29605410
GO:0046827 Positive regulation of protein export from nucleus Increases phenotype PMID:27384303
GO:0046881 Positive regulation of follicle-stimulating hormone secretion Increases phenotype PMID:35567931; PMID:37364641; PMID:37448361
GO:0046884 Follicle-stimulating hormone secretion Decreases phenotype PMID:30245359
GO:0046903 Secretion Increases phenotype PMID:32753632
GO:0046959 Habituation Decreases phenotype PMID:34601267
GO:0047810 D-alanine:2-oxoglutarate aminotransferase activity Increases phenotype PMID:26450347
GO:0047823 D-glutamyltransferase activity Increases phenotype PMID:29477810
GO:0048041 Focal adhesion assembly Increases phenotype PMID:25096985; PMID:25096985; PMID:32325111; PMID:32325111
GO:0048137 Spermatocyte division Decreases phenotype PMID:30245210
GO:0048143 Astrocyte activation Increases phenotype PMID:33254826
GO:0048484 Enteric nervous system development Affects phenotype PMID:36615857
GO:0048545 Response to steroid hormone Increases phenotype PMID:30387366
GO:0048663 Neuron fate commitment Decreases phenotype PMID:29479338
GO:0048699 Generation of neurons Affects phenotype PMID:36615857
GO:0048729 Tissue morphogenesis Affects phenotype PMID:35598803
GO:0048858 Cell projection morphogenesis Increases phenotype PMID:35250464
GO:0048870 Cell motility Affects phenotype PMID:24231043; PMID:24347325; PMID:24460192
GO:0048873 Homeostasis of number of cells within a tissue Decreases phenotype PMID:35598803
GO:0048874 Host-mediated regulation of intestinal microbiota composition Increases phenotype PMID:29778027
GO:0050000 Chromosome localization Decreases phenotype PMID:30980863
GO:0050665 Hydrogen peroxide biosynthetic process Increases phenotype PMID:30352396; PMID:31344369; PMID:31387175
GO:0050673 Epithelial cell proliferation Increases phenotype PMID:32353937
GO:0050679 Positive regulation of epithelial cell proliferation Increases phenotype PMID:26260748
GO:0050729 Positive regulation of inflammatory response Increases phenotype PMID:24824810; PMID:33847390; PMID:38029875; PMID:39788208
GO:0050746 Regulation of lipoprotein metabolic process Decreases phenotype PMID:28959593
GO:0050765 Negative regulation of phagocytosis Increases phenotype PMID:29718165; PMID:35628159
GO:0050767 Regulation of neurogenesis Affects phenotype PMID:34049886
GO:0050768 Negative regulation of neurogenesis Increases phenotype PMID:35069845
GO:0050808 Synapse organization Decreases phenotype PMID:32512148
GO:0050810 Regulation of steroid biosynthetic process Affects phenotype PMID:28973422
GO:0050890 Cognition Decreases phenotype PMID:34314248; PMID:34788942
GO:0050996 Positive regulation of lipid catabolic process Increases phenotype PMID:33847390; PMID:33847390; PMID:37682394; PMID:35567931; PMID:35887390; PMID:36153926; PMID:36153926; PMID:38440074; PMID:37448361; PMID:37682394; PMID:37715411; PMID:38042274; PMID:38103660; PMID:38440074; PMID:39117098; PMID:39260547; PMID:39549767
GO:0051001 Negative regulation of nitric-oxide synthase activity Increases phenotype PMID:29960846
GO:0051092 Positive regulation of nf-kappab transcription factor activity Increases phenotype PMID:27522653
GO:0051170 Import into nucleus Increases phenotype PMID:31415812
GO:0051225 Spindle assembly Affects phenotype PMID:28178360; PMID:30980863
GO:0051298 Centrosome duplication Increases phenotype PMID:36384894
GO:0051301 Cell division Increases phenotype PMID:31011801
GO:0051306 Mitotic sister chromatid separation Increases phenotype PMID:36384894
GO:0051315 Attachment of mitotic spindle microtubules to kinetochore Decreases phenotype PMID:30980863
GO:0051320 S phase Affects phenotype PMID:30615907
GO:0051321 Meiotic cell cycle Affects phenotype PMID:26863571
GO:0051345 Positive regulation of hydrolase activity Increases phenotype PMID:32428650
GO:0051346 Negative regulation of hydrolase activity Affects phenotype PMID:32428650
GO:0051491 Positive regulation of filopodium assembly Increases phenotype PMID:38555994
GO:0051496 Positive regulation of stress fiber assembly Increases phenotype PMID:39527977
GO:0051568 Histone h3-k4 methylation Increases phenotype PMID:36347119
GO:0051598 Meiotic recombination checkpoint signaling Increases phenotype PMID:25181051
GO:0051607 Defense response to virus Decreases phenotype PMID:37855322
GO:0051726 Regulation of cell cycle Increases phenotype PMID:31750923
GO:0051881 Regulation of mitochondrial membrane potential Increases phenotype PMID:24105817; PMID:24905940; PMID:24905940; PMID:24909818; PMID:25101517; PMID:26512966; PMID:30641872; PMID:30841469; PMID:32976987; PMID:33509759; PMID:33582411; PMID:34186417; PMID:35439536; PMID:36336871; PMID:36549428; PMID:36966614; PMID:37394128; PMID:37718616; PMID:37834465; PMID:38421590; PMID:39216304
