3,4,5,3',4'-Pentachlorobiphenyl


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000723 Telomere maintenance Affects phenotype PMID:26330309; PMID:26452299; PMID:33022284
GO:0001553 Luteinization Decreases phenotype PMID:34256052
GO:0001649 Osteoblast differentiation Decreases phenotype PMID:31820026
GO:0001780 Neutrophil homeostasis Affects phenotype PMID:29216392
GO:0001889 Liver development Increases phenotype PMID:26660635
GO:0001954 Positive regulation of cell-matrix adhesion Decreases phenotype PMID:28284859
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:26770886; PMID:28163111; PMID:37598416
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Increases phenotype PMID:33096110; PMID:39197524
GO:0004602 Glutathione peroxidase activity Decreases phenotype PMID:37598416
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:37598416
GO:0005975 Carbohydrate metabolic process Affects phenotype PMID:39197524
GO:0005977 Glycogen metabolic process Affects phenotype PMID:34848246
GO:0005981 Regulation of glycogen catabolic process Decreases phenotype PMID:27509375; PMID:29474705
GO:0006006 Glucose metabolic process Affects phenotype PMID:39197524
GO:0006094 Gluconeogenesis Decreases phenotype PMID:29474705
GO:0006111 Regulation of gluconeogenesis Affects phenotype PMID:26396156
GO:0006264 Mitochondrial dna replication Increases phenotype PMID:33677009
GO:0006306 Dna methylation Increases phenotype PMID:23933504
GO:0006629 Lipid metabolic process Affects phenotype PMID:23196670; PMID:33096110
GO:0006631 Fatty acid metabolic process Affects phenotype PMID:34848246; PMID:39197524
GO:0006633 Fatty acid biosynthetic process Increases phenotype PMID:30312631
GO:0006636 Unsaturated fatty acid biosynthetic process Decreases phenotype PMID:29947894
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:33096110; PMID:39197524
GO:0006672 Ceramide metabolic process Affects phenotype PMID:33096110
GO:0006695 Cholesterol biosynthetic process Decreases phenotype PMID:30312631
GO:0006805 Xenobiotic metabolic process Affects phenotype PMID:23196670
GO:0006878 Cellular copper ion homeostasis Affects phenotype PMID:26410179
GO:0006879 Cellular iron ion homeostasis Decreases phenotype PMID:25686467
GO:0006882 Cellular zinc ion homeostasis Affects phenotype PMID:26410179
GO:0006898 Receptor-mediated endocytosis Increases phenotype PMID:29329451
GO:0006954 Inflammatory response Increases phenotype PMID:33096110; PMID:39197524
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:26770886
GO:0006979 Response to oxidative stress Increases phenotype PMID:10771135
GO:0007049 Cell cycle Affects phenotype PMID:23196670
GO:0007154 Cell communication Affects phenotype PMID:23196670
GO:0007155 Cell adhesion Affects phenotype PMID:23196670
GO:0007173 Epidermal growth factor receptor signaling pathway Increases phenotype PMID:29329451
GO:0007179 Transforming growth factor beta receptor signaling pathway Affects phenotype PMID:23196670
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:34848246; PMID:39197524
GO:0008283 Cell population proliferation Increases phenotype PMID:15465647; PMID:25433332; PMID:38185387
GO:0008343 Adult feeding behavior Affects phenotype PMID:31820026
GO:0008610 Lipid biosynthetic process Increases phenotype PMID:26410179; PMID:26770886
GO:0010718 Positive regulation of epithelial to mesenchymal transition Increases phenotype PMID:28284859
GO:0016042 Lipid catabolic process Increases phenotype PMID:23644946
GO:0016049 Cell growth Affects phenotype PMID:23196670
GO:0016055 Wnt signaling pathway Affects phenotype PMID:23196670
GO:0019432 Triglyceride biosynthetic process Affects phenotype PMID:26693162; PMID:30312631
GO:0030199 Collagen fibril organization Increases phenotype PMID:39197524
GO:0030220 Platelet formation Affects phenotype PMID:29216392
GO:0030224 Monocyte differentiation Increases phenotype PMID:26330309
GO:0030851 Granulocyte differentiation Increases phenotype PMID:26330309
GO:0032125 Micronucleus organization Increases phenotype PMID:36372259; PMID:38823534
GO:0032204 Regulation of telomere maintenance Affects phenotype PMID:32300848
GO:0033148 Positive regulation of intracellular estrogen receptor signaling pathway Increases phenotype PMID:25686467
GO:0034101 Erythrocyte homeostasis Affects phenotype PMID:29216392; PMID:31563530
