Aroclor 1254


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0001776 Leukocyte homeostasis Affects phenotype PMID:34994547
GO:0001780 Neutrophil homeostasis Affects phenotype PMID:34994547
GO:0002260 Lymphocyte homeostasis Affects phenotype PMID:34994547
GO:0003990 Acetylcholinesterase activity Decreases phenotype PMID:21472459
GO:0004111 Creatine kinase activity Decreases phenotype PMID:21472459
GO:0004602 Glutathione peroxidase activity Decreases phenotype PMID:35822628
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:35822628
GO:0006308 Dna catabolic process Increases phenotype PMID:35822628
GO:0006520 Amino acid metabolic process Affects phenotype PMID:34994547
GO:0006631 Fatty acid metabolic process Affects phenotype PMID:34994547
GO:0006749 Glutathione metabolic process Affects phenotype PMID:34265337; PMID:35822628
GO:0006979 Response to oxidative stress Increases phenotype PMID:19389042; PMID:24394491
GO:0007033 Vacuole organization Increases phenotype PMID:33592256
GO:0007283 Spermatogenesis Decreases phenotype PMID:35822628
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:34994547
GO:0008283 Cell population proliferation Decreases phenotype PMID:30578594
GO:0008284 Positive regulation of cell population proliferation Decreases phenotype PMID:29208485
GO:0008285 Negative regulation of cell population proliferation Affects phenotype PMID:24216299
GO:0010718 Positive regulation of epithelial to mesenchymal transition Increases phenotype PMID:27481218
GO:0016042 Lipid catabolic process Increases phenotype PMID:21472459; PMID:33592256
GO:0016887 Atp hydrolysis activity Decreases phenotype PMID:21472459
GO:0018158 Protein oxidation Increases phenotype PMID:21472459
GO:0019752 Carboxylic acid metabolic process Affects phenotype PMID:34994547
GO:0019858 Cytosine metabolic process Affects phenotype PMID:34994547
GO:0030103 Vasopressin secretion Decreases phenotype PMID:17434953
GO:0030199 Collagen fibril organization Increases phenotype PMID:33592256
GO:0030335 Positive regulation of cell migration Increases phenotype PMID:27481218
GO:0031323 Regulation of cellular metabolic process Affects phenotype PMID:28965233
GO:0031547 Brain-derived neurotrophic factor receptor signaling pathway Affects phenotype PMID:24394491
GO:0034116 Positive regulation of heterotypic cell-cell adhesion Decreases phenotype PMID:27481218
GO:0040018 Positive regulation of multicellular organism growth Decreases phenotype PMID:29208485
GO:0042127 Regulation of cell population proliferation Affects phenotype PMID:24216299
GO:0042403 Thyroid hormone metabolic process Affects phenotype PMID:33592256
GO:0042981 Regulation of apoptotic process Affects phenotype PMID:24216299
GO:0043065 Positive regulation of apoptotic process Affects phenotype PMID:24216299
GO:0044237 Cellular metabolic process Decreases phenotype PMID:35822628
GO:0045669 Positive regulation of osteoblast differentiation Decreases phenotype PMID:25795401
GO:0046034 Atp metabolic process Affects phenotype PMID:34265337
GO:0046323 Glucose import Affects phenotype PMID:34265337
GO:0046466 Membrane lipid catabolic process Increases phenotype PMID:19389042
GO:0046622 Positive regulation of organ growth Decreases phenotype PMID:29208485
GO:0048011 Neurotrophin trk receptor signaling pathway Affects phenotype PMID:24394491
GO:0050665 Hydrogen peroxide biosynthetic process Increases phenotype PMID:21472459
GO:0051726 Regulation of cell cycle Affects phenotype PMID:24216299
GO:0061370 Testosterone biosynthetic process Affects phenotype PMID:35822628
GO:0070994 Detection of oxidative stress Increases phenotype PMID:35822628
GO:0071475 Cellular hyperosmotic salinity response Increases phenotype PMID:28579251
GO:0071711 Basement membrane organization Decreases phenotype PMID:33592256
GO:0072593 Reactive oxygen species metabolic process Affects phenotype PMID:24394491; PMID:34265337
GO:0097722 Sperm motility Decreases phenotype PMID:35822628; PMID:35872225
GO:2000845 Positive regulation of testosterone secretion Decreases phenotype PMID:29208485
GO:2000866 Positive regulation of estradiol secretion Decreases phenotype PMID:29208485
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.