GO:0051882 Mitochondrial depolarization Increases phenotype PMID:31404653; PMID:31830493; PMID:38029875
GO:0051897 Positive regulation of protein kinase b signaling Increases phenotype PMID:23900028
GO:0051899 Membrane depolarization Increases phenotype PMID:31312012; PMID:36549428
GO:0051901 Positive regulation of mitochondrial depolarization Increases phenotype PMID:29214717; PMID:30036487
GO:0051951 Positive regulation of glutamate uptake involved in transmission of nerve impulse Decreases phenotype PMID:28572023
GO:0051965 Positive regulation of synapse assembly Increases phenotype PMID:29278848
GO:0055069 Zinc ion homeostasis Affects phenotype PMID:32394729; PMID:33645299
GO:0055070 Copper ion homeostasis Decreases phenotype PMID:27690074; PMID:32394729; PMID:33645299
GO:0055072 Iron ion homeostasis Decreases phenotype PMID:27690074; PMID:38103660; PMID:38326183
GO:0055074 Calcium ion homeostasis Decreases phenotype PMID:18521933; PMID:20499049; PMID:26096086; PMID:26916392; PMID:27189055; PMID:27690074; PMID:28143888; PMID:28324061; PMID:28858478; PMID:29935216; PMID:30953815
GO:0055088 Lipid homeostasis Decreases phenotype PMID:32353385; PMID:33243495
GO:0055089 Fatty acid homeostasis Decreases phenotype PMID:32339907; PMID:33243495; PMID:35622622
GO:0055091 Phospholipid homeostasis Affects phenotype PMID:33243495; PMID:35890622; PMID:37718616
GO:0060004 Reflex Decreases phenotype PMID:25595991
GO:0060009 Sertoli cell development Increases phenotype PMID:30245210
GO:0060011 Sertoli cell proliferation Decreases phenotype PMID:30245210
GO:0060047 Heart contraction Decreases phenotype PMID:31566189
GO:0060048 Cardiac muscle contraction Decreases phenotype PMID:32144343
GO:0060081 Membrane hyperpolarization Increases phenotype PMID:28143888
GO:0060137 Maternal process involved in parturition Decreases phenotype PMID:30629253
GO:0060138 Fetal process involved in parturition Affects phenotype PMID:38431166
GO:0060179 Male mating behavior Decreases phenotype PMID:19906654; PMID:24265451
GO:0060180 Female mating behavior Increases phenotype PMID:24403293; PMID:31132128
GO:0060206 Estrous cycle phase Affects phenotype PMID:31129395
GO:0060207 Diestrus Increases phenotype PMID:31129395; PMID:32407858; PMID:38200540
GO:0060208 Proestrus Decreases phenotype PMID:31129395; PMID:36136478
GO:0060209 Estrus Affects phenotype PMID:24576723; PMID:29305326; PMID:36136478
GO:0060210 Metestrus Increases phenotype PMID:31129395; PMID:36136478
GO:0060291 Long-term synaptic potentiation Affects phenotype PMID:32714078
GO:0060292 Long-term synaptic depression Increases phenotype PMID:23645310
GO:0060322 Head development Increases phenotype PMID:21900077
GO:0060326 Cell chemotaxis Increases phenotype PMID:32466334; PMID:32981897; PMID:33469997; PMID:37080528; PMID:38091676; PMID:38372072
GO:0060348 Bone development Decreases phenotype PMID:28772150; PMID:34097993
GO:0060395 Smad protein signal transduction Increases phenotype PMID:27740625
GO:0060443 Mammary gland morphogenesis Affects phenotype PMID:26903627; PMID:32353937
GO:0060444 Branching involved in mammary gland duct morphogenesis Increases phenotype PMID:27178563
GO:0060526 Prostate glandular acinus morphogenesis Affects phenotype PMID:26260748
GO:0060545 Positive regulation of necroptotic process Increases phenotype PMID:30238673; PMID:37422542
GO:0060548 Negative regulation of cell death Increases phenotype PMID:37487893
GO:0060587 Regulation of lipoprotein lipid oxidation Increases phenotype PMID:39549767
GO:0060603 Mammary gland duct morphogenesis Decreases phenotype PMID:15919749; PMID:28938483
GO:0060612 Adipose tissue development Increases phenotype PMID:20019905; PMID:27187982; PMID:31551937; PMID:34165232; PMID:34165232; PMID:36469784; PMID:39886984
GO:0060613 Fat pad development Affects phenotype PMID:27641926; PMID:29220483
GO:0060737 Prostate gland morphogenetic growth Increases phenotype PMID:31771501
GO:0060741 Prostate gland stromal morphogenesis Affects phenotype PMID:26260748
GO:0060746 Parental behavior Decreases phenotype PMID:30003164
GO:0060763 Mammary duct terminal end bud growth Increases phenotype PMID:11566746; PMID:32353937; PMID:27178563; PMID:28487351
GO:0060935 Cardiac fibroblast cell differentiation Increases phenotype PMID:25862758
GO:0060996 Dendritic spine development Decreases phenotype PMID:34838597
GO:0060999 Positive regulation of dendritic spine development Increases phenotype PMID:29278848
GO:0061002 Negative regulation of dendritic spine morphogenesis Increases phenotype PMID:32027964; PMID:32278051
