Diethyl phthalate


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0001541 Ovarian follicle development Decreases phenotype PMID:34597818; PMID:35762964
GO:0001547 Antral ovarian follicle growth Decreases phenotype PMID:28013214
GO:0001568 Blood vessel development Increases phenotype PMID:37021957
GO:0004022 Alcohol dehydrogenase (nad+) activity Decreases phenotype PMID:34534558
GO:0004053 Arginase activity Increases phenotype PMID:35900689
GO:0004691 Camp-dependent protein kinase activity Increases phenotype PMID:33711355
GO:0006006 Glucose metabolic process Affects phenotype PMID:32129097
GO:0006171 Camp biosynthetic process Increases phenotype PMID:37552060
GO:0006694 Steroid biosynthetic process Decreases phenotype PMID:35762964
GO:0007281 Germ cell development Decreases phenotype PMID:30802670
GO:0007283 Spermatogenesis Decreases phenotype PMID:18570050; PMID:30802670; PMID:37364641
GO:0007286 Spermatid development Decreases phenotype PMID:30802670
GO:0008210 Estrogen metabolic process Affects phenotype PMID:34597818
GO:0008219 Cell death Increases phenotype PMID:33711355
GO:0008283 Cell population proliferation Affects phenotype PMID:24994688; PMID:34428494
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:35739755
GO:0008584 Male gonad development Affects phenotype PMID:30802670
GO:0009566 Fertilization Decreases phenotype PMID:33711355
GO:0009790 Embryo development Decreases phenotype PMID:33711355
GO:0010729 Positive regulation of hydrogen peroxide biosynthetic process Increases phenotype PMID:35900689
GO:0010744 Positive regulation of macrophage derived foam cell differentiation Increases phenotype PMID:26423653
GO:0010906 Regulation of glucose metabolic process Affects phenotype PMID:35739755; PMID:37364641
GO:0018108 Peptidyl-tyrosine phosphorylation Increases phenotype PMID:33711355
GO:0019752 Carboxylic acid metabolic process Affects phenotype PMID:39098565
GO:0030728 Ovulation Increases phenotype PMID:33316053
GO:0030850 Prostate gland development Decreases phenotype PMID:30802670
GO:0032308 Positive regulation of prostaglandin secretion Increases phenotype PMID:33316053
GO:0033327 Leydig cell differentiation Decreases phenotype PMID:29325824
GO:0034199 Activation of protein kinase a activity Increases phenotype PMID:37552060
GO:0035116 Embryonic hindlimb morphogenesis Decreases phenotype PMID:24503621
GO:0035176 Social behavior Decreases phenotype PMID:32518293
GO:0035936 Testosterone secretion Decreases phenotype PMID:28013214; PMID:30802670; PMID:31199487
GO:0035938 Estradiol secretion Decreases phenotype PMID:28013214
GO:0035941 Androstenedione secretion Decreases phenotype PMID:28013214
GO:0035943 Estrone secretion Decreases phenotype PMID:28013214
GO:0036269 Swimming behavior Affects phenotype PMID:32518293
GO:0036343 Psychomotor behavior Affects phenotype PMID:26108271
GO:0042159 Lipoprotein catabolic process Increases phenotype PMID:26423653
GO:0042161 Lipoprotein oxidation Increases phenotype PMID:26423653
GO:0042221 Response to chemical Increases phenotype PMID:34428494
GO:0042448 Progesterone metabolic process Affects phenotype PMID:34597818
GO:0042632 Cholesterol homeostasis Decreases phenotype PMID:35739755
GO:0042701 Progesterone secretion Affects phenotype PMID:33316053
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:33511402; PMID:35739755; PMID:37364641; PMID:37942807
GO:0044849 Estrous cycle Affects phenotype PMID:36929940
GO:0045019 Negative regulation of nitric oxide biosynthetic process Increases phenotype PMID:35900689
GO:0045792 Negative regulation of cell size Increases phenotype PMID:29325824
GO:0046034 Atp metabolic process Affects phenotype PMID:33711355
GO:0046621 Negative regulation of organ growth Increases phenotype PMID:29325824
GO:0046622 Positive regulation of organ growth Increases phenotype PMID:32518293
GO:0046881 Positive regulation of follicle-stimulating hormone secretion Increases phenotype PMID:37364641
GO:0048240 Sperm capacitation Increases phenotype PMID:33711355
GO:0048246 Macrophage chemotaxis Increases phenotype PMID:40323316
GO:0048599 Oocyte development Decreases phenotype PMID:28013214
GO:0050679 Positive regulation of epithelial cell proliferation Increases phenotype PMID:40323316
GO:0050729 Positive regulation of inflammatory response Increases phenotype PMID:31199487
GO:0050996 Positive regulation of lipid catabolic process Increases phenotype PMID:35900689
GO:0060305 Regulation of cell diameter Affects phenotype PMID:37021957
GO:0060376 Positive regulation of mast cell differentiation Increases phenotype PMID:37021957
GO:0060512 Prostate gland morphogenesis Decreases phenotype PMID:31199487
GO:0061107 Seminal vesicle development Decreases phenotype PMID:30802670
GO:0061370 Testosterone biosynthetic process Affects phenotype PMID:33983380; PMID:34597818
GO:0070328 Triglyceride homeostasis Decreases phenotype PMID:35739755
GO:0072520 Seminiferous tubule development Decreases phenotype PMID:30802670; PMID:37364641
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:24994688; PMID:32129097
GO:0090326 Positive regulation of locomotion involved in locomotory behavior Increases phenotype PMID:32518293
GO:0097722 Sperm motility Decreases phenotype PMID:30802670; PMID:33711355
GO:0140354 Lipid import into cell Increases phenotype PMID:35739755
GO:1900015 Regulation of cytokine production involved in inflammatory response Affects phenotype PMID:38954831
GO:1900017 Positive regulation of cytokine production involved in inflammatory response Increases phenotype PMID:40323316
GO:1902512 Positive regulation of apoptotic dna fragmentation Increases phenotype PMID:35900689
GO:1902884 Positive regulation of response to oxidative stress Increases phenotype PMID:35739755
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:30842373
GO:1903787 Negative regulation of glutathione biosynthetic process Increases phenotype PMID:35900689
GO:1903788 Positive regulation of glutathione biosynthetic process Increases phenotype PMID:37942807
GO:1904177 Regulation of adipose tissue development Affects phenotype PMID:37021957
GO:1904178 Negative regulation of adipose tissue development Increases phenotype PMID:37942807
GO:1904598 Positive regulation of connective tissue replacement involved in inflammatory response wound healing Increases phenotype PMID:35739755
GO:1904808 Positive regulation of protein oxidation Increases phenotype PMID:35900689
GO:1905867 Epididymis development Affects phenotype PMID:30802670
GO:2000184 Positive regulation of progesterone biosynthetic process Increases phenotype PMID:37552060
GO:2000225 Negative regulation of testosterone biosynthetic process Increases phenotype PMID:29325824; PMID:35739735
GO:2000611 Positive regulation of thyroid hormone generation Increases phenotype PMID:29734584
GO:2000774 Positive regulation of cellular senescence Increases phenotype PMID:26423653
GO:2000844 Negative regulation of testosterone secretion Increases phenotype PMID:37839492; PMID:39947446
GO:2000845 Positive regulation of testosterone secretion Increases phenotype PMID:37364641
GO:2000865 Negative regulation of estradiol secretion Increases phenotype PMID:37839492
GO:2000866 Positive regulation of estradiol secretion Increases phenotype PMID:37364641
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.