GO:0035702 Monocyte homeostasis Affects phenotype PMID:29216392
GO:0035938 Estradiol secretion Increases phenotype PMID:27663891
GO:0036124 Histone h3-k9 trimethylation Decreases phenotype PMID:26519613
GO:0040015 Negative regulation of multicellular organism growth Increases phenotype PMID:34256052
GO:0042593 Glucose homeostasis Decreases phenotype PMID:27509375; PMID:29474705
GO:0042759 Long-chain fatty acid biosynthetic process Increases phenotype PMID:29216392
GO:0043433 Negative regulation of dna-binding transcription factor activity Increases phenotype PMID:26022396
GO:0044237 Cellular metabolic process Decreases phenotype PMID:37598416
GO:0045444 Fat cell differentiation Decreases phenotype PMID:25304490
GO:0045821 Positive regulation of glycolytic process Increases phenotype PMID:30821169
GO:0046320 Regulation of fatty acid oxidation Affects phenotype PMID:26396156
GO:0046337 Phosphatidylethanolamine metabolic process Affects phenotype PMID:33096110
GO:0046339 Diacylglycerol metabolic process Affects phenotype PMID:33096110
GO:0046462 Monoacylglycerol metabolic process Affects phenotype PMID:33096110
GO:0046466 Membrane lipid catabolic process Increases phenotype PMID:10771135
GO:0046488 Phosphatidylinositol metabolic process Affects phenotype PMID:33096110
GO:0046621 Negative regulation of organ growth Increases phenotype PMID:34256052
GO:0046849 Bone remodeling Affects phenotype PMID:31820026
GO:0048162 Multi-layer follicle stage Decreases phenotype PMID:34256052
GO:0048165 Fused antrum stage Decreases phenotype PMID:34256052
GO:0050847 Progesterone receptor signaling pathway Decreases phenotype PMID:26022396
GO:0055069 Zinc ion homeostasis Decreases phenotype PMID:26660635; PMID:26967026
GO:0055070 Copper ion homeostasis Decreases phenotype PMID:26660635; PMID:26967026
GO:0055071 Manganese ion homeostasis Decreases phenotype PMID:26660635; PMID:26967026
GO:0055072 Iron ion homeostasis Affects phenotype PMID:26660635
GO:0060242 Contact inhibition Affects phenotype PMID:23196670
GO:0060326 Cell chemotaxis Affects phenotype PMID:38185387
GO:0060349 Bone morphogenesis Decreases phenotype PMID:32119087
GO:0060586 Multicellular organismal iron ion homeostasis Decreases phenotype PMID:25686467
GO:0061519 Macrophage homeostasis Affects phenotype PMID:29216392
GO:0061725 Cytosolic lipolysis Decreases phenotype PMID:33026256
GO:0070165 Positive regulation of adiponectin secretion Increases phenotype PMID:29474705
GO:0070265 Necrotic cell death Increases phenotype PMID:34848246
GO:0070374 Positive regulation of erk1 and erk2 cascade Increases phenotype PMID:29329451
GO:0070994 Detection of oxidative stress Affects phenotype PMID:24378064; PMID:37598416
GO:0071407 Cellular response to organic cyclic compound Increases phenotype PMID:26022396
GO:0072593 Reactive oxygen species metabolic process Affects phenotype PMID:37598416
GO:0080182 Histone h3-k4 trimethylation Increases phenotype PMID:26519613
GO:0097009 Energy homeostasis Affects phenotype PMID:29474705
GO:0140042 Lipid droplet formation Increases phenotype PMID:29216392; PMID:30312631; PMID:33096110
GO:1900017 Positive regulation of cytokine production involved in inflammatory response Increases phenotype PMID:29216392
GO:1901224 Positive regulation of nik/nf-kappab signaling Increases phenotype PMID:26519613
GO:1901522 Positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus Increases phenotype PMID:26022396
GO:1902072 Negative regulation of hypoxia-inducible factor-1alpha signaling pathway Affects phenotype PMID:24355420
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:26410179; PMID:26770886; PMID:30821169; PMID:31563530
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:26967026; PMID:28284859
GO:1903709 Uterine gland development Decreases phenotype PMID:34256052
GO:1903999 Negative regulation of eating behavior Increases phenotype PMID:29474705
GO:2000865 Negative regulation of estradiol secretion Increases phenotype PMID:34256052
GO:2000871 Negative regulation of progesterone secretion Increases phenotype PMID:34256052
GO:2001280 Positive regulation of unsaturated fatty acid biosynthetic process Increases phenotype PMID:29216392
GO:2001303 Lipoxin a4 biosynthetic process Decreases phenotype PMID:27663891
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.