GO:0061028 Establishment of endothelial barrier Affects phenotype PMID:32144343
GO:0061053 Somite development Decreases phenotype PMID:31756439
GO:0061179 Negative regulation of insulin secretion involved in cellular response to glucose stimulus Increases phenotype PMID:38844119
GO:0061370 Testosterone biosynthetic process Increases phenotype PMID:23984391; PMID:24024361; PMID:33802611; PMID:38021376; PMID:24134786; PMID:28641706; PMID:24305612; PMID:35429613; PMID:35465754; PMID:36864339; PMID:37915476; PMID:38513920; PMID:24786630; PMID:25112706; PMID:29778459; PMID:27296223; PMID:28739533; PMID:30557795; PMID:27383665; PMID:28482050; PMID:28697429; PMID:28970132; PMID:29778459; PMID:30275377; PMID:29501275; PMID:31263496; PMID:31352099; PMID:31424294; PMID:31979393; PMID:33173981; PMID:33297044; PMID:33753083; PMID:33802611; PMID:38021376; PMID:33967032; PMID:34601267; PMID:35187753; PMID:35427877; PMID:35429613; PMID:35465754; PMID:35465754; PMID:36864339; PMID:37915476; PMID:38513920; PMID:38513920
GO:0061518 Microglial cell proliferation Increases phenotype PMID:35250464
GO:0061519 Macrophage homeostasis Affects phenotype PMID:37510359
GO:0061526 Acetylcholine secretion Decreases phenotype PMID:34655688
GO:0061548 Ganglion development Affects phenotype PMID:36982030
GO:0061827 Sperm head Affects phenotype PMID:38882385
GO:0070050 Neuron cellular homeostasis Affects phenotype PMID:35489422; PMID:39000048
GO:0070059 Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Increases phenotype PMID:35940389
GO:0070091 Glucagon secretion Decreases phenotype PMID:34165232; PMID:36674557
GO:0070174 Negative regulation of enamel mineralization Increases phenotype PMID:23764278; PMID:27257137
GO:0070254 Mucus secretion Decreases phenotype PMID:30841469
GO:0070265 Necrotic cell death Increases phenotype PMID:28689058; PMID:28689058; PMID:37570835; PMID:37372067; PMID:37394128; PMID:37570835; PMID:37915476; PMID:38513920
GO:0070266 Necroptotic process Increases phenotype PMID:32144343; PMID:36549428
GO:0070288 Ferritin complex Increases phenotype PMID:38882385
GO:0070296 Sarcoplasmic reticulum calcium ion transport Affects phenotype PMID:24569941
GO:0070327 Thyroid hormone transport Decreases phenotype PMID:28119167
GO:0070328 Triglyceride homeostasis Decreases phenotype PMID:27502578; PMID:32540565; PMID:28959593; PMID:32339907; PMID:30057697; PMID:32540565; PMID:33243495; PMID:33315269; PMID:33315269; PMID:34505250; PMID:36137816; PMID:35341816; PMID:35739755; PMID:36137816
GO:0070341 Fat cell proliferation Increases phenotype PMID:25909471; PMID:33265944
GO:0070343 White fat cell proliferation Increases phenotype PMID:37105096
GO:0070371 Erk1 and erk2 cascade Increases phenotype PMID:24189132; PMID:24349194
GO:0070373 Negative regulation of erk1 and erk2 cascade Increases phenotype PMID:29778459; PMID:30036487
GO:0070374 Positive regulation of erk1 and erk2 cascade Increases phenotype PMID:23900028; PMID:26363202; PMID:28255459; PMID:30022450
GO:0070471 Uterine smooth muscle contraction Decreases phenotype PMID:23664861
GO:0070509 Calcium ion import Increases phenotype PMID:28701262; PMID:28924161; PMID:30707916
GO:0070585 Protein localization to mitochondrion Increases phenotype PMID:30615907
GO:0070665 Positive regulation of leukocyte proliferation Increases phenotype PMID:29427786; PMID:29428349
GO:0070813 Hydrogen sulfide metabolic process Affects phenotype PMID:34314248
GO:0070859 Positive regulation of bile acid biosynthetic process Increases phenotype PMID:37211107
GO:0070958 Negative regulation of neutrophil mediated killing of gram-positive bacterium Increases phenotype PMID:30088793
GO:0070992 Translation initiation complex Affects phenotype PMID:33431410
GO:0070994 Detection of oxidative stress Increases phenotype PMID:26450347; PMID:30678825; PMID:32144343; PMID:33173981; PMID:33582552; PMID:34314248; PMID:34793900; PMID:35187753; PMID:35461094; PMID:35940389; PMID:36206637; PMID:36206637; PMID:39722417; PMID:36633214; PMID:36966614; PMID:37570835; PMID:37570835; PMID:39722417; PMID:37915476; PMID:38513920; PMID:38027817; PMID:38421590; PMID:38513920; PMID:39722417
GO:0071391 Cellular response to estrogen stimulus Increases phenotype PMID:24284790
GO:0071494 Cellular response to uv-c Affects phenotype PMID:26982218
GO:0071514 Genomic imprinting Decreases phenotype PMID:23593014; PMID:24034936
GO:0071542 Dopaminergic neuron differentiation Decreases phenotype PMID:27271280
GO:0071599 Otic vesicle development Decreases phenotype PMID:31756439
GO:0071625 Vocalization behavior Affects phenotype PMID:32297422
GO:0071674 Mononuclear cell migration Increases phenotype PMID:34067838
GO:0071743 Ige immunoglobulin complex, circulating Increases phenotype PMID:32909835
GO:0071838 Cell proliferation in bone marrow Decreases phenotype PMID:31788436
GO:0071897 Dna biosynthetic process Decreases phenotype PMID:22125951
GO:0071902 Positive regulation of protein serine/threonine kinase activity Increases phenotype PMID:27539358
GO:0072079 Nephron tubule formation Decreases phenotype PMID:36206637
GO:0072089 Stem cell proliferation Affects phenotype PMID:24424067; PMID:35479511
GO:0072520 Seminiferous tubule development Decreases phenotype PMID:30275377; PMID:31201698; PMID:33173981; PMID:33802611; PMID:38882385; PMID:35700937; PMID:37364641; PMID:39549767
GO:0072539 T-helper 17 cell differentiation Increases phenotype PMID:32911021
GO:0072540 T-helper 17 cell lineage commitment Increases phenotype PMID:32702508
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:18246544; PMID:18521933; PMID:20553123; PMID:20815788; PMID:24472609; PMID:24625398; PMID:24705360; PMID:24768697; PMID:24909818; PMID:25344109; PMID:30641872; PMID:31916403; PMID:32023790; PMID:33265944; PMID:33437163; PMID:33485121; PMID:33582411; PMID:34186417; PMID:34439521; PMID:34474090; PMID:34748853; PMID:38211720; PMID:34797181; PMID:35563431; PMID:36336871; PMID:36549428; PMID:36613676; PMID:36966614; PMID:37257343; PMID:37718616; PMID:37843661; PMID:38211720; PMID:38326183; PMID:39322090; PMID:39736419
GO:0072676 Lymphocyte migration Increases phenotype PMID:31788436; PMID:34281243
GO:0072677 Eosinophil migration Increases phenotype PMID:31788436; PMID:32012983
GO:0072682 Eosinophil extravasation Increases phenotype PMID:24950052
GO:0080090 Regulation of primary metabolic process Affects phenotype PMID:30208560
GO:0080182 Histone h3-k4 trimethylation Increases phenotype PMID:25088689; PMID:25088689; PMID:27182052; PMID:27384303; PMID:28765096; PMID:29425287; PMID:33022573; PMID:35429613; PMID:36572933
GO:0086003 Cardiac muscle cell contraction Increases phenotype PMID:25723814; PMID:28324061
GO:0086006 Voltage-gated sodium channel activity involved in cardiac muscle cell action potential Decreases phenotype PMID:34240201
GO:0090023 Positive regulation of neutrophil chemotaxis Increases phenotype PMID:30088793; PMID:35533451
GO:0090038 Negative regulation of protein kinase c signaling Increases phenotype PMID:32380187
GO:0090091 Positive regulation of extracellular matrix disassembly Increases phenotype PMID:27925325
GO:0090116 C-5 methylation of cytosine Increases phenotype PMID:28496034; PMID:30015891; PMID:30044229; PMID:30126118; PMID:31610501; PMID:32105160
GO:0090136 Epithelial cell-cell adhesion Decreases phenotype PMID:33485121
GO:0090181 Regulation of cholesterol metabolic process Increases phenotype PMID:35887390; PMID:35945320; PMID:37211107
GO:0090200 Positive regulation of release of cytochrome c from mitochondria Increases phenotype PMID:34664771
GO:0090207 Regulation of triglyceride metabolic process Increases phenotype PMID:35945320; PMID:37211107
GO:0090212 Negative regulation of establishment of blood-brain barrier Increases phenotype PMID:34082316
GO:0090240 Positive regulation of histone h4 acetylation Decreases phenotype PMID:28067316
GO:0090263 Positive regulation of canonical wnt signaling pathway Increases phenotype PMID:29718440
GO:0090297 Positive regulation of mitochondrial dna replication Increases phenotype PMID:30194976
GO:0090326 Positive regulation of locomotion involved in locomotory behavior Increases phenotype PMID:32518293
GO:0090398 Cellular senescence Increases phenotype PMID:29275510
GO:0090494 Dopamine uptake Increases phenotype PMID:27494678
GO:0090557 Establishment of endothelial intestinal barrier Decreases phenotype PMID:32540565
GO:0090648 Response to environmental enrichment Affects phenotype PMID:31597243
GO:0097006 Regulation of plasma lipoprotein particle levels Affects phenotype PMID:27502578; PMID:39788208
GO:0097050 Type b pancreatic cell apoptotic process Increases phenotype PMID:24189131
GO:0097062 Dendritic spine maintenance Decreases phenotype PMID:30953815; PMID:38160929
GO:0097198 Histone h3-k36 trimethylation Decreases phenotype PMID:25748669; PMID:36347119
GO:0097212 Lysosomal membrane organization Decreases phenotype PMID:34186417
GO:0097272 Ammonium homeostasis Decreases phenotype PMID:35648353
GO:0097298 Regulation of nucleus size Affects phenotype PMID:33258555
GO:0097327 Response to antineoplastic agent Decreases phenotype PMID:28426875
GO:0097621 Monoamine oxidase activity Decreases phenotype PMID:22623521
GO:0097676 Histone h3-k36 dimethylation Decreases phenotype PMID:29718165; PMID:37315367
GO:0097707 Ferroptosis Increases phenotype PMID:38326183
GO:0097722 Sperm motility Decreases phenotype PMID:30321649; PMID:30755151; PMID:31489793; PMID:35465754; PMID:36347119; PMID:38922122; PMID:36966614; PMID:37105472; PMID:37105472; PMID:37682394; PMID:39549767; PMID:37682394; PMID:37915476; PMID:38513920; PMID:39549767
GO:0097746 Blood vessel diameter maintenance Affects phenotype PMID:34434659
GO:0098532 Histone h3-k27 trimethylation Increases phenotype PMID:36347119
GO:0098582 Innate vocalization behavior Affects phenotype PMID:29912934
GO:0098609 Cell-cell adhesion Decreases phenotype PMID:31230753
GO:0098743 Cell aggregation Increases phenotype PMID:27740625
GO:0098781 Ncrna transcription Affects phenotype PMID:29552716
GO:0098868 Bone growth Decreases phenotype PMID:29732168
GO:0098928 Presynaptic signal transduction Affects phenotype PMID:37495067
GO:0098977 Inhibitory chemical synaptic transmission Increases phenotype PMID:31997638
GO:0099611 Regulation of action potential firing threshold Affects phenotype PMID:31312012
GO:0106292 Superoxide-generating nadph oxidase activity Increases phenotype PMID:29214717
GO:0110053 Regulation of actin filament organization Affects phenotype PMID:31750923
GO:0120041 Positive regulation of macrophage proliferation Decreases phenotype PMID:29428349
GO:0120193 Tight junction organization Decreases phenotype PMID:32540565
GO:0140042 Lipid droplet formation Increases phenotype PMID:29721103; PMID:31016361; PMID:31470036; PMID:32540565; PMID:32623698; PMID:36670177; PMID:37755785; PMID:31551937; PMID:31661889; PMID:33847390; PMID:36597173; PMID:31661889; PMID:32220626; PMID:32353385; PMID:32623698; PMID:32623698; PMID:36466761; PMID:37046073; PMID:32763284; PMID:33203037; PMID:35736896; PMID:35996481; PMID:36466761; PMID:36597173; PMID:36670177; PMID:36830956; PMID:37105096; PMID:37701206; PMID:37755785
GO:0140058 Neuron projection arborization Affects phenotype PMID:27903287; PMID:33441873
GO:0140059 Dendrite arborization Decreases phenotype PMID:32027964
GO:0140131 Positive regulation of lymphocyte chemotaxis Increases phenotype PMID:29737898; PMID:35533451
GO:0140253 Cell-cell fusion Increases phenotype PMID:31278978
GO:0140354 Lipid import into cell Affects phenotype PMID:35005817; PMID:35739755; PMID:38388800; PMID:38555994; PMID:39260547
GO:0140639 Positive regulation of pyroptosis Increases phenotype PMID:35439536
GO:0140949 Histone h3k9 trimethyltransferase activity Increases phenotype PMID:31610501
GO:0140951 Histone h3k27 trimethyltransferase activity Increases phenotype PMID:31610501
GO:0140952 Histone h3k27 dimethyltransferase activity Increases phenotype PMID:36347119
GO:0150063 Visual system development Decreases phenotype PMID:31756439
GO:0150071 Negative regulation of arginase activity Increases phenotype PMID:32428650
GO:0150072 Positive regulation of arginase activity Increases phenotype PMID:32428650
GO:0150078 Positive regulation of neuroinflammatory response Increases phenotype PMID:34082316
GO:0160020 Positive regulation of ferroptosis Increases phenotype PMID:36153926; PMID:38103660
GO:0160024 Leydig cell proliferation Increases phenotype PMID:36214340
GO:1900017 Positive regulation of cytokine production involved in inflammatory response Increases phenotype PMID:29846729; PMID:30398665
GO:1900110 Negative regulation of histone h3-k9 dimethylation Increases phenotype PMID:31532523
GO:1900113 Negative regulation of histone h3-k9 trimethylation Increases phenotype PMID:31532523
GO:1900114 Positive regulation of histone h3-k9 trimethylation Increases phenotype PMID:30015891
GO:1900182 Positive regulation of protein localization to nucleus Increases phenotype PMID:27745655; PMID:33706241
GO:1900193 Regulation of oocyte maturation Affects phenotype PMID:29458137
GO:1900194 Negative regulation of oocyte maturation Increases phenotype PMID:29958887
GO:1900271 Regulation of long-term synaptic potentiation Affects phenotype PMID:28255459
GO:1900272 Negative regulation of long-term synaptic potentiation Increases phenotype PMID:29278848
GO:1900273 Positive regulation of long-term synaptic potentiation Increases phenotype PMID:28255459; PMID:29278848
GO:1900408 Negative regulation of cellular response to oxidative stress Increases phenotype PMID:32153214
GO:1900409 Positive regulation of cellular response to oxidative stress Increases phenotype PMID:36315628; PMID:39260547
GO:1900745 Positive regulation of p38mapk cascade Increases phenotype PMID:27743673; PMID:29793316; PMID:30015891
GO:1900825 Regulation of membrane depolarization during cardiac muscle cell action potential Affects phenotype PMID:38310357
GO:1901142 Insulin metabolic process Affects phenotype PMID:24705360; PMID:33315269
GO:1901216 Positive regulation of neuron death Increases phenotype PMID:32380187
GO:1901224 Positive regulation of nik/nf-kappab signaling Increases phenotype PMID:27522653
GO:1901251 Positive regulation of lung goblet cell differentiation Increases phenotype PMID:29737898
GO:1901318 Negative regulation of flagellated sperm motility Increases phenotype PMID:26862991; PMID:30245359; PMID:31532523; PMID:36315628
GO:1901568 Fatty acid derivative metabolic process Affects phenotype PMID:29627605
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:30194976; PMID:30228064; PMID:30228064; PMID:39549767; PMID:31875995; PMID:33348264; PMID:34505250; PMID:34505250; PMID:35699857; PMID:34664771; PMID:35699857; PMID:35945320; PMID:39117098; PMID:39549767
GO:1901671 Positive regulation of superoxide dismutase activity Affects phenotype PMID:27539358; PMID:28259788; PMID:30228064; PMID:39260547
GO:1901676 Positive regulation of histone h3-k27 acetylation Decreases phenotype PMID:28067316
GO:1901687 Glutathione derivative biosynthetic process Decreases phenotype PMID:28959593; PMID:30057697
GO:1901726 Negative regulation of histone deacetylase activity Increases phenotype PMID:36534918
GO:1901989 Positive regulation of cell cycle phase transition Increases phenotype PMID:35041905
GO:1902093 Positive regulation of flagellated sperm motility Decreases phenotype PMID:27539358
GO:1902225 Negative regulation of acrosome reaction Increases phenotype PMID:38922122
GO:1902412 Regulation of mitotic cytokinesis Decreases phenotype PMID:36214340
GO:1902465 Negative regulation of histone h3-k27 trimethylation Increases phenotype PMID:29425287
GO:1902466 Positive regulation of histone h3-k27 trimethylation Increases phenotype PMID:27697584; PMID:30015891
GO:1902512 Positive regulation of apoptotic dna fragmentation Increases phenotype PMID:28959593; PMID:30228064
GO:1902552 Negative regulation of catalase activity Increases phenotype PMID:35699857; PMID:35945320; PMID:39117098; PMID:39549767
GO:1902553 Positive regulation of catalase activity Increases phenotype PMID:39260547
GO:1902618 Cellular response to fluoride Increases phenotype PMID:27257137
GO:1902807 Negative regulation of cell cycle g1/s phase transition Increases phenotype PMID:37105472
GO:1902847 Regulation of neuronal signal transduction Affects phenotype PMID:26934298
GO:1902849 Positive regulation of neuronal signal transduction Increases phenotype PMID:37392660
GO:1902884 Positive regulation of response to oxidative stress Increases phenotype PMID:33348264; PMID:35739755; PMID:39260547
GO:1902957 Negative regulation of mitochondrial electron transport, nadh to ubiquinone Increases phenotype PMID:35598803
GO:1903047 Mitotic cell cycle process Decreases phenotype PMID:30615907; PMID:30980863; PMID:31601247; PMID:31601247; PMID:32466334; PMID:32466334; PMID:33516137; PMID:34585602; PMID:35429799; PMID:36181250; PMID:36633214; PMID:36982678; PMID:38211720; PMID:38372072
GO:1903078 Positive regulation of protein localization to plasma membrane Increases phenotype PMID:33706241
GO:1903087 Mitotic spindle pole body duplication Affects phenotype PMID:36384894
GO:1903142 Positive regulation of establishment of endothelial barrier Increases phenotype PMID:32559890
GO:1903209 Positive regulation of oxidative stress-induced cell death Increases phenotype PMID:35622622
GO:1903249 Negative regulation of citrulline biosynthetic process Increases phenotype PMID:31489946
GO:1903283 Negative regulation of glutathione peroxidase activity Increases phenotype PMID:28490175; PMID:30057697; PMID:31875995; PMID:34505250; PMID:34505250; PMID:35699857; PMID:35699857
GO:1903284 Positive regulation of glutathione peroxidase activity Affects phenotype PMID:27539358; PMID:28259788; PMID:30228064; PMID:39260547
GO:1903353 Regulation of nucleus organization Affects phenotype PMID:31750923
GO:1903409 Reactive oxygen species biosynthetic process Affects phenotype PMID:25101517; PMID:25693136; PMID:26512966; PMID:26916392; PMID:26982218; PMID:27189055; PMID:28709031; PMID:29128613; PMID:29275510; PMID:29964091; PMID:30841469; PMID:30953815; PMID:31387175; PMID:31424294; PMID:31453682; PMID:35427877
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Affects phenotype PMID:25933419; PMID:26049153; PMID:26376105; PMID:28259788; PMID:29940534; PMID:30036487; PMID:30088793; PMID:30194976; PMID:32023790; PMID:32040846; PMID:32515636; PMID:33039870; PMID:34174261; PMID:34664771; PMID:35439536; PMID:35622622; PMID:36858637; PMID:37105472; PMID:37944787; PMID:38006930; PMID:38029875; PMID:38042274; PMID:38134982; PMID:38555994; PMID:38844119; PMID:39059691; PMID:39117098; PMID:39260547
GO:1903537 Meiotic cell cycle process involved in oocyte maturation Decreases phenotype PMID:28178360; PMID:40036665
GO:1903626 Positive regulation of dna catabolic process Increases phenotype PMID:35005817
GO:1903703 Enterocyte differentiation Affects phenotype PMID:38563870
GO:1903709 Uterine gland development Increases phenotype PMID:26898831; PMID:27473340; PMID:30892605
GO:1903753 Negative regulation of p38mapk cascade Increases phenotype PMID:30036487
GO:1903786 Regulation of glutathione biosynthetic process Decreases phenotype PMID:35887390
GO:1903787 Negative regulation of glutathione biosynthetic process Increases phenotype PMID:34505250; PMID:35567931; PMID:35945320; PMID:38042274; PMID:38440074
GO:1903923 Positive regulation of protein processing in phagocytic vesicle Increases phenotype PMID:30228064
GO:1903966 Monounsaturated fatty acid biosynthetic process Affects phenotype PMID:30145421
GO:1904000 Positive regulation of eating behavior Affects phenotype PMID:27641926; PMID:30057697
GO:1904027 Negative regulation of collagen fibril organization Increases phenotype PMID:37224931
GO:1904028 Positive regulation of collagen fibril organization Increases phenotype PMID:27925325
GO:1904077 Negative regulation of estrogen biosynthetic process Increases phenotype PMID:37944787
GO:1904078 Positive regulation of estrogen biosynthetic process Decreases phenotype PMID:27112698
GO:1904109 Positive regulation of cholesterol import Increases phenotype PMID:28057006
GO:1904146 Positive regulation of meiotic cell cycle process involved in oocyte maturation Increases phenotype PMID:29458137
GO:1904179 Positive regulation of adipose tissue development Increases phenotype PMID:27145005; PMID:27806752; PMID:29721103
GO:1904196 Negative regulation of granulosa cell proliferation Increases phenotype PMID:29958887
GO:1904214 Positive regulation of iodide transmembrane transport Decreases phenotype PMID:26827900
GO:1904238 Pericyte cell differentiation Decreases phenotype PMID:34884472
GO:1904251 Regulation of bile acid metabolic process Increases phenotype PMID:37211107
GO:1904446 Positive regulation of establishment of sertoli cell barrier Decreases phenotype PMID:26922907
GO:1904598 Positive regulation of connective tissue replacement involved in inflammatory response wound healing Increases phenotype PMID:35739755
GO:1904659 Glucose transmembrane transport Affects phenotype PMID:37080528
GO:1904878 Negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel Increases phenotype PMID:30298846
GO:1904879 Positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel Increases phenotype PMID:30298846
GO:1904995 Negative regulation of leukocyte adhesion to vascular endothelial cell Increases phenotype PMID:32559890
GO:1905069 Allantois development Decreases phenotype PMID:31756439
GO:1905075 Positive regulation of tight junction disassembly Increases phenotype PMID:34082316
GO:1905523 Positive regulation of macrophage migration Increases phenotype PMID:31143956
GO:1905628 Negative regulation of serotonin biosynthetic process Increases phenotype PMID:34082316
GO:1905656 Positive regulation of artery smooth muscle contraction Increases phenotype PMID:30298846
GO:1905665 Positive regulation of calcium ion import across plasma membrane Increases phenotype PMID:29476780
GO:1905707 Negative regulation of mitochondrial atp synthesis coupled proton transport Affects phenotype PMID:31536778
GO:1905710 Positive regulation of membrane permeability Increases phenotype PMID:31394344
GO:1990138 Neuron projection extension Affects phenotype PMID:27903287; PMID:31812737; PMID:33441873
GO:1990182 Exosomal secretion Increases phenotype PMID:39886984
GO:1990349 Gap junction-mediated intercellular transport Increases phenotype PMID:28087314; PMID:29458137; PMID:30187510; PMID:32610363; PMID:35413382
GO:1990375 Baculum development Affects phenotype PMID:37164221
GO:1990748 Cellular detoxification Increases phenotype PMID:28123100
GO:1990834 Response to odorant Increases phenotype PMID:30185693
GO:1990911 Response to psychosocial stress Increases phenotype PMID:30185693
GO:2000018 Regulation of male gonad development Affects phenotype PMID:29741722
GO:2000111 Positive regulation of macrophage apoptotic process Increases phenotype PMID:24189131
GO:2000184 Positive regulation of progesterone biosynthetic process Decreases phenotype PMID:27112698
GO:2000224 Regulation of testosterone biosynthetic process Decreases phenotype PMID:38440074
GO:2000225 Negative regulation of testosterone biosynthetic process Increases phenotype PMID:29940534; PMID:33297044; PMID:38538260; PMID:39239657
GO:2000253 Positive regulation of feeding behavior Increases phenotype PMID:32784060; PMID:36469784
GO:2000278 Regulation of dna biosynthetic process Affects phenotype PMID:31750923
GO:2000304 Positive regulation of ceramide biosynthetic process Increases phenotype PMID:39809339
GO:2000321 Positive regulation of t-helper 17 cell differentiation Increases phenotype PMID:27693988
GO:2000323 Negative regulation of glucocorticoid receptor signaling pathway Increases phenotype PMID:27522653
GO:2000355 Negative regulation of ovarian follicle development Increases phenotype PMID:29958887
GO:2000375 Negative regulation of oxygen metabolic process Increases phenotype PMID:29214717
GO:2000376 Positive regulation of oxygen metabolic process Increases phenotype PMID:31536778
GO:2000388 Positive regulation of antral ovarian follicle growth Increases phenotype PMID:28648634
GO:2000391 Positive regulation of neutrophil extravasation Increases phenotype PMID:29737898; PMID:32339907
GO:2000421 Positive regulation of eosinophil extravasation Increases phenotype PMID:27087817; PMID:29737898
GO:2000424 Positive regulation of eosinophil chemotaxis Increases phenotype PMID:35533451
GO:2000439 Positive regulation of monocyte extravasation Increases phenotype PMID:25862758
GO:2000463 Positive regulation of excitatory postsynaptic potential Increases phenotype PMID:28255459
GO:2000469 Negative regulation of peroxidase activity Increases phenotype PMID:29940534
GO:2000538 Positive regulation of b cell chemotaxis Increases phenotype PMID:35533451
GO:2000609 Regulation of thyroid hormone generation Affects phenotype PMID:32464474
GO:2000610 Negative regulation of thyroid hormone generation Increases phenotype PMID:29305326; PMID:32681327; PMID:37682394
GO:2000617 Positive regulation of histone h3-k9 acetylation Affects phenotype PMID:27478869; PMID:28067316; PMID:31610501
GO:2000648 Positive regulation of stem cell proliferation Increases phenotype PMID:30387366; PMID:35069845; PMID:36214340
GO:2000786 Positive regulation of autophagosome assembly Increases phenotype PMID:30228064; PMID:38006930
GO:2000822 Regulation of behavioral fear response Affects phenotype PMID:24333847
GO:2000835 Negative regulation of androgen secretion Increases phenotype PMID:38966215
GO:2000844 Negative regulation of testosterone secretion Increases phenotype PMID:29777495; PMID:29777495; PMID:30228064; PMID:35005817; PMID:35567931; PMID:29940534; PMID:35598803; PMID:36315628; PMID:35810996; PMID:37682394; PMID:39239657
GO:2000845 Positive regulation of testosterone secretion Affects phenotype PMID:25575453; PMID:27539358; PMID:28393075; PMID:29524480; PMID:30228064; PMID:30245359; PMID:34973380; PMID:36214340; PMID:37084542; PMID:37364641; PMID:37837293
GO:2000853 Negative regulation of corticosterone secretion Increases phenotype PMID:29737898
GO:2000854 Positive regulation of corticosterone secretion Increases phenotype PMID:26209791
GO:2000863 Positive regulation of estrogen secretion Decreases phenotype PMID:28959593
GO:2000865 Negative regulation of estradiol secretion Increases phenotype PMID:29228121; PMID:29777495; PMID:29958887; PMID:30194976; PMID:31753310; PMID:32488702; PMID:37084542; PMID:37448361; PMID:37837293
GO:2000866 Positive regulation of estradiol secretion Increases phenotype PMID:25575453; PMID:28393075; PMID:35598803; PMID:28648634; PMID:29323181; PMID:32380187; PMID:30245359; PMID:37084542; PMID:37364641; PMID:38440074; PMID:38966215
GO:2000871 Negative regulation of progesterone secretion Increases phenotype PMID:29228121; PMID:29777495; PMID:32488702; PMID:37448361; PMID:38966215
GO:2000872 Positive regulation of progesterone secretion Increases phenotype PMID:37084542
GO:2000978 Negative regulation of forebrain neuron differentiation Increases phenotype PMID:32027964
GO:2000987 Positive regulation of behavioral fear response Increases phenotype PMID:30185693
GO:2001057 Reactive nitrogen species metabolic process Increases phenotype PMID:31387175; PMID:33485121; PMID:36336871
GO:2001170 Negative regulation of atp biosynthetic process Affects phenotype PMID:29214717; PMID:38828519
GO:2001171 Positive regulation of atp biosynthetic process Increases phenotype PMID:30194976; PMID:35597549
GO:2001246 Negative regulation of phosphatidylcholine biosynthetic process Increases phenotype PMID:38029875
GO:2001257 Regulation of cation channel activity Decreases phenotype PMID:27125968
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.